Murotomi Kazutoshi 室冨和俊

… Alternative Names

KAZUTOSHI Murotomi 室冨和俊

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Researcher Number	40635281
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2019 – 2021: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2017 – 2018: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ付 2017: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2013 – 2014: 独立行政法人産業技術総合研究所, 健康工学研究部門, 研究員
Review Section/Research Field	Principal Investigator Basic Section 59010:Rehabilitation science-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / General pharmacology / Environmental physiology(including physical medicine and nutritional physiology) Except Principal Investigator Applied health science
Keywords	Principal Investigator 糖尿病 / 血液脳関門 / 腸管バリア / 脳梗塞 / 腸内細菌 / 脂肪肝 / 非アルコール性脂肪性肝炎 / 酸化ストレス / NASH / 炎症 … More / 活性酸素種 / 一重項酸素 / 膵臓 / β細胞 / グルタミン酸受容体 / インスリン / リン酸化 / NR2サブユニット / NMDA受容体 / 行動リズム / マウス / 血管障害 / 体内時計 / 時計遺伝子 … More Except Principal Investigator 眼疾患 / 合併症 / 生活習慣病 / 細胞試験 / 動物試験 / 酸化ストレス / 発症メカニズム解析 / 機能性因子 / バイオマーカー / 早期診断 / 糖尿病 / 一重項酸素 / 酸化ストレスマーカー / ヒト試験 / 細胞モデル / 動物モデル / 非アルコール性肝障害 Less

脳内で生育する微生物は脳梗塞病態に影響を及ぼすのか?Principal Investigator
- Principal Investigator
  
  室冨和俊
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Analysis of the fucntion of singlet oxygen in vivo during the development of NASHPrincipal Investigator
- Principal Investigator
  
  Murotomi Kazutoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Elucidation of mechanism for activation of glutamate receptor in pancreatic beta-cellsPrincipal Investigator
- Principal Investigator
  
  Murotomi Kazutoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  National Institute of Advanced Industrial Science and Technology
非アルコール性肝障害の発症機序解明および早期診断法の確立と予防法の提案
- Principal Investigator
  
  吉田康一
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied health science
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Analysis of clock gene expression in diabetic vascular disorder with diabetes model mousePrincipal Investigator
- Principal Investigator
  
  KAZUTOSHI Murotomi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2022 2020 2019 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] Iron-accumulating splenocytes may exacerbate non-alcoholic steatohepatitis through the production of proinflammatory cytokines and reactive oxygen species2022
- Author(s)
  Murotomi Kazutoshi、Tawara Hirosuke、Sutoh Mitsuko、Yasunaga Mayu
- Journal Title
  
  Experimental Biology and Medicine
  
  Volume: - Issue: 10 Pages: 848-855
- DOI
  10.1177/15353702221077218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07057
[Journal Article] Quantitative kinetics of intracellular singlet oxygen generation using a fluorescence probe2020
- Author(s)
  Murotomi Kazutoshi、Umeno Aya、Sugino Sakiko、Yoshida Yasukazu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41598-020-67155-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07057
[Journal Article] Comprehensive analysis of PPARγ agonist activities of stereo-, regio-, and enantio-isomers of hydroxyoctadecadienoic acids2020
- Author(s)
  Umeno Aya、Sakashita Mami、Sugino Sakiko、Murotomi Kazutoshi、Okuzawa Tsugumi、Morita Naoki、Tomii Kentaro、Tsuchiya Yuko、Yamasaki Kazuhiko、Horie Masanori、Takahara Kentaro、Yoshida Yasukazu
- Journal Title
  
  Bioscience Reports
  
  Volume: 40 Issue: 4 Pages: 1-14
- DOI
  10.1042/bsr20193767
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18416
[Journal Article] Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse.2019
- Author(s)
  Murotomi K, Arai S, Suyama A, Harashima A, Nakajima Y
- Journal Title
  
  J Funct Foods
  
  Volume: 56 Pages: 303-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00881
[Journal Article] Switching from singlet-oxygen-mediated oxidation to free-radical-mediated oxidation in the pathogenesis of type 2 diabetes in model mouse.2015
- Author(s)
  Murotomi K, Umeno A, Yasunaga M, Shichiri M, Ishida N, Abe H, Yoshida Y, Nakajima Y.
- Journal Title
  
  Free Radical Research
  
  Volume: 49 Issue: 2 Pages: 133-138
- DOI
  10.3109/10715762.2014.985218
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860183
[Journal Article] Type 2 diabetes model TSOD mouse is exposed to oxidative stress at young age2014
- Author(s)
  Murotomi K, Umeno A, Yasunaga M, Shichiri M, Ishida N, Abe H, Yoshida Y, Nakajima Y.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 55 Issue: 3 Pages: 216-220
- DOI
  10.3164/jcbn.14-73
- NAID
  130004685066
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860183
[Patent] 活動量の低下及び/又は不安の改善用組成物2015
- Inventor(s)
  室冨和俊、中島芳浩、吉田康一、小池泰介、松尾俊輝
- Industrial Property Rights Holder
  室冨和俊、中島芳浩、吉田康一、小池泰介、松尾俊輝
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-010545
- Filing Date
  2015-01-22
- Data Source
  KAKENHI-PROJECT-25860183
[Presentation] 細胞内一重項酸素発生系の構築と定量的測定法の開発2020
- Author(s)
  室冨和俊、梅野彩、杉野紗貴子、吉田康一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07057
[Presentation] Transient cerebral ischemia induces NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density2019
- Author(s)
  K. Murotomi, N. Takagi, K. Tanonaka
- Organizer
  Neuroscience2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18416
[Presentation] TSODマウスを用いた糖尿病発症過程における酸化ストレスの解析2015
- Author(s)
  室冨和俊、梅野彩、吉田康一、中島芳浩
- Organizer
  学会名第10回TSOD（肥満・糖尿病）マウス研究会情報交換会
- Place of Presentation
  つくば
- Year and Date
  2015-03-06
- Data Source
  KAKENHI-PROJECT-25860183
[Presentation] Feeding of oleuropein-rich diet attenuates diabetic phenotypes and anxiety-like behavior in type 2 diabetes model mouse
- Author(s)
  室冨和俊、梅野彩、小池泰介、松尾俊輝、吉田康一、中島芳浩
- Organizer
  IDF world diabetes congres
- Place of Presentation
  バンクーバー
- Year and Date
  2015-11-30 – 2015-12-04
- Data Source
  KAKENHI-PROJECT-25860183
[Presentation] 2型糖尿病モデルマウスの糖尿病発症過程における酸化ストレス状態の解析
- Author(s)
  室冨和俊、梅野彩、安永茉由、七里元督、石田規子、安部博子、吉田康一、中島芳浩
- Organizer
  第68回日本酸化ストレス学会
- Place of Presentation
  鹿児島
- Year and Date
  2015-06-11 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-25860183
[Presentation] 2型糖尿病モデルTSODマウスの糖尿病発症過程における脂質酸化物量の解析
- Author(s)
  室冨和俊、梅野彩、安永茉由、七里元督、石田規子、安部博子、吉田康一、中島芳浩
- Organizer
  第29回日本糖尿病・肥満動物学会年次学集会
- Place of Presentation
  京都
- Year and Date
  2015-02-14 – 2015-02-15
- Data Source
  KAKENHI-PROJECT-25860183

1. 吉田康一 (90358333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 常山幸一 (10293341)

# of Collaborated Projects: 1 results

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3. 七里元督 (20434780)

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4. 谷戸正樹 (30284037)

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5. 堀江祐範 (30514591)

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6. 中村強 (30581912)

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7. 太田雅規 (70341526)

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8. 玉木秀幸 (00421842)

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Murotomi Kazutoshi 室冨 和俊

KAZUTOSHI Murotomi 室冨 和俊

Research Projects

Research Products

Co-Researchers

脳内で生育する微生物は脳梗塞病態に影響を及ぼすのか?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the fucntion of singlet oxygen in vivo during the development of NASHPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanism for activation of glutamate receptor in pancreatic beta-cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

非アルコール性肝障害の発症機序解明および早期診断法の確立と予防法の提案

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of clock gene expression in diabetic vascular disorder with diabetes model mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Iron-accumulating splenocytes may exacerbate non-alcoholic steatohepatitis through the production of proinflammatory cytokines and reactive oxygen species2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative kinetics of intracellular singlet oxygen generation using a fluorescence probe2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of PPARγ agonist activities of stereo-, regio-, and enantio-isomers of hydroxyoctadecadienoic acids2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse.2019

Author(s)

Journal Title

Data Source

[Journal Article] Switching from singlet-oxygen-mediated oxidation to free-radical-mediated oxidation in the pathogenesis of type 2 diabetes in model mouse.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Type 2 diabetes model TSOD mouse is exposed to oxidative stress at young age2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Patent] 活動量の低下及び/又は不安の改善用組成物2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 細胞内一重項酸素発生系の構築と定量的測定法の開発2020

Author(s)

Organizer

Data Source

[Presentation] Transient cerebral ischemia induces NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density2019

Author(s)

Murotomi Kazutoshi 室冨和俊

KAZUTOSHI Murotomi 室冨和俊