Yoshihara Chieko 芳原智恵子

… Alternative Names

YOSHIHARA Chieko 芳原智恵子

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Researcher Number	40597093
Affiliation (based on the past Project Information) *help	2015: 大妻女子大学, 家政学部, 助手 2011 – 2013: 大妻女子大学, 家政学部, 助手
Review Section/Research Field	Principal Investigator Clinical oncology Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Biomedical engineering/Biological material science
Keywords	Principal Investigator 遺伝子治療 Except Principal Investigator 遺伝子治療 / 抗腫瘍免疫 / 非ウィルスベクター / 結核菌タンパク / DNA複合体 / サイトカイン / 癌免疫療法 / デンジャーシグナル / Ag85B … More / ESAT-6 / 抗腫瘍効果 / プラスミドDNA / 免疫治療 / プラスミド / 遺伝子導入 / 抗腫瘍ワクチン / ネオエピトープ / ネオアンティジェン / 結核菌抗原 / DNAワクチン / GM-CSF / 癌免疫治療 / 薬物伝達システム Less

Development of Novel Antitumor DNA Vaccine Utilizing a Plasmid Expressing a Mycobacterium Tuberculosis Antigen
- Principal Investigator
  
  Koyama Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka Prefecture University
  Otsuma Women's University
PREPARATION OF SMALL PLASMID COMPLEX FOR CANCER THERAPY AND APPLICATION TO MEDIUM ANIMAL CLINICAL STUDYPrincipal Investigator
- Principal Investigator
  
  YOSHIHARA Chieko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Otsuma Women's University
Novel Strategy of Tumor Gene Therapy by Very Small Plasmid Complex Particles
- Principal Investigator
  
  KOYAMA Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Otsuma Women's University

All 2015 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Highly effective non-viral antitumor gene therapy system comprised of biocompatible small plasmid complex particles consisting of pDNA, anionic polysaccharide, and fully deprotected linear polyethylenimine2015
- Author(s)
  Yoshiyuki Koyama, Kikuya Sugiura, Chieko Yoshihara, Toshio Inaba, Tomoko Ito
- Journal Title
  
  Pharmaceutics
  
  Volume: 7 Issue: 3 Pages: 152-164
- DOI
  10.3390/pharmaceutics7030152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350533, KAKENHI-PROJECT-15K14888, KAKENHI-PROJECT-23380174, KAKENHI-PROJECT-25350555, KAKENHI-PROJECT-24380172
[Journal Article] Novel antitumor strategy by transfection of plasmid expressing mycobacterium tuberculosis antigen as a "Danger Signal" to block immune escape of tumor cells2015
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Tomoko Ito
- Journal Title
  
  Pharmaceutics
  
  Volume: 7 Issue: 3 Pages: 165-174
- DOI
  10.3390/pharmaceutics7030165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350533, KAKENHI-PROJECT-25350555
[Journal Article] Antitumor effect of chondroitin sulfate-coated ternary granulocyte macrophage-colony-stimulating factor plasmid complex for ovarian cancer2012
- Author(s)
  Hamada K., Yoshihara C., Ito T., Tani K., Tagawa M., Sakuragawa N., Itoh H., Koyama Y.
- Journal Title
  
  J Gene Med.
  
  Volume: 14 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012
- Author(s)
  CHIEKO YOSHIHARA, 他
- Journal Title
  
  ONCOLOGY LETTERS
  
  Volume: 3 Issue: 2 Pages: 387-390
- DOI
  10.3892/ol.2011.467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430, KAKENHI-PROJECT-23592453
[Journal Article] Novel Antitumor Strategy by Transfection of Plasmids Encoding Pathogenic Antigen- and Cytokine-Genes2012
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Tomoko Ito, Ph.D.1,2 and Masazumi Eriguchi
- Journal Title
  
  American Society of Gene & Cell Therapy 15th Annual Meeting, Philadelphia, USA
  
  Volume: May Pages: 15-19
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Oncolytic plasmid: A novel strategy for tumor immuno-gene therapy2012
- Author(s)
  Chieko Yoshihara, Katuyuki Hamada, Minako Kuroda, Yoshiyuki Koyama
- Journal Title
  
  Oncology Letters
  
  Volume: 3 Pages: 387-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Antitumor effect of chondroitin sulfate-coated Ternary-granulocytemacrophage-colony-stimul ating factor plasmid complex for ovarian cancer2012
- Author(s)
  Hamada K., Yoshihara C., Ito T., Tani K., Tagawa M., Sakuragawa N., Itoh H., Koyama Y.
- Journal Title
  
  J Gene Med.
  
