KIMURA MAKI 木村真希 (小柳真希)

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Maki Kimura-Koyanagi 木村真希

小柳真希

木村真希(小柳真希) キムラマキ

KIMURA-KOYANAGI Maki 木村真希

小柳真希

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Researcher Number	40623690
Other IDs
Affiliation (Current)	2025: 神戸大学, インクルーシブキャンパス&ヘルスケアセンター, 准教授 2025: 神戸大学, 医学部附属病院, 特命助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 神戸大学, 医学部附属病院, 特命助教 2020 – 2021: 神戸大学, 医学部附属病院, 特定助教 2017 – 2018: 神戸大学, 医学部附属病院, 特定助教 2016: 神戸大学, 医学研究科, 医学研究員 2012 – 2015: 神戸大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Endocrinology / Eating habits
Keywords	Principal Investigator mTORC1 / mTORC1活性 / アミノ酸 / 膵β細胞量調節 / 膵β細胞 / 膵β細胞量 / GCN2 / 脱分化 / 可塑性 / autophagy … More / 膵β細胞機能 / 糖尿病 / DPP-4阻害薬 / 日本人2型糖尿病 Less

Elucidation of the pathogenic mechanism of de-differentiation into pancreatic adenocytes in diabetic pancreatic beta cells.Principal Investigator
- Principal Investigator
  
  木村真希 (小柳真希)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
Evaluatiion of the effect of Japanese type 2 diabetes susceptibility gene GCN2 on pancreatic beta cell function.Principal Investigator
- Principal Investigator
  
  Maki Kimura-Koyanagi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
The effect of antihyperglycemic drugs on prevention of the diabetes via mTORC1 signalPrincipal Investigator
- Principal Investigator
  
  Maki Koyanagi-Kimura
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University
Role of GCN2 in the onset of type 2 diabetes induced by high fat diet.Principal Investigator
- Principal Investigator
  
  Maki Kimura-Koyanagi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  Kobe University
Analysis of the function of GCN2 in the regulation of pancreatic beta-cell mass.Principal Investigator
- Principal Investigator
  
  KIMURA-KOYANAGI Maki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Kobe University

All 2023 2022 2020 2019 2018 2017 2014 2013 2012

All Journal Article Presentation

[Journal Article] l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells2023
- Author(s)
  Seike M, Asahara SI, Inoue H, Kudo M, Kanno A, Yokoi A, Suzuki H, Kimura-Koyanagi M, Kido Y, Ogawa W.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 652 Pages: 121-130
- DOI
  10.1016/j.bbrc.2023.02.035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-20K08906, KAKENHI-PROJECT-22K08653, KAKENHI-PROJECT-23K07990, KAKENHI-PROJECT-21K08579
[Journal Article] Distinct hypoglycemic effect of different formulations of a fixed ratio of basal insulin plus glucagon-like peptide-1 receptor agonist in a patient with pancreatic diabetes2023
- Author(s)
  Yamada T, Asahara SI, Kimura-Koyanagi M, Tamori Y, Muramae N, Mori K, Okano M, Otsui K, Sakaguchi K.
- Journal Title
  
  Diabetol Int.
  
  Volume: 14 Issue: 3 Pages: 294-297
- DOI
  10.1007/s13340-023-00621-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07990
[Journal Article] Chlorogenic Acid and Caffeine in Coffee Restore Insulin Signaling in Pancreatic Beta Cells2023
- Author(s)
  Ihara Y, Asahara SI, Inoue H, Seike M, Ando M, Kabutoya H, Kimura-Koyanagi M, Kido Y.
- Journal Title
  
  Kobe J Med Sci.
  
  Volume: 69
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07990
[Journal Article] GCN2 regulates pancreatic β-cell mass by sensing intracellular amino acid levels.2020
- Author(s)
  Kanno A, Asahara SI, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, Takai T, Kimura-Koyanagi M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei FY, Tomizawa K, Ogawa W, Seino S, Kasuga M, Kido Y.
- Journal Title
  
  JCI Insight.
  
