Waku Tsuyoshi 和久剛

Researcher Number	40613584
Other IDs
Affiliation (Current)	2025: 同志社大学, 生命医科学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 同志社大学, 生命医科学部, 准教授 2016 – 2020: 同志社大学, 生命医科学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Functional biochemistry Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 51010:Basic brain sciences-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Applied health science
Keywords	Principal Investigator NRF3 / プロテアソーム / がん増悪 / NRF3 (NFE2L3) / ユビキチン非依存的タンパク質分解 / 20Sプロテアソーム / がん / 腫瘍免疫 / 肥満 / 肥満パラドックス … More / 免疫逃避 / Nrf3 / 翻訳 / CPEB3 / NRF1 / マクロピノサイトーシス / コレステロール / 脂質代謝 / タンパク質分解 / 腫瘍 / 遺伝子発現 / 転写制御 / 癌 / 腫瘍増大 / Retinoblastoma (Rb) / p53 … More Except Principal Investigator 遺伝子発現 / 転写因子 / シグナル伝達 / がん / マクロピノサイトーシス / NRF3 / 腫瘍微小環境 / アルギニン / タンパク質分解 / プロテアソーム / アンチエイジング / タンパク質恒常性 / 転写制御 / アミノ酸飢餓 / 腫瘍増大 / がん免疫回避 / アミノ酸トランスポータ / パーキンソン病 / ドーパミン神経細胞 / ドーパミン / 大脳基底核 / ドラッグリポジショニング / 免疫チェックポイント阻害療法 / 膵臓ガン / がん免疫 / 腫瘍悪性化機構 / CTGF / 乳酸 / 膵臓がん / LDHA / 代謝 / クラスター効果 / ペプチドライブラリー法 / 細胞内輸送 / ACE2 / 受容体結合 / SARS-CoV2 / ペプチド / 受容体結合部位 / SARSコロナウイルス / ペプチドライブラリースクリーニング / 新型コロナウイルス / 多価型ペプチド / スクリーニング / ペプチドライブラリー / Sタンパク / COVID-19 / 免疫疲弊 / 免疫回避 / アミノ酸シグナル / 腫瘍悪性化 / 寿命延長 / シグナル伝達経路 / アルギニン欠乏 / mTORC1 / 腫瘍免疫 / アミノ酸 / 染色体ダイナミクス / 連動的遺伝子発現 / 連動的制御機構 / 転写 / 老化 Less

Physiological function of arginine signaling:macropinocytosisand tumor immune evasion
- Principal Investigator
  
  小林聡
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Doshisha University
腫瘍免疫系における転写因子NRF3を介した肥満パラドックスの分子メカニズム解明Principal Investigator
- Principal Investigator
  
  和久剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Doshisha University
Development of a novel therapeutic agent against COVID-19 by targeting newly synthesized spike protein in cells
- Principal Investigator
  
  Nishikawa Kiyotaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Doshisha University
Improvement of immune checkpoint inhibition therapy for the treatment of pancreatic cancer
- Principal Investigator
  
  Kobayashi Akira
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Doshisha University
Elucidation of novel physiological effects of amino acid signaling and its mediated lifespan extension and immune exhaust
- Principal Investigator
  
  Kobayashi Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Doshisha University
Elucidation of functional dopamine neuronal subsets
- Principal Investigator
  
  藤山文乃
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51010:Basic brain sciences-related
- Research Institution
  Hokkaido University
Pathophysiological role of NRF3-mediated protein degradation in colorectal cancer developmentPrincipal Investigator
- Principal Investigator
  
  Waku Tsuyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Doshisha University
Examination of coupled gene expression mechanisms of proteasome for anti-aging
- Principal Investigator
  
  Kobayashi Akira
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Doshisha University
Functional analysis of a novel regulatory axis of a proteasome in cancer developmentPrincipal Investigator
- Principal Investigator
  
  Waku Tsuyoshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Doshisha University
Molecular analysis of the proteasome gene expression and its application to anti-aging.
- Principal Investigator
  
