Murata Yasuhiko 村田泰彦

Researcher Number	40716172
Affiliation (based on the past Project Information) *help	2016 – 2018: 東北大学, 医学系研究科, 助教 2014 – 2015: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Radiation science
Keywords	Principal Investigator 低酸素 / 低栄養 / 放射線抵抗性 / 低栄養状態 / 低酸素状態 / mTOR / AMPK / ATM / Akt / ゴルジ体 … More / GOLPH3 / 放射線感受性 / DNA2重鎖切断修復 / DNA-PKcs / 癌幹細胞 / PLDR / 癌肝細胞 Less

低酸素/低栄養のmTOR・AMPKを介したDNA修復制御による放射線抵抗性の解明Principal Investigator
- Principal Investigator
  
  村田泰彦
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Elucidation of radioresistance mechanisms in cancer stem cells focusing on mTOR activation under hypoxic/nutrient starvation conditionsPrincipal Investigator
- Principal Investigator
  
  Murata Yasuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University

All 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways2018
- Author(s)
  Hashimoto Takuma、Murata Yasuhiko、Urushihara Yusuke、Shiga Soichiro、Takeda Kazuya、Hosoi Yoshio
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 505 Issue: 1 Pages: 13-19
- DOI
  10.1016/j.bbrc.2018.09.068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06528, KAKENHI-PROJECT-17K16416
[Journal Article] Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.2018
- Author(s)
  Murata Y, Hashimoto T, Urushihara Y, Shiga S, Takeda K, Jingu K, Hosoi Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 4 Pages: 2566-2572
- DOI
  10.1016/j.bbrc.2017.12.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293271, KAKENHI-PROJECT-17H06528, KAKENHI-PROJECT-17K16416
[Journal Article] NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells2016
- Author(s)
  Y Uehara, Y Murata, S Shiga, Y Hosoi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 479 Issue: 4 Pages: 847-852
- DOI
  10.1016/j.bbrc.2016.09.120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293271, KAKENHI-PROJECT-26670547, KAKENHI-PROJECT-26860974
[Journal Article] Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.2015
- Author(s)
  Yasuhiko Murata, Yoshihiko Uehara, Yoshio Hosoi
- Journal Title
  
  Biochimical and Biophysical Research Communications
  
  Volume: 468 Issue: 4 Pages: 684-690
- DOI
  10.1016/j.bbrc.2015.11.016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860974
[Journal Article] Enhanced survival of mice infused with bone marrow-derived as compared with adipose-derived mesenchymal stem cells.2014
- Author(s)
  Shiratsuki S, Terai S, Murata Y, Takami T, Yamamoto N, Fujisawa K, Burganova G, Quintanilha LF, Sakaida I.
- Journal Title
  
  Hepatol Res
  
  Volume: - Issue: 13 Pages: 1353-1359
- DOI
  10.1111/hepr.12507
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590978, KAKENHI-PROJECT-26461009, KAKENHI-PROJECT-26860974, KAKENHI-PROJECT-15K09005
[Presentation] 低栄養状態において活性化されたDNA-PKcsによるゴルジ体膜タンパク質GOLPH3の制御2018
- Author(s)
  村田泰彦、橋本拓磨、漆原佑介、志賀壮一郎、細井義夫
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-17K16416
[Presentation] 低栄養状態はDNA-PKcsを活性化し、ゴルジ体膜タンパク質GOLPH3を制御する2018
- Author(s)
  村田泰彦、橋本拓磨、漆原佑介、志賀壮一郎、細井義夫
- Organizer
  第56回生物部会学術大会第47回放射線による制癌シンポジウム
- Data Source
  KAKENHI-PROJECT-17K16416
[Presentation] 低栄養状態で活性化されたDNA-PKcsは、MST1を制御する2018
- Author(s)
  志賀壮一郎、村田泰彦、橋本拓磨、漆原佑介、細井義夫
- Organizer
  第139回日本医学放射線学会第84回日本核医学会北日本地方会
- Data Source
  KAKENHI-PROJECT-17K16416
[Presentation] 低酸素および低栄養状態のヒト線維芽細胞におけるAMPKによる放射線抵抗性の増加2017
- Author(s)
  村田泰彦、橋本拓磨、志賀壮一郎、武田一也、細井義夫
- Organizer
  第55回生物部会学術大会第46回放射線による制癌シンポジウム
- Data Source
  KAKENHI-PROJECT-17K16416
[Presentation] 低酸素および低栄養状態のヒト線維芽細胞におけるAMPKの活性化は放射線抵抗性を増加させる2017
- Author(s)
  村田泰彦、橋本拓磨、志賀壮一郎、武田一也、細井義夫
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-17K16416
[Presentation] 低栄養状態のヒト肝癌細胞におけるmTORC1の活性化による放射線感受性の増加2016
- Author(s)
  村田泰彦、上原芳彦、細井義夫
- Organizer
  第45回制癌シンポジウム第54回生物部会学術大会
- Place of Presentation
  I-siteなんば(大阪府大阪市)
- Data Source
  KAKENHI-PROJECT-26860974
[Presentation] ヒト肝癌細胞における低栄養状態によるmTORC1の活性化は放射線感受性を増加させる2016
- Author(s)
  村田泰彦、上原芳彦、細井義夫
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ(広島県広島市)
- Data Source
  KAKENHI-PROJECT-26860974
[Presentation] 低栄養状態が培養細胞の放射線感受性に及ぼす影響2015
- Author(s)
  村田泰彦、上原芳彦、細井義夫
- Organizer
  第17回癌治療増感研究シンポジウム
- Place of Presentation
  奈良県文化会館（奈良市）
- Year and Date
  2015-02-07
- Data Source
  KAKENHI-PROJECT-26860974
[Presentation] Effects of nutrient starvation condition on radiosensitivity of cultured cells.2015
- Author(s)
  Yasuhiko Murata, Yoshihiko Uehara, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center, Kyoto, Japan
- Year and Date
  2015-05-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860974
[Presentation] Synergistic effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and ionizing radiation on ICMA-1 expression in HUVECs.2015
- Author(s)
  Yoshihiko Uehara, Yasuhiko Murata, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center, Kyoto, Japan
- Year and Date
  2015-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860974
[Presentation] 低栄養状態が培養細胞の放射線感受性に及ぼす影響2014
- Author(s)
  村田泰彦、上原芳彦、細井義夫
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島市）
- Year and Date
  2014-10-03
- Data Source
  KAKENHI-PROJECT-26860974
[Presentation] 非ステロイド抗炎症性薬は放射線と相乗的に作用してヒト血管内皮細胞におけるICAM-1の発現を亢進させる2014
- Author(s)
  上原芳彦、村田泰彦、細井義夫
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島市）
- Year and Date
  2014-10-03
- Data Source
  KAKENHI-PROJECT-26860974
[Presentation] 低栄養が放射線感受性に及ぼす影響2014
- Author(s)
  村田泰彦、上原芳彦、細井義夫
- Organizer
  第43回制癌シンポジウム第52回生物部会学術大会
- Place of Presentation
  メルパルク京都（京都市）
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PROJECT-26860974

1. YAMAMOTO Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. FUJISAWA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 細井義夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 橋本拓磨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 寺井崇二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 高見太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murata Yasuhiko 村田 泰彦

Research Projects

Research Products

Co-Researchers

低酸素/低栄養のmTOR・AMPKを介したDNA修復制御による放射線抵抗性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of radioresistance mechanisms in cancer stem cells focusing on mTOR activation under hypoxic/nutrient starvation conditionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced survival of mice infused with bone marrow-derived as compared with adipose-derived mesenchymal stem cells.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 低栄養状態において活性化されたDNA-PKcsによるゴルジ体膜タンパク質GOLPH3の制御2018

Author(s)

Organizer

Data Source

[Presentation] 低栄養状態はDNA-PKcsを活性化し、ゴルジ体膜タンパク質GOLPH3を制御する2018

Author(s)

Organizer

Data Source

[Presentation] 低栄養状態で活性化されたDNA-PKcsは、MST1を制御する2018

Author(s)

Organizer

Data Source

[Presentation] 低酸素および低栄養状態のヒト線維芽細胞におけるAMPKによる放射線抵抗性の増加2017

Author(s)

Organizer

Data Source

[Presentation] 低酸素および低栄養状態のヒト線維芽細胞におけるAMPKの活性化は放射線抵抗性を増加させる2017

Author(s)

Organizer

Data Source

[Presentation] 低栄養状態のヒト肝癌細胞におけるmTORC1の活性化による放射線感受性の増加2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ヒト肝癌細胞における低栄養状態によるmTORC1の活性化は放射線感受性を増加させる2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 低栄養状態が培養細胞の放射線感受性に及ぼす影響2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Effects of nutrient starvation condition on radiosensitivity of cultured cells.2015

Author(s)

Organizer

Murata Yasuhiko 村田泰彦