Yu Zaiqiang 于在強

… Alternative Names

YU ZAIQIANG 于在強

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Researcher Number	40624268
Affiliation (Current)	2025: 弘前大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2019 – 2024: 弘前大学, 医学研究科, 助教 2020: 弘前大学, 医学研究科, 客員研究員 2018: 弘前大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55030:Cardiovascular surgery-related Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 55030:Cardiovascular surgery-related
Keywords	Principal Investigator valve calcification / 血管内皮増殖因子受容体2 / 薬物治療 / 大動脈弁狭窄症 / 大動脈弁石灰化 / 異所性石灰化 / 動脈硬化 / Valve calcification / VEGFR2 / 石灰化 / 弁異所性石灰化 … More Except Principal Investigator … More 大動脈弁狭窄症 / 大動脈弁異所性石灰化 / テネイシンX / 大動脈弁間質細胞 / 異所性石灰化 / calcification / aortic valve / 核内受容体 / 薬物療法 / CD34陰性細胞 / Wnt5a / メノキナン-4 / 重症大動脈弁狭窄症 / 症候性大動脈弁狭窄症 / 大動脈弁石灰化 / 黄連解毒湯 / マトリックスGlaタンパク / プレグナンX受容体 / 異物受容体 / 大動脈弁 / マトリックスGlaタンパク質 Less

the transformation of aortic valve endothelial cells induced acceleration of aortic valve calcification and its mechanismPrincipal Investigator
- Principal Investigator
  
  于在強
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Hirosaki University
大動脈弁異所性石灰化に関わる核内受容体ファミリーの解析と新規治療の構築について
- Principal Investigator
  
  瀬谷和彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hirosaki University
The role and mechanism of VEGFR2 on aortic valve calcificationPrincipal Investigator
- Principal Investigator
  
  Yu Zaiqiang
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Hirosaki University
Elucidation of the mechanism of pregnane X receptor-mediated aortic valve ectopic calcification and demonstration of its pathophysiological significance
- Principal Investigator
  
  Daitoku Kazuyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Hirosaki University
Demonstration and mechanism elucidation of the inhibition of aortic valve calcification by controlling expression of extracellular matrix protein
- Principal Investigator
  
  Seya Kazuhiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hirosaki University
Elucidating the original cell and mechanism of aortic valve ectopic calcification and developing new drugs for inhibiting calcificationPrincipal Investigator
- Principal Investigator
  
  YU ZAIQIANG
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Hirosaki University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 大動脈弁はなぜ石灰化するのか2021
- Author(s)
  福田幾夫、大徳和之、瀬谷和彦、于　在強
- Total Pages
  74
- Publisher
  やまと印刷株式会社
- Data Source
  KAKENHI-PROJECT-19K09089
[Journal Article] Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells2024
- Author(s)
  Kaizuka Masatoshi、Kawaguchi Shogo、Tatsuta Tetsuya、Tachizaki Mayuki、Kobori Yuri、Tanaka Yusuke、Seya Kazuhiko、Matsumiya Tomoh、Imaizumi Tadaatsu、Sakuraba Hirotake
- Journal Title
  
  NeuroMolecular Medicine
  
  Volume: 26 Issue: 1 Pages: 16-16
- DOI
  10.1007/s12017-024-08782-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08064
[Journal Article] Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling2024
- Author(s)
  Nakamura Yuzuru、Ishibashi Hikaru Kristi、Saruga Tatsuro、Imaizumi Tadaatsu、Kurose Akira、Tachizaki Mayuki、Kawaguchi Shogo、Seya Kazuhiko、Sasaki Eiji、Ishibashi Yasuyuki
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 51 Issue: 1 Pages: 131-131
- DOI
  10.1007/s11033-023-09063-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09393, KAKENHI-PROJECT-23K08064
[Journal Article] The inhibitory effect of DIF-3 on polyinosinic?polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2024
- Author(s)
  Araya Ryusei、Men Shihu、Uekusa Yoshinori、Yu Zaiqiang、Kikuchi Haruhisa、Daitoku Kazuyuki、Minakawa Masahito、Kawaguchi Shogo、Furukawa Ken-Ichi、Oshima Yoshiteru、Imaizumi Tadaatsu、Seya Kazuhiko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 3 Pages: 157-165
- DOI
  10.1016/j.jphs.2024.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21KK0099, KAKENHI-PROJECT-23K08064
[Journal Article] Wnt5a pathway was not involved in the progression of valve calcification in calcific aortic valve stenosis2023
- Author(s)
  Zaiqiang Yu、Kazuyuki Daitoku、Ikuo Fukuda、Tadaatsu Imaizumi、Masahito Minakawa、Ken-Ichi Furukawa、Kazuhiko Seya
- Journal Title
  