  KOBAYASHI AKIRA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Doshisha University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation2023
- Author(s)
  Waku Tsuyoshi、Nakada Sota、Masuda Haruka、Sumi Haruna、Wada Ayaka、Hirose Shuuhei、Aketa Iori、Kobayashi Akira
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 1 Pages: 111906-111906
- DOI
  10.1016/j.celrep.2022.111906
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07219, KAKENHI-PROJECT-20H04135, KAKENHI-PROJECT-20J20194, KAKENHI-PROJECT-21K19743, KAKENHI-PUBLICLY-22H04659
[Journal Article] The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis2023
- Author(s)
  Hatanaka Atsushi、Nakada Sota、Matsumoto Gen、Satoh Katsuya、Aketa Iori、Watanabe Akira、Hirakawa Tomoaki、Tsujita Tadayuki、Waku Tsuyoshi、Kobayashi Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 14405-14405
- DOI
  10.1038/s41598-023-41492-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07417, KAKENHI-PUBLICLY-22H04651, KAKENHI-PUBLICLY-22H04659, KAKENHI-PROJECT-23K24214, KAKENHI-PROJECT-23K24772, KAKENHI-PROJECT-23K28007
[Journal Article] NRF3 activates mTORC1 arginine-dependently for cancer cell viability2023
- Author(s)
  Hirose Shuuhei、Waku Tsuyoshi、Tani Misato、Masuda Haruka、Endo Keiko、Ashitani Sanae、Aketa Iori、Kitano Hina、Nakada Sota、Wada Ayaka、Hatanaka Atsushi、Osawa Tsuyoshi、Soga Tomoyoshi、Kobayashi Akira
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 2 Pages: 106045-106045
- DOI
  10.1016/j.isci.2023.106045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07219, KAKENHI-PROJECT-19H03496, KAKENHI-PROJECT-20H04135, KAKENHI-PROJECT-20J20194, KAKENHI-PROJECT-21K19399, KAKENHI-PROJECT-21K19743, KAKENHI-PUBLICLY-22H04659, KAKENHI-PROJECT-23K18234, KAKENHI-PROJECT-22H04925
[Journal Article] Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic Transcription Factor in Obese Mice2023
- Author(s)
  Waku Tsuyoshi、Iwami Takuya、Masuda Haruka、Hirose Shuuhei、Aketa Iori、Kobayashi Akira
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 259 Issue: 1 Pages: 1-8
- DOI
  10.1620/tjem.2022.J090
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07219, KAKENHI-PROJECT-20H04135, KAKENHI-PROJECT-20J20194, KAKENHI-PROJECT-21K19743, KAKENHI-PUBLICLY-22H04659
[Journal Article] NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition2021
- Author(s)
  Waku Tsuyoshi、Hagiwara Toru、Tamura Natsuko、Atsumi Yuri、Urano Yasuomi、Suzuki Mikiko、Iwami Takuya、Sato Katsuya、Yamamoto Masayuki、Noguchi Noriko、Kobayashi Akira
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 10 Pages: 103180-103180
- DOI
  10.1016/j.isci.2021.103180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07093, KAKENHI-PROJECT-19K07650, KAKENHI-PROJECT-20H04135, KAKENHI-PROJECT-21K19743, KAKENHI-PROJECT-23K20318
[Journal Article] Pathophysiological Potentials of NRF3-Regulated Transcriptional Axes in Protein and Lipid Homeostasis2021
- Author(s)
  Waku Tsuyoshi、Kobayashi Akira
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 23 Pages: 12686-12686
- DOI
  10.3390/ijms222312686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07650, KAKENHI-PROJECT-20H04135, KAKENHI-PROJECT-21K19743, KAKENHI-PROJECT-23K20318
[Journal Article] New addiction to the NRF2-related factor NRF3 in cancer cells: Ubiquitin-independent proteolysis through the 20S proteasome.2020
- Author(s)
  Kobayashi A, Waku T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Issue: 1 Pages: 6-14
- DOI
  10.1111/cas.14244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07650, KAKENHI-PROJECT-19K22826, KAKENHI-PROJECT-20H04135
[Journal Article] NRF3-POMP-20S proteasome assembly axis promotes cancer development via ubiquitin-independent proteolysis of p53 and Rb.2020
- Author(s)
  Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: - Issue: 10 Pages: 1-1
- DOI
  10.1128/mcb.00597-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07062, KAKENHI-PROJECT-19K07650, KAKENHI-PROJECT-19K22826, KAKENHI-PROJECT-18J20672, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-20H04135, KAKENHI-ORGANIZER-18H05497
[Journal Article] The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection.2020
- Author(s)
  Omi J, Watanabe-Takahashi M, Igai K, Shimizu E, Tseng CY, Miyasaka T, Waku T, Hama S, Nakanishi R, Goto Y, Nishino Y, Miyazawa A, Natori Y, Yamashita M, Nishikawa K.
- Journal Title
  
  Nat Commun.
  
  Volume: 11 Issue: 1 Pages: 162-162
- DOI
  10.1038/s41467-019-13974-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07650, KAKENHI-PUBLICLY-18H04682, KAKENHI-PROJECT-17H04002
[Journal Article] NFE2L1 and NFE2L3 complementarily maintain basal proteasome activity in cancer cells through CPEB3-mediated translational repression2020
- Author(s)
  Waku, T., Katayama, H., Hiraoka, M., Hatanaka, A., Nakamura, N., Tanaka, Y., Tamura, N., Watanabe, A., and Kobayashi, A.
- Journal Title
  
