KOBAYASHI TOSHIHIKO 小林俊彦

… Alternative Names

KOBAYASHI Toshihiko 小林俊彦

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Researcher Number	40613203
Affiliation (Current)	2023: 東京大学, 医科学研究所, 特任講師
Affiliation (based on the past Project Information) *help	2016 – 2022: 国立研究開発法人国立国際医療研究センター, その他部局等, 副プロジェクト長 2016: 国立国際医療研究センター研究所, 分子炎症制御プロジェクト, 副プロジェクト長 2013 – 2014: 独立行政法人国立国際医療研究センター, その他部局等, その他
Review Section/Research Field	Principal Investigator Immunology / Cell biology / Experimental pathology / Basic Section 49030:Experimental pathology-related / Complex systems / Biological Sciences Except Principal Investigator Experimental pathology
Keywords	Principal Investigator リソソーム / トランスポーター / アミノ酸トランスポーター / 炎症 / 炎症応答 / 免疫細胞 / 自然免疫の炎症応答制御機構 / ライソゾーム / アミノ酸輸送 / TLR … More / 自己免疫疾患 / 自然免疫 / B細胞 / 炎症制御 / mTOR / ライソゾーム環境調節 / 自然免疫応答 / 自己抗体産生 / マスト細胞 / アレルギー / アレルギー応答 / TFEB / mTORC / 免疫学 / アレルギー疾患 / 免疫 / 免疫疾患 / 線維症 / マクロファージ / 代謝 / 線維化 / 炎症細胞 / オートファジー / 肺線維症 … More Except Principal Investigator 炎症 / 自己免疫疾患 / アレルギー / トランスポーター / mTOR / Toll様受容体 / マスト細胞 / 免疫学 / シグナル伝達 / アミノ酸トランスポーター / リソソーム / 全身性エリテマトーデス / 抗体 / I型インターフェロン Less

オートファジーストレスとリソソームストレスを活用した肺線維症治療戦略Principal Investigator
- Principal Investigator
  
  小林俊彦
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center for Global Health and Medicine
アミノ酸トランスポーターSLC15A3が担う炎症細胞社会構築と肺線維化メカニズムPrincipal Investigator
- Principal Investigator
  
  小林俊彦
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Center for Global Health and Medicine
Role of lysosome-resident amino acid transporters in inflammatory responsePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Toshihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Center for Global Health and Medicine
Molecular mechanism of lysosome-dependent allergic inflammationPrincipal Investigator
- Principal Investigator
  
  Kobayashi Toshihiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
  Immunology
- Research Institution
  National Center for Global Health and Medicine
A novel regulatory mechanism of autoimmune disease pathogenesis by SLC15A4
- Principal Investigator
  
  Toyama-Sorimachi Noriko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Center for Global Health and Medicine
Role of SLC15A4 in controling lysosomal environment and inflammatory responsesPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Toshihiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
  Cell biology
- Research Institution
  Research Institute, International Medical Center of Japan

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Identification of the interacting partners of a lysosomal membrane protein in living cells by BioID technique2022
- Author(s)
  Nguyen-Tien Dat、Suzuki Takehiro、Kobayashi Toshihiko、Toyama-Sorimachi Noriko、Dohmae Naoshi
- Journal Title
  
  STAR Protocols
  
  Volume: 3 Pages: 101263-101263
- DOI
  10.1016/j.xpro.2022.101263
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04959, KAKENHI-PROJECT-21K16155
[Journal Article] SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress2021
- Author(s)
  Kobayashi T, Nguyen-Tien D, Sorimachi Y, Sugiura Y, Suzuki T, Karyu H, Shimabukuro-Demoto S, Uemura T, Okamura T, Taguchi T, Ueki K, Kato N, Goda N, Dohmae N,?Takubo K, Suematsu M, Toyama-Sorimachi N.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Pages: 1-10
- DOI
  10.1073/pnas.2100295118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PUBLICLY-20H04959, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21K16155
[Journal Article] Lysosomal amino acid transporters as key players in inflammatory diseases2021
- Author(s)
  Kobayashi T, Toyama-Sorimachi N
- Journal Title
  
