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MIYAI TAKASHI  宮井 尊史

… Alternative Names

宮井 尊史  ミヤイ タカシ

MIYAI Takashi  宮井 尊史

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Researcher Number 40599007
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-5286-8272
Affiliation (Current) 2025: 東京大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2022: 東京大学, 医学部附属病院, 講師
2018 – 2019: 東京大学, 医学部附属病院, 講師
2011 – 2012: 東京大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56060:Ophthalmology-related / Ophthalmology
Keywords
Principal Investigator
角膜内皮細胞 / ゲノム編集 / フックス角膜内皮ジストロフィ / リピート病 / RNA-seq / フックス角膜内皮変性症 / RNAseq / CRISPR/Cas9 / Fuchs角膜内皮変性症 / 全ゲノムシーケンス … More / RNA seq / トリプレットリピート / Fuchs角膜変性症 / TCF4 / Fuchs角膜内皮ジストロフィ / 角膜内皮 / 角膜ジストロフィ / コラーゲンクロスリンキング / 角膜菲薄化疾患 / 角膜クロスリンキング / コラーゲン / 角膜 Less
  • Research Projects

    (3 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (4 People)
  •  Fuchs角膜内皮変性症に対するゲノム医療の開発Principal Investigator

    • Principal Investigator
      宮井 尊史
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      The University of Tokyo
  •  A study to elucidate influence of triplet repeat expansion on pathology in Fuchs endothelial corneal dystrophyPrincipal Investigator

    • Principal Investigator
      MIYAI TAKASHI
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      The University of Tokyo
  •  Study of artificial cornea transplantation by using collagen cross-linking for corneal thinning diseasePrincipal Investigator

    • Principal Investigator
      MIYAI Takashi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      The University of Tokyo

All 2020 2019 2018 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair2020

    • Author(s)
      Kitamoto Kohdai、Taketani Yukako、Fujii Wataru、Inamochi Aya、Toyono Tetsuya、Miyai Takashi、Yamagami Satoru、Kuroda Masahiko、Usui Tomohiko、Ouchi Yasuo
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 2000-2000

    • DOI

      10.1038/s41598-020-58876-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16947, KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-17K10564, KAKENHI-PROJECT-17K11446, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-17K07212
  • [Journal Article] Ultraviolet A light induced DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.2020

    • Author(s)
      Liu C, Miyajima T, Melangath G, Miyai T, Vasanth S, Deshpande N, Kumar V, Ong Tone S, Gupta R, Zhu S, Vojnovic D, Chen Y, Rogan EG, Mondal B, Zahid M, Jurkunas UV.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 117 Issue: 1 Pages: 573-583

    • DOI

      10.1073/pnas.1912546116

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Journal Article] Comparison of 5-Year Clinical Results of Descemet and Non-Descemet Stripping Automated Endothelial Keratoplasty.2020

    • Author(s)
      Omoto T, Toyono T, Inoue T, Shirakawa R, Yoshida J, Miyai T, Yamagami S, Usui T.
    • Journal Title

      Cornea.

      Volume: 39 Issue: 5 Pages: 573-577

    • DOI

      10.1097/ico.0000000000002211

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16947, KAKENHI-PROJECT-18K16917
  • [Journal Article] Retinal dystrophy associated with Danon disease and pathogenic mechanism through LAMP2-mutated retinal pigment epithelium2019

    • Author(s)
      Fukushima Masaya、Inoue Tatsuya、Miyai Takashi、Obata Ryo
    • Journal Title

      European Journal of Ophthalmology

      Volume: - Issue: 3 Pages: 570-578

    • DOI

      10.1177/1120672119832183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Journal Article] Simple oral mucosal epithelial transplantation in a rabbit model2019

    • Author(s)
      Inamochi Aya、Tomioka Akiko、Kitamoto Kohdai、Miyai Takashi、Usui Tomohiko、Aihara Makoto、Yamagami Satoru
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 18088-18088

    • DOI

      10.1038/s41598-019-54571-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16947, KAKENHI-PROJECT-17K11492
  • [Journal Article] Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy.2019

    • Author(s)
      Miyai T, Vasanth S, Melangath G, Deshpande N, Kumar V, Benischke AS, Chen Y, Price MO, Price FW Jr, Jurkunas UV.
    • Journal Title

      Am J Pathol.

