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narita yuki  成田 勇樹

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Narita Yuki  成田 勇樹

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Researcher Number 40614665
Other IDs
Affiliation (Current) 2025: 崇城大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 熊本大学, 病院, 助教
2015 – 2018: 熊本大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Except Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Keywords
Principal Investigator
セリンプロテアーゼ / 酸化ストレス / CVD / インドキシル硫酸 / 血栓塞栓症 / CKD / マルチターゲット作用 / AKI / 腎障害
Except Principal Investigator
間質線維化 … More / 間質性線維化 / 尿管結紮 / 硫酸転移酵素 / 心腎連関 / 腎線維化 / 慢性腎不全 / 急性腎障害 / 尿毒症物質 / 酸化ストレス / 腎細胞がん / ARB / 抗腫瘍効果 / スニチニブ / アンジオテンシン受容体拮抗薬 / レニンアンジオテンシン / 副作用軽減 / 分子標的治療薬 / 降圧薬 / 腎細胞癌 Less
  • Research Projects

    (5 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (8 People)
  •  Establish a preventive strategy against thromboembolism in chronic kidney disease by suppressing indoxyl sulfate production and accumulation.Principal Investigator

    • Principal Investigator
      成田 勇樹
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Investigation of the toxicological role of indoxyl sulfate and the enzyme responsible for its production, Sult1a1, in the cardiorenal syndrome

    • Principal Investigator
      齋藤 秀之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Establishment of a novel AKI treatment utilizing multi-target action by regulating serine proteasesPrincipal Investigator

    • Principal Investigator
      Narita Yuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Construction of novel CKD therapeutic strategy targeting oxidative stress regulation via serine proteasePrincipal Investigator

    • Principal Investigator
      Narita Yuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Optimization of combination therapy with antihypertensive drug to ameliorate side effects of multilinase inhibitors in kidney cancer

    • Principal Investigator
      KADOWAKI Daisuke
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Sojo University
      Kumamoto University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice2023

    • Author(s)
      Hou Huixian、Horikawa Mai、Narita Yuki、Jono Hirofumi、Kakizoe Yutaka、Izumi Yuichiro、Kuwabara Takashige、Mukoyama Masashi、Saito Hideyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 14 Pages: 11329-11329

    • DOI

      10.3390/ijms241411329

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18291, KAKENHI-PROJECT-22K08357, KAKENHI-PROJECT-23K06281, KAKENHI-PROJECT-23K07676, KAKENHI-PROJECT-21K08280, KAKENHI-PROJECT-23K24047
  • [Journal Article] Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels2022

    • Author(s)
      Kakizoe Yutaka、Nakagawa Terumasa、Iwata Yasunobu、Deng Qinyuan、Adachi Masataka、Miyasato Yoshikazu、Nakagawa Miyuki、Nagayoshi Yu、Nishiguchi Kayo、Narita Yuki、Izumi Yuichiro、Kuwabara Takashige、Tomita Kimio、Kitamura Kenichiro、Mukoyama Masashi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 150 Issue: 4 Pages: 204-210

    • DOI

      10.1016/j.jphs.2022.09.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08280, KAKENHI-PROJECT-22K08357, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-20K08638, KAKENHI-PROJECT-20K16047
  • [Journal Article] The serine protease plasmin plays detrimental roles in epithelial sodium channel activation and podocyte injury in Dahl salt-sensitive rats2022

    • Author(s)
      Deng Qinyuan、Kakizoe Yutaka、Iwata Yasunobu、Nakagawa Terumasa、Miyasato Yoshikazu、Nakagawa Miyuki、Nishiguchi Kayo、Nagayoshi Yu、Adachi Masataka、Narita Yuki、Izumi Yuichiro、Kuwabara Takashige、Tsuda Yuko、Mukoyama Masashi
    • Journal Title

      Hypertension Research

      Volume: 46 Issue: 1 Pages: 50-62

    • DOI

      10.1038/s41440-022-01064-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08280, KAKENHI-PROJECT-22K08357, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-20K16047
  • [Journal Article] Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity2019

    • Author(s)
      Narita Yuki、Hamamura Kana、Kashiyama Mami、Utsumi Sara、Kakizoe Yutaka、Kondo Yuki、Ishitsuka Yoichi、Jono Hirofumi、Irie Tetsumi、Mukoyama Masashi、Saito Hideyuki、Kadowaki Daisuke、Hirata Sumio、Kitamura Kenichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 17 Pages: 4140-4140