  International Immunology
  
  Volume: 33 Pages: 853-858
- DOI
  10.1093/intimm/dxab069
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04959
[Journal Article] Human SLC15A4 is crucial for TLR-mediated type I interferon production and mitochondrial integrity2021
- Author(s)
  Kobayashi Toshihiko、Nguyen-Tien Dat、Ohshima Daisuke、Karyu Hitomi、Shimabukuro-Demoto Shiho、Yoshida-Sugitani Reiko、Toyama-Sorimachi Noriko
- Journal Title
  
  International Immunology
  
  Volume: Online ahead of print Pages: 399-406
- DOI
  10.1093/intimm/dxab006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05354, KAKENHI-PROJECT-18K07056, KAKENHI-PUBLICLY-20H04959
[Journal Article] Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis.2019
- Author(s)
  Kobayashi T, Shimabukuro-Demoto S, Tsutsui H, Toyama-Sorimachi N
- Journal Title
  
  PLoS Biol.
  
  Volume: 17
- DOI
  10.1371/journal.pbio.3000530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07056, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-17H04070
[Journal Article] Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.2017
- Author(s)
  Kobayashi Toshihiko、Tsutsui Hidemitsu、Shimabukuro-Demoto Shiho、Yoshida-Sugitani Reiko、Karyu Hitomi、Furuyama-Tanaka Kaori、Ohshima Daisuke、Kato Norihiro、Okamura Tadashi、Toyama-Sorimachi Noriko
- Journal Title
  
  Int Immunol.
  
  Volume: 29 Pages: 551-566
- DOI
  10.1093/intimm/dxx063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05903, KAKENHI-PROJECT-17H04070, KAKENHI-PROJECT-16K21654, KAKENHI-PROJECT-16K21655
[Journal Article] C4b binding protein negatively regulates TLR1/2 response2017
- Author(s)
  Naoko Morita, Ikuko Yamai, Koichiro Takahashi,Yutaka Kusumoto, Takuma Shibata, Toshihiko Kobayashi, Mayumi I Nonaka, Isao Ichimonji, Hidekazu Takagi, Kensuke Miyake and Sachiko A Takamura.
- Journal Title
  
  Innate Immunity
  
  Volume: 23 Pages: 11-19
- DOI
  10.1177/1753425916672312
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09491, KAKENHI-PROJECT-16K21654
[Journal Article] 自己免疫疾患治療標的としてのアミノ酸トランスポーターSLC15A42016
- Author(s)
  小林俊彦、大島大輔、反町典子
- Journal Title
  
  別冊 BIO Clinica 慢性炎症と疾患
  
  Volume: 2016 Pages: 164-167
- Data Source
  KAKENHI-PROJECT-26293090
[Journal Article] The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.2015
- Author(s)
  Seto E, Yoshida-Sugitani R, Kobayashi T, Toyama-Sorimachi N
- Journal Title
  
  PloS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0123223
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25871165, KAKENHI-PROJECT-26860256, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05903, KAKENHI-PROJECT-26293090
[Journal Article] Separation of Intracellular Vesicles for Immunoassays.2015
- Author(s)
  Kobayashi T, Tanaka T, and Toyama-Sorimachi N.
- Journal Title
  
  Bio-protocol
  
  Volume: 5 (16)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293090
[Journal Article] The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production.2014
- Author(s)
  Kobayashi T, Demoto-Shimabukuro S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N
- Journal Title
  
  Immunity
  
  Volume: 41 Pages: 375-388
- DOI
  10.1016/j.immuni.2014.08.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25871165, KAKENHI-PROJECT-26293090
[Journal Article] Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System2013
- Author(s)
  Imanishi H, Takibuchi G, Kobayashi T, Ishikawa K, Nakada K, Mori M, Kikkawa Y, Takenaga K, Toyama-Sorimachi N, Hayashi J
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0075981
- NAID
  120007136806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PUBLICLY-24117503, KAKENHI-PROJECT-24500487, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-25430110, KAKENHI-PROJECT-25871165
[Journal Article] The endosome-lysosome system in inflammatory signal transduction2013
- Author(s)
  Tanaka T, Kobayashi T, Toyama-Sorimachi N.
- Journal Title
  