  Volume: 14 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Antitumor effect of chondroitin sulfate-coated ternary granulocyte macrophage-colony-stimulating factor plasmid complex for ovarian cancer2012
- Author(s)
  Katsuyuki Hamada、Chieko Yoshihara、Tomoko Ito、Kenzaburo Tani、Masatoshi Tagawa、Norio Sakuragawa、Hiroshi Itoh、Yoshiyuki Koyama
- Journal Title
  
  THE JOURNAL OF GENE MEDICINE
  
  Volume: 14 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012
- Author(s)
  Yoshihara C., Hamada K., Kuroda M., Koyama Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 3 Pages: 387-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012
- Author(s)
  Yoshihara C., Hamada K., Kuroda M., Koyama Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 3 Pages: 387-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Masahiko Tojyo, Tomoko Ito, and Katsuyuki Hamada
- Journal Title
  
  American Society of Gene & Cell Therapy 14th Annual Meeting,Seattle, Washington,USA
  
  Volume: 2011.5
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Highly Effective Non-viral Antitumor Gene Therapy System Comprising Biocompatible Small Plasmid Complex Particles2011
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara
- Journal Title
  
  American Society of Gene & Cell Therapy 14th Annual Meeting,Seattle, Washington,USA
  
  Volume: 2011.5
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Loosening of DNA/polycation complexes by synthetic polyampholyte to improve the transcription efficiency : effect of charge balance in the polyampholyte2010
- Author(s)
  Yoshihara C., Shew C-Y., Ito T., Koyama Y.
- Journal Title
  
  Biophys J.
  
  Volume: 98 Pages: 1257-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] DNA/polyethyleneimine/hyaluronic acid small complex particles and tumor suppression in mice2010
- Author(s)
  Ito T., Yoshihara C., Hamada K., Koyama Y.
- Journal Title
  
  Biomaterials
  
  Volume: 31 Pages: 2912-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Loosening of DNA/Polycation Complexes by Synthetic Polyampholyte to Improve the Transcription Efficiency : Effect of Charge Balance in the Polyampholyte2010
- Author(s)
  C.Yoshihara, et.al.
- Journal Title
  
