Takahashi Daisuke 高橋大輔

… Alternative Names

TAKAHASHI DAISUKE 高橋大輔

高橋大輔タカハシダイスケ

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Researcher Number	40612130
Other IDs	https://orcid.org/0000-0001-8624-1160
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 慶應義塾大学, 薬学部(芝共立), 講師 2016 – 2020: 慶應義塾大学, 薬学部(芝共立), 助教 2015: 慶應義塾大学, 薬学部, 助教 2012: 独立行政法人理化学研究所, その他部局等, 研究員 2011: 独立行政法人理化学研究所, 免疫系構築研究チーム, リサーチアソシエイト
Review Section/Research Field	Principal Investigator Immunology / Transformative Research Areas, Section (III) / Basic Section 49070:Immunology-related
Keywords	Principal Investigator 自己免疫疾患 / 腸内細菌 / 濾胞制御性T細胞 / AP-1B / 共生関係 / 腸恒常性 / γδT17細胞 / アレルギー疾患 / 自己抗体 / 濾胞制御性 T 細胞 … More / イメーサイトメトリー / TFR細胞分化誘導系 / イメージサイトメトリー / ケミカルバイオロジー / Tfr細胞 / 自己反応抗体 / コラーゲン誘発関節炎 / 濾胞性制御性T細胞 (Tfr) / 濾胞性制御性T細胞 / コラーゲン誘発性関節炎 / 関節リウマチ / 胚中心反応 / HDAC / 間接リウマチ / 濾胞制御性T細胞数 / 酪酸 / 腸上皮細胞 / 腸上皮細胞間リンパ球 / 腸上皮細 / 上皮細胞間Tリンパ球 / 上皮細胞 / 極性輸送 / IEL / 腸管上皮細胞 Less

腸内細菌による、濾胞ヘルパーT細胞とIgA産生の誘導、抗腫瘍免疫応答の増強Principal Investigator
- Principal Investigator
  
  高橋大輔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Keio University
γδT細胞が自己として腸内細菌を認識する功罪の解明Principal Investigator
- Principal Investigator
  
  高橋大輔
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
腸内細菌を自己として認識するγδT17細胞による宿主-腸内細菌共生関係構築Principal Investigator
- Principal Investigator
  
  高橋大輔
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
ケミカルバイオロジーを利用した濾胞制御性T細胞分化機序の解明Principal Investigator
- Principal Investigator
  
  高橋大輔
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Keio University
Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Takahashi Daisuke
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Keio University
Study of IEC-IEL interraction in the development of gut epithelial immune system.Principal Investigator
- Principal Investigator
  
  TAKAHASHI DAISUKE
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Keio University
上皮細胞特有の膜タンパク質輸送が腸管粘膜面の生体防御に果たす役割と分子機構の解明Principal Investigator
- Principal Investigator
  
  高橋大輔
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2016 2011

All Journal Article Presentation Patent

[Journal Article] Purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations2024
- Author(s)
  Hiroaki Shiratori, Kisara M Hattori, Kazuaki Nakata, Takuma Okawa, Seiga Komiyama, Yusuke Kinashi, Yuma Kabumoto, Yuria Kaneko, Motoyoshi Nagai, Tomoko Shindo, Nobuko Moritoki, Yuki I Kawamura, Taeko Dohi, Daisuke Takahashi, Shunsuke Kimura, Koji Hase
- Journal Title
  
  International Immunology
  
  Volume: 36 (5) Issue: 5 Pages: 223240-223240
- DOI
  10.1093/intimm/dxae003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ3161, KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-22K19445, KAKENHI-PUBLICLY-23H04788, KAKENHI-PROJECT-23H05482
[Journal Article] Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation2023
- Author(s)
  Shiratori Hiroaki、Oguchi Hiroyuki、Isobe Yosuke、Han Kyu-Ho、Sen Akira、Yakebe Kyosuke、Takahashi Daisuke、Fukushima Michihiro、Arita Makoto、Hase Koji
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8903-8903
- DOI
  10.1038/s41598-023-35097-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-22K19445, KAKENHI-PUBLICLY-23H04788, KAKENHI-PROJECT-23H05482, KAKENHI-PROJECT-20H00495
[Journal Article] α-Glucosidase inhibitors boost gut immunity by inducing IgA responses in Peyer’s patches2023
- Author(s)
  Hattori-Muroi Kisara、Naganawa-Asaoka Hanako、Kabumoto Yuma、Tsukamoto Kei、Fujisaki Yosuke、Fujimura Yumiko、Komiyama Seiga、Kinashi Yusuke、Kato Miki、Sato Shintaro、Takahashi Daisuke、Hase Koji
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1277637-1277637
- DOI
  10.3389/fimmu.2023.1277637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19472, KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-22K19445, KAKENHI-PUBLICLY-23H04788, KAKENHI-PROJECT-23H05482, KAKENHI-PROJECT-23K27420
[Journal Article] Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles2023
- Author(s)
  Li Shunyi、Toriumi Hiroki、Takahashi Daisuke、Kamasaki Tomoko、Fujioka Yoichiro、Nagatoishi Satoru、Li Jinting、Liu Yiwei、Hosokawa Takanatsu、Tsumoto Kouhei、Ohba Yusuke、Katayama Yoshiki、Murakami Daisuke、Hase Koji、Mori Takeshi
- Journal Title
  
