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Hayashi Akimasa  林 玲匡

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HAYASHI Akimasa  林 玲匡

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Researcher Number 40735396
Other IDs
Affiliation (Current) 2025: 杏林大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2023: 杏林大学, 医学部, 准教授
2020 – 2022: 杏林大学, 医学部, 講師
2014 – 2017: 東京大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Human pathology / Basic Section 49020:Human pathology-related / 0901:Oncology and related fields
Keywords
Principal Investigator
腫瘍内不均一性 / 膵癌 / クロマチン構造 / ゲノム / エピゲノム / FAIRE / 肝細胞癌 / 空間的遺伝子発現解析 / クローン進展 / 腫瘍不均一性 … More / DNAメチル化 / 遺伝子 / 癌 / β-catenin / CTNNB1 / ARID / クロマチン / 網羅的解析 Less
  • Research Projects

    (4 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (3 People)
  •  膵癌の局所空間における分子遺伝学的不均一性とその病理形態学的意義の探索Principal Investigator

    • Principal Investigator
      林 玲匡
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Kyorin University
  •  Heterogeneity and Plasticity of DNA Methylation during Clonal Evolution in Pancreatic CancerPrincipal Investigator

    • Principal Investigator
      Hayashi Akimasa
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Kyorin University
  •  Identification of new beta-catenin target genes using genome-wide analyses of chromatin structurePrincipal Investigator

    • Principal Investigator
      Hayashi Akimasa
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Human pathology
    • Research Institution
      The University of Tokyo
  •  Comprehensive Analysis of Chromatin Structure in Hepatocellular Carcinoma Based on Somatic MutationPrincipal Investigator

    • Principal Investigator
      HAYASHI Akimasa
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Human pathology
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer2023

    • Author(s)
      Zhang Haochen、Karnoub Elias-Ramzey、Umeda Shigeaki、Chalign? Ronan、Masilionis Ignas、McIntyre Caitlin A.、Sashittal Palash、Hayashi Akimasa、Zucker Amanda、Mullen Katelyn、Hong Jungeui、Makohon-Moore Alvin、Iacobuzio-Donahue Christine A.
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 749-749

    • DOI

      10.1038/s41467-023-36344-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06968
  • [Journal Article] The pancreatic cancer genome revisited2021

    • Author(s)
      Hayashi Akimasa、Hong Jungeui、Iacobuzio-Donahue Christine A.
    • Journal Title

      Nature Reviews Gastroenterology & Hepatology

      Volume: 18 Issue: 7 Pages: 469-481

    • DOI

      10.1038/s41575-021-00463-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K22821
  • [Journal Article] Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas2020

    • Author(s)
      Lenkiewicz Elizabeth、Malasi Smriti、Hogenson Tara L.、Flores Luis F.、Barham Whitney、Phillips William J.、Roesler Alexander S.、Chambers Kendall R.、Rajbhandari Nirakar、Hayashi Akimasa、…、Fernandez-Zapico Martin E.、Barrett Michael T.
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 20 Pages: 4324-4334

    • DOI

      10.1158/0008-5472.can-20-0078

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K22821
  • [Journal Article] Contrast-enhanced intraoperative ultrasound in the resection of colorectal liver metastases with intrabiliary growth.2018

    • Author(s)
      Hiroyoshi J, Yamashita S, Tanaka M, Hayashi A, Ushiku T, Kaneko J, Akamatsu N, Arita J, Sakamoto Y, Hasegawa K.
    • Journal Title

      Clin J Gastroenterol.

      Volume: Apr 9. Issue: 5 Pages: 348-353

    • DOI

      10.1007/s12328-018-0858-0

    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity2018

    • Author(s)
      Fujiwara Naoto、Nakagawa Hayato、Enooku Kenichiro、Otsuka Motoyuki、Tateishi Keisuke、Koike Kazuhiko
    • Journal Title

      Gut

      Volume: 67 Issue: 8 Pages: 1493-1504

    • DOI

      10.1136/gutjnl-2017-315193

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K19313, KAKENHI-PROJECT-16K19075, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-16K09342
  • [Journal Article] Reversion of serum VZV-IgG antibody preceding disseminated visceral varicella zoster after hematopoietic stem cell transplantation.2017

    • Author(s)
      Arakawa S, Kage H, Chino H, Hinata M, Hayashi A, Toya T, Noguchi S, Ushiku T, Yamauchi Y, Kurokawa M, Fukayama M, Nagase T.
    • Journal Title

      Ann Hematol.

