SAKAI Hiroyasu 境浩康

… Alternative Names

境浩康サカイヒロヤス

Sakai Hiroyasu 境浩康

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Researcher Number	40738259
Other IDs
Affiliation (Current)	2025: 岐阜大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2023: 岐阜大学, 医学部附属病院, 助教 2015 – 2018: 岐阜大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator RXRα / メタボリック症候群 / レチノイド核内受容体 / 肝化学発癌 / 核内受容体 / レチノイド / 肝細胞癌 / 大腸癌 / 高脂肪食 / 肥満 … More / 遺伝子改変マウス / レチノイド受容体 / 肝癌 / 肝発癌 / マウスモデル / 感発癌 / RXRα受容体 / NASH / 非アルコール性脂肪肝炎 Less

RXRα遺伝子改変マウスを用いた肥満関連大腸癌の発癌機序の解明Principal Investigator
- Principal Investigator
  
  境浩康
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
The development of novel therapy for NASH-related hepatocellular carcinoma using RXR-alpha genetically modified micePrincipal Investigator
- Principal Investigator
  
  SAKAI HIROYASU
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
The development of novel therapy for hepatocellular carcinoma using RXR-alpha genetically modified micePrincipal Investigator
- Principal Investigator
  
  Sakai Hiroyasu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University

All 2024 2023 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Inhibitory effects of pentoxifylline on inflammation-related tumorigenesis in rat colon2018
- Author(s)
  Shirakami Yohei、Kochi Takahiro、Kubota Masaya、Sakai Hiroyasu、Ibuka Takashi、Yoshimi Kazuto、Kuramoto Takashi、Tanaka Takuji、Shimizu Masahito、Seishima Mitsuru
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 74 Pages: 33972-33981
- DOI
  10.18632/oncotarget.26119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15936, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-17K15937
[Journal Article] Activation of NLRP3 signalling accelerates skin wound healing2017
- Author(s)
  Ito Hiroyasu、Kanbe Ayumu、Sakai Hiroyasu、Seishima Mitsuru
- Journal Title
  
  Exp Dermatol
  
  Volume: 27 Issue: 1 Pages: 80-86
- DOI
  10.1111/exd.13441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15937
[Journal Article] Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation2017
- Author(s)
  Shirakami Yohei、Ohnishi Masaya、Sakai Hiroyasu、Tanaka Takuji、Shimizu Masahito
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18 Issue: 5 Pages: 908-908
- DOI
  10.3390/ijms18050908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15937, KAKENHI-PROJECT-16K19336
[Journal Article] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice.2017
- Author(s)
  Obara K, Shirakami Y, Maruta A, Ideta T, Miyazaki T, Kochi T, Sakai H, Tanaka T, Seishima M, Shimizu M.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 35 Pages: 58353-58363
- DOI
  10.18632/oncotarget.16874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-17K15937, KAKENHI-PROJECT-16K19336
[Journal Article] Preventative Effects of Pentoxifylline on the Development of Colonic Premalignant Lesions in Obese and Diabetic Mice2017
- Author(s)
  Fukuta K, Shirakami Y, Maruta A, Obara K, Iritani S, Nakamura N, Kochi T, Kubota M, Sakai H, Tanaka T, Shimizu M
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18(2) Issue: 2 Pages: 413-413
- DOI
  10.3390/ijms18020413
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-16K19336, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-17K15936
[Journal Article] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage2017
- Author(s)
  Ideta, T. Shirakami, Y. Ohnishi, M. Maruta, A. Obara, K. Miyazaki, T. Kochi, T. Sakai, H. Tomita, H. Tanaka, T. Blaner, W. S. Shimizu, M.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 41 Pages: 70695-70706
- DOI
  10.18632/oncotarget.19978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08735, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-17K15937, KAKENHI-PROJECT-16K19336
[Journal Article] Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice.2016
- Author(s)
  Ohno T, Shimizu M, Shirakami Y, Miyazaki T, Ideta T, Kochi T, Kubota M, Sakai H, Tanaka T, Moriwaki H.
- Journal Title
  
  Hepatol Res.
  
  Volume: 46(3) Issue: 3 Pages: 201-209
- DOI
  10.1111/hepr.12550
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.2016
- Author(s)
  Miyazaki T, Shirakami Y, Kubota M, Ideta T, Kochi T, Sakai H, Tanaka T, Moriwaki H, Shimizu M.
- Journal Title
  
  Oncotarget
  
  Volume: - Issue: 9 Pages: 10448-10458
- DOI
  10.18632/oncotarget.7249
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Catechins and Its Role in Chronic Disease2016
- Author(s)
  Shirakami Y, Sakai H, Kochi T, Seishima M, Shimizu M
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 929 Pages: 67-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19320
[Journal Article] Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents.2016
- Author(s)
  Sakai H, Shirakami Y, Shimizu M.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22(1) Issue: 1 Pages: 394-406
- DOI
  10.3748/wjg.v22.i1.394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19336
[Journal Article] The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice.2015
- Author(s)
  Ideta T, Shirakami Y, Miyazaki T, Kochi T, Sakai H, Moriwaki H, Shimizu M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16(12) Issue: 12 Pages: 29207-29218
- DOI
  10.3390/ijms161226156
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26860498
[Journal Article] Retinoid roles in blocking hepatocellular carcinoma.2015
- Author(s)
  Shirakami Y, Sakai H, Shimizu M.
- Journal Title
  
  Hepatobiliary Surg Nutr.
  
