Kobayakawa Yuko 小早川優子

… Alternative Names

KOBAYAKAWA YUKO 小早川優子

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Researcher Number	40733788
Other IDs
Affiliation (Current)	2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 九州大学, 大学病院, 助教 2019 – 2021: 九州大学, 大学病院, 医員 2015 – 2016: 九州大学, 大学病院, 学術研究員 2015: 九州大学, 大学病院, 研究員 2014: 九州大学, 大学病院, その他
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator 筋萎縮性側索硬化症 / 電気シナプス / コネキシン36 / 努力肺活量 / 進行速度 / 病態解明 / Cx36 / 変異SOD1 / シナプス / 神経科学 / 変異SOD1マウス / オリゴデンドロサイト / コネキシン … More Except Principal Investigator … More ミクログリア / 診断マーカー / 脳脊髄液 / グリア性炎症 / 筋萎縮性側索硬化症 / ALFoC / グリア性炎症惹起性 / CCL2 / MCP1 / パルブアルブミン / カルビンディン / 培養ミクログリア / カルシウム結合蛋白 / 培養実験 / カルレチニン / galectin-3 / 炎症 / galectin3 / p22 / ガレクチン3 / 動物モデル / ELISA / 血液脳関門 / 髄鞘淡明化 / 脊髄前・側索 Less

Elucidation of the pathogenesis and identification of novel therapeutic targets using a new scale assessing the clinical diversity of ALSPrincipal Investigator
- Principal Investigator
  
  小早川優子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Detection of ALS origin with reference to calcium-binding proteins, those generate glial inflammation
- Principal Investigator
  
  林信太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Significance of and treatment against galectin-3 and p22 accompanied with glial inflamation in ALS spinal cord
- Principal Investigator
  
  HAYASHI SHINTARO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation of excitability control in motor neuron via electrical synapse and exploration of treatment for ALS by synaptic recoveryPrincipal Investigator
- Principal Investigator
  
  KOBAYAKAWA YUKO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
筋萎縮性側索硬化症における電気シナプス喪失による運動ニューロン死の促進とその制御Principal Investigator
- Principal Investigator
  
  小早川優子
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Roles of oligodendrocytic connexins in the pathogenesis of ALSPrincipal Investigator
- Principal Investigator
  
  Kobayakawa Yuko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2016 2015

All Journal Article Presentation

[Journal Article] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, et al.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 24 Issue: sup1 Pages: 115-127
- DOI
  10.1080/21678421.2023.2260193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07517
[Journal Article] Distinct effects among calcium-binding proteins for microglia to produce chemokines associated with the clinical severity of ALS.2023
- Author(s)
  Hayashi S, Yamasaki R, Kira JI, Isobe N.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 14 Issue: 1 Pages: 69-73
- DOI
  10.1111/cen3.12738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07517
[Journal Article] The first evaluation of calretinin in the spinal axons encompassed in anterolateral funiculi outside the cortical tract and cerebrospinal fluids of ALS patients.2022
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, Kira JI, Isobe N.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 23 Issue: sup1 Pages: 101-102
- DOI
  10.1080/21678421.2022.2120682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07517
[Journal Article] Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression2021
- Author(s)
  白石渉、山﨑亮、橋本侑、江千里、小早川優子、磯部紀子、松下拓也、吉良潤一
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 16438-16438
- DOI
  10.1038/s41598-021-96064-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07963, KAKENHI-PROJECT-19K17010
[Journal Article] 抗GAD抗体が関連する神経症候群2019
- Author(s)
  小早川優子
- Journal Title
  
