FUJIWARA Ryoichi 藤原亮一

… Alternative Names

藤原亮一フジワラリョウイチ

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Researcher Number	40631643
Affiliation (Current)	2025: 北里大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2015 – 2018: 北里大学, 薬学部, 講師 2012 – 2014: 北里大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Biological pharmacy Except Principal Investigator Embryonic/Neonatal medicine
Keywords	Principal Investigator グルクロン酸抱合 / UGT1A1 / 薬物代謝酵素 / 新生児黄疸 / ビリルビン / 核黄疸 / 抗酸化作用 / T4 / 脳発達 / 甲状腺ホルモン / 皮膚 / 母乳 / ビリルビン代謝 … More Except Principal Investigator … More 体質性黄疸 / 新生児黄疸 / 新生児高ビリルビン血症 / 核黄疸 / 新生児 / Gilbert症候群 / UGT1A1 / ビリルビンUDP-グルクロン酸転移酵素 / 遺伝性非抱合型高ビリルビン血症 / 母乳性黄疸 Less

Making of the management method for breast milk jaundice using transgenic mice
- Principal Investigator
  
  MARUO YOSHIHIRO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Shiga University of Medical Science
Role of UDP-glucuronosyltransferase in bilirubin and thyroxine metabolismPrincipal Investigator
- Principal Investigator
  
  Fujiwara Ryoichi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Importance of UGT1A1 in breast milk-induced neonatal hyperbilirubinemiaPrincipal Investigator
- Principal Investigator
  
  FUJIWARA Ryoichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University

All 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain.2015
- Author(s)
  Sakamoto M, Itoh T, Tukey RH, Fujiwara R.
- Journal Title
  
  Drug Metab. Pharmacokinet.
  
  Volume: 30 Issue: 4 Pages: 269-75
- DOI
  10.1016/j.dmpk.2015.04.004
- NAID
  50014429962
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460204, KAKENHI-PROJECT-26870562
[Journal Article] Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain2015
- Author(s)
  Yuki Kutsuno, Rika Hirashima, Masaya Sakamoto, Hiroko Ushikubo, Hirofumi Michimae, Tomoo Itoh, Robert H. Tukey, and Ryoichi Fujiwara
- Journal Title
  
  Drug Metabolism & Disposition
  
  Volume: 43 Issue: 7 Pages: 1071-1076
- DOI
  10.1124/dmd.115.063719
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870562
[Journal Article] Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.2015
- Author(s)
  Fujiwara R, Maruo Y, Chen S, Tukey RH
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 289 Issue: 1 Pages: 124-132
- DOI
  10.1016/j.taap.2015.08.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09710, KAKENHI-PROJECT-26870562
[Journal Article] Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia2014
- Author(s)
  Naoya Aoshima, Yoshiko Fujie, Tomoo Itoh, Robert H. Tukey, and Ryoichi Fujiwara
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 6343-6343
- DOI
  10.1038/srep06343
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870562
[Journal Article] Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia2013
- Author(s)
  Kyohei Sumida, Makiko Kawana, Emi Kouno, Tomoo Itoh, Shuhei Takano, Tomoya Narawa, Robert H. Tukey, and Ryoichi Fujiwara
- Journal Title
  
  Molecular pharmacology
  
  Volume: 84 Issue: 5 Pages: 679-686
- DOI
  10.1124/mol.113.088112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890224
[Journal Article] Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia2013
- Author(s)
  Ayako Shibuya, Tomoo Itoh, Robert H. Tukey, and Ryoichi Fujiwara
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 2903-2903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890224
[Journal Article] Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia2013
- Author(s)
  Ayako Shibuya, Tomoo Itoh, Robert H. Tukey, and Ryoichi Fujiwara
- Journal Title
  