  Hirosaki Medical Journal
  
  Volume: 73 Pages: 20-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08064
[Journal Article] Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2022
- Author(s)
  Liu Xu, Zaiqiang Yu, Yoshinori Uekusa, Shogo Kawaguchi, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minagawa, Shigeru Motomura, Ken-Ichi Furukawa, Yoshiteru Oshima, Kazuhiko Seya, and Tadaatsu Imaizumi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089
[Journal Article] Elucidation of the inhibitory effect of hopeaphenol on polynosinic- polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2022
- Author(s)
  Xu L, Yu Z, Uesaka Y, Kawaguchi S, Kikuchi H, Daitoku K, MInakawa M, MOtomura S, Furukawa KI, Oshima Y, Seya K, Imaizumi T
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 149 Issue: 3 Pages: 147-157
- DOI
  10.1016/j.jphs.2022.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09117
[Journal Article] Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification.2021
- Author(s)
  Liu Xu、Yu Zaiqiang、Daitoku Kazuyuki、Fukuda Ikuo、Motomura Shigeru、Matsumiya Tomoh、Imaizumi Tadaatsu、Furukawa Ken-Ichi、Seya Kazuhiko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 145 Issue: 2 Pages: 213-221
- DOI
  10.1016/j.jphs.2020.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-18K16381, KAKENHI-PROJECT-20K09117
[Journal Article] Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat2021
- Author(s)
  Zaiqiang Yu，Xu Liu，Kazuyuki Daitoku，Ken-Ichi Furukawa， Ikuo Fukuda，Shigeru Motomura，and Kazuhiko Seya
- Journal Title
  
  Hirosaki Med.J.
  
  Volume: 71 Pages: 101-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16381
[Journal Article] Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells2021
- Author(s)
  Kawaguchi Shogo、Sakuraba Hirotake、Kikuchi Hidezumi、Numao Noriyuki、Asari Taka、Hiraga Hiroto、Ding Jiangli、Matsumiya Tomoh、Seya Kazuhiko、Fukuda Shinsaku、Imaizumi Tadaatsu
- Journal Title
  
  Molecular Immunology
  
  Volume: 129 Pages: 32-38
- DOI
  10.1016/j.molimm.2020.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-19K09089
[Journal Article] Daily Brazilian green propolis intake elevates blood artepillin C levels in humans2021
- Author(s)
  Ding Jiangli、Matsumiya Tomoh、Hayakari Ryo、Shiba Yuko、Kawaguchi Shogo、Seya Kazuhiko、Ueno Kayo、Imaizumi Tadaatsu
- Journal Title
  
  Journal of the Science of Food and Agriculture
  
  Volume: － Issue: 11 Pages: 4855-4861
- DOI
  10.1002/jsfa.11132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10012, KAKENHI-PROJECT-19K09089
[Journal Article] Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat2021
- Author(s)
  Zaiqiang Yu, Xu Liu, Kazuyuki Daitoku, Ken-Ichi Furukawa, Ikuo Fukuda, Shigeru Motomura, Kazuhiko Seya
- Journal Title
  