  脳神経内科
  
  Volume: 90 Pages: 397-401
- Data Source
  KAKENHI-PROJECT-19K17010
[Presentation] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, et al.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, et al.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] 活性化ミクログリアが産生する蛋白に着目した運動神経細胞変性相関因子の同定と診断バイオマーカーの探求2023
- Author(s)
  林信太郎、山﨑亮、小早川優子、他.
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] The first evaluation of calretinin in the spinal axons and cerebrospinal fluids of ALS patients.2022
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, Kira JI, Isobe N.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] The role of dysregulated connexin 30 expression in amyotrophic lateral sclerosis model mice.2022
- Author(s)
  Yu Hashimoto, Senti Ko, Yuko Kobayakawa, Ryo Yamasaki, Noriko Isobe
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17010
[Presentation] The first evaluation of calretinin in the spinal axons encompassed in anterolateral funiculi outside the cortical tract and cerebrospinal fluids of ALS patients.2022
- Author(s)
  Hayashi S, Yamasaki R, Kobayakawa Y, Kira JI, Isobe N.
- Organizer
  33rd International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07517
[Presentation] CCR2-positive macrophages infiltrated into the peripheral nerves protect motor neuron disease2020
- Author(s)
  白石渉、山﨑亮、橋本侑、小早川優子、吉良潤一
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17010
[Presentation] Downregulation of Cx36-made electrical synapses without glutamatergic axon terminals in ALS.2019
- Author(s)
  小早川優子、眞﨑勝久、山崎亮、白石渉、林信太郎、岡本幸市、吉良潤一
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17010
[Presentation] CCR2-positive peripheral blood macrophages play protective roles in ALS mouse model.2019
- Author(s)
  白石渉、山﨑亮、小早川優子、吉良潤一
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17010
[Presentation] Involvement of electrical synapse in the pathogenesis of amyotrophic lateral sclerosis2016
- Author(s)
  小早川優子
- Organizer
  第57回日本神経学会学術総会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-16K19514
[Presentation] Involvement of electrical synapse in the pathogenesis of ALS2016
- Author(s)
  小早川優子
- Organizer
  第57回日本神経学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26893184
[Presentation] ZO-1 as scaffolding protein of gap junction is impaired in ALS model mice2015
- Author(s)
  小早川優子
- Organizer
  第56回日本神経学会学術総会
- Place of Presentation
  新潟
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26893184
[Presentation] ZO-1 as a scaffolding protein of gap junction is impaired in ALS model mice2015
- Author(s)
  小早川優子
- Organizer
  第56回日本神経学会学術総会
- Place of Presentation
  新潟
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26893184

1. HAYASHI SHINTARO (90312876)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. 山崎亮 (10467946)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results

Kobayakawa Yuko 小早川 優子

KOBAYAKAWA YUKO 小早川 優子

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenesis and identification of novel therapeutic targets using a new scale assessing the clinical diversity of ALSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Detection of ALS origin with reference to calcium-binding proteins, those generate glial inflammation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of and treatment against galectin-3 and p22 accompanied with glial inflamation in ALS spinal cord

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of excitability control in motor neuron via electrical synapse and exploration of treatment for ALS by synaptic recoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

筋萎縮性側索硬化症における電気シナプス喪失による運動ニューロン死の促進とその制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of oligodendrocytic connexins in the pathogenesis of ALSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct effects among calcium-binding proteins for microglia to produce chemokines associated with the clinical severity of ALS.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The first evaluation of calretinin in the spinal axons encompassed in anterolateral funiculi outside the cortical tract and cerebrospinal fluids of ALS patients.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 抗GAD抗体が関連する神経症候群2019

Author(s)

Journal Title

Data Source

[Presentation] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023

Author(s)

Organizer

Data Source

[Presentation] Calretinin activates microglia to produce CC-motif ligand 2 relevant to clinical severity of ALS2023

Author(s)

Organizer

Data Source

[Presentation] 活性化ミクログリアが産生する蛋白に着目した運動神経細胞変性相関因子の同定と診断バイオマーカーの探求2023

Author(s)

Organizer

Data Source

[Presentation] The first evaluation of calretinin in the spinal axons and cerebrospinal fluids of ALS patients.2022

Author(s)

Organizer

Kobayakawa Yuko 小早川優子

KOBAYAKAWA YUKO 小早川優子