      Volume: Mar;96(3) Issue: 3 Pages: 529-530

    • DOI

      10.1007/s00277-016-2876-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] Small colorectal cancers resembling submucosal tumor with massive submucosal invasion and lymph node metastasis: A report of two cases and review of the literature.2017

    • Author(s)
      Shinagawa T, Ishihara S, Nozawa H, Murono K, Nishikawa T, Otani K, Sasaki K, Yasuda K, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Yamaguchi H, Hayashi A, Tanaka M, Ushiku T, Fukayama M, Watanabe T.
    • Journal Title

      Clin Res Hepatol Gastroenterol.

      Volume: Mar;41(2) Issue: 2 Pages: e19-e23

    • DOI

      10.1016/j.clinre.2016.07.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] Non-occlusive mesenteric ischemia localized in the transverse colon: a case report.2017

    • Author(s)
      Murono K, Ishihara S, Kawai K, Kaneko M, Sasaki K, Yasuda K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Hayashi A, Ushiku T, Fukayama M, Watanabe T.
    • Journal Title

      Surg Case Rep.

      Volume: Dec;3(1) Issue: 1 Pages: 23-23

    • DOI

      10.1186/s40792-017-0299-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] Safety and efficacy of venous reconstruction in liver resection using cryopreserved homologous veins.2017

    • Author(s)
      Yamamoto M, Akamatsu N, Hayashi A, Togashi J, Sakamoto Y, Tamura S, Hasegawa K, Fukayama M, Makuuchi M, Kokudo N.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: Sep;24(9) Issue: 9 Pages: 511-519

    • DOI

      10.1002/jhbp.488

    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and PBRM1 expression, and demonstrates specific clinicopathological and genetic characteristics with BAP1 loss.2017

    • Author(s)
      Misumi K*, Hayashi A* (*equal cotributions), Shibahara J, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M.
    • Journal Title

      Histopathology.

      Volume: Apr;70(5) Issue: 5 Pages: 766-774

    • DOI

      10.1111/his.13127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] PIK3CA and AKT1 mutations in hidradenoma papilliferum.2017

    • Author(s)
      Goto K, Maeda D, Kudo-Asabe Y, Hibiya T, Hayashi A, Fukayama M, Ohashi K, Goto A.
    • Journal Title

      J Clin Pathol.

      Volume: May;70(5) Issue: 5 Pages: 424-427

    • DOI

      10.1136/jclinpath-2016-204003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075, KAKENHI-PROJECT-16K08646
  • [Journal Article] Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma.2016

    • Author(s)
      Hayashi A, Misumi K, Shibahara J, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M.
    • Journal Title

      Am J Surg Pathol.

      Volume: Aug;40(8) Issue: 8 Pages: 1021-30

    • DOI

      10.1097/pas.0000000000000670

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] Immunohistochemistry Using Monoclonal Antibody MsMab-2 Is Useful to Detect IDH1 R132L in Intrahepatic Cholangiocarcinoma.2016

    • Author(s)
      Hayashi A, Misumi K, Shibahara J, Kokudo N, Kato Y and Fukayama M.
    • Journal Title

      Pathology international

      Volume: 66 Issue: 10 Pages: 578-582

    • DOI

      10.1111/pin.12459

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K10748, KAKENHI-PROJECT-16K19075
  • [Journal Article] Distinct clinicopathologic and genetic features of 2 histologic subtypes of intrahepatic cholangiocarcinoma.2016

    • Author(s)
      Hayashi A, Misumi K, Shibahara J, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M.
    • Journal Title

      Am J Surg Pathol.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Journal Article] Primary hepatic schwannoma: A case report.2016

    • Author(s)
      Yamamoto M, Hasegawa K, Arita J, Maeno R, Akamatsu N, Kaneko J, Watadani T, Okura N, Hayashi A, Shibahara J, Sakamoto Y, Ohtomo K, Fukayama M, Kokudo N.
    • Journal Title

      Int J Surg Case Rep.