  Seikagaku
  
  Volume: 85(12) Pages: 1083-1086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25871165
[Journal Article] How do cells optimize luminal environments of endosomes/lysosomes for efficient inflammatory responses?2013
- Author(s)
  Kobayashi T, Tanaka T, Toyama-Sorimachi N.
- Journal Title
  
  J Biochem
  
  Volume: 154(6) Pages: 491-499
- DOI
  10.1093/jb/mvt099
- NAID
  40019909473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] Endolysosome: Intersection of inflammation and metabolism2021
- Author(s)
  Toshihiko Kobayashi, Dat Nguyen-Tien, Noriko Toyama-Sorimachi
- Organizer
  50th Annual Meeting of the Japanese Society for Immunology
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04959
[Presentation] アミノ酸トランスポーターによるマクロファージの炎症と代謝の統合的制御2021
- Author(s)
  小林俊彦
- Organizer
  第30回東京免疫フォーラム
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04959
[Presentation] A novel mechanisms of lung fibrosis mediated by SLC15A32021
- Author(s)
  Dat Nguyen-Tien, Toshihiko Kobayashi, Shigeyuki Shichino, Satoshi Ueha, Masato Kubo, Kouji Matsushima, Noriko Toyama-Sorimachi
- Organizer
  50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PUBLICLY-20H04959
[Presentation] A novel therapeutic strategy of pulmonary fibrosis based on arginine metabolism in macrophages2021
- Author(s)
  Noriko Toyama-Sorimachi, Dat Nguyen-Tien, Toshihiko Kobayashi
- Organizer
  50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PUBLICLY-20H04959
[Presentation] A novel mechanisms of lung fibrosis mediated by an amino acid transporter2020
- Author(s)
  Nguyen-Tien D, Kobayashi T, Toyama-Sorimachi N
- Organizer
  Keystone Symposia, Fibrosis and tissue repair
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07056
[Presentation] Unique role of an oligopeptide transporter SLC15A3 in the lung inflammation and resolution2019
- Author(s)
  Kobayashi T, Nguyen-Tien Dat, Toyama-Sorimachi N
- Organizer
  第48回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K07056
[Presentation] SLC15A3 inhibits autophagy in macrophage and dendritic cells2019
- Author(s)
  Nguyen-Tien D, Kobayashi T, Toyama-Sorimachi N
- Organizer
  第48回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K07056
[Presentation] Controlling the innate immune responses by the lysosome-resident oligopeptide transporters.2019
- Author(s)
  Kobayashi T, Toyama-Sorimachi N
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07056
[Presentation] 肺組織の炎症と修復におけるペプチドトランスポーターSLC15A3の役割2018
- Author(s)
  小林俊彦、筒井英充、反町典子
- Organizer
  第13回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18K07056
[Presentation] Regulation of allergic response by non-canonical type I interferon signaling.2018
- Author(s)
  Kobayashi T, Tsutsui H, Toyama-Sorimachi N
- Organizer
  6th Annual meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07056
[Presentation] Regulatory role of SLC15A3 in the systemic inflammation2017
- Author(s)
  Kobayashi T, Tsutsui H, Ohshima D, Toyama-Sorimachi N
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K21654
[Presentation] Regulatory role of a lysosome-resident oligopeptide transporter SLC15A4 in the inflammatory responses of mast cells2017
- Author(s)
  Kobayashi T, Tsutsui H, Ohshima D, Toyama-Sorimachi N
- Organizer
  5th Annual meeting of the International Cytokine and Interferon Society (Cytokines 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21654
[Presentation] リソソーム局在型オリゴペプチドトランスポーターSLC15A4によるマスト細胞の炎症応答制御機構2017
- Author(s)
  小林俊彦, 筒井英充，大島大輔，反町典子
- Organizer
  第12回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-16K21654
[Presentation] Transporter SLC15A4 Regulates Allergic Reactions by Controlling Mast Cell Homeostasis and Inflammatory Response2016
- Author(s)
  Kobayashi T, Ohshima D, Toyama-Sorimachi N.
- Organizer
  Gordon Research Conference “Membrane Transport Proteins”
- Place of Presentation
  Lucca (Barga), Italy
- Year and Date
  2016-06-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] Regulation of innate immune responses by oligopeptide transporter SLC15A3.2016
- Author(s)
  Ohshima D, Kobayashi T, Toyama-Sorimachi N.
- Organizer
  The 45th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] Rac guanine nucleotide exchange factor, P-Rex1, is crucial for differentiation and/or maintenance of liver tissue-resident NK cells.2016
- Author(s)
  Machida A, Kobayashi T, Toyama-Sorimachi N.
- Organizer
  The 45th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] Regulation of innate immune responses by oligopeptide transporter SLC15A3.2016
- Author(s)
  Ohshima D, Kobayashi T, Toyama-Sorimachi N
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  Okinawa, Japan
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K21654
[Presentation] Oligopeptide Transporter SLC15A4 Regulates Allergic Reactions by Controlling Mast Cell Homeostasis and Inflammatory Response.2016
- Author(s)
  Kobayashi T, Ohshima D, Toyama-Sorimachi N