  Volume: 4(4) Pages: 222-228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320
[Journal Article] Chemopreventive potential of green tea catechins in hepatocellular carcinoma.2015
- Author(s)
  Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Ideta T, Miyazaki T, Moriwaki H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16(3) Issue: 3 Pages: 6124-6139
- DOI
  10.3390/ijms16036124
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498
[Presentation] The role of the Retinoid X Receptor-α in liver regeneration in mice2024
- Author(s)
  Hiroyasu Sakai, Yohei Shirakami, Masahito Shimizu
- Organizer
  The 33rd Annual Meeting of the Asian Pacific Association for the Study of the Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07414
[Presentation] クローン病モデルマウスを用いた腸管免疫制御におけるRetinoid X Receptor-αの役割に関する研究2023
- Author(s)
  境浩康、田口大輔、前田俊英、白上洋平、清水雅仁
- Organizer
  日本レチノイド研究会第34回学術集会
- Data Source
  KAKENHI-PROJECT-23K07414
[Presentation] マウス肝再生におけるRetinoid X Receptor-αの役割に関する研究2018
- Author(s)
  境浩康、白上洋平、清水雅仁
- Organizer
  日本レチノイド研究会　第29回学術集会
- Data Source
  KAKENHI-PROJECT-17K15937
[Presentation] The role of the phosphorylated RXRα on Diethylnitrosamine-induced liver tumorigenesis in mice2016
- Author(s)
  Hiroyasu Sakai, Yasuhiro Yamada, Yohei Shirakami, Akira Hara, and Masahito Shimizu
- Organizer
  APASL 2016 in Tokyo
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19320
[Presentation] The role of the phosphorylated RXR-alpha on cellular proliferation and liver tumorigenesis2016
- Author(s)
  Hiroyasu Sakai, Yohei Shirakami, Masahito Shimizu
- Organizer
  AACR annual meeting 2016
- Place of Presentation
  ニューオーリンズ（アメリカ合衆国）
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19320
[Presentation] The role of the phosphorylated RXRα on Diethylnitrosamine-induced liver tumorigenesis in mice2015
- Author(s)
  Hiroyasu Sakai, Yasuhiro Yamada, Yohei Shirakami, Akira Hara, and Masahito Shimizu
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K19320
[Presentation] The role of the phosphorylated RXRα on cellular proliferation and liver tumorigenesis in mice2015
- Author(s)
  Hiroyasu Sakai, Yohei Shirakami, and Masahito Shimizu
- Organizer
  2015 AACR annual meeting
- Place of Presentation
  フィラデルフィア（アメリカ合衆国）
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19320
[Presentation] The role of the phosphorylated RXRα on Diethylnitrosamine-induced liver tumorigenesis in mice2015
- Author(s)
  Hiroyasu Sakai, Yasuhiro Yamada, Yohei Shirakami, Akira Hara, and Masahito Shimizu
- Organizer
  第3回国際レチノイド研究会
- Place of Presentation
  岐阜グランドホテル（岐阜）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19320

1. SHIMIZU Masahito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 白上洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 久保田全哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 宮崎龍彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAI Hiroyasu 境 浩康

境 浩康 サカイ ヒロヤス

Sakai Hiroyasu 境 浩康

Research Projects

Research Products

Co-Researchers

RXRα遺伝子改変マウスを用いた肥満関連大腸癌の発癌機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of novel therapy for NASH-related hepatocellular carcinoma using RXR-alpha genetically modified micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of novel therapy for hepatocellular carcinoma using RXR-alpha genetically modified micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibitory effects of pentoxifylline on inflammation-related tumorigenesis in rat colon2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of NLRP3 signalling accelerates skin wound healing2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preventative Effects of Pentoxifylline on the Development of Colonic Premalignant Lesions in Obese and Diabetic Mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catechins and Its Role in Chronic Disease2016

Author(s)

Journal Title

Data Source

[Journal Article] Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinoid roles in blocking hepatocellular carcinoma.2015

Author(s)

SAKAI Hiroyasu 境浩康

境浩康サカイヒロヤス

Sakai Hiroyasu 境浩康