Adachi Keishi 安達圭志

… Alternative Names

ADACHI Keishi 安達圭志

Less

Researcher Number	40598611
Other IDs
External Links
Affiliation (Current)	2025: 山口大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 山口大学, 大学院医学系研究科, 講師 2023: 山口大学, 大学院医学系研究科, 講師 2018 – 2021: 山口大学, 大学院医学系研究科, 講師 2017: 山口大学, 大学院医学系研究科, 助教 2012 – 2016: 山口大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Parasitology (including Sanitary zoology) Except Principal Investigator Tumor therapeutics
Keywords	Principal Investigator がん / CAR-T細胞 / CCL19 / IL-7 / キメラ抗原受容体 / サイトカイン / T細胞 / 他系（アロ） / 樹状細胞 / エピトープスプレッディング … More / 細胞内シグナル / CAR / 概念実証実験 / 抗核抗体 / 抗がん作用 / 抗がん効果 / ケモカイン / 次世代型キメラ抗原受容体発現T細胞 / 住血吸虫 / 肝臓 … More Except Principal Investigator 免疫学 / 癌 Less

新規がん治療薬として使用可能なCAR発現細胞外小胞開発に向けた概念実証試験Principal Investigator
- Principal Investigator
  
  安達圭志
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Yamaguchi University
Analysis of epitope-spreading induction mechanism applicable to the development of the next-generation CAR T-cell therapyPrincipal Investigator
- Principal Investigator
  
  Adachi Keishi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Yamaguchi University
Development of next generation chimeric antigen receptor T cells that regulate intracellular signaling in the tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  ADACHI Keishi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Yamaguchi University
Cancer immunology research to enhance therapeutic effects of immune checkpoint blockade
- Principal Investigator
  
  TAMADA Koji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Yamaguchi University
Development of novel chimeric antigen receptor-expressing T cells promoting immune cell infiltration and survival in the tumor tissuePrincipal Investigator
- Principal Investigator
  
  ADACHI Keishi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Yamaguchi University
Analysis of the unique hepatic T cell population induced during Schistosoma mansoni infection in micePrincipal Investigator
- Principal Investigator
  
  ADACHI Keishi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Yamaguchi University

All 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] 遺伝子改変T細胞療法と免疫チェックポイント阻害剤2019
- Author(s)
  安達圭志、玉田耕治
- Journal Title
  
  Medical Science Digest
  
  Volume: Vol45(2) Pages: 40-44
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] 複合免疫療法のあり方2019
- Author(s)
  安達圭志、玉田耕治
- Journal Title
  
  実験医学
  
  Volume: 37(15) Pages: 109-115
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells2019
- Author(s)
  Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K
- Journal Title
  
  Cancer Sci
  
  Volume: 110(10) Issue: 10 Pages: 3079-3088
- DOI
  10.1111/cas.14169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08646, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-16H02474
[Journal Article] 固形がんを標的とするCAR-T細胞の新しいプラットフォーム技術2019
- Author(s)
  安達圭志、玉田耕治
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 72(2) Pages: 180-187
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] 固形がんに対するIL-7/CCL19産生型CAR-T細胞療法の研究開発2019
- Author(s)
  安達圭志、玉田耕治
- Journal Title
  
  医学のあゆみ
  
  Volume: 271(9) Pages: 908-913
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment.2019
- Author(s)
  Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
- Journal Title
  
  Cancer Immunology and Immunotheraoy
  
  Volume: 68 Issue: 2 Pages: 201-211
- DOI
  10.1007/s00262-018-2263-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10603, KAKENHI-PROJECT-16H02474, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-16K15623
[Journal Article] Microbial biomarkers for immune checkpoint blockade therapy against cancer2018
- Author(s)
  Adachi K., Tamada K
- Journal Title
  
  J Gastroenterol
  
  Volume: 53 Issue: 9 Pages: 999-1005
- DOI
  10.1007/s00535-018-1492-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor.2018
- Author(s)
  1.Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda, Koji Tamada
- Journal Title
  
