MIYAI TAKASHI 宮井尊史

… Alternative Names

宮井尊史ミヤイタカシ

MIYAI Takashi 宮井尊史

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Researcher Number	40599007
Other IDs	https://orcid.org/0000-0001-5286-8272
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 東京大学, 医学部附属病院, 講師 2018 – 2019: 東京大学, 医学部附属病院, 講師 2011 – 2012: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology
Keywords	Principal Investigator 角膜内皮細胞 / ゲノム編集 / フックス角膜内皮ジストロフィ / リピート病 / RNA-seq / フックス角膜内皮変性症 / RNAseq / CRISPR/Cas9 / Fuchs角膜内皮変性症 / 全ゲノムシーケンス … More / RNA seq / トリプレットリピート / Fuchs角膜変性症 / TCF4 / Fuchs角膜内皮ジストロフィ / 角膜内皮 / 角膜ジストロフィ / コラーゲンクロスリンキング / 角膜菲薄化疾患 / 角膜クロスリンキング / コラーゲン / 角膜 Less

Fuchs角膜内皮変性症に対するゲノム医療の開発Principal Investigator
- Principal Investigator
  
  宮井尊史
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  The University of Tokyo
A study to elucidate influence of triplet repeat expansion on pathology in Fuchs endothelial corneal dystrophyPrincipal Investigator
- Principal Investigator
  
  MIYAI TAKASHI
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  The University of Tokyo
Study of artificial cornea transplantation by using collagen cross-linking for corneal thinning diseasePrincipal Investigator
- Principal Investigator
  
  MIYAI Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair2020
- Author(s)
  Kitamoto Kohdai、Taketani Yukako、Fujii Wataru、Inamochi Aya、Toyono Tetsuya、Miyai Takashi、Yamagami Satoru、Kuroda Masahiko、Usui Tomohiko、Ouchi Yasuo
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 2000-2000
- DOI
  10.1038/s41598-020-58876-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16947, KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-17K10564, KAKENHI-PROJECT-17K11446, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-17K07212
[Journal Article] Ultraviolet A light induced DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.2020
- Author(s)
  Liu C, Miyajima T, Melangath G, Miyai T, Vasanth S, Deshpande N, Kumar V, Ong Tone S, Gupta R, Zhu S, Vojnovic D, Chen Y, Rogan EG, Mondal B, Zahid M, Jurkunas UV.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 117 Issue: 1 Pages: 573-583
- DOI
  10.1073/pnas.1912546116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16947
[Journal Article] Comparison of 5-Year Clinical Results of Descemet and Non-Descemet Stripping Automated Endothelial Keratoplasty.2020
- Author(s)
  Omoto T, Toyono T, Inoue T, Shirakawa R, Yoshida J, Miyai T, Yamagami S, Usui T.
- Journal Title
  
  Cornea.
  
  Volume: 39 Issue: 5 Pages: 573-577
- DOI
  10.1097/ico.0000000000002211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16947, KAKENHI-PROJECT-18K16917
[Journal Article] Retinal dystrophy associated with Danon disease and pathogenic mechanism through LAMP2-mutated retinal pigment epithelium2019
- Author(s)
  Fukushima Masaya、Inoue Tatsuya、Miyai Takashi、Obata Ryo
- Journal Title
  
  European Journal of Ophthalmology
  
  Volume: - Issue: 3 Pages: 570-578
- DOI
  10.1177/1120672119832183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16947
[Journal Article] Simple oral mucosal epithelial transplantation in a rabbit model2019
- Author(s)
  Inamochi Aya、Tomioka Akiko、Kitamoto Kohdai、Miyai Takashi、Usui Tomohiko、Aihara Makoto、Yamagami Satoru
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 18088-18088
- DOI
  10.1038/s41598-019-54571-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16947, KAKENHI-PROJECT-17K11492
[Journal Article] Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy.2019
- Author(s)
  Miyai T, Vasanth S, Melangath G, Deshpande N, Kumar V, Benischke AS, Chen Y, Price MO, Price FW Jr, Jurkunas UV.
- Journal Title
  
  Am J Pathol.
  
  Volume: 189 Issue: 10 Pages: 2061-2076
- DOI
  10.1016/j.ajpath.2019.06.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16947
[Journal Article] Huge Corneal Fibroma.2019
- Author(s)
  Fujita A, Ushiku T, Miyai T.
- Journal Title
  
  Ophthalmology.
  
