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Okamoto Yoshimi  岡本 好海 (内田 好海)

ORCIDConnect your ORCID iD *help
… Alternative Names

岡本 好海  オカモト ヨシミ(ウチダヨシミ)

内田好海

Okamoto-Uchida Yoshimi  岡本 好海

内田

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Researcher Number 40716792
Other IDs
Affiliation (Current) 2025: 東京科学大学, 総合研究院, 助教
Affiliation (based on the past Project Information) *help 2023: 東京医科歯科大学, 難治疾患研究所, 助教
2015 – 2018: 国立医薬品食品衛生研究所, 医薬安全科学部, 任期付研究員
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Medical pharmacy / Applied pharmacology
Except Principal Investigator
Otorhinolaryngology
Keywords
Principal Investigator
副作用 / 医薬品 / HLA / 中毒性表皮壊死症 / スティーブンス・ジョンソン症候群 / YAP / Yes-associated protein / Hippo経路 / 肝細胞がん / 抗てんかん薬 … More / 解熱鎮痛剤 / ペプチド / 重篤副作用 / 中毒性表皮壊死症(TEN) / スティーブンス・ジョンソン症候群(SJS) / ヒト白血球抗原 / 分子間相互作用 … More
Except Principal Investigator
アレルギー / EXiLE / 舌下免疫療法 / ルシフェラーゼ / バイオマーカー / IgG / IgE / EXiLE法 / アレルゲン舌下免疫療法 Less
  • Research Projects

    (4 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (9 People)
  •  Molecular mechanisms of the transcriptional cofactor YAP in the pathogenesis of hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      岡本 好海 (内田好海)
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  HLAの関与する解熱鎮痛薬誘因性重症薬疹の初期発症メカニズムの解明Principal Investigator

    • Principal Investigator
      岡本 好海 (内田)
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Study of the mechanism and therapeutic biomarkers for sublingual immunotherapy by using the EXiLE method

    • Principal Investigator
      Nakamura Ryosuke
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      National Institute of Health Sciences
  •  Study for mechanisms of drug-induced severe cutaneous reactionsPrincipal Investigator

    • Principal Investigator
      Okamoto-Uchida Yoshimi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      National Institute of Health Sciences

All 2023 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book Other

  • [Book] Circadian Clock: Regulations, Genetic and External Factors2018

    • Author(s)
      Yoshimi Okamoto-Uchida, Jun Hirayama. 他16名
    • Total Pages
      136
    • Publisher
      Nova Science publishers
    • ISBN
      9781536133721
    • Data Source
      KAKENHI-PROJECT-17K08482
  • [Book] アレルギー疾患のすべて2016

    • Author(s)
      岡本美孝
    • Total Pages
      367
    • Publisher
      日本医師会
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Journal Article] Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation2023

    • Author(s)
      Pu Jing、Kofuji Satoshi、Okamoto-Uchida Yoshimi、Danzaki Keiko、Yu Ruoxing、Suzuki Akira、Kitajima Satoshi、Nishina Hiroshi
    • Journal Title

      Stem Cells

      Volume: 41 Issue: 12 Pages: 1142-1156

    • DOI

      10.1093/stmcls/sxad071

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06628, KAKENHI-PROJECT-21K06544, KAKENHI-PROJECT-21H04806
  • [Journal Article] Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis2018

    • Author(s)
      Iinuma T.、Okamoto Y.、Morimoto Y.、Arai T.、Sakurai T.、Yonekura S.、Sakurai D.、Hirahara K.、Nakayama T.
    • Journal Title

      Allergy

      Volume: 73 Issue: 2 Pages: 479-489

    • DOI

      10.1111/all.13295

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-16H05483
  • [Journal Article] Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy2018

    • Author(s)
      1.Ihara F, Saurai D, Yonekura S, Iinuma T, Matsuura A, Morimoto Y, Arai T, Suzuki S, Katayama K, Nakayama T, Okamoto Y
    • Journal Title

      Allergy

      Volume: 73 Issue: 9 Pages: 1823-1832

    • DOI

      10.1111/all.13436

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Journal Article] Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells2018

    • Author(s)
      Sakurai D, Uchida R, Ihara F, Kunii N, Nakagawa T, Chazono H, Hanazawa T, Motohashi S, Okamoto Y
    • Journal Title

      BMC Research Notes

      Volume: 11 Issue: 1 Pages: 479-479

    • DOI

      10.1186/s13104-018-3587-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
  • [Journal Article] An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis2018

    • Author(s)
      Yonekura S, Okamoto Y, Sakurai D, Okubo K, Gotoh M, Kaneko S, Konno A.
    • Journal Title

      Allergol. Int.

      Volume: 67 Issue: 2 Pages: 201-208

    • DOI

      10.1016/j.alit.2017.07.005

    • NAID

      130006721780

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10778, KAKENHI-PROJECT-16H05483
  • [Journal Article] 薬物アレルギーの発症機序2018

    • Author(s)
      岡本(内田)好海、中村亮介、斎藤嘉朗
    • Journal Title

      アレルギー・免疫

      Volume: 25 Pages: 92-97

    • Data Source
      KAKENHI-PROJECT-17K08482
  • [Journal Article] The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison to the USA FDA Label.2018

    • Author(s)
      Wang YH, Chen CB, Tassaneeyakul W, Saito Y, Aihara M, 他7名, Okamoto-Uchida Y, Man-Tung Cheung C, Huang JW, Ji C, Cheng B, Chung-Yee Hui R, Chu CY, Chen YJ, Wu CY, Hsu CK, Chiu TM, Ho HC, Lin JY, Yang CH, Chang YC, Su SC, Wang CW, Chung WH; Asian Severe Cutaneous Adverse Reaction Consortium
    • Journal Title

      Clin Pharmacol Ther.

      Volume: in press Issue: 1 Pages: 112-120

    • DOI

      10.1002/cpt.1071

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08482
  • [Journal Article] Effect of Infectious Diseases on the Pathogenesis of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis2017

    • Author(s)
      Okamoto-Uchida Y, Nakamura R, Sai K, Imatoh T, Matsunaga K, Aihara M, Saito Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 9 Pages: 1576-1580

    • DOI

      10.1248/bpb.b17-00207

    • NAID

      130006038757

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08433, KAKENHI-PROJECT-17K08482
  • [Journal Article] House dust mite sublingual tablet is effective and safe in patients with allergic rhinitis.2017

    • Author(s)
      Okamoto Y, Fujieda S, Okano M, Yoshida Y, Kakudo S, Masuyama K.
    • Journal Title

      Allergy

      Volume: 72 Issue: 3 Pages: 435-443

    • DOI

      10.1111/all.12996

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-26293368, KAKENHI-PROJECT-15H04987
  • [Journal Article] Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK72017

    • Author(s)
      Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 7348-7348

    • DOI

      10.1038/s41598-017-07845-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08521, KAKENHI-PROJECT-17K08482, KAKENHI-PUBLICLY-17H05996, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-17H03982, KAKENHI-PROJECT-17H03541
  • [Journal Article] The mevalonate pathway regulates primitive streak formation via protein farnesylation2016

    • Author(s)
      Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 37697-37697

    • DOI

      10.1038/srep37697

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-15H02566, KAKENHI-PROJECT-14J04687, KAKENHI-PROJECT-26293012, KAKENHI-PROJECT-15K15640, KAKENHI-PROJECT-15K19168, KAKENHI-PROJECT-15K09568, KAKENHI-PROJECT-16K08588, KAKENHI-PROJECT-16K11309, KAKENHI-PUBLICLY-16H01644
  • [Journal Article] Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization2016

    • Author(s)
      Okamoto-Uchida Y, Nakamura R, Matsuzawa Y, Soma M, Kawakami H, Ishii-Watabe A, Nishimaki-Mogami T, Teshima R, Saito Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 10 Pages: 1662-1666

    • DOI

      10.1248/bpb.b16-00389

    • NAID

      130005598496

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-15K19168
  • [Journal Article] Th2 cells in health and disease.2016

    • Author(s)
      Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, Tumes DJ, Okamoto Y.
    • Journal Title

      Annu Rev Immunol.