  Biomaterials
  
  Volume: 303 Pages: 122381-122381
- DOI
  10.1016/j.biomaterials.2023.122381
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-22K19445, KAKENHI-PROJECT-22KF0004, KAKENHI-PROJECT-22KJ2442, KAKENHI-PLANNED-20H05872, KAKENHI-PUBLICLY-23H04788, KAKENHI-PROJECT-23H05482
[Journal Article] Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection2022
- Author(s)
  Goo-Young Seo*, Daisuke Takahashi , Qingyang Wang*, Zbigniew Mikulski, Angeline Chen, Ting-Fang Chou, Paola Marcovecchio, Sara McArdle, Ashu Sethi, Jr-Wen Shui, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg (*equal contribution)
- Journal Title
  
  Sci Immuno.
  
  Volume: 7 Issue: 73
- DOI
  10.1126/sciimmunol.abm6931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07552
[Journal Article] A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production2022
- Author(s)
  Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase*, Daisuke Takahashi* (*equal correspondence)
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 9 Pages: 1364-1372
- DOI
  10.1248/bpb.b22-00321
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-21H04795
[Journal Article] Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon2021
- Author(s)
  Nakamura Atsuo、Kurihara Shin、Takahashi Daisuke、Ohashi Wakana、Nakamura Yutaka、Kimura Shunsuke、Onuki Masayoshi、Kume Aiko、Sasazawa Yukiko、Furusawa Yukihiro、Obata Yuuki、Fukuda Shinji、Saiki Shinji、Matsumoto Mitsuharu、Hase Koji
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 2105-2105
- DOI
  10.1038/s41467-021-22212-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19738, KAKENHI-PUBLICLY-20H05340, KAKENHI-PROJECT-20H00575, KAKENHI-PROJECT-17K15734, KAKENHI-PROJECT-19K07239, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-21K07425
[Journal Article] Identification of Novel Histone Deacetylase 6‐Selective Inhibitors Bearing 3,3,3‐Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group2021
- Author(s)
  Kurohara Takashi、Tanaka Keita、Takahashi Daisuke、Ueda Satoshi、Yamashita Yasunobu、Takada Yuri、Takeshima Hirokazu、Yu Shengwang、Itoh Yukihiro、Hase Koji、Suzuki Takayoshi
- Journal Title
  
  ChemBioChem
  
  Volume: 22 Issue: 22 Pages: 3158-3163
- DOI
  10.1002/cbic.202100255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-20K07552
[Journal Article] A Retinoid X Receptor agonist directed to the large intestine ameliorates T-cell-mediated colitis in mce.2021
- Author(s)
  Matsumoto R, Hase K et al.
- Journal Title
  
  Front Pharmacol. 2021, 12:
  
  Volume: 12 Pages: 715752-715752
- DOI
  10.3389/fphar.2021.715752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-20K07552
[Journal Article] Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells2020
- Author(s)
  Daisuke Takahashi, Naomi Hoshina, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Hiyori Tanabe, Junya Isobe, Takahiro Yamada, Kisara Muroi, Yuto Yanagisawa, Atsuo Nakamura, ... Koji Hase
- Journal Title
  
  EBioMedicine
  
  Volume: 58 Pages: 102913-102913
- DOI
  10.1016/j.ebiom.2020.102913
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-20K21515, KAKENHI-PROJECT-20K22788, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-18H02636, KAKENHI-PROJECT-17K15734
[Journal Article] Epithelial HVEM promotes basement membrane synthesis and intraepithelial T cell survival and migration2020
- Author(s)
  Daisuke Takahashi*, Qingyang Wang*, Goo-Young Seo* (*equal contribution), Jr-wen Shui, Zbigniew Mikulski, Paola Marcovecchio, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.09.30.317628
- Open Access
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-17K15734
[Journal Article] Polyamines polarized Th2/Th9 cell-fate decision by regulating GATA3 expression2020
- Author(s)
  Atsuo Nakamura, Daisuke Takahashi*, Yutaka Nakamura, Takahiro Yamada, Mitsuharu Matsumoto* (*equal correspondence), Koji Hase
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 693 Pages: 108587-108587
- DOI
  10.1016/j.abb.2020.108587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-17K15734
[Journal Article] Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon.2020
- Author(s)
  Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, Ikuo Kimura, Stefan Offermanns, Takahiro Adachi, Atsuhito Nakao, Hiroshi Kiyono, Daisuke Takahashi, Koji Hase
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 4 Pages: 243-258
- DOI
  10.1093/intimm/dxz078
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15734, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17H05068, KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-18H05280
[Journal Article] The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases2019
- Author(s)
  Kobayashi Nobuhide、Takahashi Daisuke、Takano Shunsuke、Kimura Shunsuke、Hase Koji
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 2345-2345
- DOI
  10.3389/fimmu.2019.02345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07239, KAKENHI-PROJECT-17K15734, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17KT0055
[Journal Article] Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis.2016
- Author(s)
  Motoyoshi Nagai, Yuuki Obata, Daisuke Takahashi, Koji Hase
- Journal Title
  