  Scientific reports
  
  Volume: 3 Issue: 1 Pages: 2903-2903
- DOI
  10.1038/srep02903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890224
[Journal Article] Importance of UDP-Glucuronosyltransferase 1A1 Expression in Skin and Its Induction by UVB in Neonatal Hyperbilirubinemia2013
- Author(s)
  Kyohei Sumida, Makiko Kawana, Emi Kouno, Tomoo Itoh, Shuhei Takano, Tomoya Narawa, Robert H. Tukey, and Ryoichi Fujiwara
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 84 Pages: 679-686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] Importance of extrahepatic UDP-glucuronosyltransferase 1A1 in bilirubin metabolism2015
- Author(s)
  Ryoichi Fujiwara
- Organizer
  Annual Meeting of the German Pharmaceutical Society 2015 DPhG
- Place of Presentation
  Dusseldorf, Germany
- Year and Date
  2015-09-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870562
[Presentation] 周産期におけるUDP-グルクロン酸転移酵素の誘導が神経発達に及ぼす影響2015
- Author(s)
  久津野　友貴，藤原　亮一，伊藤　智夫
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26870562
[Presentation] UDP-グルクロン酸転移酵素 (UGT) の誘導が新生児期甲状腺ホルモン機能に及ぼす影響2015
- Author(s)
  久津野　友貴，藤原　亮一，伊藤　智夫
- Organizer
  第28回北里大学バイオサイエンスフォーラム
- Place of Presentation
  相模原
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-26870562
[Presentation] UDP-グルクロン酸転移酵素1A1の誘導によるチロキシン代謝の亢進および神経発達障害2015
- Author(s)
  藤原　亮一，久津野　友貴，伊藤　智夫
- Organizer
  日本薬物動態学会第３０回年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26870562
[Presentation] ヒト化UGT1マウスを用いた薬物のグルクロン酸抱合能及び毒性の評価2014
- Author(s)
  久津野友貴、藤原亮一、伊藤智夫
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia2014
- Author(s)
  Ryoichi Fujiwara, Ayako Shibuya, Robert H. Tukey, Tomoo Itoh
- Organizer
  SOT 2014 53rd Annual Meeting
- Place of Presentation
  Phoenix, Arizona
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] ヒト化UGT1マウスを用いた薬物のグルクロン酸抱合能及び毒性の評価2014
- Author(s)
  久津野友貴,藤原亮一,伊藤智夫
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] ヒト化UGT1マウスにおける薬物のグルクロン酸抱合能の評価2014
- Author(s)
  藤原亮一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia2014
- Author(s)
  Ryoichi Fujiwara, Ayako Shibuya, Robert H. Tukey, Tomoo Itoh
- Organizer
  SOT 2014 53^<rd> Annual Meeting
- Place of Presentation
  Phoenix (Arizona)
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] ヒト化 UGT1 マウスにおける薬物のグルクロン酸抱合能の評価2013
- Author(s)
  久津野友貴、藤原亮一、澄田恭平、伊藤智夫
- Organizer
  P450とUGT/SULT 研究会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] 皮膚に発現するUDP-グルクロン酸転移酵素(UGT)1A1のビリルビン代謝への寄与2013
- Author(s)
  澄田恭平,伊藤智夫,藤原亮一
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] GLUCURONIDATION OF DRUGS IN HUMANIZED UDP-GLUCURONOSYLTRANSFERASE 1 MICE: SIMILARITY WITH GLUCURONIDATION IN HUMAN LIVER MICROSOMES2013
- Author(s)
  Yuki Kutsuno, Ryoichi Fujiwara, Kyohei Sumida, Tomoo Itoh
- Organizer
  日本薬物動態学会　第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] 母乳に含まれる遊離脂肪酸によるUDP-グルクロン酸転移酵素(UGT)阻害2013
- Author(s)
  藤原亮一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice : similarity with glucuronidation in human liver microsomes2013
- Author(s)
  Yuki Kutsuno, Ryoichi Fujiwara, Kyohei Sumida, Tomoo Itoh
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] 転写因子SP-1を介したグルコースによるUDP-グルクロン酸転移酵素(UGT)1A1の誘導2013
- Author(s)
  青島直也,藤江恵子,伊藤智夫,藤原亮一
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] 皮膚に発現するUDP-グルクロン酸転移酵素 (UGT) 1A1のビリルビン代謝への寄与2013
- Author(s)