      Volume: 35 Issue: 1 Pages: 53-84

    • DOI

      10.1146/annurev-immunol-051116-052350

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K08876, KAKENHI-PUBLICLY-16H01352, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H06224, KAKENHI-PROJECT-15K08522
  • [Journal Article] A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis2015

    • Author(s)
      Ruoxing Yu, Norio Miyamura, Yoshimi Okamoto-Uchida, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika and Hiroshi Nishina
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 12 Pages: e0145286-e0145286

    • DOI

      10.1371/journal.pone.0145286

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293012, KAKENHI-PROJECT-15K19168
  • [Journal Article] Drugs causing severe ocular surface involvements in Japanese patients with StevenseJohnson syndrome/toxic epidermal necrolysis2015

    • Author(s)
      Kaniwa N, Ueta M, Nakamura R, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y.
    • Journal Title

      Allergol. Int.

      Volume: 64 Issue: 4 Pages: 379-381

    • DOI

      10.1016/j.alit.2015.05.002

    • NAID

      130005290406

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460082, KAKENHI-PROJECT-25293355, KAKENHI-PROJECT-26293122, KAKENHI-PROJECT-15K19168
  • [Journal Article] 臨床における重症薬疹とゲノムマーカー2015

    • Author(s)
      岡本(内田)好海、児玉進、中村亮介、斎藤嘉朗
    • Journal Title

      毒性質問箱

      Volume: 17 Pages: 18-23

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] ドライバー変異の少ないがん発症における転写共役因子YAP の分子的 役割の解明2023

    • Author(s)
      岡本好海
    • Organizer
      第32 回日本肝臓医生物学研究会
    • Data Source
      KAKENHI-PROJECT-23K06628
  • [Presentation] スギ花粉症の舌下免疫療法の奏効性は血清中IgEの架橋能と相関する2019

    • Author(s)
      中村亮介, 秋山晴代, 櫻井大樹, 松澤由美子, 斎藤嘉朗, 岡本美孝
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Presentation] セツキシマブによる牛肉アレルギー患者血清中IgE架橋活性の解析2018

    • Author(s)
      中村亮介, 岡本(内田)好海, 千貫祐子, 斎藤嘉朗, 森田栄伸
    • Organizer
      第67回日本アレルギー学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Presentation] 舌下免疫療法実施時における血清中中和抗体活性のin vitro評価法の開発2018

    • Author(s)
      秋山晴代, 中村亮介, 櫻井大樹, 平野吉彬, 根来孝治, 岡本美孝
    • Organizer
      第67回日本アレルギー学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Presentation] Crosslinking ability of the serum IgE correlates to the effectiveness of allergen immunotherapy for Japanese cedar pollen2018

    • Author(s)
      Nakamura R, Akiyama H, Sakurai D, Matsuzawa Y, Saito Y, Okamoto Y
    • Organizer
      WISC 2018
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Presentation] 日本人の重症眼障害併発性風邪薬誘発性スティーブンス・ジョンソン症候群/中毒性表皮壊死症に関連する遺伝子多型の解析2017

    • Author(s)
      岡本(内田) 好海、中村亮介、松永佳世子、相原道子、齋藤嘉朗
    • Organizer
      第24回日本免疫毒性学会年会
    • Data Source
      KAKENHI-PROJECT-17K08482
  • [Presentation] Risk Factors for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Severe Ocular Involvements2017

    • Author(s)
      Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
    • Organizer
      SJS symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08482
  • [Presentation] Involvement of Infectious Diseases in Pathogenesis of Stevens -Johnson Syndrome and Toxic Epidermal Necrolysis.2017

