Hayashi Yushi 林裕史

… Alternative Names

林裕史ハヤシユウシ

HAYASHI Yushi 林裕史

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Researcher Number	40715166
Affiliation (Current)	2025: 日本医科大学, 大学院医学研究科, 研究生
Affiliation (based on the past Project Information) *help	2023: 日本医科大学, 大学院医学研究科, 研究生 2015 – 2018: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 2016: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 政策医療企画研究部, 研究員 2014: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 政策医療企画研究部, 医師 2013: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 政策医療企画研究部, 研究員
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator ウイルス感染 / 有毛細胞 / 蝸牛 / 突発性難聴 / 感音難聴 / 支持細胞 / マスイメージング解析 / ダメージ関連分子パターン / 免疫細胞 / ネクロプトーシス … More / 蝸牛コルチ器 / ウイルス / サイトカイン / 免疫 / 組織特異的マクロファージ / マイクロアレイ / 定量的RT-PCR / 免疫化学染色 / 有毛細胞・支持細胞 / マイクロアレイ・定量的RT-PCR / 免疫組織染色 / マクロファージ / Ｉ型IFN / RIG-I family / I型IFN / 自然免疫 … More Except Principal Investigator 内リンパ水腫 / 鑑別診断 / 前庭眼反射 / 前庭誘発筋電位 / 馴化 / 聴性誘発電位 / 前庭性片頭痛「 / メニエール病 / 半規管 / 耳石器 / 前庭系 / 内耳 / 聴覚誘発電位 / 片頭痛 / めまい Less

Search for damage-associated molecular patterns (DAMPs) derived from cochlear hair cells and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  林裕史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Nippon Medical School
Establishment of diagnostic methods for vestibular migraine from an vewpoint of habituation to repetitive auditory and accelerative stimuli
- Principal Investigator
  
  MUROFUSHI TOSHIHISA
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Teikyo University
Research on the functional analysis of tissue-specific macrophages in the cochlea and the etiology of sensorineural hearing lossPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yushi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Prevention and treatment for sensorineural hearing loss by controlling the system of innate immunityPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yushi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Otorhinolaryngology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)

All 2023 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] Microtia and Atretia. Temporal bone computed tomography of patients with poor postoperative hearing improvement after surgery for atresia of the external auditory canal.2014
- Author(s)
  Hayashi Y, Kaga K.
- Total Pages
  4
- Publisher
  Karger
- Data Source
  KAKENHI-PROJECT-25893299
[Journal Article] Signaling pathways regulating the immune function of cochlear supporting cells and their involvement in cochlear pathophysiology2023
- Author(s)
  Hayashi Yushi
- Journal Title
  
  Glia
  
  Volume: 72 Issue: 4 Pages: 665-676
- DOI
  10.1002/glia.24476
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08924
[Journal Article] Activation of IGF1 Signaling in the Cochlea Induces the Transcription of Its Mediators During the Protection of Cochlear Hair Cells Against Aminoglycoside.2017
- Author(s)
  Hayashi Y, Yamamoto N, Nakagawa T, Omori K, Ito J.
- Journal Title
  
  Otol Neurotol.
  
  Volume: 38 Issue: 2 Pages: 278-282
- DOI
  10.1097/mao.0000000000001276
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462638, KAKENHI-PROJECT-26462557, KAKENHI-PROJECT-15K20240, KAKENHI-PROJECT-15K10749
[Journal Article] VEMP所見異常と治療による回復を認めた中枢神経系脱髄疾患の一症例．2016
- Author(s)
  小宮山櫻子林裕史　松崎真樹　室伏利久
- Journal Title
  
  Ｅｑｕｉｌｉｂｒｉｕｍ　Ｒｅｓｅａｒｃｈ
  
  Volume: 75 Pages: 16-21
- NAID
  130005142019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10764
[Journal Article] Is otolithic vertigo accompanied by hearing loss caused by sacculocochlear endolymphatic hydrops?2016
- Author(s)
  Murofushi T, Komiyama S, Hayashi Y, Yoshimura E.
- Journal Title
  
  Acta Otolaryngol.
  
  Volume: 136(1) Issue: 1 Pages: 38-42
- DOI
  10.3109/00016489.2015.1081277
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20240, KAKENHI-PROJECT-15K10764
[Journal Article] VEMP所見異常と治療による回復を認めた中枢神経系脱髄疾患の一症例2016
- Author(s)
  室伏利久、林裕史、松崎真樹、室伏利久
- Journal Title
  
  Equilibrium Research
  
  Volume: 75 Pages: 16-21
- NAID
  130005142019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10764
[Journal Article] Frequency preference in cervical vestibular evoked myogenic potential of idiopathic otolithic vertigo. Does it reflect otolithic endolymphatic hydrops?2015
- Author(s)
  Murofushi T, Komiyama S, Hayashi Y, Yoshimura E
- Journal Title
  
  Acta Otolaryngologica
  
  Volume: 135 Issue: 10 Pages: 995-999
- DOI
  10.3109/00016489.2015.1022834
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10764, KAKENHI-PROJECT-15K20240
[Journal Article] Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.2013
- Author(s)
  Hayashi Y, Onomoto K, Narita R, Yoneyama M, Kato H, Nakagawa T, Ito J, Taura A, Fujita T.
- Journal Title
  
  Microbes Infect.
  
  Volume: 15 Issue: 8-9 Pages: 592-598
- DOI
  10.1016/j.micinf.2013.04.008
- NAID
  120005312147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229009, KAKENHI-PUBLICLY-25115503, KAKENHI-PROJECT-25893299
[Journal Article] Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea.2013
- Author(s)
  Hayashi Y, Yamamoto N, Nakagawa T, Ito J.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 560 Pages: 7-11
- DOI
  10.1016/j.neulet.2013.11.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229009, KAKENHI-PROJECT-24592545, KAKENHI-PROJECT-25893299
[Journal Article] Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice.2013
- Author(s)
  Hayashi Y, Yamamoto N, Nakagawa T, Ito J.
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 56 Pages: 29-38
- DOI
  10.1016/j.mcn.2013.03.003
- NAID
  120005244788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229009, KAKENHI-PROJECT-24592545, KAKENHI-PROJECT-25893299
[Presentation] Virus-infection in cochlear supporting cells induces hair cell death by Trail-induced necroptosis2023
- Author(s)
  Yushi Hayashi, Hidenori Suzuki, Wataru Nakajima, Toshiki Himeda, Tatsuya Katsuno, Shin-ichiro Kitajiri, Naoto Koyanagi, Yasushi Kawaguchi, Koji Onomoto, Hiroki Kato, Mitsutoshi Yoneyama, Takashi Fujita, Nobuyuki Tanaka
- Organizer
  Inner Ear Biology Workshop & Symposium 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08924
[Presentation] メニエール病およびその類縁疾患における内リンパ水腫推定検査としてのグリセロールcVEMPの判定法の検討2015
- Author(s)
  室伏利久、林　裕史
- Organizer
  第25回日本耳科学会
- Place of Presentation
  長崎
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10764
[Presentation] 難聴を伴う耳石器性めまい症例．2015
- Author(s)
  室伏利久、小宮山櫻子、林　裕史、松﨑真樹、津田幸子、吉村恵理子
- Organizer
  第116回日本耳鼻咽喉科学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-14
- Data Source
  KAKENHI-PROJECT-15K10764
[Presentation] IFN/IFNAR1 SIGNALING IS CRUCIAL IN THE CONTROL OF VIRAL INFECTION IN THE COCHLEAR SENSORY EPITHELIUM2015
- Author(s)
  Yushi Hayashi, Koji Onomoto, Mitsutoshi Yoneyama, Takashi Fujita, Nobuyuki Tanaka
- Organizer
  Inner Ear Biology Workshop 2015
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20240
[Presentation] ウイルス感染時に支持細胞において発現するtype I interferonが蝸牛感覚上皮に与える影響2015
- Author(s)
  林裕史
- Organizer
  第25回日本耳科学会総会
- Place of Presentation
  長崎
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-15K20240
[Presentation] Type I IFN is produced in supporting cells against virus infection of the cochlear sensory epithelium via RIG-I like receptor signaling pathway.2014
- Author(s)
  Hayashi Y, Onomoto K, Narita R, Yoneyama M, Kato H, Taura A, Nakagawa T, Ito J, Fujita T, Kaga K.
- Organizer
  ARO 37th MidWinter Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-25893299
[Presentation] 全身III度の熱傷に対する加療で薬剤性に両耳聾となり、人工内耳埋め込み手術を実施するに至った成人の1例2013
- Author(s)
  林　裕史、竹腰英樹、加我君孝
- Organizer
  第23回日本耳科学会総会
- Place of Presentation
  宮崎市
- Data Source
  KAKENHI-PROJECT-25893299
[Presentation] Type I IFN is produced in supporting cells against virus infection of the cochlear sensory epithelium via RIG-I like receptor signaling pathway
- Author(s)
  Yushi Hayashi, Koji Onomoto, Ryo Narita, Mitsutoshi Yoneyama, Hiroki Kato, Akiko Taura, Takayuki Nakagawa, Juichi Ito, Kimitaka Kaga, Takashi Fujita
- Organizer
  51st Inner Ear Biology Workshop
- Place of Presentation
  Sheffield, UK
- Year and Date
  2014-08-30 – 2014-09-02
- Data Source
  KAKENHI-PROJECT-25893299
[Presentation] The Pathogenesis of Sensorineural Hearing Loss During Virus Infection of the Cochlear Sensory Epithelium
- Author(s)
  Yushi Hayashi, Koji Onomoto, Mitsutoshi Yoneyama, Kimitaka Kaga, Takashi Fujita, Nobuyuki Tanaka
- Organizer
  38th Association for Research in Otolaryngology MidWinter Meeting
- Place of Presentation
  Baltimore, USA
- Year and Date
  2015-02-21 – 2015-02-25
- Data Source
  KAKENHI-PROJECT-25893299
[Presentation] Type I IFN is produced in supporting cells against virus infection of the cochlear sensory epithelium via RIG-I like receptor signaling pathway
- Author(s)
  Yushi Hayashi, Koji Onomoto, Ryo Narita, Mitsutoshi Yoneyama, Hiroki Kato, Akiko Taura, Takayuki Nakagawa, Juichi Ito, Kimitaka Kaga, Takashi Fujita
- Organizer
  Inner Ear Biology 2014 in Kyoto
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-11-01 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-25893299

1. MUROFUSHI TOSHIHISA (30242176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. TANAKA Nobuyuki (80222115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. FUJITA Takashi (10156870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. YONEYAMA Mitsutoshi (40260335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 小宮山櫻子 (20645923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 坪田雅仁 (90436791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 酒井真志人 (40643490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAURA Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YAMAMOTO Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 伊藤壽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 中川隆之

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Hayashi Yushi 林 裕史

林 裕史 ハヤシ ユウシ

HAYASHI Yushi 林 裕史

Research Projects

Research Products

Co-Researchers

Search for damage-associated molecular patterns (DAMPs) derived from cochlear hair cells and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of diagnostic methods for vestibular migraine from an vewpoint of habituation to repetitive auditory and accelerative stimuli

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on the functional analysis of tissue-specific macrophages in the cochlea and the etiology of sensorineural hearing lossPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention and treatment for sensorineural hearing loss by controlling the system of innate immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Microtia and Atretia. Temporal bone computed tomography of patients with poor postoperative hearing improvement after surgery for atresia of the external auditory canal.2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Signaling pathways regulating the immune function of cochlear supporting cells and their involvement in cochlear pathophysiology2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of IGF1 Signaling in the Cochlea Induces the Transcription of Its Mediators During the Protection of Cochlear Hair Cells Against Aminoglycoside.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VEMP所見異常と治療による回復を認めた中枢神経系脱髄疾患の一症例．2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Is otolithic vertigo accompanied by hearing loss caused by sacculocochlear endolymphatic hydrops?2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VEMP所見異常と治療による回復を認めた中枢神経系脱髄疾患の一症例2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Frequency preference in cervical vestibular evoked myogenic potential of idiopathic otolithic vertigo. Does it reflect otolithic endolymphatic hydrops?2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice.2013

Author(s)

Journal Title

DOI

Hayashi Yushi 林裕史

林裕史ハヤシユウシ

HAYASHI Yushi 林裕史