  Hirosaki Medical Journal
  
  Volume: 71 Issue: 2-4 Pages: 101-107
- DOI
  10.32216/hirosakiigaku.71.2-4_101
- NAID
  130007998247
- ISSN
  0439-1721, 2434-4656
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089
[Journal Article] Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR2019
- Author(s)
  Yang Wei、Yu Zaiqiang、Chiyoya Mari、Liu Xu、Daitoku Kazuyuki、Motomura Shigeru、Imaizumi Tadaatsu、Fukuda Ikuo、Furukawa Ken-Ichi、Tsuji Motonori、Seya Kazuhiko
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 372 Issue: 3 Pages: 277-284
- DOI
  10.1124/jpet.119.263160
- NAID
  130007811872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-16K10619
[Journal Article] Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor2019
- Author(s)
  Yu Zaiqiang、Seya Kazuhiko、Chiyoya Mari、Daitoku Kazuyuki、Motomura Shigeru、Imaizumi Tadaatsu、Fukuda Ikuo、Furukawa Ken-Ichi
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: in oress Issue: 6 Pages: 944-956
- DOI
  10.1007/s00774-019-01001-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10449, KAKENHI-PROJECT-19K09089, KAKENHI-PROJECT-18K16381, KAKENHI-PROJECT-16K10619, KAKENHI-PROJECT-17K10916
[Presentation] Orengetokuto inhibits aortic valve calcification: Confirming by animal model of SHR rat2023
- Author(s)
  Zaiqiang Yu, Shihu Men, Kazuyuki Daitoku, Tadaatsu Imaizumi, Masahito Minakawa, Kazuhiko Seya
- Organizer
  第53回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09117
[Presentation] Orengedokuto inhibits TNF-α-induced HAVIC calcification obtained from calcific aortic valve stenosis patients2023
- Author(s)
  Zaiqiang Yu, Kazuyuki Daitoku, Tadaatsu Imaizumi, Masahito Minakawa, Kazuhiko Seya
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K09117
[Presentation] Inhibitory effect of CD34 on human aortic valve calcification2023
- Author(s)
  Shihu Men, Zaiqiang Yu, Liu Xu, Kazuyuki Daitoku, Tadaatsu Imaizumi, Masahito Minakawa, Ken-Ichi Furukawa, Kazuhiko Seya
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K09117
[Presentation] Property analysis of human aortic valve interstitial cell from AS patients and attempting to inhibit aortic valve calcification2021
- Author(s)
  Zaiqiang Yu、Xu Liu、Kazuyuki Daitoku 、Ken-ichi Furukawa、Ikuo Fukuda、Dadaatsu Imaizumi、Kazuhiko Seya
- Organizer
  第51回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16381
[Presentation] 石灰化大動脈弁狭窄症患者より得た大動脈弁間質細胞はVEGFR2陽性であり、異所性石灰化に寄与する2021
- Author(s)
  劉　旭，○于　在強,　大徳和之,　福田幾夫，元村　成,　松宮朋穂, 今泉忠淳，古川賢一, 瀬谷和彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K09089
[Presentation] Human aortic valve interstitial cells obtained from patients with calcified aortic valve stenosis are VEGFR2 positive and contribute to ectopic calcification2021
- Author(s)
  于在強、劉旭、大徳和之、福田幾夫、元村成、今泉忠淳、古川賢一、松宮朋穂、瀬谷和彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K16381
[Presentation] 分子生物学的手法による大動脈弁石灰化の抑制機序解明：石灰化予防薬の開発から生体弁石灰化予防治療法の確立へ2020
- Author(s)
  于在強、瀬谷和彦、劉旭、楊薇、大徳和之、今泉忠淳、古川賢一、福田幾夫
- Organizer
  第50回日本心臓血管外科学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16381
[Presentation] Menaquinone-4 accelerates calcification of human aortic valve interstitial cells in high-phosphate medium through PXR2020
- Author(s)
  Kazuhiko Seya, Wei Yang, Zaiqiang Yu, Mari Chiyoya, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K09089
[Presentation] 大動脈弁異所性石灰化におけるWnt5aがは果たす役割の解析2020
- Author(s)
  于在強、大徳和之、福田幾夫
- Organizer
  日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09117
[Presentation] CD34 negative mesenchymal stem cell has higher calcific activity by decreasing tenascin-X gene expression2019
- Author(s)
  Zaiqiang YU、Kazuyuki Daitoku、Fukuda Ikuo、Kazuhiko Seya
- Organizer
  The Heart Valve Society annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16381
[Presentation] 黄連解毒湯の大動脈弁石灰化の抑制作用：大動脈弁間質細胞を用いた検討2019
- Author(s)
  于　在強、大徳　和之、瀬谷　和彦、福田　幾夫
- Organizer
  日本心臓血管外科学会
- Data Source
  KAKENHI-PROJECT-18K16381

1. Seya Kazuhiko (40281919)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. Daitoku Kazuyuki (50374822)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
3. 今泉忠淳 (90232602)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
4. 福田幾夫 (50344594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 皆川正仁 (50374830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ISHIBASHI Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SASAKI Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 石橋恭太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 松宮朋穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 古川賢一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 植草義徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yu Zaiqiang 于 在強

YU ZAIQIANG 于 在強

Research Projects

Research Products

Co-Researchers

the transformation of aortic valve endothelial cells induced acceleration of aortic valve calcification and its mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大動脈弁異所性石灰化に関わる核内受容体ファミリーの解析と新規治療の構築について

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role and mechanism of VEGFR2 on aortic valve calcificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of pregnane X receptor-mediated aortic valve ectopic calcification and demonstration of its pathophysiological significance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Demonstration and mechanism elucidation of the inhibition of aortic valve calcification by controlling expression of extracellular matrix protein

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the original cell and mechanism of aortic valve ectopic calcification and developing new drugs for inhibiting calcificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 大動脈弁はなぜ石灰化するのか2021

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The inhibitory effect of DIF-3 on polyinosinic?polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wnt5a pathway was not involved in the progression of valve calcification in calcific aortic valve stenosis2023

Author(s)

Journal Title

Data Source

[Journal Article] Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2022

Author(s)

Journal Title

Data Source

[Journal Article] Elucidation of the inhibitory effect of hopeaphenol on polynosinic- polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat2021

Yu Zaiqiang 于在強

YU ZAIQIANG 于在強