    • Author(s)
      Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
    • Organizer
      International Stevens-Johnson syndrome symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      2017-01-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] Different responses of basophils to allergen between sensitized-asymptomatic subjects and patients with allergic rhinitis.2017

    • Author(s)
      Okamoto Y, Yonekura S, Arai T, Sakurai D.
    • Organizer
      AAAAI2017
    • Place of Presentation
      アトランタ
    • Year and Date
      2017-03-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Presentation] The mevalonate pathway regulates primitive streak formation via protein farnesylation2017

    • Author(s)
      Ruoxing Yu, Yoshimi Okamoto-Uchida, Hiroshi Nishina
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] セルベーストアッセイによる牛肉アレルギー患者血清中IgEの糖鎖抗原への反応性の解析2016

    • Author(s)
      岡本(内田)好海, 中村亮介, 千貫祐子, 若林翼, 打田光宏, 土屋敏行, 斎藤嘉朗, 森田栄伸
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] Current concepts on immune mechanisms of sublingual immunotherapy2016

    • Author(s)
      Okamoto Y.
    • Organizer
      18th Asian Research Symposium of Rhinology
    • Place of Presentation
      クアラルンプール
    • Year and Date
      2016-05-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Presentation] Efficacy and safety of S-524101 in mono-sensitized and poly-sensitized patients with allergic rhinitis in Japan Phase 2/3 study2016

    • Author(s)
      Okamoto Y, Fujieda S, Masuyaka K, Okano M, Kakudo M.
    • Organizer
      EAACI2016
    • Place of Presentation
      ウィーン
    • Year and Date
      2016-06-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05483
  • [Presentation] Drugs and HLA types associated with Stevens–Johnson syndrome/toxic epidermal necrolysis with severe ocular surface involvements in Japanese patients2016

    • Author(s)
      Nakamura R, Kaniwa N, Ueta M, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Tokunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y.
    • Organizer
      1st Internati- onal Stevens- Johnson Syndrome Symposium
    • Place of Presentation
      京都
    • Year and Date
      2016-01-23
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] スティーブンスジョンソン症候群・中毒性壊死症における感染症併発の影響2016

    • Author(s)
      岡本(内田) 好海、中村亮介、佐井君江、今任拓也、松永佳代子、相原道子、斎藤嘉朗
    • Organizer
      第23回日本免疫毒性学会年会
    • Place of Presentation
      北九州
    • Year and Date
      2016-09-06
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] スティーブンス・ジョンソン症候群/中毒性表皮壊死症の病態に対する感染症の影響2016

    • Author(s)
      岡本(内田)好海、中村亮介、佐井君江、今任拓也、松永佳世子、相原道子、斎藤嘉朗
    • Organizer
      次世代を担う若手のためのレギュラトリーサイエンスフォーラム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] 重症眼粘膜障害を伴うSJS/TENの発症と関連する被疑薬およびHLA型について2015

    • Author(s)
      中村亮介, 鹿庭なほ子,上田真由美, 岡本(内田)好海, 杉山永見子, 高橋幸利, 古谷博和, 矢上晶子, 松倉節子, 池澤善郎, 松永佳世子, 徳永勝士, 外園千恵, 相原道子, 木下茂, 斎藤嘉朗
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-26
    • Data Source
      KAKENHI-PROJECT-15K19168
  • [Presentation] 重篤副作用発症における感染症併発の影響 ― 横紋筋融解症及び重症薬疹の事例 ―2015

    • Author(s)
      佐井君江, 中村亮介, 今任拓也, 岡本好海, 梶波康二, 松永佳世子, 相原道子, 斎藤嘉朗
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-06-29
    • Data Source
      KAKENHI-PROJECT-15K19168
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  • 1.  Nakamura Ryosuke (50333357)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 2.  岡本 美孝 (40169157)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 3.  秋山 晴代 (50420229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  橋井 則貴 (20425672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Kanoh Naoki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Miyamura Norio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  平原 潔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  仁科 博史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  平山 順
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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