      Volume: 29 Pages: 146-150

    • DOI

      10.1016/j.ijscr.2016.11.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] Clinicopathologic Characteristics of Hepatocellular Carcinoma With Reactive Ductule-like Components, a Subset of Liver Cancer Currently Classified as Combined Hepatocellular-Cholangiocarcinoma With Stem-Cell Features, Typical Subtype.2016

    • Author(s)
      Shibahara J, Hayashi A, Misumi K, Sakamoto Y, Arita J, Hasegawa K, Kokudo N, Fukayama M.
    • Journal Title

      Am J Surg Pathol.

      Volume: 40(5) Issue: 5 Pages: 608-616

    • DOI

      10.1097/pas.0000000000000579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Journal Article] Heart Failure Complicated by Alveolar Hemorrhage due to Vascular Collapse and Amyloid Deposits in Wild-Type Transthyretin Amyloidosis.2016

    • Author(s)
      Kido Y, Takahashi M, Fukuma N, Kawata T, Tanaka A, Hayashi A, Shibahara J, Daimon M, Morita H, Akazawa H, Komuro I.
    • Journal Title

      Cardiology.

      Volume: 135(4) Pages: 216-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Journal Article] Altered expression of AT-rich interactive domain 1A in hepatocellular carcinoma2015

    • Author(s)
      Hayashi A, Abe H, Kunita A, Sakamoto Y, Hasegawa K, Shibahara J, Kokudo N, Fukayama M
    • Journal Title

      International Journal of Clinical and Experimental Pathology

      Volume: in press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Journal Article] β-catenin alteration is rare in hepatocellular carcinoma with steatohepatitic features: immunohistochemical and mutational study.2015

    • Author(s)
      Ando S, Shibahara J, Hayashi A, Fukayama M.
    • Journal Title

      Virchows Archiv

      Volume: 467(5) Issue: 5 Pages: 535-42

    • DOI

      10.1007/s00428-015-1836-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Journal Article] Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.2014

    • Author(s)
      Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, …, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata T
    • Journal Title

      Nat Genet.

      Volume: 46 Issue: 12 Pages: 1267-73

    • DOI

      10.1038/ng.3126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249068, KAKENHI-PUBLICLY-25134720, KAKENHI-PROJECT-25860521, KAKENHI-PROJECT-26893045
  • [Presentation] 空間的遺伝子発現解析を用いた膵癌退形成変化の分子生物学的探索2024

    • Author(s)
      林玲匡, 笹川翔太, 柴山隆宏, 田邉一成, 阪本良弘, 中川英刀, 柴原純二
    • Organizer
      第113回 日本病理学会
    • Data Source
      KAKENHI-PROJECT-22K06968
  • [Presentation] 膵癌における腫瘍内の形態学的・分子遺伝学的不均一性2023

    • Author(s)
      林玲匡
    • Organizer
      日本病理学会カンファレンス
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K06968
  • [Presentation] 膵管癌におけるDNAメチル化の腫瘍内不均一性と遍在性2022

    • Author(s)
      林玲匡、Christine Iacobuzio-Donahue.
    • Organizer
      第111回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K22821
  • [Presentation] 膵管癌における DNA メチル化の腫瘍内不均一性と遍在性2022

    • Author(s)
      林玲匡
    • Organizer
      第111回日本病理学会
    • Data Source
      KAKENHI-PROJECT-22K06968
  • [Presentation] 膵癌の非翻訳領域のクローン進展動態2021

    • Author(s)
      林玲匡、Christine A. Iacobuzio-Donahue
    • Organizer
      第110回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K22821
  • [Presentation] 膵癌の発生・進展過程におけるエピゲノム異常2021