  Nature Biotechnology
  
  Volume: 36(4) Issue: 4 Pages: 346-351
- DOI
  10.1038/nbt.4086
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02474, KAKENHI-PROJECT-26830107, KAKENHI-PROJECT-16H05420
[Journal Article] 免疫チェックポイント阻害剤のもたらしたインパクト2017
- Author(s)
  安達圭志、玉田耕治
- Journal Title
  
  遺伝子医学MOOK がん免疫療法
  
  Volume: - Pages: 37-42
- Data Source
  KAKENHI-PROJECT-16H02474
[Journal Article] Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion.2016
- Author(s)
  Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107(4) Issue: 4 Pages: 398-406
- DOI
  10.1111/cas.12861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26640104, KAKENHI-PROJECT-25290057, KAKENHI-PROJECT-16H02474
[Journal Article] Involvement of IL-18 in the expansion of unique hepatic T cells with unconventional cytokine profiles during Schistosoma mansoni infection2014
- Author(s)
  Keishi Adachi, Risa Nakamura, Yoshio Osada, Masachika Senba, Koji Tamada, Shinjiro Hamano
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 5 Pages: e96042-e96042
- DOI
  10.1371/journal.pone.0096042
- NAID
  120006986559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790402, KAKENHI-PROJECT-25460523, KAKENHI-PROJECT-25670204
[Journal Article] Unique T Cells with Unconventional Cytokine Profiles Induced in the Livers of Mice during Schistosoma mansoni Infection2013
- Author(s)
  Keishi Adachi, Yoshio Osada, Risa Nakamura, Koji Tamada, Shinjiro Hamano
- Journal Title
  
  PLOS ONE
  
  Volume: 8 Issue: 12 Pages: e82698-e82698
- DOI
  10.1371/journal.pone.0082698
- NAID
  120006986731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790402, KAKENHI-PROJECT-25460523
[Patent] 免疫機能制御因子を発現する免疫担当細胞及び発現ベクター2017
- Inventor(s)
  玉田耕治, 佐古田幸美, 安達圭志
- Industrial Property Rights Holder
  国立大学法人山口大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-26830107
[Patent] CAR発現ベクター及びCAR発現T細胞2016
- Inventor(s)
  玉田耕治, 佐古田幸美, 安達圭志
- Industrial Property Rights Holder
  国立大学法人山口大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2016
- Overseas
- Data Source
  KAKENHI-PROJECT-26830107
[Presentation] Development of functionally improved, novel chimeric antigen receptor-expressing T cells against tumors2015
- Author(s)
  Keishi Adachi and Koji Tamada
- Organizer
  International Conference of Cancer Immunotherapy and Macrophages 2015
- Place of Presentation
  東京大学伊藤国際学術センター内伊藤謝恩ホール（東京都文京区）
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830107
[Presentation] マンソン住血吸虫感染マウスの肝臓内に認められる、ユニークなT細胞集団の解析2013
- Author(s)
  Keishi Adachi, Shinjiro Hamano
- Organizer
  第82回日本寄生虫学会大会
- Place of Presentation
  東京都文京区(東京医科歯科大学)
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] マンソン住血吸虫感染マウスの肝臓内に認められる、ユニークなT細胞集団の解析2013
- Author(s)
  安達圭志
- Organizer
  第82回日本寄生虫学会大会
- Place of Presentation
  東京都文京区　東京医科歯科大学
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] マンソン住血吸虫感染時にマウスの肝臓内で増加する、ユニークなサイトカイン産生能を有するT細胞集団について2013
- Author(s)
  Keishi Adachi, Yoshio Osada, Risa Nakamura, Koji Tamada, Shinjiro Hamano
- Organizer
  第54回日本熱帯医学会大会
- Place of Presentation
  長崎県長崎市（長崎ブリックホール）
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] マンソン住血吸虫感染時にマウスの肝臓内で増加する、ユニークなサイトカイン産生能を有するT細胞集団について2013
- Author(s)
  Keishi Adachi, Yoshio Osada, Risa Nakamura, Koji Tamada, Shinjiro Hamano
- Organizer
  第54回日本熱帯医学会大会
- Place of Presentation
  長崎県長崎市(長崎ブリックホール)
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] マンソン住血吸虫感染マウスの肝臓に誘導される、ユニークなT細胞について2012
- Author(s)
  安達圭志、濱野真二郎
- Organizer
  第6回蠕虫研究会
- Place of Presentation
  宮崎県宮崎市(青島サンクマール)
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] マンソン住血吸虫感染マウスの肝臓に誘導される、ユニークなT細胞について2012
- Author(s)
  安達圭志
- Organizer
  第６回蠕虫研究会
- Place of Presentation
  宮崎県宮崎市　青島サンクマール
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] Analysis of the unique hepatic T cell population induced during Schistosoma mansoni infection in mice2012
- Author(s)
  Keishi Adachi, Shinjiro Hamano
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  兵庫県神戸市(神戸国際会議場)
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] Analysis of the unique hepatic T cell population induced during Schistosoma mansoni infection in mice2012
- Author(s)
  Keishi Adachi, Shinjiro Hamano
- Organizer
  第10回分子寄生虫マラリアフォーラム
- Place of Presentation
  群馬県前橋市(群馬大学医学部刀城会館)
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] Analysis of the unique hepatic T cell population induced during Schistosoma mansoni infection in mice2012
- Author(s)
  Keishi Adachi, Shinjiro Hamano
- Organizer
  The 6^<th> Nagasaki Symposium on Tropical and Emerging Infectious Disease
- Place of Presentation
  長崎県長崎市(長崎大学良順会館)
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] マンソン住血吸虫感染が誘導するユニークな肝臓内免疫反応について2012
- Author(s)
  安達圭志、濱野真二郎(発表は濱野)
- Organizer
  第65回日本寄生虫学会・第62回日本衛生動物学会南日本支部合同大会
- Place of Presentation
  長崎県長崎市(長崎大学医学部ポンペ会館)
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] Analysis of the unique hepatic T cell population induced during Schistosoma mansoni infection in mice2012
- Author(s)
  安達圭志
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  兵庫県神戸市　神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] Analysis of the enigmatic immune responses in the liver induced by Schistosoma mansoni infection2012
- Author(s)
  安達圭志
- Organizer
  第10回分子寄生虫マラリアフォーラム
- Place of Presentation
  群馬県前橋市　群馬大学医学部刀城会館
- Data Source
  KAKENHI-PROJECT-24790402
[Presentation] Analysis of the unique hepatic T cell population induced during Schistosoma mansoni infection in mice2012
- Author(s)
  安達圭志
- Organizer
  The 6th Nagasaki Symposium on Tropical and Emerging Infectious Diseases
- Place of Presentation
  長崎県長崎市　長崎大学良順会館
- Data Source
  KAKENHI-PROJECT-24790402