  Biophysical Journal
  
  Volume: 98 Pages: 1257-1266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Patent] 新規な複合体、それを含有する医薬及び癌の治療方法2011
- Inventor(s)
  小山義之、芳原智恵子
- Industrial Property Rights Holder
  アルファ・ナノ・メディカ(株)
- Industrial Property Number
  2011-201136
- Filing Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-21500430
[Patent] 新規なベクター、それを含有する医薬及び癌の治療方法2010
- Inventor(s)
  濱田雄行、小山義之、芳原智恵子、伊藤智子
- Industrial Property Rights Holder
  アルファ・ナノ・メディカ(株)
- Industrial Property Number
  2010-020766
- Filing Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] 結核菌抗原遺伝子をコードしたプラスミド複合体の調製と癌治療効果2013
- Author(s)
  芳原智恵子、小山義之
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 抗原性の強い微生物タンパクをコードしたプラスミド複合体による新しいガン免疫遺伝子治療戦略2013
- Author(s)
  芳原智恵子
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] 微生物抗原遺伝子導入による抗腫瘍免疫の亢進2013
- Author(s)
  芳原智恵子、伊藤智子、牛草貴博、小山義之
- Organizer
  第13回遺伝子・デリバリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Evaluation by the electron microscope of the oncolytic adenovirus by polymer multiplex processing treatment2013
- Author(s)
  Takagi Kazuko、Hamada Katsuyuki,、Tomoko Ito、Chieko Yoshihara、Yoshiyuki Koyama
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 腫瘍細胞への結核菌抗原遺伝子導入による抗腫瘍免疫治療効果2013
- Author(s)
  芳原智恵子、小山義之
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Novel strategy for tumor immunotherapy with a transfection of plasmid encoding pathogenic antigens2013
- Author(s)
  芳原智恵子、伊藤智子、牛草貴博、小山義之
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] プロタミン／ヒアルロン酸高分子イオン複合体を用いたサイトカイン徐放システムの創成2012
- Author(s)
  芳原智恵子、伊藤智子、黒田美奈子、江里口正純、小山義之
- Organizer
  第28回日本DDS学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 結核菌抗原タンパク遺伝子を用いた免疫治療－免疫賦活化機能とガン治療への応用－2012
- Author(s)
  小山義之、芳原智恵子、伊藤智子
- Organizer
  第87回結核病学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Novel Antitumor Strategy by Transfection of Plasmids Encoding Pathogenic Antigen-and Cytokine-Genes2012
- Author(s)
  Y. Koyama, C. Yoshihara, T. Ito, and M. Eriguchi
- Organizer
  American Society of Gene and Cell Therapy
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] Novel Antitumor Strategy by Transfection of Plasmids Encoding Pathogenic Antigen- and Cytokine-Genes2012
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Tomoko Ito, and Masazumi Eriguchi
- Organizer
  American Society of Gene & Cell Therapy　15th Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 結核菌抗原遺伝子をコードしたプラスミド複合体の調製と動物臨床の応用2012
- Author(s)
  芳原智恵子、伊藤智子、牛草貴博, Min Chai,小山義之
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 高分子イオン複合体を用いたサイトカイン徐放システムの開発2011
- Author(s)
  黒田美奈子、芳原智恵子、小山義之
- Organizer
  第33回バイオマテリアル学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Masahiko Tojyo, Tomoko Ito, Katsuyuki Hamada
- Organizer
  American Society of Gene & Cell Therapy 14th Annual Meeting
- Place of Presentation
  Seattle, Washington,USA
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 微生物抗原遺伝子を用いた新しい癌治療の試み2011
- Author(s)
  芳原智恵子、黒田美奈子、小山義之
- Organizer
  第33回バイオマテリアル学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 高分子イオン複合体を用いたサイトカイン徐放デバイスの創製とその抗腫瘍効果2011
- Author(s)
  黒田美奈子、芳原智恵子、小山義之
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Oncolytic Plasmid, A Novel Antitumor Strategy With Plasmid Encoding adenovirus Protein2011
- Author(s)
  小山義之、芳原智恵子、黒田美奈子、東條雅彦、濱田雄行
- Organizer
  第17回日本遺伝子治療学会年次学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] ウィルス抗原遺伝子を用いたガン免疫治療の新しい考えかた2011
- Author(s)
  小山義之、芳原智恵子、黒田美奈子、濱田雄行
- Organizer
  第21回バイオ・高分子シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 微生物抗原遺伝子を用いた腫瘍免疫遺伝子治療システムの開発2011
- Author(s)
  芳原智恵子, 黒田美奈子, 東條雅彦, 小山義之
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム 2011
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Highly Effective Non-viral Antitumor Gene Therapy System Comprising Biocompatible Small Plasmid Complex Particles2011
- Author(s)
  Chieko Yoshihara, Tomoko Ito, Yoshiyuki Koyama
- Organizer
  American Society of Gene & Cell Therapy 14th Annual Meeting
- Place of Presentation
  Seattle, Washington,USA
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Preparation Of Small Plasmid Complex For Cancer Therapy And Application To Medium Animal Clinical Study2011
- Author(s)
  芳原智恵子、小山義之、伊藤智子、岡野正三
- Organizer
  第17回日本遺伝子治療学会年次学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 微生物抗原遺伝子を用いた腫瘍免疫遺伝子治療システムの開発2011
- Author(s)
  芳原智恵子, 黒田美奈子, 東條雅彦, 小山義之
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2011
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011
- Author(s)
  Y. Koyama, M. Tojyo, C. Yoshihara, K. Hamada, and T. Ito
- Organizer
  American Society of Gene and Cell Therapy
- Place of Presentation
  Seattle
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] Novel Adenovirus Complexes Having Artificial Envelope For Tumor Gene Therapy2011
- Author(s)
  小山義之、芳原智恵子、濱田雄行
- Organizer
  第17回日本遺伝子治療学会年次学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 微生物抗原遺伝子によるがん治療2011
- Author(s)
  小山義之、黒田美奈子、芳原智恵子
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Small Plasmid/PEI/Anionic Polysaccharide Ternary Complex Particles : Toxicity and Animal Clinical Study2010
- Author(s)
  Y. Koyama, M. Tojyo, C. Yoshihara, K. Hamada, and T. Ito
- Organizer
  American Society of Gene and Cell Therapy
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] 微生物抗原遺伝子導入による抗腫瘍免疫の亢進
- Author(s)
  芳原智恵子
- Organizer
  遺伝子・デリバリー研究会第１３回シンポジウム
- Place of Presentation
  帝京大学板橋キャンパス
- Data Source
  KAKENHI-PROJECT-25350555