      Volume: 189 Issue: 10 Pages: 2061-2076

    • DOI

      10.1016/j.ajpath.2019.06.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Journal Article] Huge Corneal Fibroma.2019

    • Author(s)
      Fujita A, Ushiku T, Miyai T.
    • Journal Title

      Ophthalmology.

      Volume: 126 Issue: 11 Pages: 1526-1526

    • DOI

      10.1016/j.ophtha.2019.06.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Journal Article] Severity Assessment of Acute Hydrops Due to Recurrent Keratoconus after Penetrating Keratoplasty Using Anterior Segment Optical Coherence Tomography2019

    • Author(s)
      Fujita Asahi、Yoshida Junko、Toyono Tetsuya、Usui Tomohiko、Miyai Takashi
    • Journal Title

      Current Eye Research

      Volume: 44 Issue: 11 Pages: 1189-1194

    • DOI

      10.1080/02713683.2019.1629597

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16917, KAKENHI-PROJECT-18K16947
  • [Journal Article] Fuchs Endothelial Corneal Dystrophy and Mitochondria2018

    • Author(s)
      Miyai Takashi
    • Journal Title

      Cornea

      Volume: 37 Issue: 1 Pages: S74-S77

    • DOI

      10.1097/ico.0000000000001746

    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Journal Article] 【リピート病の病態機構UPDATE-RNA毒性とRAN翻訳】 Fuchs角膜内皮変性症におけるリピート病態2018

    • Author(s)
      宮井尊史
    • Journal Title

      医学のあゆみ

      Volume: 267 Pages: 814-816

    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Journal Article] Characteristics and risk factors of recurrent keratoconus over the long term after penetrating keratoplasty2018

    • Author(s)
      Yoshida Junko、Murata Hiroshi、Miyai Takashi、Shirakawa Rika、Toyono Tetsuya、Yamagami Satoru、Usui Tomohiko
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 256 Issue: 12 Pages: 2377-2383

    • DOI

      10.1007/s00417-018-4131-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K20306, KAKENHI-PROJECT-18K16917, KAKENHI-PROJECT-18K16947
  • [Journal Article] Descemet Stripping Automated Endothelial Keratoplasty for Failed Penetrating Keratoplasty2018

    • Author(s)
      Omoto Takashi、Sakisaka Toshihiro、Toyono Tetsuya、Yoshida Junko、Shirakawa Rika、Miyai Takashi、Yamagami Satoru、Usui Tomohiko
    • Journal Title

      Cornea

      Volume: 37 Issue: 4 Pages: 462-465

    • DOI

      10.1097/ico.0000000000001531

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K20306, KAKENHI-PROJECT-18K16947
  • [Journal Article] Corneal thickness and volume measurements by swept source anterior segment optical coherence tomography in normal subjects2013

    • Author(s)
      Fukuda R, Usui T, Miyai T, Mori Y, Miyata K, Amano S
    • Journal Title

      Curr Eye Res

      Volume: 38(5) Pages: 531-536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] Influences of cycloplegia with topical atropine on ocular higher-order aberrations2013

    • Author(s)
      Hiraoka T, Miyata K, Nakamura Y, Miyai T, Ogata M, Okamoto F, Oshika T
    • Journal Title

      Ophthalmology

      Volume: 120(1) Pages: 8-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] 円錐角膜の新しい治療 海外の現状2013

    • Author(s)
      宮井尊史
    • Journal Title

      IOL & RS

      Volume: 27 Pages: 44-47

    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] Tear meniscus evaluation by anterior segment swept-source optical coherence tomography2013

    • Author(s)
      Fukuda R, Usui T, Miyai T, Yamagami S, Amano S
    • Journal Title

      Am J Ophthalmol

      Volume: 155(4) Pages: 620-624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] Relationship between total tear IgE and specific serum IgE in autumnal allergic conjunctivitis2013

    • Author(s)
      Mimura T, Usui T, Yamagami S, Miyai T, Amano S
    • Journal Title

