Yokomizo Takako 横溝貴子

Researcher Number	40636867
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 特任助教
Affiliation (based on the past Project Information) *help	2025: 東京大学, 医科学研究所, 特任助教 2022 – 2023: 東京大学, 医科学研究所, 特任助教 2020 – 2021: 熊本大学, 国際先端医学研究機構, 特定事業研究員 2019: 熊本大学, 国際先端医学研究機構, 特別研究員(SPD・PD・RPD) 2018: 熊本大学, 国際先端医学研究機構, 特別研究員(RPD) 2017: 熊本大学, 国際先端医学研究機構, 特別研究員(PD・RPD) 2016: 熊本大学, 国際先端医学研究機構, 日本学術振興会特別研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 白血病 / MDS / 造血器腫瘍 / Aging / 骨髄ニッチ / 加齢 / エピゲノム / 造血幹細胞 / Hmga2 / 癌 … More / CRISPR / MYC / RUNX3 / Runx1 / Myc / エンハンサー / Runx3 Less

クローン性造血を制御するエピゲノム制御因子の探索Principal Investigator
- Principal Investigator
  
  横溝貴子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
加齢骨髄ニッチによる高齢者造血器腫瘍発症機序の解明Principal Investigator
- Principal Investigator
  
  横溝貴子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Regulation of cancer specific chromatin and transcriptional network by Hmga2Principal Investigator
- Principal Investigator
  
  Yokomizo Takako
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
RUNX3 over-expression promotes the development of myelodysplastic syndromePrincipal Investigator
- Principal Investigator
  
  Yokomizo Takako
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University

All 2022 2021 2019 2017

All Journal Article Presentation

[Journal Article] The acidic domain of Hmga2 and the domain’s linker region are critical for driving self-renewal of hematopoietic stem cell2022
- Author(s)
  Yuqi Sun; Sho Kubota; Mihoko Iimori; Ai Hamashima; Haruka Murakami; Jie Bai; Mariko Morii; Takako Yokomizo-Nakano; Motomi Osato; Kimi Araki; Goro Sashida
- Journal Title
  
  International Journal of Hematology
  
  Volume: 115 Pages: 553-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08842
[Journal Article] YAP1/TAZ activity maintains vascular integrity and organismal survival2022
- Author(s)
  Uemura Shun、Yamashita Masayuki、Aoyama Kazumasa、Yokomizo-Nakano Takako、Oshima Motohiko、Nishio Miki、Masuko Masayoshi、Takizawa Jun、Sone Hirohito、Yamada Yasuhiro、Suzuki Akira、Iwama Atsushi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 619 Pages: 117-123
- DOI
  10.1016/j.bbrc.2022.06.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K08457, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21H04806, KAKENHI-PLANNED-19H05746
[Journal Article] Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation2021
- Author(s)
  Bai Jie、Yokomizo-Nakano Takako、Kubota Sho、Sun Yuqi、Kanai Akinori、Iimori Mihoko、Harada Hironori、Iwama Atsushi、Sashida Goro
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 8 Pages: 1531-1541
- DOI
  10.1038/s41388-020-01629-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K08842, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-21K19512
[Presentation] RUNX3 overexpression impedes RUNX1 and promotes the development of MDS/MPN2019
- Author(s)
  横溝　貴子
- Organizer
  造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-16K19579
[Presentation] Super enhancer mediated-RUNX3 overexpression promotes myeloid malignancies2017
- Author(s)
  横溝　貴子
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19579
[Presentation] RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet22017
- Author(s)
  横溝　貴子
- Organizer
  59th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19579

1. 白潔 (60775336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. OHSHIMA Motohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokomizo Takako 横溝 貴子

Research Projects

Research Products

Co-Researchers

クローン性造血を制御するエピゲノム制御因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢骨髄ニッチによる高齢者造血器腫瘍発症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of cancer specific chromatin and transcriptional network by Hmga2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RUNX3 over-expression promotes the development of myelodysplastic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The acidic domain of Hmga2 and the domain’s linker region are critical for driving self-renewal of hematopoietic stem cell2022

Author(s)

Journal Title

Data Source

[Journal Article] YAP1/TAZ activity maintains vascular integrity and organismal survival2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] RUNX3 overexpression impedes RUNX1 and promotes the development of MDS/MPN2019

Author(s)

Organizer

Data Source

[Presentation] Super enhancer mediated-RUNX3 overexpression promotes myeloid malignancies2017

Author(s)

Organizer

Data Source

[Presentation] RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet22017

Author(s)

Organizer

Data Source

Yokomizo Takako 横溝貴子