  Molecular and cellular biology
  
  Volume: 40 Issue: 14
- DOI
  10.1128/mcb.00010-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04135, KAKENHI-PROJECT-18J20672, KAKENHI-PROJECT-19K22826, KAKENHI-PROJECT-19K07650
[Journal Article] β-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells.2019
- Author(s)
  Aono S, Hatanaka A, Hatanaka A, Gao Y, Hippo Y, Taketo MM, Waku T, Kobayashi A.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 13 Pages: 3344-3344
- DOI
  10.3390/ijms20133344
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07650, KAKENHI-PROJECT-19K22826, KAKENHI-PROJECT-18J20672, KAKENHI-PROJECT-17K19624
[Journal Article] Klf5 suppresses ERK signaling in mouse pluripotent stem cells2018
- Author(s)
  Azami T, Matsumoto K, Jeon H, Waku T, Muratani M, Niwa , Takahashi S, Ema M.
- Journal Title
  
  PLos One
  
  Volume: 13 Issue: 11 Pages: e0207321-e0207321
- DOI
  10.1371/journal.pone.0207321
- NAID
  120007128320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18234
[Journal Article] Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation2017
- Author(s)
  Chowdhury A. M. Masudul Azad、Katoh Hiroki、Hatanaka Atsushi、Iwanari Hiroko、Nakamura Nanami、Hamakubo Takao、Natsume Tohru、Waku Tsuyoshi、Kobayashi Akira
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-017-12675-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18234, KAKENHI-PROJECT-16H03265
[Journal Article] Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.2017
- Author(s)
  Taniguchi, H., Okamuro, S., Kohji, M., Waku, T., Kubo, K., Hatanaka, A., Sun, Y., A M Chowdhury, AM A., Fukamizu, A., Kobayashi, A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 484 Issue: 1 Pages: 176-183
- DOI
  10.1016/j.bbrc.2017.01.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03265
[Journal Article] USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression.2016
- Author(s)
  Fukagai, K., Waku, T., Chowdhury, AM., Kubo, K., Matsumoto, M., Kato, H., Natsume, T., Tsuruta, F., Chiba, T., Taniguchi, H., Kobayashi, A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 478 Issue: 1 Pages: 363-370
- DOI
  10.1016/j.bbrc.2016.07.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H03265, KAKENHI-PROJECT-16K07339
[Journal Article] NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.2016
- Author(s)
  Waku T., Nakajima Y., Yokoyama W., Nomura N., Kako K., Kobayashi A., Shimizu T., and Fukamizu A.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 129 Issue: 12 Pages: 2382-2393
- DOI
  10.1242/jcs.183723
- NAID
  120007129526
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-16H03265, KAKENHI-PROJECT-26350957
[Patent] 抗がん剤2017
- Inventor(s)
  和久剛、小林聡、加藤裕紀、糀美早紀、渡辺秀教
- Industrial Property Rights Holder
  和久剛、小林聡、加藤裕紀、糀美早紀、渡辺秀教
- Industrial Property Rights Type
  特許
- Filing Date
  2017-03-15
- Overseas
- Data Source
  KAKENHI-PROJECT-16H03265
[Patent] 抗HIV治療薬を利用した抗がん剤2017
- Inventor(s)
  和久剛、小林聡、畠中惇至
- Industrial Property Rights Holder
  和久剛、小林聡、畠中惇至
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-087470
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H03265
[Patent] 細胞抽出装置、細胞抽出プログラム及び細胞抽出方法2017
- Inventor(s)
  廣安知之、和久剛、日和悟、小林聡、藤井光央、廣瀬修平
- Industrial Property Rights Holder
  廣安知之、和久剛、日和悟、小林聡、藤井光央、廣瀬修平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-236063
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H03265
[Patent] 抗がん剤2016
- Inventor(s)
  和久剛、小林聡、加藤裕紀、渡辺秀教
- Industrial Property Rights Holder
  和久剛、小林聡、加藤裕紀、渡辺秀教
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-230449
- Filing Date
  2016-11-28
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 膵臓の腫瘍悪性化機構の解明に向けた転写因子NRF3の機能解析2023
- Author(s)
  佐藤克哉、山元康平、〇佐藤健、道原琢登、浅野太我、河合穂高、江口傑徳、松本光代、五十嵐和彦、和久剛、小林聡
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.2023
- Author(s)
  Hatanaka A, Nakada S, Matsumoto G, Satoh K, Aketa I, Watanabe A, Hirakawa T, Tsujita T, Waku T, Kobayashi A.
- Organizer
  The Environmental Response VI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] 転写因子NRF3によるMHC-Iのオートファジー分解を介した腫瘍免疫抑制メカニズム解析2023
- Author(s)
  温品美綺、和田恵佳、牧野安優花、明田伊鳳、廣瀬修平、和久剛、小林聡
- Organizer
  第５回マルチモードオートファジー班会議
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] 転写因子NRF3はオートファジーを介してがん細胞のMHC-Iを分解する2023
- Author(s)
  温品美綺、和田恵佳、明田伊鳳、廣瀬修平、和久剛、小林聡
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] 転写因子Nrf3によるオートファジー-MHC-I分解経路を介したがん免疫逃避メカニズムの解明2023