      Cornea

      Volume: 32(1) Pages: 14-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] Relation between total tear IgE and severity of acute seasonal allergic conjunctivitis2012

    • Author(s)
      Mimura T, Usui T, Yamagami S, Miyai T, Amano S
    • Journal Title

      Curr Eye Res

      Volume: 37(10) Pages: 864-870

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] Noninvasive observations of peripheral angle in eyes after penetrating keratoplasty using anterior segment fourier-domain optical coherence tomography2012

    • Author(s)
      Fukuda R, Usui T, Tomidokoro A, Mishima K, Matagi N, Miyai T, Amano S, Araie M
    • Journal Title

      Cornea

      Volume: 31(3) Pages: 259-263

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] Intraoperative mydriasis by intracameral injection of mydriatic eye drops: in vivo efficacy and in vitro safety studies2011

    • Author(s)
      Mori Y, Miyai T, Kagaya F, Nagai N, Osakabe Y, Miyata K, Amano S.
    • Journal Title

      Clin Experiment Ophthalmol.

      Volume: 39(5) Pages: 456-461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Journal Article] Limbal relaxing incisions using a reference point and corneal topography for intraoperative identification of the steepest meridian2011

    • Author(s)
      Miyata K, Miyai T, Minami K, Bissen-Miyajima H, Maeda N, Amano S
    • Journal Title

      J Refract Surg

      Volume: 27(5) Pages: 339-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Presentation] Effect of mitochondrial fission inhibitor, Mdivi-1, on apoptosis related pathway in corneal endothelium2019

    • Author(s)
      Takashi Miyai
    • Organizer
      The 16th Conference of Asian Society for Mitochondrial Research and Medicine & The 19th Conference of Japanese Society of Mitochondrial Research and Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Presentation] 角膜クロスリンキング2019

    • Author(s)
      宮井尊史
    • Organizer
      第73回 日本臨床眼科学会
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Presentation] CTG repeat excision in TCF4 gene of corneal endothelium with CRISPR-cas92019

    • Author(s)
      Takashi Miyai, Kodai Kitamoto, Yukako Taketani, Yasuo Ouchi, Tomohiko Usui
    • Organizer
      第123回 日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Presentation] CRISPR-Cas9を用いた角膜内皮細胞におけるTCF4遺伝子のCTGリピート部位の切除2019

    • Author(s)
      宮井尊史
    • Organizer
      日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Presentation] Genome-editing with CRISPR-Cas9 system targeting intronic CTG repeat of TCF4 gene in corneal endothelium.2019

    • Author(s)
      Takashi Miyai
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Presentation] Genome-editing with CRISPR-cas9 system targeting intronic CTG repeat of TCF4 gene in corneal endothelium.2019

    • Author(s)
      Takashi Miyai, Kodai Kitamoto, Yukako Taketani, Yasuo Ouchi, Tomohiko Usui
    • Organizer
      The Association forResearch in Vision and Ophthalmology 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16947
  • [Presentation] Frequencies and characteristics of renewing rigid gas permeable contact lenses in keratoconus patients2012

    • Author(s)
      Miyai T, Mimura T, Usui T, Yamagami S, Amano S.
    • Organizer
      The Association for Research in Vision and Ophthalmology 2012 annual meeting
    • Place of Presentation
      アメリカ、フォートローダーデール
    • Year and Date
      2012-05-09
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Presentation] インストラクションコース円錐角膜の最新の治療今後の展望2012

    • Author(s)
      宮井尊史
    • Organizer
      第27回日本白内障屈折矯正手術学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-16
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Presentation] Frequencies and characteristics of renewing rigid gas permeable contact lenses in keratoconus patients

    • Author(s)
      Takashi Miyai
    • Organizer
      2012 Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Data Source
      KAKENHI-PROJECT-23791970
  • [Presentation] 円錐角膜の新しい治療 今後の展望

    • Author(s)
      宮井尊史
    • Organizer
      第27回日本白内障屈折矯正手術学会学術総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791970
  • 1.  高地 雄太 (60415156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  真下 知士 (80397554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  白川 理香
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 4.  吉田 絢子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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