  Volume: 126 Issue: 11 Pages: 1526-1526
- DOI
  10.1016/j.ophtha.2019.06.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16947
[Journal Article] Severity Assessment of Acute Hydrops Due to Recurrent Keratoconus after Penetrating Keratoplasty Using Anterior Segment Optical Coherence Tomography2019
- Author(s)
  Fujita Asahi、Yoshida Junko、Toyono Tetsuya、Usui Tomohiko、Miyai Takashi
- Journal Title
  
  Current Eye Research
  
  Volume: 44 Issue: 11 Pages: 1189-1194
- DOI
  10.1080/02713683.2019.1629597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16917, KAKENHI-PROJECT-18K16947
[Journal Article] Fuchs Endothelial Corneal Dystrophy and Mitochondria2018
- Author(s)
  Miyai Takashi
- Journal Title
  
  Cornea
  
  Volume: 37 Issue: 1 Pages: S74-S77
- DOI
  10.1097/ico.0000000000001746
- Data Source
  KAKENHI-PROJECT-18K16947
[Journal Article] 【リピート病の病態機構UPDATE-RNA毒性とRAN翻訳】 Fuchs角膜内皮変性症におけるリピート病態2018
- Author(s)
  宮井尊史
- Journal Title
  
  医学のあゆみ
  
  Volume: 267 Pages: 814-816
- Data Source
  KAKENHI-PROJECT-18K16947
[Journal Article] Characteristics and risk factors of recurrent keratoconus over the long term after penetrating keratoplasty2018
- Author(s)
  Yoshida Junko、Murata Hiroshi、Miyai Takashi、Shirakawa Rika、Toyono Tetsuya、Yamagami Satoru、Usui Tomohiko
- Journal Title
  
  Graefe's Archive for Clinical and Experimental Ophthalmology
  
  Volume: 256 Issue: 12 Pages: 2377-2383
- DOI
  10.1007/s00417-018-4131-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20306, KAKENHI-PROJECT-18K16917, KAKENHI-PROJECT-18K16947
[Journal Article] Descemet Stripping Automated Endothelial Keratoplasty for Failed Penetrating Keratoplasty2018
- Author(s)
  Omoto Takashi、Sakisaka Toshihiro、Toyono Tetsuya、Yoshida Junko、Shirakawa Rika、Miyai Takashi、Yamagami Satoru、Usui Tomohiko
- Journal Title
  
  Cornea
  
  Volume: 37 Issue: 4 Pages: 462-465
- DOI
  10.1097/ico.0000000000001531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20306, KAKENHI-PROJECT-18K16947
[Journal Article] Corneal thickness and volume measurements by swept source anterior segment optical coherence tomography in normal subjects2013
- Author(s)
  Fukuda R, Usui T, Miyai T, Mori Y, Miyata K, Amano S
- Journal Title
  
  Curr Eye Res
  
  Volume: 38(5) Pages: 531-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] Influences of cycloplegia with topical atropine on ocular higher-order aberrations2013
- Author(s)
  Hiraoka T, Miyata K, Nakamura Y, Miyai T, Ogata M, Okamoto F, Oshika T
- Journal Title
  
  Ophthalmology
  
  Volume: 120(1) Pages: 8-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] 円錐角膜の新しい治療　海外の現状2013
- Author(s)
  宮井尊史
- Journal Title
  
  IOL　＆　RS
  
  Volume: 27 Pages: 44-47
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] Tear meniscus evaluation by anterior segment swept-source optical coherence tomography2013
- Author(s)
  Fukuda R, Usui T, Miyai T, Yamagami S, Amano S
- Journal Title
  
  Am J Ophthalmol
  
  Volume: 155(4) Pages: 620-624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] Relationship between total tear IgE and specific serum IgE in autumnal allergic conjunctivitis2013
- Author(s)
  Mimura T, Usui T, Yamagami S, Miyai T, Amano S
- Journal Title
  
  Cornea
  
  Volume: 32(1) Pages: 14-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] Relation between total tear IgE and severity of acute seasonal allergic conjunctivitis2012
- Author(s)
  Mimura T, Usui T, Yamagami S, Miyai T, Amano S
- Journal Title
  
  Curr Eye Res
  
  Volume: 37(10) Pages: 864-870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] Noninvasive observations of peripheral angle in eyes after penetrating keratoplasty using anterior segment fourier-domain optical coherence tomography2012
- Author(s)
  Fukuda R, Usui T, Tomidokoro A, Mishima K, Matagi N, Miyai T, Amano S, Araie M
- Journal Title
  
  Cornea
  
  Volume: 31(3) Pages: 259-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] Intraoperative mydriasis by intracameral injection of mydriatic eye drops: in vivo efficacy and in vitro safety studies2011
- Author(s)
  Mori Y, Miyai T, Kagaya F, Nagai N, Osakabe Y, Miyata K, Amano S.
- Journal Title
  
  Clin Experiment Ophthalmol.
  