- Author(s)
  温品美綺、和田恵佳、明田伊鳳、廣瀬修平、牧野安優花、和久剛、小林聡
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] The NRF2-related transcription factor NRF3 protects pancreatic cancer cells from ferroptosis by inducing the expression of redox-related genes.2023
- Author(s)
  Shi TY, Hatanaka A, Minase M, 〇Soga K, Sato K, Hatanaka A, Satoh K, Yamamoto K, Nishikawa K, Waku T, Kobayashi A.
- Organizer
  The Environmental Response VI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] Functional analysis of NRF2-related factor NRF3 in pancreatic tumor growth and malignancy.2023
- Author(s)
  Satoh K, Michihara T, Yamamoto K, Sato K, Matsumoto M, Igarashi K, Waku T, Kobayashi A.
- Organizer
  The Environmental Response VI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] 転写因子NRF3によるMHC-Iのオートファジー分解を介した腫瘍免疫抑制メカニズム解析2023
- Author(s)
  温品美綺、和田恵佳、牧野安優花、明田伊鳳、廣瀬修平、和久剛、小林聡
- Organizer
  第1５回オートファジー研究会若手の会
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] 膵臓がんにおける新たな腫瘍増大因子としての転写因子NRF3の機能解析2023
- Author(s)
  佐藤克哉、道原琢登、山元康平、佐藤健、松本光代、五十嵐和彦、和久剛、小林聡
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K28007
[Presentation] NRF3はアルギニンによるmTORC1活性化を介して腫瘍を増大させる2022
- Author(s)
  廣瀬修平、和久　剛、増田　遥、明田伊鳳、畠中敦至、大澤　毅、曽我朋義、小林　聡
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] 膵臓がんのシステイン依存性におけるNRF3-xCT経路の機能2022
- Author(s)
  史　天宇、畑中彩里、水瀬雅己、和久　剛、小林　聡
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] 転写因子Nrf3は細胞膜輸送系の制御を介してメラニン産生カスケードを最適化する2022
- Author(s)
  和田恵佳、中田創太、増田　遥、住　春菜、廣瀬修平、明田伊鳳、和久　剛、小林　聡
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] 転写因子Nrf3は細胞膜輸送系の制御を介してメラニン産生カスケードを最適化する2022
- Author(s)
  和田恵佳、中田創太、増田　遥、住　春菜、廣瀬修平、明田伊鳳、和久　剛、小林　聡
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] 転写因子Nrf3は細胞膜輸送系の制御を介してメラニン産生カスケードを最適化する2022
- Author(s)
  和田恵佳、中田創太、増田　遥、住春　菜、和久剛、小林　聡
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] Identification of Pathological Function of the NRF3-CTGF Axis in Pancreatic Cancer Malignancies.2022
- Author(s)
  Takuto Michihara, Katsuya Satoh, Kohei Yamamoto, Yue Gao, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The 7th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] 膵臓がんのシステイン依存性におけるNRF3-xCT経路の機能2022
- Author(s)
  史　天宇、畑中彩里、水瀬雅己、和久　剛、小林　聡
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] A transcription factor NRF1(NFE2L1) activates selective autophagy by inducing p62 and GABARAPL1 expression upon proteasome inhibition.2022
- Author(s)
  Atsushi Hatanaka, Sota Nakada, Iori Aketa, Katsuya Satoh, Gen Matsumoto, Akira Watanabe, Tomofumi Yoshida, Shigeo Takamori, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The 10th International Symposium on Autophagy (ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3はアルギニンによるmTORC1活性化を介して腫瘍を増大させる2022
- Author(s)
  廣瀬修平、和久　剛、増田　遥、明田伊鳳、畠中敦至、大澤　毅、曽我朋義、小林　聡
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] 転写因子Nrf3は細胞膜輸送系の制御を介してメラニン産生カスケードを最適化する2022
- Author(s)
  和田恵佳、中田創太、増田　遥、住春　菜、和久剛、小林　聡
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] 転写因子NRF3によるミトコンドリア動態制御の可能性2022
- Author(s)
  明田伊鳳、廣瀬修平、増田　遥、和田恵佳、佐藤清敏、曽我朋義、和久　剛、小林　聡
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] A transcription factor NRF1(NFE2L1) activates selective autophagy by inducing p62 and GABARAPL1 expression upon proteasome inhibition.2022
- Author(s)
  Atsushi Hatanaka, Sota Nakada, Iori Aketa, Katsuya Satoh, Gen Matsumoto, Akira Watanabe, Tomofumi Yoshida, Shigeo Takamori, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The 10th International Symposium on Autophagy (ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] 転写因子NRF3によるミトコンドリア動態制御の可能性2022
- Author(s)
  明田伊鳳、廣瀬修平、増田　遥、和田恵佳、佐藤清敏、曽我朋義、和久　剛、小林　聡
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] Identification of Pathological Function of the NRF3-CTGF Axis in Pancreatic Cancer Malignancies.2022
- Author(s)
  Takuto Michihara, 〇Katsuya Satoh, Kohei Yamamoto, Yue Gao, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The 7th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF3-CTGF経路による膵臓がん悪性化機構の解明2021
- Author(s)
  道原琢登、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3-CTGF経路による膵臓がん悪性化機構の解明2021
- Author(s)
  道原琢登、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF3はアミノ酸取り込みおよび葉酸代謝を介したmTORC1活性化によって腫瘍増大に寄与する2021
- Author(s)
  廣瀬修平、増田遥、曽我朋義、和久剛、小林聡
- Organizer
  第80回日本癌学会学術年会、横浜
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF3-TAZ経路による膵がん浸潤・転移機構の解析2021
