Kawamoto Shimpei 河本新平

… Alternative Names

KAWAMOTO SHIMPEI 河本新平

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Researcher Number	40612081
Other IDs
Affiliation (Current)	2025: 大阪大学, 微生物病研究所, 准教授
Affiliation (based on the past Project Information) *help	2023: 大阪大学, 微生物病研究所, 准教授 2018 – 2022: 大阪大学, 微生物病研究所, 助教 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 2013: 独立行政法人理化学研究所, 統合生命医科学研究センター, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 49070:Immunology-related / Immunology
Keywords	Principal Investigator 細胞老化 / 皮膚細菌 / パイエル板 / IgA / 免疫グロブリンA / 皮膚老化 / 老化 / 皮膚 / 皮膚腫瘍 / 線維芽細胞 … More / p16INK4a / 老化細胞 / 腸内フローラ / 腸内細菌 / 濾胞制御性T細胞 / 濾胞性ヘルパーT細胞 / Foxp3+T細胞 / 腸内細菌叢 Less

Elucidating the mechanism of skin aging by skin bacteria and cellular senescencePrincipal Investigator
- Principal Investigator
  
  河本新平
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Osaka University
Impact of skin bacteria and cellular senescence on cutaneous tumor malignant conversionPrincipal Investigator
- Principal Investigator
  
  Kawamoto Shimpei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Osaka University
Elucidation of the role of p16INK4a in aging process of gut immune system and microbiotaPrincipal Investigator
- Principal Investigator
  
  Kawamoto Shimpei
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
The influence of TCR specificity of T follicular helper cells on gut IgA productionPrincipal Investigator
- Principal Investigator
  
  KAWAMOTO SHIMPEI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 実験医学2023年10月号2023
- Author(s)
  河本新平、原英二
- Total Pages
  4
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23K06481
[Book] 消化器病学サイエンス7巻4号2023
- Author(s)
  河本新平、原英二
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-23K06481
[Journal Article] Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice2024
- Author(s)
  Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, Mayo Kodani, Yu Ishikawa-Yamauchi, Daisuke Motooka, Eiji Hara, Masahito Ikawa
- Journal Title
  
  Communications Biology
  
  Volume: 7(1) Issue: 1 Pages: 1-6
- DOI
  10.1038/s42003-023-05685-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14456, KAKENHI-PROJECT-23K20043, KAKENHI-PROJECT-23K05587, KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-23K27084
[Journal Article] Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype2023
- Author(s)
  Matsudaira Tatsuyuki、Nakano Sosuke、Konishi Yusuke、Kawamoto Shimpei、Uemura Ken、Kondo Tamae、Sakurai Koki、Ozawa Takaaki、Hikida Takatoshi、Komine Okiru、Yamanaka Koji、Fujita Yuki、Yamashita Toshihide、Matsumoto Tomonori、Hara Eiji
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 665-665
- DOI
  10.1038/s42003-023-05027-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-21K18557, KAKENHI-PROJECT-22KJ2043, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-23K22376, KAKENHI-PROJECT-23K24205
[Journal Article] Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota2023
- Author(s)
  Kawamoto Shimpei、Uemura Ken、Hori Nozomi、Takayasu Lena、Konishi Yusuke、Katoh Kazutaka、Matsumoto Tomonori、Suzuki Masae、Sakai Yusuke、Matsudaira Tatsuyuki、Adachi Takahiro、Ohtani Naoko、Standley Daron M.、Suda Wataru、Fukuda Shinji、Hara Eiji
- Journal Title
  
  Nature Cell Biology
  
  Volume: 25 Issue: 6 Pages: 865-876
- DOI
  10.1038/s41556-023-01145-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-23K24798
[Journal Article] SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response2022
- Author(s)
  Tsuji Shunya、Minami Shohei、Hashimoto Rina、Konishi Yusuke、Suzuki Tatsuya、Kondo Tamae、Sasai Miwa、Torii Shiho、Ono Chikako、Shichinohe Shintaro、Sato Shintaro、et al.
- Journal Title
  
