SAITO Takashi 齊藤崇

Researcher Number	40625969
Affiliation (based on the past Project Information) *help	2015: 国立研究開発法人国立精神・神経医療研究センター, 遺伝子疾患治療研究部, 客員研究員 2015: 国立研究開発法人国立精神・神経医療研究センター, 遺伝子疾患治療研究部, 流動研究員 2015: 国立研究開発法人国立精神・神経医療研究センター, 遺伝子疾患治療研究部, 研究員 2015: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 流動研究員 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 科研費研究員 2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 研究員 2013: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 研究員
Review Section/Research Field	Principal Investigator Applied pharmacology Except Principal Investigator Neurology
Keywords	Principal Investigator エクソン・スキップ / アンチセンス / 重複変異 / ジストロフィン / 筋ジストロフィー / 遺伝子診断・治療 / 応用薬理学 Except Principal Investigator アンチセンス・オリゴヌクリオチド / デュシェンヌ型筋ジストロフィー / デュシェンヌ型筋ジストロフィー … More / アデノ随伴ベクター / アンチセンス・オリゴヌクレオチド / トランスレーショナルリサーチ / エクソン・スキップ Less

Development of Antisense Mediated Therapy for Exons Duplication in Duchenne Muscular Dystrophy.Principal Investigator
- Principal Investigator
  
  SAITO Takashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Center of Neurology and Psychiatry
Development of AAV-induced exonskipping therapy for Duchenne muscular dystrophy
- Principal Investigator
  
  Nagata Tetsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry

All 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発2014
- Author(s)
  齊藤崇（情報技術協会編）
- Total Pages
  600
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-25460666
[Journal Article] 選択的スプライシングを調節するアンチセンス医薬品の開発について2014
- Author(s)
  齊藤崇、武田伸一
- Journal Title
  
  医薬品医療機器レギュラトリーサイエンス
  
  Volume: 45 Pages: 23-32
- NAID
  40019946374
- Data Source
  KAKENHI-PROJECT-25460666
[Journal Article] Identification of a Duplication Breakpoint in the DMD Gene Using Array Comparative Genomic Hybridization2013
- Author(s)
  Saito T, Ishigaki K, Murakami T, Sato T, Kajino S, Takeda S, Osawa M
- Journal Title
  