  Volume: 39(5) Pages: 456-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Journal Article] Limbal relaxing incisions using a reference point and corneal topography for intraoperative identification of the steepest meridian2011
- Author(s)
  Miyata K, Miyai T, Minami K, Bissen-Miyajima H, Maeda N, Amano S
- Journal Title
  
  J Refract Surg
  
  Volume: 27(5) Pages: 339-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791970
[Presentation] Effect of mitochondrial fission inhibitor, Mdivi-1, on apoptosis related pathway in corneal endothelium2019
- Author(s)
  Takashi Miyai
- Organizer
  The 16th Conference of Asian Society for Mitochondrial Research and Medicine & The 19th Conference of Japanese Society of Mitochondrial Research and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16947
[Presentation] 角膜クロスリンキング2019
- Author(s)
  宮井尊史
- Organizer
  第73回　日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-18K16947
[Presentation] CTG repeat excision in TCF4 gene of corneal endothelium with CRISPR-cas92019
- Author(s)
  Takashi Miyai, Kodai Kitamoto, Yukako Taketani, Yasuo Ouchi, Tomohiko Usui
- Organizer
  第123回　日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-18K16947
[Presentation] CRISPR-Cas9を用いた角膜内皮細胞におけるTCF4遺伝子のCTGリピート部位の切除2019
- Author(s)
  宮井尊史
- Organizer
  日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-18K16947
[Presentation] Genome-editing with CRISPR-Cas9 system targeting intronic CTG repeat of TCF4 gene in corneal endothelium.2019
- Author(s)
  Takashi Miyai
- Organizer
  Association for Research in Vision and Ophthalmology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16947
[Presentation] Genome-editing with CRISPR-cas9 system targeting intronic CTG repeat of TCF4 gene in corneal endothelium.2019
- Author(s)
  Takashi Miyai, Kodai Kitamoto, Yukako Taketani, Yasuo Ouchi, Tomohiko Usui
- Organizer
  The Association　forResearch in Vision and Ophthalmology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16947
[Presentation] Frequencies and characteristics of renewing rigid gas permeable contact lenses in keratoconus patients2012
- Author(s)
  Miyai T, Mimura T, Usui T, Yamagami S, Amano S.
- Organizer
  The Association for Research in Vision and Ophthalmology 2012 annual meeting
- Place of Presentation
  アメリカ、フォートローダーデール
- Year and Date
  2012-05-09
- Data Source
  KAKENHI-PROJECT-23791970
[Presentation] インストラクションコース円錐角膜の最新の治療今後の展望2012
- Author(s)
  宮井尊史
- Organizer
  第27回日本白内障屈折矯正手術学会総会
- Place of Presentation
  東京
- Year and Date
  2012-06-16
- Data Source
  KAKENHI-PROJECT-23791970
[Presentation] Frequencies and characteristics of renewing rigid gas permeable contact lenses in keratoconus patients
- Author(s)
  Takashi Miyai
- Organizer
  2012 Annual Meeting of the Association for Research in Vision and Ophthalmology
- Place of Presentation
  Fort Lauderdale, FL, USA
- Data Source
  KAKENHI-PROJECT-23791970
[Presentation] 円錐角膜の新しい治療　今後の展望
- Author(s)
  宮井尊史
- Organizer
  第27回日本白内障屈折矯正手術学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791970

1. 高地雄太 (60415156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 真下知士 (80397554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 白川理香

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 吉田絢子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYAI TAKASHI 宮井 尊史

宮井 尊史 ミヤイ タカシ

MIYAI Takashi 宮井 尊史

Research Projects

Research Products

Co-Researchers

Fuchs角膜内皮変性症に対するゲノム医療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study to elucidate influence of triplet repeat expansion on pathology in Fuchs endothelial corneal dystrophyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of artificial cornea transplantation by using collagen cross-linking for corneal thinning diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ultraviolet A light induced DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of 5-Year Clinical Results of Descemet and Non-Descemet Stripping Automated Endothelial Keratoplasty.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinal dystrophy associated with Danon disease and pathogenic mechanism through LAMP2-mutated retinal pigment epithelium2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simple oral mucosal epithelial transplantation in a rabbit model2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Huge Corneal Fibroma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severity Assessment of Acute Hydrops Due to Recurrent Keratoconus after Penetrating Keratoplasty Using Anterior Segment Optical Coherence Tomography2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fuchs Endothelial Corneal Dystrophy and Mitochondria2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【リピート病の病態機構UPDATE-RNA毒性とRAN翻訳】 Fuchs角膜内皮変性症におけるリピート病態2018

Author(s)

Journal Title

Data Source

[Journal Article] Characteristics and risk factors of recurrent keratoconus over the long term after penetrating keratoplasty2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Descemet Stripping Automated Endothelial Keratoplasty for Failed Penetrating Keratoplasty2018

Author(s)

MIYAI TAKASHI 宮井尊史

宮井尊史ミヤイタカシ

MIYAI Takashi 宮井尊史

[Journal Article] 円錐角膜の新しい治療　海外の現状2013