Morita Daisuke 森田大輔

Researcher Number	40706173
Other IDs
Affiliation (Current)	2025: 京都大学, 医生物学研究所, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 京都大学, 医生物学研究所, 助教 2016 – 2021: 京都大学, ウイルス・再生医科学研究所, 助教 2013 – 2015: 京都大学, ウイルス研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology
Keywords	Principal Investigator リポペプチド / ミリスチン酸修飾 / MHCクラス1 / エイズ / 自己免疫 / HLA / Nef / 抗原提示 / MHC class I / 内在性リガンド … More / リゾリン脂質 / T細胞エピトープ / ウイルス感染 / MHCクラス１ / HIV / MHC Less

リポペプチド免疫応答を起点とした、新たな自己免疫病態の解明と制御Principal Investigator
- Principal Investigator
  
  森田大輔
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Lipopeptide Immunity: A novel approach to autoimmunityPrincipal Investigator
- Principal Investigator
  
  Morita Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Novel strategy of host defense targeted for "viral lipopeptides"Principal Investigator
- Principal Investigator
  
  Morita Daisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Identification and functional analysis of a novel class of human MHC class I molecules presenting lipopeptide antigensPrincipal Investigator
- Principal Investigator
  
  Morita Daisuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Crystallographic analysis of the MHC class I:lipopeptide complex and identification of the lipopepitide-angigen presentation pathwayPrincipal Investigator
- Principal Investigator
  
  Morita Daisuke
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
「リポペプチド」を提示するMHCクラスI分子の同定とその免疫機能解析Principal Investigator
- Principal Investigator
  
  森田大輔
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Engagement with the TCR induces plasticity in antigenic ligands bound to MHC class I and CD1 molecules2023
- Author(s)
  Daisuke Morita, Minori Asa, Masahiko Sugita
- Journal Title
  
  International Immunology
  
  Volume: 35 Issue: 1 Pages: 7-17
- DOI
  10.1093/intimm/dxac046
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07078, KAKENHI-PROJECT-21H02968, KAKENHI-PROJECT-20J23335, KAKENHI-PROJECT-20K21615
[Journal Article] Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding2022
- Author(s)
  Minori Asa, Daisuke Morita, Jin Kuroha, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 7 Pages: 102100-102100
- DOI
  10.1016/j.jbc.2022.102100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07078, KAKENHI-PROJECT-22K05441, KAKENHI-PROJECT-21H02968, KAKENHI-PROJECT-20J23335, KAKENHI-PROJECT-20K21615
[Journal Article] Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides.2020
- Author(s)
  Morita D, Iwashita C, Mizutani T, Mori N, Mikami B, Sugita M.
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 12 Pages: 805-810
- DOI
  10.1093/intimm/dxaa050
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04805, KAKENHI-PROJECT-18H02852, KAKENHI-PROJECT-18K07172
[Journal Article] Crystal structures of lysophospholipid-bound MHC class I molecules2020
- Author(s)
  Shima Yoko、Morita Daisuke、Mizutani Tatsuaki、Mori Naoki、Mikami Bunzo、Sugita Masahiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: in press Issue: 20 Pages: 6983-6991
- DOI
  10.1074/jbc.ra119.011932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07172, KAKENHI-PUBLICLY-19H04805, KAKENHI-PROJECT-18H02852, KAKENHI-PROJECT-18K19563
[Journal Article] Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells2019
- Author(s)
  Yamamoto Y, Morita D, Shima Y, Midorikawa A, Mizutani T, Suzuki J, Mori N, Shiina T, Inoko H, Tanaka Y, Mikami B, Sugita M.
- Journal Title
  
  Journal of Immunology
  
  Volume: 202 Issue: 12 Pages: 3349-3358
- DOI
  10.4049/jimmunol.1900087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19563, KAKENHI-PUBLICLY-17H05791, KAKENHI-PROJECT-18H02852, KAKENHI-PROJECT-18K07172, KAKENHI-PLANNED-16H06502
[Journal Article] Neutrophils and the S100A9 protein critically regulate granuloma formation2016
- Author(s)
  Yuya Yoshioka, Tatsuaki Mizutani, Satoshi Mizuta, Ayumi Miyamoto, Satoru Murata, Toshiaki Ano, Hiroshi Ichise, Daisuke Morita, Hiroyuki Yamada, Yoshihiko Hoshino, Tatsuaki Tsuruyama and Masahiko Sugita
- Journal Title
  