    • DOI

      10.3390/ijms20174140

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06774, KAKENHI-PROJECT-17K08955, KAKENHI-PROJECT-17K09705, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-18K08237, KAKENHI-PROJECT-17K15509
  • [Journal Article] Knowledge and awareness of nonpharmacist salespersons regarding over-the-counter drug use in patients with chronic kidney disease in Japan2019

    • Author(s)
      Kondo Yuki、Ishitsuka Yoichi、Kawabata Nobuhiro、Iwamoto Nobuhide、Takahashi Risa、Narita Yuki、Kadowaki Daisuke、Hirata Sumio、Uchino Satoru、Irie Tetsumi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 3 Pages: e0213763-e0213763

    • DOI

      10.1371/journal.pone.0213763

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Journal Article] Coefficient of Determination between Estimated and Measured Renal Function in Japanese Patients with Sarcopenia May Be Improved by Adjusting for Muscle Mass and Sex: A Prospective Study2019

    • Author(s)
      Nakatani Sakura、Maeda Keisuke、Akagi Junji、Ichigi Misato、Murakami Marina、Harada Yoshihiko、Utsumi Sara、Fukunaga Masaki、Narita Yuki、Kondo Yuki、Ishitsuka Yoichi、Irie Tetsumi、Kadowaki Daisuke、Hirata Sumio
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 8 Pages: 1350-1357

    • DOI

      10.1248/bpb.b19-00154

    • NAID

      130007686738

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-08-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06774, KAKENHI-PROJECT-17K15509
  • [Journal Article] Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects2018

    • Author(s)
      Nakagawa T, Kakizoe Y, Iwata Y, Miyasato Y, Mizumoto T, Adachi M, Izumi Y, Kuwabara T, Suenaga N, Narita Y, Jono H, Saito H, Kitamura K, Mukoyama M
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 315 Issue: 5 Pages: 1347-1357

    • DOI

      10.1152/ajprenal.00648.2017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09705, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-18K08247, KAKENHI-PROJECT-17K15509, KAKENHI-PROJECT-17K16090
  • [Journal Article] Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats2018

    • Author(s)
      Muraya Nanako、Kadowaki Daisuke、Miyamura Shigeyuki、Kitamura Kenichiro、Uchimura Kohei、Narita Yuki、Miyamoto Yohei、Chuang Victor Tuan Giam、Taguchi Kazuaki、Maruyama Toru、Otagiri Masaki、Hirata Sumio
    • Journal Title

      Oxidative Medicine and Cellular Longevity

      Volume: 2018 Issue: 1 Pages: 1-8

    • DOI

      10.1155/2018/7635274

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06774, KAKENHI-PROJECT-18K08237, KAKENHI-PROJECT-17K15509
  • [Journal Article] A simple formula for predicting drug removal rates during hemodialysis2018

    • Author(s)
      Urata M, Narita Y, Fukunaga M, Kadowaki D, Hirata S
    • Journal Title

      Ther Apher Dial

      Volume: in print Issue: 5 Pages: 485-493

    • DOI

      10.1111/1744-9987.12675

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08450, KAKENHI-PROJECT-18K06774, KAKENHI-PROJECT-17K15509
  • [Journal Article] Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.2016

    • Author(s)
      Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 130 Issue: 2 Pages: 110-116

    • DOI

      10.1016/j.jphs.2016.01.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461226, KAKENHI-PROJECT-26461234, KAKENHI-PROJECT-15K19459, KAKENHI-PROJECT-15K19460, KAKENHI-PROJECT-15K08100
  • [Journal Article] NSAIDsとアセトアミノフェンの安全性~特に腎機能障害に着目して~2016

    • Author(s)
      平田純生,門脇大介,成田勇樹,近藤悠希,石塚洋一
    • Journal Title

      日本医薬品安全性学会会誌

      Volume: 1 Pages: 13-29

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08100
  • [Presentation] 糖尿病-造影剤腎症の発症機序解明に基づく予防策の検証2023

