Watanabe Yukihide 渡邊幸秀

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WATANABE Yukihide 渡邊幸秀

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Researcher Number	40618534
Affiliation (Current)	2025: 筑波大学, 医学医療系, 助教
Affiliation (based on the past Project Information) *help	2023: 筑波大学, 医学医療系, 助教 2013 – 2021: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 47040:Pharmacology-related / Experimental pathology / Tumor biology Except Principal Investigator Experimental pathology
Keywords	Principal Investigator TMEPAI / 腫瘍形成 / TGF-betaシグナル / 休眠 / イメージング / TGF-bシグナル / 休眠期 / がん幹細胞 / 新規抗がん剤 / 抗腫瘍 … More / LDLRAD4 / 癌関連タンパク質 / TMEPAI/PMEPA1 / 抗腫瘍薬 / 特殊環状ペプチド / 結合環状ペプチド / がん促進タンパク質 / 実験病理学 / 腫瘍学 / 生体内機能解析 / がん関連遺伝子 / Wnt / 足場非依存的増殖 / TGF-b/Smad / がん / 癌関連遺伝子 / EGF / TGF-beta / 発現制御 … More Except Principal Investigator Gpnmb / 幹細胞 / 上皮間葉転換 / MAFK / 特殊環状ペプチド / GPNMB / MafK / TMEPAI / TGF-β / トランスフォーミング増殖因子β / がん幹細胞 / 足場非依存性増殖 / がん Less

Elucidation of the stemness induction mechanism in sustained proliferation of cancer cellsPrincipal Investigator
- Principal Investigator
  
  Watanabe Yukihide
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Tsukuba
Development of targeting cancer therapy against TMEPAI using macrocyclic peptidePrincipal Investigator
- Principal Investigator
  
  Watanabe Yukihide
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  University of Tsukuba
The molecular function of TMEPAI in tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Watanabe Yukihide
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Tsukuba
The Roles of TMEPAI on tumorigenesisPrincipal Investigator
- Principal Investigator
  
  WATANABE Yukihide
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  University of Tsukuba
Roles of TGF-beta target genes TMEPAI and MafK on cancer development
- Principal Investigator
  
  Kato Mitsuyasu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Tsukuba

All 2021 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells2021
- Author(s)
  Md Anwarul Haque, Mohammed Abdelaziz, Meidi Utami Puteri, Thanh Thao Vo Nguyen, Kosei Kudo, Yukihide Watanabe, Mitsuyasu Kato
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 19 Pages: 4934-4934
- DOI
  10.3390/cancers13194934
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06942, KAKENHI-PROJECT-20K20597
[Journal Article] 2)TGF-β-Induced TMEPAI attenuates the response of triple-negative breast cancer cells to Doxorubicin and Paclitaxel.2020
- Author(s)
  Wardhani BWK, Puteri MU, Watanabe Y, Louisa M, Setiabudy R, Kato M
- Journal Title
  
  J Exp Pharmacol.
  
  Volume: 12 Pages: 17-26
- DOI
  10.2147/jep.s235233
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06682
[Journal Article] PMEPA1/TMEPAI isoforms function via its PY and Smad interaction motifs for tumorigenic activities of breast cancer cells.2020
- Author(s)
  Puteri MU, Watanabe Y, Wardhani BWK, Amalia R, Abdelaziz M, Kato M.
- Journal Title
  
  Genes to Cells
  
  Volume: in press Issue: 6 Pages: 375-390
- DOI
  10.1111/gtc.12766
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06682, KAKENHI-PROJECT-20K20597, KAKENHI-PROJECT-18H02676
[Journal Article] TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells.2019
- Author(s)
  Amalia R, Abdelaziz M, Puteri MU, Hwang J, Anwar F, Watanabe Y, Kato M.
- Journal Title
  