- Author(s)
  浅野太我、道原琢登、和久剛、小林聡
- Organizer
  第67回日本生化学会近畿支部例会　オンライン開催
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF3はアミノ酸取り込みおよび葉酸代謝を介したmTORC1活性化によって腫瘍増大に寄与する2021
- Author(s)
  廣瀬修平、増田遥、曽我朋義、和久剛、小林聡
- Organizer
  第80回日本癌学会学術年会、横浜
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] 転写因子NRF3によるアミノ酸独占を介したがん免疫回避仮説の検証2021
- Author(s)
  増田遥、廣瀬修平、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF1 and NRF3 complementarily maintain basal proteasome activity in cancer cells through CPEB3-Mediated translational repression.2021
- Author(s)
  Tsuyoshi Waku, Akira Kobayashi
- Organizer
  第44回日本分子生物学会年会、シンポジウム（招待講演）横浜
- Invited
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF1 and NRF3 complementarily maintain basal proteasome activity in cancer cells through CPEB3-Mediated translational repression.2021
- Author(s)
  Tsuyoshi Waku, Akira Kobayashi
- Organizer
  第44回日本分子生物学会年会、シンポジウム（招待講演）横浜
- Invited
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3-TAZ経路による膵がん浸潤・転移機構の解明2021
- Author(s)
  浅野太我、道原琢登、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF3はアミノ酸取り込みを介したmTORC1活性化によって腫瘍増大に寄与する2021
- Author(s)
  廣瀬修平、増田遥、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF1 and NRF3 complementarily maintain basal proteasome activity in cancer cells through CPEB3-Mediated translational repression2021
- Author(s)
  和久剛, 小林聡
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07650
[Presentation] NRF1はプロテアソーム阻害時にp62を介した選択的オートファジーを誘導する2021
- Author(s)
  中田創太、畠中惇至、松本弦、和久剛、貫名信行、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] 転写因子NRF3によるアミノ酸独占を介したがん免疫回避仮説の検証2021
- Author(s)
  増田遥、廣瀬修平、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3-TAZ経路による膵がん浸潤・転移機構の解明2021
- Author(s)
  浅野太我、道原琢登、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3はアミノ酸取り込みを介したmTORC1活性化によって腫瘍増大に寄与する2021
- Author(s)
  廣瀬修平、増田遥、和久剛、小林聡
- Organizer
  第44回日本分子生物学会年会、横浜
- Data Source
  KAKENHI-PROJECT-21K19743
[Presentation] NRF3-TAZ経路による膵がん浸潤・転移機構の解析2021
- Author(s)
  浅野太我、道原琢登、和久剛、小林聡
- Organizer
  第67回日本生化学会近畿支部例会　オンライン開催
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF1はプロテアソーム阻害時にp62を介した選択的オートファジーを誘導する2021
- Author(s)
  中田創太、畠中惇至、松本弦、和久剛、貫名信行、小林聡
- Organizer
  第15回日本臨床ストレス学会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3-CTGF経路による膵がん悪性化機構の解明2020
- Author(s)
  道原琢登、和久剛、小林聡
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3-CTGF経路による膵がん悪性化機構の解明2020
- Author(s)
  道原琢登、和久剛、小林聡
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3によるSREBP2活性とLDL取込みを介したコレステロール代謝制御メカニズムの解明2020
- Author(s)
  渥美友里、萩原透、田村奈都子、浦野泰臣、和久剛、小林聡
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H04135
[Presentation] NRF3によるSREBP2活性とLDL取込みを介したコレステロール代謝制御メカニズムの解明2020
- Author(s)
  渥美友里、萩原透、田村奈都子、浦野泰臣、和久剛、小林聡
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] 転写因子NRF3はがん細胞内のセリン代謝を制御する2020
- Author(s)
  和久剛、廣瀬修平1、谷美里、佐藤清敏、大澤毅、曽我朋義、小林聡
- Organizer
  先端モデル動物プラットフォーム若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-19K07650
[Presentation] NRF1とNRF3は翻訳制御を介してがん細胞の構成的プロテアソーム活性を相補的に維持する2019
- Author(s)
  平岡　都、片山寛之、和久　剛、小林　聡
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3-POMP経路を介したユビキチン非依存的なタンパク質分解の誘導によるがん増悪メカニズム2019
- Author(s)
  和久剛
- Organizer
  第7回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-19K07650
[Presentation] ApcΔ716マウスを用いたNrf3による腫瘍増大機構の解析2019
- Author(s)
  高越、武藤誠、和久剛、小林聡
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3-POMP 経路を介したユビキチン非依存的なタンパク質分解の誘導によるがん増悪メカニズム2019
- Author(s)
  和久剛、濱崎純、浜窪隆雄、渡辺亮、村田茂穂、小林聡
- Organizer
  第5回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] Genome-wide transcriptome analyses for NRF1 and NRF3 upon proteasome inhibition2019
- Author(s)
  Atsushi Hatanaka, Natsuko Tamura, Tsuyoshi Waku, Akira Watanabe, Akira Kobayashi
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] The NRF3-POMP axis promotes tumorigenesis through activating ubiquitin-independent protein degradation by 20S proteasome2019
- Author(s)
  Tsuyoshi Waku, Takao Hamakubo, Akira Watanabe, Shigeo Murata, Akira Kobayashi
- Organizer
  Cold Spring Harbor meeting: Mechanisms of Metabolic Signaling
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] 膵ガンにおける転写因子NRF3（NFE2L3）のVEGF-Aを介した血管新生の可能性2019
- Author(s)
  畑中彩里、青野栞、道原琢登、和久剛、小林聡
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] がん細胞における転写因子NRF3 とNRF1による相補的な構成的プロテアソーム活性制御機構2019
- Author(s)