  Volume: 5 Issue: 9 Pages: 128820-128820
- DOI
  10.1172/jci.insight.128820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-19K09192, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-20K08906, KAKENHI-PROJECT-20K17535, KAKENHI-PUBLICLY-20H04943, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-19H03713, KAKENHI-PROJECT-20H04102, KAKENHI-PROJECT-18KT0020
[Journal Article] Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes2019
- Author(s)
  Kanno A, Asahara SI, Kawamura M, Furubayashi A, Tsuchiya S, Suzuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Okada Y, Ogawa W, Kido Y.
- Journal Title
  
  J Diabetes Invest.
  
  Volume: 10 Issue: 3 Pages: 577-590
- DOI
  10.1111/jdi.12945
- NAID
  120006645694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-16K09803, KAKENHI-PROJECT-19K17963
[Journal Article] Docosahexaenoic acid reduces palmitic acid-induced endoplasmic reticulum stress in pancreatic β cells2018
- Author(s)
  Suzuki E, Matsuda T, Kawamoto T, Takahashi H, Mieda Y, Matsuura Y, Takai T, Kanno A, Kimura-Koyanagi M, Asahara S.-i, Inoue H, Ogawa W, Kido Y
- Journal Title
  
  Kobe J.Med.Sci.
  
  Volume: 64
- NAID
  120006523798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09803
[Journal Article] Casein kinase 2 phosphorylates and stabilizes C/EBPβ in pancreatic β cells.2018
- Author(s)
  Takai T, Matsuda T, Matsuura Y, Inoue K, Suzuki E, Kanno A, Kimura-Koyanagi M, Asahara SI, Hatano N, Ogawa W, Kido Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 497 Issue: 1 Pages: 451-456
- DOI
  10.1016/j.bbrc.2018.02.108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09803, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-16K16277
[Journal Article] Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells.2017
- Author(s)
  Kawada Y, Asahara SI, Sugiura Y, Sato A, Furubayashi A, Kawamura M, Bartolome A, Terashi-Suzuki E, Takai T, Kanno A, Koyanagi-Kimura M, Matsuda T, Hashimoto N, Kido Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 12 Issue: 9 Pages: e0184435-e0184435
- DOI
  10.1371/journal.pone.0184435
- NAID
  120006353753
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09803, KAKENHI-PROJECT-17K09882, KAKENHI-PROJECT-17H01966, KAKENHI-PROJECT-16K16277
[Presentation] 膵β細胞におけるmTOR;恒常的活性化と膵島可塑性の関連についての検討2022
- Author(s)
  清家雅子, 淺原俊一郎, 伊東春香, 木村真希, 鈴木宏隆, 横井愛紗, 神野歩, 木戸良明, 小川渉
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08906
[Presentation] ヒトiPS細胞を用いた膵内分泌細胞への分化誘導法の確立2017
- Author(s)
  山田瑞姫、淺原俊一郎、下野名奈子、田中孝一、松田友和、木村真希、神野歩、高井智子、鈴木江美、青井貴之、木戸良明
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09803
[Presentation] 膵β細胞の小胞体ストレス誘導性アポトーシスにおけるCK2βの役割2017
- Author(s)
  井上佳歩、高井智子、松田友和、鈴木江美、神野歩、木村真希、淺原俊一郎、木戸良明
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09803
[Presentation] 高脂肪食負荷GCN2欠損マウスの膵島におけるmTORC1シグナル調節機構の解明2017
- Author(s)
  古林鮎子、神野歩、増田勝久、吉富理紗、木村真希、松田友和、淺原俊一郎、木戸良明
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09803
[Presentation] 脂肪酸が膵β細胞の小胞体に及ぼす影響2017
- Author(s)
  鈴木江美、松田友和、川本剛士、松浦有希、高井智子、神野歩、木村真希、淺原俊一郎、小川渉、木戸良明
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09803
[Presentation] ヒトiPS細胞を用いた2型糖尿病発症機序の解明2017
- Author(s)
  下野名奈子、淺原俊一郎、原瑞季、田中孝一、松田友和、木村真希、神野歩、高井智子、鈴木江美、青井貴之、木戸良明
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09803
[Presentation] 膵β細胞の小胞体ストレス誘導性アポトーシスにおけるCK2βの役割2017
- Author(s)
  高井智子、松田友和、井上佳歩、松浦有希、鈴木江美、神野歩、木村真希、淺原俊一郎、小川渉、木戸良明
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09803
[Presentation] 2型糖尿病感受性遺伝子GCN2 は膵β 細胞量の調節に関与する2014
- Author(s)
  神野歩, 吉冨理紗, 増田勝久, 小柳真希, 松田友和, 淺原俊一郎, 春日雅人, 清野進, 木戸良明
- Organizer
  第28回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2014-02-13
- Data Source
  KAKENHI-PROJECT-24790944
[Presentation] GCN2, a type 2 diabetes mellitus susceptibility gene, is associated with the regulation of pancreatic β cell mass2013
- Author(s)
  神野歩, 吉冨理紗, 小柳真希, 松田友和, 淺原俊一郎, 春日雅人, 清野進, 木戸良明
- Organizer
  Beta cell wprk shop 2013
- Place of Presentation
  京都
- Year and Date
  2013-04-23
- Data Source
  KAKENHI-PROJECT-24790944
[Presentation] 2型糖尿病感受性遺伝子GCN2 は膵β 細胞量の調節に関与する2013
- Author(s)
  神野歩, 吉冨理紗, 増田勝久, 小柳真希, 松田友和, 淺原俊一郎, 春日雅人, 清野進, 木戸良明
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Year and Date
  2013-05-16
- Data Source
  KAKENHI-PROJECT-24790944
[Presentation] 2型糖尿病発症におけるeIF2α キナーゼGCN2 の機能解析2012
- Author(s)
  神野歩, 吉冨理紗, 小柳真希, 松田友和, 淺原俊一郎, 春日雅人, 清野進, 木戸良明
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-24790944
[Presentation] Functional analysis of eIF2α kinase GCN2 in the onset of type 2 diabetes2012
- Author(s)
  神野歩, 吉冨理紗, 小柳真希, 松田友和, 淺原俊一郎, 春日雅人, 清野進, 木戸良明
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-24790944