  Cellular Signalling
  
  Volume: 16 Pages: 24-33
- DOI
  10.1016/j.cellsig.2019.03.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06682
[Journal Article] PMEPA1/TMEPAI knockout impairs tumour growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth.2019
- Author(s)
  Abdelaziz M, Watanabe Y, Kato M.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 165 Issue: 5 Pages: 411-414
- DOI
  10.1093/jb/mvz022
- NAID
  40021880564
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06682
[Journal Article] Regulation of bone morphogenetic protein signaling by ADP-ribosylation.2016
- Author(s)
  Watanabe Y, Papoutsoglou, Maturi V, Tsubakihara Y, Hottiger OM, Heldin C-H, Moustakas A
- Journal Title
  
  J Biol Chem.
  
  Volume: 291 Issue: 24 Pages: 12706-12723
- DOI
  10.1074/jbc.m116.729699
- NAID
  120007135347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19100
[Journal Article] The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.2016
- Author(s)
  Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Moren A, Watanabe Y, Voytruk I, Botling J, Soderberg O, Micke P, Pyrowolakis G, Heldin C-H, Moustakas A
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 2 Pages: 1120-1143
- DOI
  10.18632/oncotarget.6683
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19100
[Journal Article] がんの増殖・進展とTGF-beta　慢性炎症とがん2016
- Author(s)
  渡邊幸秀、加藤光保
- Journal Title
  
  別冊BIO Clinica　慢性炎症と疾患
  
  Volume: 5 Pages: 54-59
- Data Source
  KAKENHI-PROJECT-16K19100
[Journal Article] Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-b and epidermal growth factor signaling.2015
- Author(s)
  Azami S, Vo Nguyen TT, Watanabe Y, Kato M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 456 Issue: 2 Pages: 580-585
- DOI
  10.1016/j.bbrc.2014.11.107
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870093, KAKENHI-PUBLICLY-26116707, KAKENHI-PROJECT-25293092
[Journal Article] TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells2014
- Author(s)
  2) Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S and Kato M.
- Journal Title
  
  Cancer Science
  
  Volume: 105 Pages: 334-341
- NAID
  120007136725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870093
[Journal Article] C18 ORF1: A Novel Negative Regulator of TGF-β Signaling.2014
- Author(s)
  Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Thanh Thao Vo Nguyen TT, Watanabe Y, Kato M and Itoh S.
- Journal Title
  
  Jounal of Biological Chemistry
  
  Volume: 289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293092
[Journal Article] TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells.2014
- Author(s)
  3) Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S and Kato M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 3 Pages: 334-341
- DOI
  10.1111/cas.12355
- NAID
  120007136725
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293092, KAKENHI-PUBLICLY-26116707, KAKENHI-PROJECT-26305006
[Journal Article] C18ORF1: a novel negative regulator of TGF-b signaling.2014
- Author(s)
  1) Nakano N, Maeyama K, Sakata N, Itoh F, Akutsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870093
[Journal Article] C18ORF1: A Novel Negative Regulator of TGF-β Signaling.2014
- Author(s)
  2. Nakano N, Maeyama K, Ikeno S, Itoh F, Togawa Y, Katsu Y, Thanh Thao, VN, Watanabe Y, Kato M & Itoh, S.
- Journal Title
  