  Nature Aging
  
  Volume: 2 Issue: 2 Pages: 115-124
- DOI
  10.1038/s43587-022-00170-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-21H02739, KAKENHI-PROJECT-20K07446, KAKENHI-PROJECT-21K19379, KAKENHI-PROJECT-22K07189, KAKENHI-PROJECT-21K15008, KAKENHI-PROJECT-21K15974, KAKENHI-PROJECT-20K16156
[Journal Article] The 6th international cell senescence association conference2022
- Author(s)
  Kawamoto Shimpei、Matsumoto Tomonori、Takasugi Masaki、Hara Eiji
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 8 Pages: 517-525
- DOI
  10.1111/gtc.12970
- Data Source
  KAKENHI-PROJECT-20K07446
[Journal Article] Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion2021
- Author(s)
  Okumura Shintaro、Konishi Yusuke、Narukawa Megumi、Sugiura Yuki、Yoshimoto Shin、Arai Yuriko、Sato Shintaro、Yoshida Yasuo、Tsuji Shunya、Uemura Ken、Wakita Masahiro、Matsudaira Tatsuyuki、Matsumoto Tomonori、Kawamoto Shimpei、Takahashi Akiko、Itatani Yoshiro、Miki Hiroaki ら
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5674-5674
- DOI
  10.1038/s41467-021-25965-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05272, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03515, KAKENHI-PROJECT-20K07446, KAKENHI-PROJECT-20K09930, KAKENHI-PROJECT-21K19406, KAKENHI-PROJECT-21K15974, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-20K16156
[Journal Article] A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.2020
- Author(s)
  Wakita M, Takahashi A, Sano O, Loo TM, Imai Y, Narukawa M, Iwata H, Matsudaira T, Kawamoto S, Ohtani N, Yoshimori T, Hara E.
- Journal Title
  
  Nat Commun
  
  Volume: 1935 Issue: 1 Pages: 1935-1935
- DOI
  10.1038/s41467-020-15719-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15188, KAKENHI-PROJECT-20K07446, KAKENHI-PROJECT-20K16163, KAKENHI-PROJECT-19K16612, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-18K15065, KAKENHI-PROJECT-19K22571, KAKENHI-PROJECT-20K16156
[Journal Article] Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis2020
- Author(s)
  Tanabe Yamato、Kawamoto Shimpei、Takaku Tomoiku、Morishita Soji、Hirao Atsushi、Komatsu Norio、Hara Eiji、Mukaida Naofumi、Baba Tomohisa
- Journal Title
  
  Blood Advances
  
  Volume: 4 Issue: 24 Pages: 6175-6188
- DOI
  10.1182/bloodadvances.2020003117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07446, KAKENHI-PROJECT-20K08749, KAKENHI-PROJECT-19H01033
[Journal Article] The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.2015
- Author(s)
  Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A
- Journal Title
  
  Nat Immunol.
  
  Volume: 16 Issue: 3 Pages: 276-285
- DOI
  10.1038/ni.3085
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22229004, KAKENHI-PROJECT-25670235, KAKENHI-PROJECT-25860375, KAKENHI-PROJECT-26293110
[Journal Article] 濾胞性ヘルパーT細胞による免疫グロブリンAの選択機構2015
- Author(s)
  河本新平、Fagarasan Sidonia
- Journal Title
  
  炎症と免疫
  
  Volume: 23 Pages: 27-31
- Data Source
  KAKENHI-PROJECT-25860375
[Journal Article] Gut TFH and IgA : key players for regulation of bacterial communities and immune homeostasis2014
- Author(s)
  Kato LM, Kawamoto S, Maruya M, Fagarasan S
- Journal Title
  
  Immunology and Cell Biology
  
  Volume: 92 Issue: 1 Pages: 49-56
- DOI
  10.1038/icb.2013.54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03216, KAKENHI-PROJECT-25293118, KAKENHI-PROJECT-25860375
[Journal Article] Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis2014
- Author(s)
  Shimpei Kawamoto, Mikako Maruya, Lucia M. Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, and Sidonia Fagarasan
- Journal Title
  
  Immunity
  
  Volume: 41 Issue: 1 Pages: 152-165
- DOI
  10.1016/j.immuni.2014.05.016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13F03216, KAKENHI-PLANNED-22113006, KAKENHI-PROJECT-25293118, KAKENHI-PROJECT-25860375
[Journal Article] The role of the adaptive immune system in regulation of gut microbiota2014
- Author(s)
  Lucia M. Kato, Shimpei Kawamoto, Mikako Maruya, Sidonia Fagarasan
- Journal Title
  