  澄田恭平、伊藤智夫、藤原亮一
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] ヒト化UGT1マウスにおける薬物のグルクロン酸抱合能の評価2013
- Author(s)
  久津野友貴,藤原亮一,澄田恭平,伊藤智夫
- Organizer
  P450とUGT/SULT研究会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] Ultraviolet B-irradiated L-tryptophan induces human UDP-glucuronosyltransferase 1A1 and 1A8 expressed in the human skin2013
- Author(s)
  Ryoichi Fujiwara
- Organizer
  SOT 2013 52nd Annual Meeting
- Place of Presentation
  サンアントニオ（テキサス）
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] 母乳に含まれる遊離脂肪酸によるUDP-グルクロン酸転移酵素(UGT)阻害2013
- Author(s)
  藤原亮一
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] The importance of gastrointestinal UDP-glucuronosyltransferase (UGT) 1A1 in bilirubin metabolism in neonatal hyperbilirubinemia2012
- Author(s)
  藤原亮一
- Organizer
  27th JSSX Annual Meeting
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] The importance of gastrointestinal UDP-glucuronosyltransferase (UGT) 1A1 in bilirubin metabolism in neonatal hyperbilirubinemia2012
- Author(s)
  藤原亮一
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24890224
[Presentation] 脳におけるヒトUDP-グルクロン酸転移酵素 (UGT) の発現と機能解析 ~ヒト化UGT1マウスを用いて~
- Author(s)
  久津野友貴, 平島梨夏, 坂本聖弥, 藤原亮一, 伊藤智夫
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸サンボーホール（神戸）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26870562
[Presentation] ニコチンによる脳内UDP‐グルクロン酸転移酵素（UGT）発現量の調節
- Author(s)
  坂本聖弥, 藤原亮一, 伊藤智夫
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸サンボーホール（神戸）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26870562
[Presentation] Acyl Glucuronide Formation in Human and Humanized UDP-Glucuronosyltransferase (UGT) 1 Mice
- Author(s)
  Ryoichi Fujiwara, Yuki Kutsuno, Tomoo Itoh, Robert H. Tukey
- Organizer
  Society of Toxicology (SOT) 54nd Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-03-22 – 2015-03-26
- Data Source
  KAKENHI-PROJECT-26870562

1. MARUO YOSHIHIRO (80314160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 松井克之 (60595924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Yanagi Takahide

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Tukey Robert H

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ITOH Tomoo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJIWARA Ryoichi 藤原 亮一

藤原 亮一 フジワラ リョウイチ

Research Projects

Research Products

Co-Researchers

Making of the management method for breast milk jaundice using transgenic mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of UDP-glucuronosyltransferase in bilirubin and thyroxine metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Importance of UGT1A1 in breast milk-induced neonatal hyperbilirubinemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia2013

Author(s)

Journal Title

Data Source

[Journal Article] Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of UDP-Glucuronosyltransferase 1A1 Expression in Skin and Its Induction by UVB in Neonatal Hyperbilirubinemia2013

Author(s)

Journal Title

Data Source

[Presentation] Importance of extrahepatic UDP-glucuronosyltransferase 1A1 in bilirubin metabolism2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 周産期におけるUDP-グルクロン酸転移酵素の誘導が神経発達に及ぼす影響2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] UDP-グルクロン酸転移酵素 (UGT) の誘導が新生児期甲状腺ホルモン機能に及ぼす影響2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

FUJIWARA Ryoichi 藤原亮一

藤原亮一フジワラリョウイチ