Yanagisawa Hiromi 柳沢裕美

Researcher Number	40746301
Other IDs	https://orcid.org/0000-0002-7576-9186
Affiliation (Current)	2020: 筑波大学, 生存ダイナミクス研究センター, 教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 筑波大学, 生存ダイナミクス研究センター, 教授 2016 – 2017: 筑波大学, 生命領域学際研究センター, 教授
Review Section/Research Field	Principal Investigator Cardiovascular surgery / Basic Section 55030:Cardiovascular surgery-related Except Principal Investigator Pathological medical chemistry / Cardiovascular medicine / Basic Section 44020:Developmental biology-related
Keywords	Principal Investigator 大動脈瘤 / 細胞外マトリクス / 血管平滑筋細胞 / 血管平滑筋細胞’ / メカニカルストレス / マトリセルラータンパク質 / フィブリン４ / シグナル伝達 / アクチン / メカノセンサー … More Except Principal Investigator 大動脈瘤 / TGFβ / メカニカルストレス / 大動脈瘤破裂 / TGF-β / 血管平滑筋細胞 / 細胞外マトリックス / 表皮幹細胞 / ニッチ / 幹細胞不均一性 / 三次元培養 / 生体イメージング Less

上皮幹細胞コンパートメントを規定する分子機構と生物学的意義の解明Ongoing
- Principal Investigator
  
  佐田亜衣子
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Kumamoto University
Elucidation of the mechanism of aortic aneurysm development based on mechanotransduction and prediction of aortic aneurysm rupturePrincipal InvestigatorOngoing
- Principal Investigator
  
  柳沢裕美
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  University of Tsukuba
Altered response to mechanical stress and aortic aneurysm developmentPrincipal InvestigatorOngoing
- Principal Investigator
  
  柳沢裕美
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  University of Tsukuba
TGFb signaling pathways involved in rupture of aortic aneurysms
- Principal Investigator
  
  YAMASHIRO Yoshito
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
  Cardiovascular medicine
- Research Institution
  University of Tsukuba

All 2019 2018 2017 2015

All Journal Article Presentation

[Journal Article] Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling.2019
- Author(s)
  J. Burger, N. van Vliet, P. van Heijningen, H. Kumra, G. J. Kremers, M. Alves, G. van Cappellen, H. Yanagisawa, D. P. Reinhardt, R. Kanaar, I. van der Pluijm, J. Essers
- Journal Title
  
  Cell Signaling
  
  Volume: 58 Pages: 65-78
- DOI
  10.1016/j.cellsig.2019.02.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Journal Article] Elastic fibers and biomechanics of the aorta: Insights from mouse studies.2019
- Author(s)
  Yanagisawa H, Wagenseil J
- Journal Title
  
  Matrix Biology
  
  Volume: 印刷中
- DOI
  10.1016/j.matbio.2019.03.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Journal Article] Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.2018
- Author(s)
  Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-O M and Yanagisawa H.
- Journal Title
  
  Matrix Biology
  
  Volume: 74 Pages: 5-20
- DOI
  10.1016/j.matbio.2018.04.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15057, KAKENHI-PROJECT-17H04289
[Journal Article] Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans2018
- Author(s)
  Yamashiro Y, Thang BQ, Shin SJ, Lino CA, Nakamura T, Kim J, Sugiyama K, Tokunaga C, Sakamoto H, Osaka M, Davis EC, Wagenseil JE, Hiramatsu Y and Yanagisawa H.
- Journal Title
  
  Circulation Research
  
  Volume: 123(6) Pages: 660-672
- DOI
  10.1161/circresaha.118.313105
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15057, KAKENHI-PROJECT-16H05145, KAKENHI-PROJECT-17H04289, KAKENHI-PROJECT-17K19534
[Journal Article] Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.2018
- Author(s)
  I. van der Pluijm, J. Burger, (24名中２１）, H. Yanagisawa, H. Dietz, R. Kanaar, and J. Essers
- Journal Title
  
  Cardiovascular Research
  
  Volume: 114(13) Pages: 1776-1793
- DOI
  10.1093/cvr/cvy150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Journal Article] Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms2018
- Author(s)
  Yamashiro Y, Yanagisawa H.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 25(2) Issue: 2 Pages: 99-110
- DOI
  10.5551/jat.rv17015
  10.5551/jat.RV17015
- NAID
  130006328449
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04289
[Journal Article] Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.2017
- Author(s)
  C. Bellini, M. R. Bersi, A. W. Caulk, J. Ferruzzi, D. M. Milewicz, F. Ramirez, D. B. Rifkin, G. Tellides, H. Yanagisawa, J. D. Humphrey
- Journal Title
  