  Journal of Tokyo Women's Medical College
  
  Volume: 83(E1)
- NAID
  110009559372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460666
[Presentation] First-in-Human Study of NS-065/NCNP-01; the Morpholino Based Antisense Oligonucleotide for Exon 53 Skipping in Duchenne Muscular Dystrophy2015
- Author(s)
  Saito T, Nagata T, Masuda S, Aoki Y, Suzuki M, Nakamura H, Komaki H, Takeda S
- Organizer
  American society of gene & cell therapy 18th Annual meeting
- Place of Presentation
  Hyatt Regency, New Orleans, USA
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460666
[Presentation] First-in-Human Study of NS-065/NCNP-01; the Morpholino Based Antisense Oligonucleotide for Exon 53 Skipping in Duchenne Muscular Dystrophy.2015
- Author(s)
  Saito T, Nagata T, Masuda S, Aoki Y, Suzuki M, Nakamura H, Komaki H, Takeda S
- Organizer
  American society of gene & cell therapy 18th Annual meeting
- Place of Presentation
  Hyatt Regency
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] デュシェンヌ型筋ジストロフィーに対するエクソン53スキップ治療薬の早期探索的臨床試験2015
- Author(s)
  永田哲也, 齊藤崇, 増田智, 鈴木麻衣子, 中村治雅, 小牧宏文, 武田伸一.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53スキップ治療薬の早期探索的臨床試験2015
- Author(s)
  永田哲也, 齊藤崇, 増田智, 鈴木麻衣子, 中村治雅, 小牧宏文, 武田伸一.
- Organizer
  第33回日本神経治療学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53 スキップによる早期探索的臨床試験2013
- Author(s)
  永田哲也，齊藤　崇，清水玲子，小牧宏文，武田伸一
- Organizer
  第31回日本神経治療学会総会
- Place of Presentation
  東京ドームホテル，千代田区
- Data Source
  KAKENHI-PROJECT-25460666
[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53 スキップによる早期探索的臨床試験2013
- Author(s)
  永田哲也，齊藤崇，清水玲子，小牧宏文，武田伸一
- Organizer
  第31 回日本神経治療学会総会
- Place of Presentation
  東京ドームホテル　東京
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] Exon45-55 を欠失した短縮型dystrophin の機能的役割の解明2013
- Author(s)
  谷端淳，永田哲也，齊藤崇，青木吉嗣，清水裕子，中村昭則，武田伸一
- Organizer
  第68 回日本体力医学会
- Place of Presentation
  日本教育会館東京
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] Truncated dystrophin with exon 45-55 deletion induced muscle atrophy and fiber type change through the hyper- nitrosylation of the ryanodine receptor type-1 and constant release of Ca2+ to the cytosol.
- Author(s)
  Tanihata J, Nagata T, Saito T, Ito N, Aoki Y, Nakamura A, Takeda S.
- Organizer
  19th International Congress of the World Muscle Societ
- Place of Presentation
  Humboldt Graduate School
- Year and Date
  2014-10-07 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53スキップ治療薬の早期探索的臨床試験
- Author(s)
  永田哲也，齊藤　崇，清水玲子，谷端淳，青木吉嗣，小牧宏文，武田伸一
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] Assessment of the Dystrophin Gene Exon 53 Skipping Using DMD Patient-Derived Fibroblasts for Exploratory Clinical Trial of Antisense Drug NS-065/NCNP-01
- Author(s)
  Saito T, Nagata T, Masuda S, Tanihata J, Ohata M, Tamaura A, Kanazawa M, Minami N, Goto K, Hayashi Y, Iwasawa K, Tatezawa K, Fukuda K, Mizutani T, Shimizu R, Suzuki M, Yamaguchi K, Tachimori H, Nishino I, Goto Y, Komaki H, Takeda S
- Organizer
  American society of gene & cell therapy 17th Annual meeting
- Place of Presentation
  Marriott Wardman Park, Washington, DC, USA
- Year and Date
  2014-05-20 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-25460666
[Presentation] Assessment of the Dystrophin Gene Exon 53 Skipping Using DMD Patient-Derived Fibroblasts for Exploratory Clinical Trial of Antisense Drug NS-065/NCNP-01.
- Author(s)
  Saito T, Nagata T, Masuda S, Tanihata J, Ohata M, Tamaura A, Kanazawa M, Minami N, Goto K, Hayashi Y, Iwasawa K, Tatezawa K, Fukuda K, Mizutani T, Shimizu R, Suzuki M, Yamaguchi K, Tachimori H, Nishino I, Goto Y, Komaki H, Takeda S.
- Organizer
  American society of gene & cell therapy 17th Annual meeting
- Place of Presentation
  Marriott Wardman Park Hotel
- Year and Date
  2014-05-20 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461303
[Presentation] Exon45-55を欠失した短縮型dystrophinはRyR1をニトロシル化し、細胞内Ca2＋濃度を上昇させる
- Author(s)
  谷端　淳，永田哲也，齊藤　崇，伊藤尚基，中村昭則，武田伸一
- Organizer
  第69回日本体力医学会大会
- Place of Presentation
  長崎大学文教キャンパス
- Year and Date
  2014-09-19 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-25461303

1. NAGATA Tetsuya (50362976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. TAKEDA Shin'ichi (90171644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. Okada Takashi (00326828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. AOKI Yoshitsugu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TANIHATA Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. NAKAMURA Akinori

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MASUDA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MOTOHASHI Yuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YOKOTA Toshifumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAITO Takashi 齊藤 崇

Research Projects

Research Products

Co-Researchers

Development of Antisense Mediated Therapy for Exons Duplication in Duchenne Muscular Dystrophy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of AAV-induced exonskipping therapy for Duchenne muscular dystrophy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] 選択的スプライシングを調節するアンチセンス医薬品の開発について2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Identification of a Duplication Breakpoint in the DMD Gene Using Array Comparative Genomic Hybridization2013

Author(s)

Journal Title

NAID

Data Source

[Presentation] First-in-Human Study of NS-065/NCNP-01; the Morpholino Based Antisense Oligonucleotide for Exon 53 Skipping in Duchenne Muscular Dystrophy2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] First-in-Human Study of NS-065/NCNP-01; the Morpholino Based Antisense Oligonucleotide for Exon 53 Skipping in Duchenne Muscular Dystrophy.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] デュシェンヌ型筋ジストロフィーに対するエクソン53スキップ治療薬の早期探索的臨床試験2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53スキップ治療薬の早期探索的臨床試験2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53 スキップによる早期探索的臨床試験2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Duchenne 型筋ジストロフィーに 対するエクソン53 スキップによる早期探 索的臨床試験2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Exon45-55 を欠失した短縮型dystrophin の機能的役割 の解明2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Truncated dystrophin with exon 45-55 deletion induced muscle atrophy and fiber type change through the hyper- nitrosylation of the ryanodine receptor type-1 and constant release of Ca2+ to the cytosol.

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53スキップ治療薬の早期探索的臨床試験

Author(s)

Organizer

Place of Presentation

SAITO Takashi 齊藤崇

[Presentation] Duchenne 型筋ジストロフィーに対するエクソン53 スキップによる早期探索的臨床試験2013

[Presentation] Exon45-55 を欠失した短縮型dystrophin の機能的役割の解明2013