  Blood Advances
  
  Volume: 1 Issue: 3 Pages: 184-192
- DOI
  10.1182/bloodadvances.2016000497
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04869, KAKENHI-PROJECT-26713041, KAKENHI-PROJECT-16K19151
[Journal Article] Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.2015
- Author(s)
  Morita D, Yamamoto Y, Mizutani T, Ishikawa T, Suzuki J, Igarashi T, Mori N, Shiina T, Inoko H, Fujita H, Iwai K, Tanaka Y, Mikami B, Sugita M,
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 10356-10356
- DOI
  10.1038/ncomms10356
- NAID
  120005743661
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19007, KAKENHI-PUBLICLY-15H01257, KAKENHI-PROJECT-26670483, KAKENHI-PROJECT-26860323, KAKENHI-PLANNED-24120006
[Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle.2014
- Author(s)
  Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 289(22) Issue: 22 Pages: 15405-12
- DOI
  10.1074/jbc.m114.566489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-14J03573, KAKENHI-PROJECT-24390255, KAKENHI-PROJECT-25460543, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213, KAKENHI-PROJECT-26860323
[Presentation] N-myristoylated lipopeptide-specific T cell development independently of TAP transporters.2024
- Author(s)
  Hiromu Suzuki, and Daisuke Morita.
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21K07078
[Presentation] A molecular basis for specific recognition of lipopeptides by TCRs2022
- Author(s)
  Daisuke Morita, Masahiko Sugita
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07078
[Presentation] Dynamic B-pocket remodeling is a basis for HLA class I molecules to bind peptides and lipopeptides.2022
- Author(s)
  Minori Asa, Daisuke Morita, Masahiko Sugita
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07078
[Presentation] リポペプチドを提示するMHCクラスI分子の構造と機能2022
- Author(s)
  麻実乃莉、森田大輔、杉田昌彦
- Organizer
  第33回日本生体防御学会
- Data Source
  KAKENHI-PROJECT-21K07078
[Presentation] Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides2021
- Author(s)
  森田大輔、杉田昌彦
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07078
[Presentation] T-cell recognition of the lipopeptide-bound MHC class I complex; evidence from the crystal structure2020
- Author(s)
  Morita, D., Iwashita, C., and Sugita, M.
- Organizer
  The 15th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07172
[Presentation] リポペプチド：エイズウイルス制御の新しい免疫標的分子2018
- Author(s)
  森田大輔
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K19151
[Presentation] 霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構2018
- Author(s)
  森田　大輔、嶋燿子、杉田昌彦
- Organizer
  第２９回日本生体防御学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19151
[Presentation] リポペプチドを提示する MHC class I 分子の内因性リガンドの同定2018
- Author(s)
  嶋燿子、森田大輔、杉田昌彦
- Organizer
  第29回日本生体防御学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07172
[Presentation] 霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構2018
- Author(s)
  森田大輔、嶋燿子、杉田昌彦
- Organizer
  第29回日本生体防御学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07172
[Presentation] Discovery of N-myristoylated lipopeptide Ag-presenting MHC class I molecules.2016
- Author(s)
  Morita D
- Organizer
  The 23rd East Asia Joint Symposium
- Place of Presentation
  Taipei (Taiwan)
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19151
[Presentation] 「リポペプチド免疫応答」の発見とその分子機構の解明2016
- Author(s)
  森田大輔、杉田昌彦
- Organizer
  第２７回日本生体防御学会学術集会
- Place of Presentation
  九州大学　病院キャンパス内コラボステーションI（福岡県・福岡市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-16K19151
[Presentation] Discovery of lipopeptide Ag-presenting molecules: its molecular identity and X-ray crystallographic structure2015
- Author(s)
  Morita D and Sugita M.
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26860323
[Presentation] Discovery of a lipopeptide Ag-presenting molecule: its molecular identity and X-ray crystallographic structure2015
- Author(s)
  Morita D and Sugita M
- Organizer
  The 10th International Symposium of the Institute Network
- Place of Presentation
  北海道大学医学部（北海道・札幌市）
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860323
[Presentation] Lipopeptide Ag presentation by MHC class I molecules: evidence from SIV-infected monkeys.2013
- Author(s)
  Daisuke Morita and Masahiko Sugita
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25893102
[Presentation] 霊長類研究から見えて来た、新しい獲得免疫応答2013
- Author(s)
  森田大輔
- Organizer
  第30回藤田カンファレンス
- Place of Presentation
  滋賀県大津市アヤハレークサイドホテル
- Invited
- Data Source
  KAKENHI-PROJECT-25893102

1. 杉田昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 藤田宏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morita Daisuke 森田 大輔

Research Projects

Research Products

Co-Researchers

リポペプチド免疫応答を起点とした、新たな自己免疫病態の解明と制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lipopeptide Immunity: A novel approach to autoimmunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel strategy of host defense targeted for "viral lipopeptides"Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and functional analysis of a novel class of human MHC class I molecules presenting lipopeptide antigensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crystallographic analysis of the MHC class I:lipopeptide complex and identification of the lipopepitide-angigen presentation pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

「リポペプチド」を提示するMHCクラスI分子の同定とその免疫機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Engagement with the TCR induces plasticity in antigenic ligands bound to MHC class I and CD1 molecules2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structures of lysophospholipid-bound MHC class I molecules2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neutrophils and the S100A9 protein critically regulate granuloma formation2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle.2014

Author(s)

Journal Title

DOI

Morita Daisuke 森田大輔

[Presentation] 霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構2018

[Presentation] 霊長類研究から見えてきた、非ペプチド抗原を標的とする新しい獲得免疫機構2018