  小林　聡、和久　剛
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF1 and NRF3 complementarily maintain a basal proteasome activity via CPEB3-mediated translational repression in cancer2019
- Author(s)
  Hiroyuki Katayama, Tsuyoshi Waku, Miyako Hiraoka, Atsushi Hatanaka, Akira Kobayashi
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3 acts as a tumorigenic transcription factor for the assembly of a ubiquitin-independent 20S proteasome2019
- Author(s)
  Tsuyoshi Waku
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07650
[Presentation] NRF1とNRF3は翻訳制御を介してがん細胞の構成的プロテアソーム活性を相補的に維持する2019
- Author(s)
  平岡　都、片山寛之、和久　剛、小林　聡
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3(NFE2L3) contributes to colorectal cancer development through 20S proteasome assembly and the ubiquitin-independent proteolysis.2019
- Author(s)
  Tsuyoshi Waku, Jun Hamazaki, Takao Hamakubo, Akira Watanabe, Shigeo Murata, Akira Kobayashi
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] A CNC family transcription factor NRF3 (NFE2L3) induces cholesterol metabolic genes through SREBP2 activation2019
- Author(s)
  Natsuko Tamura, Toru Hagiwara, Yuri Atsumi, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] 転写因子NRF3によるSREBP2発現を介したコレステロール代謝リプログラミングの可能性2019
- Author(s)
  萩原　透、田村奈都子、渥美友里、和久　剛、浦野泰臣、小林　聡
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] A tumorigenic transcription factor NRF3 activates mTORC1 through amino acid uptake2019
- Author(s)
  Shuuhei Hirose, Misato Tani, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] MALAT1 lncRNA expression is regulated by NRF3 and induces proliferation in cancer cells.2019
- Author(s)
  Svetlana Ivanoff, Atsushi Hatanaka, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3-POMP経路を介したユビキチン非依存的なタンパク質分解の誘導によるがん増悪メカニズム2019
- Author(s)
  和久剛
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-19K07650
[Presentation] がん増悪性転写因子 NRF3 によるアミノ酸取り込みを介した mTORC1 シグナル活性化メカニズム2019
- Author(s)
  廣瀬修平、谷美里、和久剛、小林聡
- Organizer
  第5回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] Colorectal cancer addicts ubiquitin-independent 20S proteasomes assembled by the NRF3-POMP axis2019
- Author(s)
  Tsuyoshi Waku, Atsushi Hatanaka, Jun Hamazaki, Takao Hamakubo, Akira Watanabe, Shigeo Murata, Akira Kobayashi
- Organizer
  Cold Spring Harbor meeting: Ubiquitins, Autophagy & Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] β-catenin/TCF4 Complex-Mediated Induction of The NRF3 (NFE2L3) Gene in Cancer Cells2019
- Author(s)
  Shiori Aono, Ayari Hatanaka, Atsushi Hatanaka, Yue Gao, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] 転写因子NRF3(NFE2L3)はアミノ酸取り込みを介してmTORシグナルを活性化する2019
- Author(s)
  廣瀬修平、谷美里、畠中惇至、萩原透、田村奈都子、和久剛、小林聡
- Organizer
  第66回日本生化学会近畿支部会例会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3 (NFE2L3) contributes to colorectal cancer development through 20S proteasome assembly and the ubiquitinindependent proteolysis2019
- Author(s)
  Tsuyoshi Waku
- Organizer
  The Environmental Response V /17th JBS Biofrontier Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07650
[Presentation] Colorectal cancer addicts ubiquitin-independent 20S proteasomes assembled by the NRF3-POMP axis2019
- Author(s)
  Tsuyoshi Waku
- Organizer
  2019 Meeting on Ubiquitin, Autophagy & Disease (Cold Spring Harbor Laboratory Meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07650
[Presentation] タンパク質恒常性(プロテオスタシス)の破綻による新たな癌増悪メカニズム2019
- Author(s)
  和久　剛
- Organizer
  第一回日本医学会連合Rising Starリトリート
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] 転写因子NRF3(NFE2L3)はアミノ酸取り込みを介してmTORC1シグナルを活性化する2019
- Author(s)
  谷　美里、廣瀬修平、北野妃菜、和久　剛、小林　聡
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] NRF3によるSREBP2発現を介したコレステロール代謝リプログラミングの可能性2019
- Author(s)
  萩原　透、田村奈都子、渥美友里、和久　剛、浦野泰臣、小林　聡
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] がん細胞におけるβ-catenin/TCF4複合体によるNRF#(NFE2L3)遺伝子の誘導2019
- Author(s)
  畑中彩里、青野栞、畠中惇至、高越、和久剛、小林聡
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-19K22826
[Presentation] プロテオスタシスの破綻による新たな腫瘍増大メカニズム2018
- Author(s)
  和久剛, 小林聡
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] プロテアソーム制御因子の翻訳制御を介したタンパク質分解調節メカニズムの解明2018
- Author(s)
  片山寛之, 和久剛, 小林聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] ストレス応答性転写因子NRF3の20Sプロテアソーム活性化による新たな発ガン機構2018
- Author(s)
  小林聡、和久剛
- Organizer
  第13回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] NRF3-POMP-20Sプロテアソーム軸の異常によるプロテオスタシスの破綻は腫瘍増大に寄与する2018