- Organizer
  Gordon Research Conference “Membrane Transport Proteins”
- Place of Presentation
  Lucca (Barga), Italy
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21654
[Presentation] Ca2+/カルモジュリン依存性プロテインキナーゼ阻害ペプチドを用いた破骨細胞分化制御2016
- Author(s)
  7.西川喜代孝, 田口祐, 大西弘晃, 藤原誠, 西園貴志, 西村浩輝, 小林俊彦, 反町典子, 高柳広, 尾藤晴彦, 井上純一郎, 高橋美帆
- Organizer
  第２回日本骨免疫学会
- Place of Presentation
  沖縄
- Year and Date
  2016-07-06
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] Regulatory role of Prex1 in the T cell-dependent antibody production.2016
- Author(s)
  Kobayashi T, Toyama-Sorimachi N.
- Organizer
  The 45th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] Regulatory role of an oligopeptide transporter SLC15A4 in inflammatory responses in mast cells.2016
- Author(s)
  Kobayashi T, Ohshima D, Toyama-Sorimachi N
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21654
[Presentation] Regulatory role of an oligopeptide transporter SLC15A4 in inflammatory responses in mast cells.2016
- Author(s)
  Kobayashi T, Ohshima D, Toyama-Sorimachi N
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia.
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] The Histidine transporter SLC15A4 regulates allergic responses by tuning the endo/lysosomal condition of mast cells.2015
- Author(s)
  Kobayashi T, Ohshima D, Toyama-Sorimachi N.
- Organizer
  第４４回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] A possible involvement of endo-exocytosis coupling machinery in granule-dependent NK cytotoxicity.2015
- Author(s)
  Machida A, Kobayashi T, Toyama-Sorimachi N.
- Organizer
  第４４回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] リソソーム局在型アミノ酸トランスポーターSLC15A4の変異による局在変化とモノクローナル抗体作製への応用2015
- Author(s)
  小林俊彦、大島大輔、反町典子
- Organizer
  第１０回トランスポーター研究会
- Place of Presentation
  慶応義塾大学薬学部
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] SLC15A4 regulates IgG2a autoantibody production through IRF7-type I IFN activation loop in B cells2013
- Author(s)
  Kobayashi T, Sorimachi N
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉、日本
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] Lysosomal transporter SLC15A4 regulates TLR7/9-mediated antibody production2013
- Author(s)
  Kobayashi T, Okamura T, Toyama-Sorimachi N
- Organizer
  第８回トランスポーター研究会年会
- Place of Presentation
  熊本、日本
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] Lysosomal transporter SLC15A4 regulates TLR7/9-mediated antibody production2013
- Author(s)
  Kobayashi T, Toyama-Sorimachi N
- Organizer
  100th Annual meeting of American Association of Immunologists
- Place of Presentation
  ホノルル、ハワイ州、アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] Lysosomal oligopeptide transporter SLC15A4 regulates Toll-like receptor 7/9-mediated autoantibody production2013
- Author(s)
  Kobayashi T, Okamura T, Toyama-Sorimachi N
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  ミラノ、イタリア
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] A lysosomal oligopeptide transporter SLC15A4 regulates homeostasis and inflammatory responses of mast cells
- Author(s)
  Toyama-Sorimachi N, Kobayashi T
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、日本
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] A lysosomal oligopeptide transporter SLC15A4 regulates homeostasis and inflammatory responses of mast cells.
- Author(s)
  Toyama-Sorimachi N, Kobayashi T.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] SLC15A4によるライソゾームのアミノ酸調節とI型インターフェロン産生機構の相互作用
- Author(s)
  小林俊彦，反町典子
- Organizer
  第9回トランスポーター研究会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] Lysosomal oligopeptide transporter SLC15A4 is critical for TLR7/9-mediated inflammatory responses.
- Author(s)
  Kobayashi T, Okamura T, Toyama-Sorimachi N.
- Organizer
  第22回マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-06-02 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] SLC15A4 regulates TLR7/9-triggered type I interferon responses coordinating mTORC activity at lysosome.
- Author(s)
  Kobayashi T, Toyama-Sorimachi N.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293090
[Presentation] Lysosomal oligopeptide transporter SLC15A4 is critical for TLR7/9-mediated inflammatory responses
- Author(s)
  Kobayashi T, Okamura T, Toyama-Sorimachi N
- Organizer
  第22回マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  神戸、日本
- Year and Date
  2014-06-02 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] SLC15A4によるライソゾームのアミノ酸調節とI型インターフェロン産生機構の相互作用
- Author(s)
  Kobayashi T, Toyama-Sorimachi N
- Organizer
  第9回トランスポーター研究会年会
- Place of Presentation
  名古屋、日本
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-25871165
[Presentation] SLC15A4 regulates TLR7/9-triggered type I interferon responses coordinating mTORC activity at lysosome
- Author(s)
  Kobayashi T, Toyama-Sorimachi N
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、日本
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25871165