    • Author(s)
      成田勇樹、大井桃、黒木香吉、城野博史、齋藤秀之
    • Organizer
      第17回日本腎臓病薬物療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-23K06281
  • [Presentation] Inhibition of indoxyl sulfate production and accumulation prevents renal fibrosis in sulfotransferase (Sult)1a1-deficient mice2023

    • Author(s)
      Huixian Hou, Mai Horikawa, Yuki Narita, Hirofumi Jono, Hideyuki Saito
    • Organizer
      第 6 回日本 Uremic Toxin 研究会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06281
  • [Presentation] Unilateral ureteral obstruction (UUO) - induced renal fibrosis is attenuated by suppression of indoxyl sulfate (IS) accumulation in sulfotransferase (Sult) 1a1-deficient mice2023

    • Author(s)
      Huixian Hou, Mai Horikawa, Yuki Narita, Hirofumi Jono, Hideyuki Saito
    • Organizer
      第66回(令和5年度)日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K06281
  • [Presentation] 糖尿病モデルラットを用いた造影剤腎症の発症機序解明に基づく予防策の基盤検証2023

    • Author(s)
      大井 桃、成田 勇樹、黒木 香吉、城野 博史、齋藤 秀之
    • Organizer
      第66回(令和5年度)日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K06281
  • [Presentation] Unilateral ureteral obstruction (UUO)-induced renal fibrosis is attenuated by suppression of indoxyl sulfate (IS) accumulation in sulfotransferase (Sult)1a1-deficient mice2023

    • Author(s)
      HOU Huixian, Horikawa Mai, Narita Yuki, Jono Hirofumi, Saito Hideyuki
    • Organizer
      第66回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] 糖尿病モデルラットを用いた造影剤腎症の発症機序解明に基づく予防策の基盤検証2023

    • Author(s)
      大井桃、成田勇樹、黒木香吉、城野博史、齋藤秀之
    • Organizer
      第66回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] Inhibition of indoxyl sulfate production and accumulation prevents renal fibrosis in sulfotransferase (Sult)1a1-deficient mice2023

    • Author(s)
      Hou H, Horikawa M, Narita Y, Jono H, Saito H.
    • Organizer
      第6回日本Uremic Toxin研究会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] Attenuation of cardiac pathological alterations in sulfotransferase 1a1-deficient mice with chronic kidney failure through decreased indoxyl sulfate accumulation2022

    • Author(s)
      Aina Nishigaki、Yuki Narita、Yuichiro Arima、Kenichi Tsujita、Hirofumi Jono、Hideyuki Saito
    • Organizer
      第32回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-20K16047
  • [Presentation] 硫酸転移酵素 Sult1a1 欠損マウスを用いた慢性腎臓病の心血管 疾患発症に対するインドキシル硫酸の寄与解明2022

    • Author(s)
      西垣愛奈、成田勇樹、有馬勇一郎、辻田 賢一、城野 博史、齋藤秀之
    • Organizer
      第65回(令和4年度)日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16047
  • [Presentation] 血清トラフ濃度25μg/mLを目標としたテイコプラニン維持投与量に関する後方視的検討2022

    • Author(s)
      近藤 昭志, 尾田 一貴, 片野田 朋美, 成田 勇樹, 岩村 耕次, 野坂 生郷, 城野 博史, 齋藤 秀之
    • Organizer
      日本TDM学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] シスプラチン誘発急性腎障害におけるインドキシル硫酸の毒性学的役割の解明2022

    • Author(s)
      堀川 真衣, 薮内 希実, 成田 勇樹, 城野 博史, 齋藤 秀之
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] 硫酸転移酵素Sult1a1欠損マウスを用いた慢性腎臓病の心血管疾患発症に対するインドキシル硫酸の寄与解明2022

    • Author(s)
      西垣 愛奈, 成田 勇樹, 有馬 勇一郎, 辻田 賢一, 城野 博史, 齋藤 秀之
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] CKD及び糖尿病モデルラットを用いた造影剤誘発急性腎障害の発症リスクおよび生理食塩水の予防効果の検証2022

    • Author(s)
      黒木 香吉, 田中 仁美, 成田 勇樹, 城野 博史, 齋藤 秀之
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] LPS 誘発性急性腎障害に対するセリンプロテアーゼ阻害薬の腎保護作用の検討2021