- Author(s)
  和久　剛
- Organizer
  先端モデル動物プラットフォーム若手支援技術講習会2018
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] A transcription factor NRF3 (NFE2L3) promotes tumor growth by enhancing 20S proteasome assembly2018
- Author(s)
  和久　剛
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] 腫瘍増大に寄与するプロテオスタシス制御機構2018
- Author(s)
  和久剛、小林聡
- Organizer
  第６回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3（NFE2L3）によるがん細胞の脂質代謝制御の可能性2018
- Author(s)
  田村奈都子、萩原透、和久剛、小林聡
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 大腸がんの細胞増殖を制御するβ-catenin-NRF3-20Sプロテアソーム経路2018
- Author(s)
  小林聡、青野栞、Chowdhury AM Masudul、畠中惇至、筆宝義隆、和久剛
- Organizer
  第６回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 腫瘍増大に寄与するプロテオスタシス制御機構2018
- Author(s)
  和久　剛
- Organizer
  第6回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] NRF3-POMP-20S proteasome axis enhances tumor growth2018
- Author(s)
  和久　剛
- Organizer
  日本癌学会第77回学術総会
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] 転写因子NRF1とNRF3の翻訳制御を介した新たなプロテアソーム活性調節メカニズムの解明2018
- Author(s)
  片山寛之、平岡都、和久剛、小林聡
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3（NFE2L3）は20Sプロテアソームアッセンブリを亢進して腫瘍増大に寄与する2018
- Author(s)
  和久剛、村田茂穂、小林聡
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] プロテオスタシスの破綻による新たな腫瘍増大メカニズム2018
- Author(s)
  和久　剛
- Organizer
  日本生化学会第91回大会
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] トランスクリプトーム解析による転写因子NRF1のがん細胞における機能解明2018
- Author(s)
  畠中惇至、和久剛、渡辺亮、小林聡
- Organizer
  第６回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 大腸ガン細胞におけるNRF3遺伝子の発現誘導メカニズムの解明2018
- Author(s)
  青野栞, 和久剛, 筆宝義隆, 小林聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NFE2L3 (NRF3) はin vitroにおいてがん細胞の浸潤と遊走を促進する2018
- Author(s)
  廣瀬修平、谷美里、和久剛、小林聡
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] プロテオスタシスの破綻による新たな腫瘍増大メカニズム2018
- Author(s)
  和久剛、小林聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] プロテオスタシスの破綻による新たな腫瘍増大メカニズム2018
- Author(s)
  和久剛、小林聡
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] HIV-1プロテアーゼ阻害剤による転写因子NRF3を標的とした新たな抗がん作用機構2017
- Author(s)
  畠中惇至、行武拓哉、糀美早紀、和久　剛、小林　聡
- Organizer
  第22回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3（NFE2L3）は20Sプロテアソームの活性亢進を介して腫瘍増大に寄与する2017
- Author(s)
  和久剛、糀美早紀、鎌田七海、辰巳千夏、畠中惇至、小林聡
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K18234
[Presentation] 転写因子NRF3はプロテアソーム発現亢進を介してp53依存的なガン抑制シグナルを阻害する2017
- Author(s)
  和久　剛、小林　聡
- Organizer
  転写研究会・新学術領域「転写サイクル」共催　冬の若手ワークショップ2017
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3（NFE2L3）を過剰発現するヒト肺がん細胞H1299を用いたマウス移植解析2017
- Author(s)
  糀美早紀、和久剛、小林聡
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3は20プロテアソーム活性亢進を介してガン細胞の増殖を亢進する2017
- Author(s)
  鎌田七海、糀美早紀、和久　剛、小林　聡
- Organizer
  第64回日本生化学会近畿支部会
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3（NFE2L3）は20Sプロテアソームの活性亢進を介して腫瘍増大に寄与する2017
- Author(s)
  和久剛、糀美早紀、鎌田七海、辰巳千夏、畠中惇至、小林聡
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 遺伝子発現の変調によるガン進展メカニズム解明2017
- Author(s)
  和久　剛
- Organizer
  第五回　四私大合同生命科学シンポジウム ”数理・情報による生命科学の新たな潮流”
- Place of Presentation
  関西学院（兵庫県・西宮市）
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3（NFE2L3）はTGF-β/SMADシグナルを制御する2017
- Author(s)
  廣瀬修平、和久剛、小林　聡
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 構成的プロテアソーム活性の転写因子NRF1とNRF3による協調的制御の可能性2017
- Author(s)
  片山寛之、鎌田七海、和久剛、小林聡
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] The HRD1-NRF3 axis regulates the proliferation of colon cancer cells by inducing the UHMK1 gene expression.2016
- Author(s)
  AM Masudul Azad Chowdhury, Hiroki Kato, Tsuyoshi Waku, Akira Kobayashi
- Organizer
  Targeting Cancer: 81st Cold Spring Harbor Symposium.
- Place of Presentation
  Cold Spring harbor (USA)
- Year and Date
  2016-06-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF1の活性化メカニズムにおけるシグナルペプチダーゼSEC11Aの機能解析2016
- Author(s)
  畠中惇至、和久剛、谷口浩章、小林聡
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3によるガン細胞におけるプロテアソーム発現機構2016
- Author(s)
  田中裕也、○鎌田七海、和久剛、小林聡
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3はp53依存的なガン細胞の増殖抑制を阻害する2016
- Author(s)
  和久剛、加藤裕紀、渡辺秀教、岩成宏子、辰巳千夏、畠中惇至、浜窪隆雄、小林聡
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H03265
[Presentation] 転写因子NRF3はガン細胞の20Sプロテアソーム発現を制御する2016
- Author(s)
  鎌田七海、畠中惇至、糀美早紀、和久剛、小林聡
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜みなとみらい21（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H03265

