• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Yanagisawa Hiromi  柳沢 裕美

Researcher Number 40746301
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-7576-9186
Affiliation (Current) 2020: 筑波大学, 生存ダイナミクス研究センター, 教授
Affiliation (based on the past Project Information) *help 2018 – 2020: 筑波大学, 生存ダイナミクス研究センター, 教授
2016 – 2017: 筑波大学, 生命領域学際研究センター, 教授
Review Section/Research Field
Principal Investigator
Cardiovascular surgery / Basic Section 55030:Cardiovascular surgery-related
Except Principal Investigator
Pathological medical chemistry / Cardiovascular medicine / Basic Section 44020:Developmental biology-related
Keywords
Principal Investigator
大動脈瘤 / 細胞外マトリクス / 血管平滑筋細胞 / 血管平滑筋細胞’ / メカニカルストレス / マトリセルラータンパク質 / フィブリン4 / シグナル伝達 / アクチン / メカノセンサー … More / マトリセルラータンパク / 大血管外科学 / 分子生物学 / マウスモデル / 破裂 / メカ二カルストレス … More
Except Principal Investigator
大動脈瘤 / TGFβ / メカニカルストレス / 大動脈瘤破裂 / TGF-β / 血管平滑筋細胞 / 細胞外マトリックス / 表皮幹細胞 / ニッチ / 幹細胞不均一性 / 三次元培養 / 生体イメージング Less
  • Research Projects

    (4 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (7 People)
  •  上皮幹細胞コンパートメントを規定する分子機構と生物学的意義の解明Ongoing

    • Principal Investigator
      佐田 亜衣子
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Kumamoto University
  •  Elucidation of the mechanism of aortic aneurysm development based on mechanotransduction and prediction of aortic aneurysm rupturePrincipal InvestigatorOngoing

    • Principal Investigator
      柳沢 裕美
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      University of Tsukuba
  •  Altered response to mechanical stress and aortic aneurysm developmentPrincipal InvestigatorOngoing

    • Principal Investigator
      柳沢 裕美
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      University of Tsukuba
  •  TGFb signaling pathways involved in rupture of aortic aneurysms

    • Principal Investigator
      YAMASHIRO Yoshito
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
      Cardiovascular medicine
    • Research Institution
      University of Tsukuba

All 2019 2018 2017 2015

All Journal Article Presentation

  • [Journal Article] Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling.2019

    • Author(s)
      J. Burger, N. van Vliet, P. van Heijningen, H. Kumra, G. J. Kremers, M. Alves, G. van Cappellen, H. Yanagisawa, D. P. Reinhardt, R. Kanaar, I. van der Pluijm, J. Essers
    • Journal Title

      Cell Signaling

      Volume: 58 Pages: 65-78

    • DOI

      10.1016/j.cellsig.2019.02.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Journal Article] Elastic fibers and biomechanics of the aorta: Insights from mouse studies.2019

    • Author(s)
      Yanagisawa H, Wagenseil J
    • Journal Title

      Matrix Biology

      Volume: 印刷中

    • DOI

      10.1016/j.matbio.2019.03.001

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Journal Article] Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.2018

    • Author(s)
      Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-O M and Yanagisawa H.
    • Journal Title

      Matrix Biology

      Volume: 74 Pages: 5-20

    • DOI

      10.1016/j.matbio.2018.04.014

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15057, KAKENHI-PROJECT-17H04289
  • [Journal Article] Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans2018

    • Author(s)
      Yamashiro Y, Thang BQ, Shin SJ, Lino CA, Nakamura T, Kim J, Sugiyama K, Tokunaga C, Sakamoto H, Osaka M, Davis EC, Wagenseil JE, Hiramatsu Y and Yanagisawa H.
    • Journal Title

      Circulation Research

      Volume: 123(6) Pages: 660-672

    • DOI

      10.1161/circresaha.118.313105

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15057, KAKENHI-PROJECT-16H05145, KAKENHI-PROJECT-17H04289, KAKENHI-PROJECT-17K19534
  • [Journal Article] Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.2018

    • Author(s)
      I. van der Pluijm, J. Burger, (24名中21), H. Yanagisawa, H. Dietz, R. Kanaar, and J. Essers
    • Journal Title

      Cardiovascular Research

      Volume: 114(13) Pages: 1776-1793

    • DOI

      10.1093/cvr/cvy150

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Journal Article] Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms2018

    • Author(s)
      Yamashiro Y, Yanagisawa H.
    • Journal Title

      J Atheroscler Thromb

      Volume: 25(2) Issue: 2 Pages: 99-110

    • DOI

      10.5551/jat.rv17015

      10.5551/jat.RV17015

    • NAID

      130006328449

    • ISSN
      1340-3478, 1880-3873
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Journal Article] Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.2017

