TAKAHASHI Masato 高橋正人

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Takahashi Masato 高橋正人

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Researcher Number	40738770
Other IDs
Affiliation (Current)	2025: 千葉科学大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2017 – 2021: 千葉科学大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Keywords	Principal Investigator 有機化学 / 薬学 / 生体機能利用 / 加水分解酵素 / プロドラッグ / 水溶性 / インドメタシン / アトルバスタチン / カルボキシルエステラーゼ

Development of a water-soluble modifying group that is metabolically activated regardless of the chemical structure of the parent compoundPrincipal Investigator
- Principal Investigator
  
  Takahashi Masato
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Chiba Institute of Science
Molecular design of organ-specific prodrugs considering substrate specificity of carboxylesterasesPrincipal Investigator
- Principal Investigator
  
  Takahashi Masato
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba Institute of Science

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] Recent Advancement in Prodrugs (chapter 11)2020
- Author(s)
  Takahashi Masato、Masakiyo Hosokawa
- Total Pages
  15
- Publisher
  CRC press
- Data Source
  KAKENHI-PROJECT-19K16421
[Journal Article] Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase2021
- Author(s)
  Takahashi Masato、Hirota Ibuki、Nakano Tomoyuki、Kotani Tomoyuki、Takani Daisuke、Shiratori Kana、Choi Yura、Haba Masami、Hosokawa Masakiyo
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 38 Pages: 100391-100391
- DOI
  10.1016/j.dmpk.2021.100391
- NAID
  210000176808
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16421
[Journal Article] Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 12020
- Author(s)
  Takahashi Masato、Lee Yeon Joo、Kanayama Teruhiko、Kondo Yusuke、Nishio Kazuki、Mukai Kota、Haba Masami、Hosokawa Masakiyo
- Journal Title
  
  European Journal of Pharmaceutical Sciences
  
  Volume: 152 Pages: 105455-105455
- DOI
  10.1016/j.ejps.2020.105455
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16421
[Journal Article] Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters2019
- Author(s)
  Takahashi Masato、Takani Daisuke、Haba Masami、Hosokawa Masakiyo
- Journal Title
  
  Chirality
  
  Volume: 32 Issue: 1 Pages: 73-80
- DOI
  10.1002/chir.23141
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16421
[Journal Article] Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase.2019
- Author(s)
  Takahashi M, Uehara T, Nonaka M, Minagawa Y, Yamazaki R, Haba M, Hosokawa M.
- Journal Title
  
  Eur J Pharm Sci.
  
  Volume: 132 Pages: 125-131
- DOI
  10.1016/j.ejps.2019.03.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-17K15519
[Journal Article] Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases2019
- Author(s)
  Mizoi Kenta、Takahashi Masato、Sakai Sachiko、Ogihara Takuo、Haba Masami、Hosokawa Masakiyo
- Journal Title
  
  Xenobiotica
  
  Volume: 50 Issue: 3 Pages: 261-269
- DOI
  10.1080/00498254.2019.1625083
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16421
[Journal Article] Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1.2018
- Author(s)
  Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 28 Issue: 6 Pages: 997-1000
- DOI
  10.1016/j.bmcl.2018.02.035
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08378, KAKENHI-PROJECT-17K15519
[Presentation] ヒトカルボキシルエステラーゼによる代謝活性化におけるエステルプロドラッグの立体障害、電子密度および立体化学の影響2022
- Author(s)
  高橋　正人、高荷　大輔、細川　正清
- Organizer
  日本薬学会142年会
- Data Source
  KAKENHI-PROJECT-19K16421
[Presentation] Effects of steric hindrance, electron density and stereochemistry of ester prodrugs on the metabolic activation by human carboxylesterase2021
- Author(s)
  高橋　正人、高荷　大輔、細川　正清
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K16421
[Presentation] ヒトカルボキシルエステラーゼ1のキラル認識能の解明：インドメタシンエステルの光学分割への応用2019
- Author(s)
  高荷大輔、高橋正人、巾正美、細川正清
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15519
[Presentation] カルボキシルエステラーゼ1による代謝活性化におけるインドメタシンプロドラッグの立体的および電子的影響2019
- Author(s)
  廣田伊吹、中野智之、高橋正人、巾正美、細川正清
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K15519
[Presentation] インドメタシンプロドラッグの合成とカルボキシルエステラーゼ 1 による代謝活性化2018
- Author(s)
  高橋正人、小川悌央、柏木裕史、福島史也、吉次美咲、巾正美、細川正清
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K15519
[Presentation] Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 12018
- Author(s)
  高橋正人、小川悌央、柏木裕史、福島史也、吉次美咲、巾正美、細川正清
- Organizer
  日本薬物動態学会第33回年会
- Data Source
  KAKENHI-PROJECT-17K15519
[Presentation] Species differences of mouse, cynomolgus monkey and human carboxylesterase using atorvastatin esters with various steric and electronic properties2017
- Author(s)
  堺早知子、溝井健太、高橋正人、巾正美、宇野泰広、今井輝子、細川正清
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17K15519

1. 細川正清

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKAHASHI Masato 高橋 正人

Takahashi Masato 高橋 正人

Research Projects

Research Products

Co-Researchers

Development of a water-soluble modifying group that is metabolically activated regardless of the chemical structure of the parent compoundPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular design of organ-specific prodrugs considering substrate specificity of carboxylesterasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Recent Advancement in Prodrugs (chapter 11)2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] ヒトカルボキシルエステラーゼによる代謝活性化におけるエステルプロドラッグの立体障害、電子密度および立体化学の影響2022

Author(s)

Organizer

Data Source

[Presentation] Effects of steric hindrance, electron density and stereochemistry of ester prodrugs on the metabolic activation by human carboxylesterase2021

Author(s)

Organizer

Data Source

[Presentation] ヒトカルボキシルエステラーゼ1のキラル認識能の解明：インドメタシンエステルの光学分割への応用2019

Author(s)

Organizer

Data Source

[Presentation] カルボキシルエステラーゼ1による代謝活性化におけるインドメタシンプロド ラッグの立体的および電子的影響2019

Author(s)

Organizer

Data Source

[Presentation] インドメタシンプロドラッグの合成とカルボキシルエステラーゼ 1 による代謝活性化2018

Author(s)

Organizer

Data Source

[Presentation] Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 12018

Author(s)

Organizer

Data Source

[Presentation] Species differences of mouse, cynomolgus monkey and human carboxylesterase using atorvastatin esters with various steric and electronic properties2017

Author(s)

Organizer

TAKAHASHI Masato 高橋正人

Takahashi Masato 高橋正人

[Presentation] カルボキシルエステラーゼ1による代謝活性化におけるインドメタシンプロドラッグの立体的および電子的影響2019