  Immunological Reviews
  
  Volume: 260 Issue: 1 Pages: 67-75
- DOI
  10.1111/imr.12185
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13F03216, KAKENHI-PROJECT-25293118, KAKENHI-PROJECT-25860375
[Presentation] 細胞老化の誘導に関わる腸内細菌の特定と個体老化に与える影響の解明2024
- Author(s)
  河本新平
- Organizer
  文部科学省共同利用・共同研究システム形成事業学際領域展開ハブ形成プログラムキックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K06481
[Presentation] Bacterial induction of B-cell senescence promotes age-related changes in gut microbiota2024
- Author(s)
  Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Kazutaka Katoh, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06481
[Presentation] 加齢に伴う免疫グロブリンAを介した宿主と腸内細菌叢の相互作用の破綻2023
- Author(s)
  河本新平、原英二
- Organizer
  第19回　日本食品免疫学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06481
[Presentation] Age-related disruption of the crosstalk between host and gut microbiota through Immunoglobulin A2023
- Author(s)
  Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Kazutaka Katoh, Tomonori Matsumoto, Yusuke Sakai, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara
- Organizer
  18th International Symposium of The Institute Network
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06481
[Presentation] 免疫グロブリンAを介した宿主と腸内細菌叢のクロストーク生体恒常性維持における重要性とその破綻が老化に及ぼす影響2023
- Author(s)
  河本新平
- Organizer
  関西共創の場　第28回若手人材セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K06481
[Presentation] Bacterial induction of B-cell senescence promotes age-related changes in gut microbiota2023
- Author(s)
  Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Yusuke Konishi, Kazutaka Katoh, Tomonori Matsumoto, Masae Suzuki, Yusuke Sakai, Tatsuyuki Matsudaira, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara
- Organizer
  8th International Cell Senescence Association (ICSA) Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06481
[Presentation] Identification and characterization of skin bacteria involved in obesity-induced skin carcinogenesis in mice2021
- Author(s)
  Ken Uemura, Olivia MIsaki Kyama, Shimpei Kawamoto, Masahiro Wakita, Eiji Hara
- Organizer
  6th International Cell Senescence Association（ICSA）Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07446
[Presentation] 皮膚腫瘍の悪性化に関わる皮膚細菌の単離同定2020
- Author(s)
  植村憲、河本新平、脇田将裕、原英二
- Organizer
  第93回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K15188
[Presentation] Identification and characterization of skin bacteria involved in skin carcinogenesis in mice2020
- Author(s)
  Ken Uemura, Shimpei Kawamoto, Masahiro Wakita, Eiji Hara
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07446
[Presentation] 腸内細菌による細胞老化を介した発がん促進機構2019
- Author(s)
  河本新平
- Organizer
  第47回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15188
[Presentation] Foxp3+T 細胞、IgA 及び腸内細菌叢の間に見られる相互制御ループの解明2014
- Author(s)
  河本新平
- Organizer
  第42 回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-25860375
[Presentation] The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut.2013
- Author(s)
  Kawamoto Shimpei, Tran Huy Thinh, Maruya Mikako, Suzuki Keiichiro, Doi Yasuko, Tsutsui Yumi, Kato Lucia Megumi, Fagarasan Sidonia
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-25860375
[Presentation] 抑制性受容体PD-1が腸管IgA産生および腸内細菌制御に与える影響の検討2013
- Author(s)
  河本新平、丸谷美香子、加藤ルシア、Fagarasan Sidonia
- Organizer
  第23回フローサイトメトリー学会
- Place of Presentation
  日本医科大学（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-25860375
[Presentation] 腸内細菌叢と腸管免疫
- Author(s)
  河本新平
- Organizer
  第56 回日本老年医学会学術集会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2014-06-12 – 2014-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-25860375
[Presentation] Foxp3+T細胞および免疫グロブリンAによる腸内細菌制御機構
- Author(s)
  河本新平
- Organizer
  Midwinter Seminar 2015
- Place of Presentation
  ANAインターコンチネンタル万座ビーチホテル（沖縄）
- Year and Date
  2015-02-25 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-25860375
[Presentation] Symbiotic regulatory loop between Foxp3+ T cells, IgA and gut microbiota
- Author(s)
  河本新平
- Organizer
  2014年度　日本免疫学会総会
- Place of Presentation
  京都国際会議場（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860375

1. 丸谷美香子

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 加藤ルシア

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MORO Kazuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SATO Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. SIDONIA Fagarasan

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 小安重夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山内祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 三木裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawamoto Shimpei 河本 新平

KAWAMOTO SHIMPEI 河本 新平

Research Projects

Research Products

Co-Researchers

Elucidating the mechanism of skin aging by skin bacteria and cellular senescencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of skin bacteria and cellular senescence on cutaneous tumor malignant conversionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of p16INK4a in aging process of gut immune system and microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The influence of TCR specificity of T follicular helper cells on gut IgA productionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学2023年10月号2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 消化器病学サイエンス7巻4号2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The 6th international cell senescence association conference2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.2015

Kawamoto Shimpei 河本新平

KAWAMOTO SHIMPEI 河本新平

[Presentation] 免疫グロブリンAを介した宿主と腸内細菌叢のクロストーク生体恒常性維持における重要性とその破綻が老化に及ぼす影響2023