  J. Biol. Chem.,
  
  Volume: 289 Issue: 18 Pages: 12680-12680
- DOI
  10.1074/jbc.m114.558981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689023, KAKENHI-PUBLICLY-25118728, KAKENHI-PROJECT-25293092, KAKENHI-PROJECT-25670168, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-26460479
[Presentation] TMEPAI functions via its PY and a Smad Interaction motif (SIM) for tumorigenic activities of breast cancer cells2021
- Author(s)
  Puteri Meidi Utami, Wardhani Bantari W.K., Amalia Riezki, Yukihide Watanabe, Mitsuyasu Kato
- Organizer
  The 1st International Conference on Pharmaceutical Sciences and Military Pharmacy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06942
[Presentation] PMEPAI/TMEPAI promotes tumorigenesis in triple negative breast cancer by sustaining PI3K/AKT signaling2020
- Author(s)
  Md Anwarul Haque; Watanabe Yukihide; Kato Mitsuyasu
- Organizer
  第79回日本癌学会学術総会/2020-10-01--2020-10-03
- Data Source
  KAKENHI-PROJECT-18K06682
[Presentation] TMEPAI drives anchorage-independent growth in breast cancer cells through its SIM and PY motifs2019
- Author(s)
  Watanabe Y, Puteri MU, Amalia R, Abdelaziz M, Wardhani BWK, Anwar F, Kato M
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06682
[Presentation] TMEPAI promotes stemness of breast cancer cells by regulating AKT signaling2019
- Author(s)
  Watanabe Y
- Organizer
  The TGF-b signaling meeting in Leiden
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06682
[Presentation] Roles of TMEPAI in breast cancer cells2017
- Author(s)
  Yukihide Watanabe, Mitsuyasu Kato
- Organizer
  The 17th TGF-b meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19100
[Presentation] TMEPAI is involved in cancer development2016
- Author(s)
  Yukihide Watanabe, Mitsuyasu Kato
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19100
[Presentation] ADPリボース化によるBMPシグナルの制御2015
- Author(s)
  渡邊幸秀、Aristidis Moustakas、加藤光保
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293092
[Presentation] Roles of PARP on BMP signaling pathway2013
- Author(s)
  Yukihide Watanabe
- Organizer
  14ｔｈ TGF-b meeting in Uppsala
- Place of Presentation
  Uppsala, Sweden
- Data Source
  KAKENHI-PROJECT-25870093
[Presentation] TMEPAI, a negative regulator of TGF-b signal, is involved in cancer development2013
- Author(s)
  渡邊幸秀
- Organizer
  第72回　日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25870093
[Presentation] 腫瘍形成におけるTMEPAIの役割
- Author(s)
  渡邊幸秀、Thanh Thao Vo Guyen、青井春輝、工藤広静、加藤光保
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜、日本
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25870093
[Presentation] TMEPAI cross regulation with multiple signaling pathways during tumorigenesis
- Author(s)
  Yukihide Watanabe, Vo Guyen Thanh Thao, Shun Azami, Amalia Riezki, Kosei Kudo, Mitsuyasu Kato
- Organizer
  Joint international symposium on TGF-b family and cancer, signaling network in tumor microenvironment
- Place of Presentation
  つくば、日本
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-25870093

1. Kato Mitsuyasu (20194855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. OKITA Yukari (30743710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Meidi Utami Puteri

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Riezki Amalia

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Mohammed Abdelaziz

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Bantari Wisynu Kusuma Wardhani

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 伊東史子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Yukihide 渡邊 幸秀

WATANABE Yukihide 渡邊 幸秀

Research Projects

Research Products

Co-Researchers

Elucidation of the stemness induction mechanism in sustained proliferation of cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of targeting cancer therapy against TMEPAI using macrocyclic peptidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular function of TMEPAI in tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Roles of TMEPAI on tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of TGF-beta target genes TMEPAI and MafK on cancer development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2)TGF-β-Induced TMEPAI attenuates the response of triple-negative breast cancer cells to Doxorubicin and Paclitaxel.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PMEPA1/TMEPAI isoforms function via its PY and Smad interaction motifs for tumorigenic activities of breast cancer cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PMEPA1/TMEPAI knockout impairs tumour growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Regulation of bone morphogenetic protein signaling by ADP-ribosylation.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] がんの増殖・進展とTGF-beta 慢性炎症とがん2016

Author(s)

Journal Title

Data Source

[Journal Article] Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-b and epidermal growth factor signaling.2015

Author(s)

Journal Title

DOI

Watanabe Yukihide 渡邊幸秀

WATANABE Yukihide 渡邊幸秀

[Journal Article] がんの増殖・進展とTGF-beta　慢性炎症とがん2016