Hasei Jyo 長谷井嬢

… Alternative Names

Hasei Joe 長谷井嬢

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Researcher Number	40636213
Other IDs	https://orcid.org/0000-0002-4028-0786
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 教授
Affiliation (based on the past Project Information) *help	2023: 岡山大学, 医歯薬学域, 准教授 2022: 岡山大学, 学術研究院医歯薬学域, 准教授 2020 – 2021: 岡山大学, 医学部, 客員研究員 2018 – 2019: 岡山大学, 医歯薬学総合研究科, 助教 2016 – 2017: 岡山大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Principal Investigator TWIST1 / 骨肉腫 / SaMD / 骨腫瘍 / Ｘ線画像 / 深層学習 / 人工知能 / 原発性悪性骨腫瘍 / ゲノムワイド / エンハンサー … More / 転写因子 / 老化 / 臨床 / MMPs / OA / 軟骨 / 5hmC … More Except Principal Investigator 骨軟部肉腫 / 体液診断 / エクソソーム / 体液分子診断 / 免疫モニタリング / 代謝制御 / メトホルミン / 免疫療法 / 骨軟部悪性腫瘍 / tumor microenvironment / tumor immunity / 腫瘍浸潤マクロファージ(TAMs) / 骨髄由来免疫抑制細胞(MDSCs) / cancer immunotherapy / osteosarcoma / metformin / 腫瘍浸潤マクロファージ / 骨髄球由来抑制細胞 / immunometabolism Less

Title: Development and Clinical Application of a Radiographic Interpretation System for Primary Malignant Bone Tumors Utilizing Artificial Intelligence-Based Object DetectioPrincipal Investigator
- Principal Investigator
  
  Hasei Joe
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Development of diagnostic techniques using liquid biopsy and identification of novel mechanisms of tumor progression through circulating molecules in sarcoma
- Principal Investigator
  
  Ozaki Toshifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Elucidating the mechanism of TWIST1 contribution to OA using genome-wide enhancer analysisPrincipal Investigator
- Principal Investigator
  
  Hasei Joe
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Comprehensive analysis of OA-related gene using NGS and pathophysiological mechanism revealed by 5-hmc status changePrincipal Investigator
- Principal Investigator
  
  Hasei Joe
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University
Development of novel immune system analysis and immunotherapy for bone and soft tissue sarcomas
- Principal Investigator
  
  OZAKI toshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University

All 2023 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma2021
- Author(s)
  Yokoo Suguru、Fujiwara Tomohiro、Yoshida Aki、Uotani Koji、Morita Takuya、Kiyono Masahiro、Hasei Joe、Nakata Eiji、Kunisada Toshiyuki、Iwata Shintaro、Yonemoto Tsukasa、Ueda Koji、Ozaki Toshifumi
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 8 Pages: 1823-1823
- DOI
  10.3390/cancers13081823
- NAID
  120007037389
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03784, KAKENHI-PROJECT-19K09650, KAKENHI-PROJECT-19K18466
[Journal Article] Clinical relevance and functional significance of cell-free microRNA-1260b expression profiles in infiltrative myxofibrosarcoma2020
- Author(s)
  Takuya Morita, Tomohiro Fujiwara, Aki Yoshida, Koji Uotani, Masahiro Kiyono, Suguru Yokoo, Joe Hasei, Toshiyuki Kunisada, Toshifumi Ozaki
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 9414-9414
- DOI
  10.1038/s41598-020-66120-8
- NAID
  120006883488
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09650, KAKENHI-PROJECT-19K18466, KAKENHI-PROJECT-19H03784
[Journal Article] TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes.2017
- Author(s)
  Hasei J, Teramura T, Takehara T, Onodera Y, Horii T, Olmer M, Hatada I, Fukuda K, Ozaki T, Lotz M, Asahara H*.
- Journal Title
  
  Sci Rep.
  
  Volume: ７ Issue: 1 Pages: 42990-42990
- DOI
  10.1038/srep42990
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-26861217, KAKENHI-PROJECT-15K15544, KAKENHI-INTERNATIONAL-15K21720, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-16K20075
[Presentation] 希少疾患に対するAI開発戦略2023
- Author(s)
  長谷井嬢, 中原龍一, 藤原智洋, 中田英二, 国定俊之, 尾崎敏文
- Organizer
  第38回日本整形外科学会基礎学術総会
- Data Source
  KAKENHI-PROJECT-21K09228
[Presentation] AIを用いた骨肉腫X線読影における転移学習の効果2023
- Author(s)
  長谷井嬢, 中原龍一, 藤原智洋, 中田英二, 国定俊之, 尾崎敏文
- Organizer
  第96回　日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09228
[Presentation] AIの変遷と、腫瘍を含めた股関節周囲疾患における開発動向2021
- Author(s)
  長谷井　嬢
- Organizer
  第48回日本股関節学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09228
[Presentation] 人工知能を用いた骨肉腫X線像読影ツールの開発2021
- Author(s)
  長谷井　嬢
- Organizer
  第36回　日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09228
[Presentation] 人工知能による骨肉腫X線像読影システム2021
- Author(s)
  長谷井　嬢
- Organizer
  第54回　日本整形外科学会　骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-21K09228
[Presentation] Development of a detection system for osteosarcoma radiographs using deep learning2021
- Author(s)
  Joe Hasei
- Organizer
  13Th APMSTS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09228
[Presentation] Establishment of Liquid Biopsy Targetting Exosomes Derived from Synovial Sarcoma2020
- Author(s)
  Suguru Yokoo, Tomohiro Fujiwara, Koji Uotani, Aki Yoshida, Takuya Morita, Masahiro Kiyono, Joe Hasei, Eiji Nakata, Toshiyuki Kunisada, Toshifumi Ozaki
- Organizer
  Orthopaedic Research Society 2020 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] 次世代シークエンサーを用いた変形性膝関節症発症メカニズムの解明2019
- Author(s)
  長谷井嬢
- Organizer
  第132回中部日本整形外科災害外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-18K09065
[Presentation] 骨肉腫由来エクソソームが関与する骨肉腫細胞転移の機序についての検討2019
- Author(s)
  清野正普、藤原智洋、吉田晶、横尾賢、出宮光二、望月雄介、上甲良二、長谷井嬢、中田英二、国定俊之、尾崎敏文
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] TWIST1はヒト軟骨細胞において、DNAのヒドロキシメチル化によりMMP3発現を誘導し、軟骨異化を促進する2019
- Author(s)
  長谷井嬢
- Organizer
  第32回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K09065
[Presentation] メトホルミンは腫瘍内骨髄球系細胞の代謝を制御し骨肉腫増殖を抑制する2018
- Author(s)
  上原健敬、榮川伸吾、吉田　晶、長谷井嬢、中田英二、国定俊之、尾﨑敏文、鵜殿平一郎
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K15666
[Presentation] TWIST1による5-ヒドロキシメチルシトシン(5hmC)ステータス変動を介した新規OA発症エピジェネティクスの解明2017
- Author(s)
  長谷井　嬢
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K20075
[Presentation] TWIST1による5-ヒドロキシメチルシトシン(5hmC)ステータス変動を介した新規OA発症エピジェネティクスの解明2016
- Author(s)
  長谷井　嬢
- Organizer
  日本整形外科学会基礎
- Place of Presentation
  福岡
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K20075

1. OZAKI toshifumi (40294459)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. 藤原智洋 (80639211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 寺村岳士 (40460901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 村川泰裕 (50765469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 榮川伸吾 (40635265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 杉原進介 (60314671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 畑利彰 (50880887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 横尾賢 (00781204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 清野正普 (60756097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 中原龍一 (30509477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. UEHARA takenori

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. UDONO heiichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 淺原弘嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 国定俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasei Jyo 長谷井 嬢

Hasei Joe 長谷井 嬢

Research Projects

Research Products

Co-Researchers

Title: Development and Clinical Application of a Radiographic Interpretation System for Primary Malignant Bone Tumors Utilizing Artificial Intelligence-Based Object DetectioPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of diagnostic techniques using liquid biopsy and identification of novel mechanisms of tumor progression through circulating molecules in sarcoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the mechanism of TWIST1 contribution to OA using genome-wide enhancer analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of OA-related gene using NGS and pathophysiological mechanism revealed by 5-hmc status changePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel immune system analysis and immunotherapy for bone and soft tissue sarcomas

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Clinical relevance and functional significance of cell-free microRNA-1260b expression profiles in infiltrative myxofibrosarcoma2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 希少疾患に対するAI開発戦略2023

Author(s)

Organizer

Data Source

[Presentation] AIを用いた骨肉腫X線読影における転移学習の効果2023

Author(s)

Organizer

Data Source

[Presentation] AIの変遷と、腫瘍を含めた股関節周囲疾患における開発動向2021

Author(s)

Organizer

Data Source

[Presentation] 人工知能を用いた骨肉腫X線像読影ツールの開発2021

Author(s)

Organizer

Data Source

[Presentation] 人工知能による骨肉腫X線像読影システム2021

Author(s)

Organizer

Data Source

[Presentation] Development of a detection system for osteosarcoma radiographs using deep learning2021

Author(s)

Organizer

Data Source

[Presentation] Establishment of Liquid Biopsy Targetting Exosomes Derived from Synovial Sarcoma2020

Author(s)

Organizer

Data Source

Hasei Jyo 長谷井嬢

Hasei Joe 長谷井嬢