  J R Soc Interface
  
  Volume: 130
- DOI
  10.1098/rsif.2016.1036
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Journal Article] Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta.2017
- Author(s)
  Kim J, Staiculescu MC, Cocciolone AJ, Yanagisawa H, Mecham RP, Wagenseil JE.
- Journal Title
  
  J Biomech
  
  Volume: 61 Pages: 199-207
- DOI
  10.1016/j.jbiomech.2017.07.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Journal Article] Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1.2017
- Author(s)
  Kim CW, Pokutta-Paskaleva A, Kumar S, Timmins LH, Morris AD, Kang DW, Dalal S, Chadid T, Kuo KM, Raykin J, Li H, Yanagisawa H, Gleason RL Jr, Jo H, Brewster LP.
- Journal Title
  
  Circulation
  
  Volume: 136(13) Pages: 1217-1232
- DOI
  10.1161/circulationaha.116.026361
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Journal Article] Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice2015
- Author(s)
  Y. Yamashiro, C. L. Papke, J. Kim, L.-J. Ringuette, Q.-J. Zhang, Z.-P. Liu, H. Mirzaei, J. E. Wagenseil, E. C. Davis, and H. Yanagisawa
- Journal Title
  
  Science Signaling
  
  Volume: 8(399)
- DOI
  10.1126/scisignal.aab3141
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20898
[Journal Article] MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment2015
- Author(s)
  C. L. Papke, Y. Yamashiro, and H. Yanagisawa
- Journal Title
  
  Circulation Research
  
  Volume: 117 Pages: 109-112
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20898
[Journal Article] Loss of fibulin-4 disrupts collagen synthesis and maturation: Implications for pathology resulting from EFEMP2 mutations2015
- Author(s)
  C. L. Papke, J. Tsunezumi, L.-J. Ringuette, H. Nagaoka, M. Terajima, Y. Yamashiro, G. Urquhart, M. Yamauchi, E. C. Davis, and H. Yanagisawa
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 15;24(20) Pages: 5867-79
- DOI
  10.1093/hmg/ddv308
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20898
[Presentation] メカニカスストレス応答破綻による大動脈瘤形成とトロンボスポンディンの役割2019
- Author(s)
  柳沢裕美
- Organizer
  日本心脈管作動物質学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] Roles of Mechanotransduction and Thrombospondin-1 in Development of Thoracic Aortic Aneurysm2019
- Author(s)
  Hiromi Yanagisawa
- Organizer
  Japanese Circulation Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] Fibulin-7は腎尿細管石灰化に関与するヘパリン結合性マトリセルラータンパク質である2018
- Author(s)
  柳沢裕美
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] Role of Short Fibulins in Maintenance of Vessel Walls2018
- Author(s)
  Hiromi Yanagisawa
- Organizer
  American Society for Matrix Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] 腎・血管における短鎖 Fibulins の役割2018
- Author(s)
  柳沢裕美
- Organizer
  日本生化学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] Recent Progress in Short Fibulin Family2017
- Author(s)
  Hiromi Yanagisawa
- Organizer
  日本結合組織学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] The role of thrombospoindin-1 in ascending aortic aneurysms in fibulin-4 mutant mice2017
- Author(s)
  Hiromi Yanagisawa
- Organizer
  North American Vascular Biology Organization
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] Comparison of Signaling Pathways involved in Aortic Aneurysms Using Fibulin-4 and Fibulin-5 Mutant Mice2017
- Author(s)
  Hiromi Yanagisawa
- Organizer
  第81回日本循環器病学会
- Data Source
  KAKENHI-PROJECT-17H04289
[Presentation] メカニカルストレスによる心血管リモデリングと細胞外マトリックス2017
- Author(s)
  柳沢裕美
- Organizer
  心筋生検研究会ジョイントセッション第81回日本循環器学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04289

1. YAMASHIRO Yoshito (70751923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 佐田亜衣子 (80779059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 泉健次 (80242436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 水野秀信 (00567159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 平松祐司 (30302417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 安藤正浩 (50620803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中邨智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yanagisawa Hiromi 柳沢 裕美

Research Projects

Research Products

Co-Researchers

上皮幹細胞コンパートメントを規定する分子機構と生物学的意義の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of aortic aneurysm development based on mechanotransduction and prediction of aortic aneurysm rupturePrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Altered response to mechanical stress and aortic aneurysm developmentPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TGFb signaling pathways involved in rupture of aortic aneurysms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elastic fibers and biomechanics of the aorta: Insights from mouse studies.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice2015

Author(s)

Journal Title

DOI

Yanagisawa Hiromi 柳沢裕美

[Presentation] メカニカスストレス応答破綻による大動脈瘤形成とトロンボスポンディンの役割2019

[Presentation] メカニカルストレスによる心血管リモデリングと細胞外マトリックス2017