  International Immunopharmacology
  
  Volume: 37 Pages: 79-86
- DOI
  10.1016/j.intimp.2016.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06589
[Journal Article] The diet-microbiota-metabolite axis regulates the host physiology.2016
- Author(s)
  Yamada T, Takahashi D, Hase K.
- Journal Title
  
  J. Biochem.
  
  Volume: in press Issue: 1 Pages: 1-10
- DOI
  10.1093/jb/mvw022
- NAID
  40020880708
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26116709, KAKENHI-PROJECT-25293114, KAKENHI-PROJECT-15H06589
[Patent] 濾胞性制御性T細胞の製造方法2019
- Inventor(s)
  長谷耕二、高橋大輔
- Industrial Property Rights Holder
  学校法人慶應義塾
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-185826
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K15734
[Presentation] Microbiota-derived Butyrate Limits the Autoimmune Response by promoting the Differentiation of Follicular Regulatory T cells2019
- Author(s)
  Daisuke Takahashi, Koji Hase
- Organizer
  アメリカ免疫学会年次総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15734
[Presentation] Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.2018
- Author(s)
  Daisuke Takahashi, Trevor Lockett, Julie M Clarke, David L Topping, Koji Hase
- Organizer
  The 46th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K15734
[Presentation] AP-1B-dependent sorting of basolateral membrane protein is required for maintenance of intestinal intraepithelial lymphocytes2018
- Author(s)
  Daisuke Takahashi, Ryohtaroh Matsumoto, Koji Hase
- Organizer
  日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15734
[Presentation] Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.2016
- Author(s)
  Daisuke Takahashi
- Organizer
  International Congress of Immunology 2016 (ICI 2016)
- Place of Presentation
  Melbourne Convention and Exhibition Centre, Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06589
[Presentation] 腸内細菌代謝物の酪酸によるIgA産生細胞誘導機構の解明2016
- Author(s)
  高橋　大輔
- Organizer
  第46回日本腎臓学会西部学術大会
- Place of Presentation
  宮崎県宮崎市、シーガイアコンベンションセンター
- Year and Date
  2016-10-15
- Invited
- Data Source
  KAKENHI-PROJECT-15H06589
[Presentation] The microbial metabolite butyrate attenuates autoimmune arthritis in mice2016
- Author(s)
  Daisuke Takahashi
- Organizer
  フォーラム2016
- Place of Presentation
  東京品川区、昭和大学旗の台キャンパス
- Year and Date
  2016-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-15H06589
[Presentation] Distinct roles for CXCR6^+ and CXCR6^- CD4^+ T cells in pathogenesis of chronic colitis2011
- Author(s)
  Daisuke Takahashi
- Organizer
  Cold Sprig Harbor Laboratory Meetings HARNES SING IMMUNITY TO PREVENT AND TREAT DISEASE
- Place of Presentation
  Cold Sprig Harbor Laboratory, NY, USA(口頭発表)(査読有)
- Data Source
  KAKENHI-PROJECT-23890249
[Presentation] Distinct roles for CXCR6^+ and CXCR6^- CD4^+ T cells in pathogenesis of chronic colitis2011
- Author(s)
  Daisuke Takahashi, Koji Hase, Hiroshi Ohno
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  幕張(口頭発表)(査読有)
- Data Source
  KAKENHI-PROJECT-23890249

1. Kronenberg Mitch

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2. Seo Goo-young

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3. KIMURA Shunsuke

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4. SUZUKI Takayoshi

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5. ITOH Yukihiro

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6. 久米愛子

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7. 加藤美樹

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8. 山下泰信

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9. 高田悠里

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10. 長谷耕二

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# of Collaborated Products: 2 results

Takahashi Daisuke 高橋 大輔

TAKAHASHI DAISUKE 高橋 大輔

高橋 大輔 タカハシ ダイスケ

Research Projects

Research Products

Co-Researchers

腸内細菌による、濾胞ヘルパーT細胞とIgA産生の誘導、抗腫瘍免疫応答の増強Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

γδT細胞が自己として腸内細菌を認識する功罪の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸内細菌を自己として認識するγδT17細胞による宿主-腸内細菌共生関係構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ケミカルバイオロジーを利用した濾胞制御性T細胞分化機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of IEC-IEL interraction in the development of gut epithelial immune system.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

上皮細胞特有の膜タンパク質輸送が腸管粘膜面の生体防御に果たす役割と分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] α-Glucosidase inhibitors boost gut immunity by inducing IgA responses in Peyer’s patches2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Takahashi Daisuke 高橋大輔

TAKAHASHI DAISUKE 高橋大輔

高橋大輔タカハシダイスケ