1. 木戸良明 (10335440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 堀裕一 (80248004)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Kannno Ayumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. Asahara Shun-ichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results

KIMURA MAKI 木村 真希 (小柳 真希)

Maki Kimura-Koyanagi 木村 真希

小柳真希

木村 真希(小柳真希) キムラ マキ

KIMURA-KOYANAGI Maki 木村 真希

小柳 真希

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenic mechanism of de-differentiation into pancreatic adenocytes in diabetic pancreatic beta cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluatiion of the effect of Japanese type 2 diabetes susceptibility gene GCN2 on pancreatic beta cell function.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of antihyperglycemic drugs on prevention of the diabetes via mTORC1 signalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of GCN2 in the onset of type 2 diabetes induced by high fat diet.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the function of GCN2 in the regulation of pancreatic beta-cell mass.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct hypoglycemic effect of different formulations of a fixed ratio of basal insulin plus glucagon-like peptide-1 receptor agonist in a patient with pancreatic diabetes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chlorogenic Acid and Caffeine in Coffee Restore Insulin Signaling in Pancreatic Beta Cells2023

Author(s)

Journal Title

Data Source

[Journal Article] GCN2 regulates pancreatic β-cell mass by sensing intracellular amino acid levels.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Docosahexaenoic acid reduces palmitic acid-induced endoplasmic reticulum stress in pancreatic β cells2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Casein kinase 2 phosphorylates and stabilizes C/EBPβ in pancreatic β cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells.2017

Author(s)

Journal Title

DOI

NAID

Data Source

KIMURA MAKI 木村真希 (小柳真希)

Maki Kimura-Koyanagi 木村真希

木村真希(小柳真希) キムラマキ

KIMURA-KOYANAGI Maki 木村真希

小柳真希