1. TAMADA Koji (00615841)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. 佐古田幸美 (30629754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. OJIMA Toshiyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 永野浩昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山上裕機

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Adachi Keishi 安達 圭志

ADACHI Keishi 安達 圭志

Research Projects

Research Products

Co-Researchers

新規がん治療薬として使用可能なCAR発現細胞外小胞開発に向けた概念実証試験Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of epitope-spreading induction mechanism applicable to the development of the next-generation CAR T-cell therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next generation chimeric antigen receptor T cells that regulate intracellular signaling in the tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cancer immunology research to enhance therapeutic effects of immune checkpoint blockade

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel chimeric antigen receptor-expressing T cells promoting immune cell infiltration and survival in the tumor tissuePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the unique hepatic T cell population induced during Schistosoma mansoni infection in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 遺伝子改変T細胞療法と免疫チェックポイント阻害剤2019

Author(s)

Journal Title

Data Source

[Journal Article] 複合免疫療法のあり方2019

Author(s)

Journal Title

Data Source

[Journal Article] Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 固形がんを標的とするCAR-T細胞の新しいプラットフォーム技術2019

Author(s)

Journal Title

Data Source

[Journal Article] 固形がんに対するIL-7/CCL19産生型CAR-T細胞療法の研究開発2019

Author(s)

Journal Title

Data Source

[Journal Article] Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microbial biomarkers for immune checkpoint blockade therapy against cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 免疫チェックポイント阻害剤のもたらしたインパクト2017

Author(s)

Journal Title

Adachi Keishi 安達圭志

ADACHI Keishi 安達圭志