1. KOBAYASHI AKIRA (50292214)

# of Collaborated Projects: 8 results

# of Collaborated Products: 101 results
2. Nishikawa Kiyotaka (40218128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 依馬正次 (60359578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤山文乃 (20244022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高橋晋 (20510960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 苅部冬紀 (60312279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 平井康治 (30648431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Murata Shigeo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Hamazaki Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. Hamakubo Takao

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Watanabe Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. URANO Yasuomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 佐藤克也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 深水昭吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Waku Tsuyoshi 和久 剛

Research Projects

Research Products

Co-Researchers

Physiological function of arginine signaling:macropinocytosisand tumor immune evasion

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腫瘍免疫系における転写因子NRF3を介した肥満パラドックスの分子メカニズム解明Principal Investigator

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Development of a novel therapeutic agent against COVID-19 by targeting newly synthesized spike protein in cells

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Improvement of immune checkpoint inhibition therapy for the treatment of pancreatic cancer

Principal Investigator

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Elucidation of novel physiological effects of amino acid signaling and its mediated lifespan extension and immune exhaust

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Elucidation of functional dopamine neuronal subsets

Principal Investigator

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Pathophysiological role of NRF3-mediated protein degradation in colorectal cancer developmentPrincipal Investigator

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Examination of coupled gene expression mechanisms of proteasome for anti-aging

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Functional analysis of a novel regulatory axis of a proteasome in cancer developmentPrincipal Investigator

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Molecular analysis of the proteasome gene expression and its application to anti-aging.

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[Journal Article] The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation2023

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[Journal Article] The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis2023

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[Journal Article] NRF3 activates mTORC1 arginine-dependently for cancer cell viability2023

Author(s)

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[Journal Article] Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic Transcription Factor in Obese Mice2023

Waku Tsuyoshi 和久剛