1. KOYAMA Yoshiyuki (00162090)

# of Collaborated Projects: 3 results

# of Collaborated Products: 37 results
2. ITO Tomoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yoshihara Chieko 芳原 智恵子

YOSHIHARA Chieko 芳原 智恵子

Research Projects

Research Products

Co-Researchers

Development of Novel Antitumor DNA Vaccine Utilizing a Plasmid Expressing a Mycobacterium Tuberculosis Antigen

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PREPARATION OF SMALL PLASMID COMPLEX FOR CANCER THERAPY AND APPLICATION TO MEDIUM ANIMAL CLINICAL STUDYPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel Strategy of Tumor Gene Therapy by Very Small Plasmid Complex Particles

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Highly effective non-viral antitumor gene therapy system comprised of biocompatible small plasmid complex particles consisting of pDNA, anionic polysaccharide, and fully deprotected linear polyethylenimine2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel antitumor strategy by transfection of plasmid expressing mycobacterium tuberculosis antigen as a "Danger Signal" to block immune escape of tumor cells2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor effect of chondroitin sulfate-coated ternary granulocyte macrophage-colony-stimulating factor plasmid complex for ovarian cancer2012

Author(s)

Journal Title

Data Source

[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Antitumor Strategy by Transfection of Plasmids Encoding Pathogenic Antigen- and Cytokine-Genes2012

Author(s)

Journal Title

Data Source

[Journal Article] Oncolytic plasmid: A novel strategy for tumor immuno-gene therapy2012

Author(s)

Journal Title

Data Source

[Journal Article] Antitumor effect of chondroitin sulfate-coated Ternary-granulocytemacrophage-colony-stimul ating factor plasmid complex for ovarian cancer2012

Author(s)

Journal Title

Data Source

[Journal Article] Antitumor effect of chondroitin sulfate-coated ternary granulocyte macrophage-colony-stimulating factor plasmid complex for ovarian cancer2012

Author(s)

Journal Title

Data Source

[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012

Author(s)

Journal Title

Data Source

[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012

Author(s)

Journal Title

Data Source

[Journal Article] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011

Author(s)

Journal Title

Data Source

[Journal Article] Highly Effective Non-viral Antitumor Gene Therapy System Comprising Biocompatible Small Plasmid Complex Particles2011

Author(s)

Journal Title

Data Source

[Journal Article] Loosening of DNA/polycation complexes by synthetic polyampholyte to improve the transcription efficiency : effect of charge balance in the polyampholyte2010

Author(s)

Journal Title

Data Source

[Journal Article] DNA/polyethyleneimine/hyaluronic acid small complex particles and tumor suppression in mice2010

Author(s)

Yoshihara Chieko 芳原智恵子

YOSHIHARA Chieko 芳原智恵子

[Presentation] 抗原性の強い微生物タンパクをコードしたプラスミド複合体による新しいガン免疫遺伝子治療戦略2013