    • Author(s)
      緒方文香、成田勇樹、柿添豊、石塚洋一、門脇大介、平田純生
    • Organizer
      第64回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16047
  • [Presentation] 慢性腎臓病患者のポリファーマシーに対する 総合的戦略に関する研究 :プレイオトロピック効果による酸化ストレス制御の治療応用2021

    • Author(s)
      成田勇樹
    • Organizer
      第31回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-20K16047
  • [Presentation] セリンプロテアーゼ阻害薬による急性腎障害抑制効果の検討及び抗酸化機序の探索2021

    • Author(s)
      成田勇樹、緒方文香、柿添豊、近藤悠希、石塚洋一、門脇大介、平田純生、齋藤秀之
    • Organizer
      第15回日本腎臓病薬物療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-20K16047
  • [Presentation] 低酸素誘発腎障害後の線維化亢進機序におけるインドキシル硫酸の毒性学的役割2020

    • Author(s)
      郡田 菜緒, 山下 真実, 成田 勇樹, 城野 博史, 齋藤 秀之
    • Organizer
      第63回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16047
  • [Presentation] ノイロトロピンの抗酸化作用及び腎保護効果への寄与2019

    • Author(s)
      福永雅樹、内田朱美、末吉美優、前田仁志、成田勇樹、渡邊博志、丸山徹、瀬尾量、平田純生、門脇大介
    • Organizer
      第13回日本腎臓病薬物療法学会学術集会・総会2019
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] 第Xa因子阻害剤エドキサバンの腎疾患治療への応用を目指した抗酸化作用の解析2019

    • Author(s)
      成田勇樹、浜村佳奈、樫山真美、近藤悠希、石塚洋一、入江徹美、門脇大介、平田純生
    • Organizer
      第5回 日本医薬品安全性学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] 腎疾患治療への応用を目指したカモスタットの抗酸化作用解析2019

    • Author(s)
      樫山真美、成田勇樹、浜村佳奈、柿添豊、向山政志、門脇大介、平田純生、北村健一郎
    • Organizer
      第62回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] 第Xa因子阻害剤エドキサバンの抗酸化作用の解析と腎疾患治療への応用2018

    • Author(s)
      浜村佳奈、成田勇樹、樫山真美、門脇大介、平田純生
    • Organizer
      第12回日本腎臓病薬物療法学会学術集会・総会2018
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] アセトアミノフェン及びその代謝物の抗酸化作用の解析と慢性腎臓病治療への応用2018

    • Author(s)
      福永雅樹、兵藤沙耶、門脇大介、小谷俊介、成田勇樹、平田純生
    • Organizer
      第61回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] 腎と遠隔臓器保護を目指して~臨床につながる視点~2018

    • Author(s)
      成田勇樹、門脇 大介、平田 純生
    • Organizer
      第28回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] ストレプトゾトシン誘発早期糖尿病モデルラットにおけるラクツロースの腎機能と腸内環境に及ぼす影響2018

    • Author(s)
      末吉美優、門脇大介、福永雅樹、目井瑞絵、成田勇樹、平田純生
    • Organizer
      第61回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] アセトアミノフェン及びその代謝物の抗酸化作用の解析と慢性腎臓病治療への応用2017

    • Author(s)
      兵藤 沙耶、門脇 大介、成田 勇樹、平田 純生
    • Organizer
      第27回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-17K15509
  • [Presentation] 腎細胞癌治療における降圧薬の併用による抗腫瘍効果の比較2016

    • Author(s)
      中村希,門脇大介,高森紀衣,成田勇樹,小田切優樹,丸山徹,平田純生
    • Organizer
      第25回日本医療薬学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-21
    • Data Source
      KAKENHI-PROJECT-15K08100
  • [Presentation] 腎細胞癌治療におけるチロシンキナーゼ阻害薬による高血圧に対する降圧薬の適正使用に向けての基礎的検討2016

    • Author(s)
      中村希,門脇大介,高森紀衣,成田勇樹,小田切優樹,丸山徹,平田純生
    • Organizer
      第9回日本腎臓薬物療法学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K08100
  • 1.  KADOWAKI Daisuke (70433000)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  平田 純生 (10432999)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 3.  齋藤 秀之 (40225727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  IZUMI Yuichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  森 潔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  向山 政志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  斎藤 秀之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results
  • 8.  柿添 豊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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