    • Author(s)
      林玲匡ら
    • Organizer
      第110回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K22821
  • [Presentation] 膵癌の発生・進展過程におけるエピゲノム異常2021

    • Author(s)
      林玲匡
    • Organizer
      第110回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K22821
  • [Presentation] Alpha-Fetoprotein(AFP)産生胃癌のゲノム解析2016

    • Author(s)
      田頭周、谷内田真一、垣内美和子、六反啓文、林玲匡、辰野健二、山本尚吾、永江玄太、阿部浩幸、石川俊平、柴田 龍弘、深山正久、油谷浩幸
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Presentation] 次世代シーケンスによる肝細胞癌のクロマチンアクセシビリティ解析2016

    • Author(s)
      吉川修平、牧瀬尚大、林玲匡、藤田隆教、野村征太郎、永江玄太、緑川泰、深山正久、油谷浩幸
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Presentation] 肝細胞癌における腫瘍内リンパ球・形質細胞浸潤の組織学的アプローチ2016

    • Author(s)
      林玲匡、柴原純二、三角健人、有田 淳一、阪本良弘、長谷川潔、國土典弘、深山正久
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-05-12
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Presentation] 高感度ISH法による肝内胆管癌におけるアルブミンmRNA発現検討2016

    • Author(s)
      三角健人、柴原純二、林玲匡、國土 典弘、深山正久
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-05-12
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Presentation] Lymphocyte Infiltration is a New Promising Prognostic Factor in Hepatocellular Carcinoma2016

    • Author(s)
      Hayashi A, Shibahara J, Misumi K, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M
    • Organizer
      The 105th Annual Meeting of the United States and Canadian Academy of Pathology
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2016-03-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Presentation] 肝内胆管癌における2つのサブタイプの臨床病理学的および遺伝学的特徴2016

    • Author(s)
      林玲匡、三角健人、柴原純二、有田 淳一、阪本良弘、長谷川潔、國土典弘、深山正久
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-05-12
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Presentation] 肝細胞がんの非癌部でのドライバー遺伝子変異2016

    • Author(s)
      辰野健二、山本尚吾、永江玄太、林玲匡、緑川泰、油谷浩幸
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Presentation] 肝がんにおけるエンハンサー領域のエピゲノム異常2016

    • Author(s)
      永江玄太、Renard-Guillet, Claire、辰野健二、山本尚吾、上田宏生、林玲匡、牧瀬尚大、緑川 泰、中川英刀、柴田龍弘、油谷 浩幸
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K19075
  • [Presentation] Distinct Clinicopathologic and Genetic Features of Two Histologic Subsets of Intrahepatic Cholangiocarcinoma2016

    • Author(s)
      Hayashi A, Misumi K, Shibahara J, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M
    • Organizer
      The 105th Annual Meeting of the United States and Canadian Academy of Pathology
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2016-03-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Presentation] 次世代シーケンスによる肝細胞癌のクロマチン構造解析2015

    • Author(s)
      牧瀬 尚大, 林 玲匡, 藤田 貴教, 永江 玄太, 緑川 泰, 深山 正久, 油谷 浩幸
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場,愛知県名古屋市
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Presentation] 肝細胞癌背景肝組織におけるH3K27ac修飾レベルの臨床病理学的検討.2015

    • Author(s)
      林玲匡, 柴原純二, 山内直子, 木村宏, 阪本良弘, 石川俊平, 國土典宏, 油谷浩幸,深山正久.
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場,愛知県名古屋市
    • Year and Date
      2015-04-30
    • Data Source
      KAKENHI-PROJECT-26893045
  • [Presentation] Multi lesion analysis of alpha fetoprotein producing gastric cancer2015

    • Author(s)
      田頭 周, 谷内田 真一, 垣内 美和子, 六反 啓文, 林 玲匡, 辰野 健二, 山本 尚吾, 永江 玄太, 阿部 浩幸, 石川 俊平, 柴田 龍弘, 深山 正久, 油谷 浩幸
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場,愛知県名古屋市
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26893045
  • 1.  KATO Yukinari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  油谷 浩幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  小池 和彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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