1. SHIMIZU YUKIKO (00469983)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. OKAMURA TADASHI (00333790)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. DEMOTO Shiho

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. TANAKA Kaori

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. YOSHIDA Reiko

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. KARIU Hitomi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Toyama-Sorimachi Noriko (30217468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHSHIMA Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. TSUTSUI Hidemitsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 遠山典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 20 results
12. 中田和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 林純一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 森政之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 竹永啓三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 岡村孝司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 瀬戸絵理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 赤司祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI TOSHIHIKO 小林 俊彦

KOBAYASHI Toshihiko 小林 俊彦

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Co-Researchers

オートファジーストレスとリソソームストレスを活用した肺線維症治療戦略Principal Investigator

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アミノ酸トランスポーターSLC15A3が担う炎症細胞社会構築と肺線維化メカニズムPrincipal Investigator

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Role of lysosome-resident amino acid transporters in inflammatory responsePrincipal Investigator

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Molecular mechanism of lysosome-dependent allergic inflammationPrincipal Investigator

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A novel regulatory mechanism of autoimmune disease pathogenesis by SLC15A4

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Role of SLC15A4 in controling lysosomal environment and inflammatory responsesPrincipal Investigator

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[Journal Article] Identification of the interacting partners of a lysosomal membrane protein in living cells by BioID technique2022

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[Journal Article] SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress2021

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[Journal Article] Lysosomal amino acid transporters as key players in inflammatory diseases2021

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[Journal Article] Human SLC15A4 is crucial for TLR-mediated type I interferon production and mitochondrial integrity2021

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[Journal Article] Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis.2019

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[Journal Article] Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.2017

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[Journal Article] C4b binding protein negatively regulates TLR1/2 response2017

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[Journal Article] 自己免疫疾患治療標的としてのアミノ酸トランスポーターSLC15A42016

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KOBAYASHI TOSHIHIKO 小林俊彦

KOBAYASHI Toshihiko 小林俊彦