    • Author(s)
      C. Bellini, M. R. Bersi, A. W. Caulk, J. Ferruzzi, D. M. Milewicz, F. Ramirez, D. B. Rifkin, G. Tellides, H. Yanagisawa, J. D. Humphrey
    • Journal Title

      J R Soc Interface

      Volume: 130

    • DOI

      10.1098/rsif.2016.1036

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Journal Article] Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta.2017

    • Author(s)
      Kim J, Staiculescu MC, Cocciolone AJ, Yanagisawa H, Mecham RP, Wagenseil JE.
    • Journal Title

      J Biomech

      Volume: 61 Pages: 199-207

    • DOI

      10.1016/j.jbiomech.2017.07.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Journal Article] Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1.2017

    • Author(s)
      Kim CW, Pokutta-Paskaleva A, Kumar S, Timmins LH, Morris AD, Kang DW, Dalal S, Chadid T, Kuo KM, Raykin J, Li H, Yanagisawa H, Gleason RL Jr, Jo H, Brewster LP.
    • Journal Title

      Circulation

      Volume: 136(13) Pages: 1217-1232

    • DOI

      10.1161/circulationaha.116.026361

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Journal Article] Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice2015

    • Author(s)
      Y. Yamashiro, C. L. Papke, J. Kim, L.-J. Ringuette, Q.-J. Zhang, Z.-P. Liu, H. Mirzaei, J. E. Wagenseil, E. C. Davis, and H. Yanagisawa
    • Journal Title

      Science Signaling

      Volume: 8(399)

    • DOI

      10.1126/scisignal.aab3141

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20898
  • [Journal Article] MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment2015

    • Author(s)
      C. L. Papke, Y. Yamashiro, and H. Yanagisawa
    • Journal Title

      Circulation Research

      Volume: 117 Pages: 109-112

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20898
  • [Journal Article] Loss of fibulin-4 disrupts collagen synthesis and maturation: Implications for pathology resulting from EFEMP2 mutations2015

    • Author(s)
      C. L. Papke, J. Tsunezumi, L.-J. Ringuette, H. Nagaoka, M. Terajima, Y. Yamashiro, G. Urquhart, M. Yamauchi, E. C. Davis, and H. Yanagisawa
    • Journal Title

      Human Molecular Genetics

      Volume: 15;24(20) Pages: 5867-79

    • DOI

      10.1093/hmg/ddv308

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20898
  • [Presentation] メカニカスストレス応答破綻による 大動脈瘤形成とトロンボスポンディンの役割2019

    • Author(s)
      柳沢裕美
    • Organizer
      日本心脈管作動物質学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] Roles of Mechanotransduction and Thrombospondin-1 in Development of Thoracic Aortic Aneurysm2019

    • Author(s)
      Hiromi Yanagisawa
    • Organizer
      Japanese Circulation Society
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] Fibulin-7は腎尿細管石灰化に関与するヘパリン結合性マトリセルラータンパク質である2018

    • Author(s)
      柳沢裕美
    • Organizer
      日本結合組織学会
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] Role of Short Fibulins in Maintenance of Vessel Walls2018

    • Author(s)
      Hiromi Yanagisawa
    • Organizer
      American Society for Matrix Biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] 腎・血管における短鎖 Fibulins の役割2018

    • Author(s)
      柳沢裕美
    • Organizer
      日本生化学会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] Recent Progress in Short Fibulin Family2017

    • Author(s)
      Hiromi Yanagisawa
    • Organizer
      日本結合組織学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] The role of thrombospoindin-1 in ascending aortic aneurysms in fibulin-4 mutant mice2017

    • Author(s)
      Hiromi Yanagisawa
    • Organizer
      North American Vascular Biology Organization
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] Comparison of Signaling Pathways involved in Aortic Aneurysms Using Fibulin-4 and Fibulin-5 Mutant Mice2017

    • Author(s)
      Hiromi Yanagisawa
    • Organizer
      第81回日本循環器病学会
    • Data Source
      KAKENHI-PROJECT-17H04289
  • [Presentation] メカニカルストレスによる心血管リモデリングと 細胞外マトリックス2017

    • Author(s)
      柳沢裕美
    • Organizer
      心筋生検研究会ジョイントセッション 第81回日本循環器学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04289
  • 1.  YAMASHIRO Yoshito (70751923)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  佐田 亜衣子 (80779059)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  泉 健次 (80242436)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  水野 秀信 (00567159)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  平松 祐司 (30302417)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  安藤 正浩 (50620803)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  中邨 智之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi