Morimoto Daichi 森本大智

Researcher Number	40746616
Other IDs	https://orcid.org/0000-0002-7672-2136
Affiliation (Current)	2025: 京都大学, 工学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 京都大学, 工学研究科, 助教 2016 – 2023: 京都大学, 工学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Transformative Research Areas, Section (II) / Structural biochemistry Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43040:Biophysics-related / Medium-sized Section 13:Condensed matter physics and related fields
Keywords	Principal Investigator ユビキチン / 構造揺らぎ / 非定型鎖 / 線維 / NMR / 構造ゆらぎ / ストレス顆粒 / 物性 / 凝集 / タンパク質物性 … More / 遊離ユビキチン鎖 / 非定型ユビキチン鎖 / ユビキチン鎖 / 環状 / ATP / 生物物理 / 蛋白質 / アミロイド / 線維重水素交換 / 線維反応中間体 / 流体力学的応力 / レオロジーNMR / 反応中間体 / 重水素交換 / アミロイド線維 / ポリユビキチン … More Except Principal Investigator Rheo-NMR / 分子動力学計算 / 凝集 / 電気泳動 / タンパク質 / NMR / 電場 / アミロイド線維 / 剪断流 / αシヌクレイン / アミロイド線維化 / 液-液相分離 / 線維化 / タンパク質凝集 / 乱流 / off-center Couette cell / 速度イメージング Less

流れストレスセンサータンパク質の開発Principal Investigator
- Principal Investigator
  
  森本大智
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyoto University
Development of analytical platform for proteins in electric field and its application
- Principal Investigator
  
  菅瀬謙治
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
Elucidation of chain shape-dependent physical properties of polyubiquitin related with stress granule formationPrincipal Investigator
- Principal Investigator
  
  森本大智
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Kyoto University
Elucidation of the mechanism of amyloid fibrillation of alpha-synuclein starting from liquid-liquid phase separation
- Principal Investigator
  
  Sugase Kenji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Kyoto University
Elucidation of physical properties and intracellular functions of unanchored atypical ubiquitin chainsPrincipal Investigator
- Principal Investigator
  
  Morimoto Daichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Kyoto University
Velocity imaging of turbulence flow using Rheo-NMR
- Principal Investigator
  
  Sugase Kenji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 13:Condensed matter physics and related fields
- Research Institution
  Kyoto University
Analysis of structure and formation mechanism of polyubiquitin fibrilsPrincipal Investigator
- Principal Investigator
  
  Morimoto Daichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] ＮＭＲによる有機材料分析とその試料前処理、データ解釈2021
- Author(s)
  森本大智、菅瀬謙治
- Total Pages
  676
- Publisher
  技術情報協会
- ISBN
  9784861048609
- Data Source
  KAKENHI-PROJECT-18KK0075
[Journal Article] An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi‐domain protein2023
- Author(s)
  Sorada Tomoki、Walinda Erik、Shirakawa Masahiro、Sugase Kenji、Morimoto Daichi
- Journal Title
  
  Protein Science
  
  Volume: 32 Issue: 10
- DOI
  10.1002/pro.4768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06161, KAKENHI-PROJECT-22K06168, KAKENHI-PROJECT-23KJ1276
[Journal Article] タンパク質を多角的に捉えるNMR測定法2023
- Author(s)
  森本大智、菅瀬謙治
- Journal Title
  
  技術情報協会、タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例
  
  Volume: 2 Pages: 18-27
- Data Source
  KAKENHI-PROJECT-22K06168
[Journal Article] Conformational Fluctuations and Induced Orientation of a Protein, Its Solvation Shell, and Bulk Water in Weak Non-Unfolding External Electric Fields2023
- Author(s)
  Shuto Yusuke、Walinda Erik、Morimoto Daichi、Sugase Kenji
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 127 Issue: 34 Pages: 7417-7430
- DOI
  10.1021/acs.jpcb.3c01683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0098, KAKENHI-PROJECT-22K06161, KAKENHI-PROJECT-22K06168, KAKENHI-PLANNED-22H05088, KAKENHI-PROJECT-21H02442
[Journal Article] NMRによるアミロイド形成の原子レベル機構解明2023
- Author(s)
  森本大智
- Journal Title
  
  日本核磁気共鳴学会
  
  Volume: 13 Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06168
[Journal Article] Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity2023
- Author(s)
  Walinda Erik、Sugase Kenji、Ishii Naoki、Shirakawa Masahiro、Iwai Kazuhiro、Morimoto Daichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 9 Pages: 105165-105165
- DOI
  10.1016/j.jbc.2023.105165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06161, KAKENHI-PROJECT-22K06168, KAKENHI-PROJECT-22H04988
[Journal Article] Structural Insights into Methylated DNA Recognition by the Methyl-CpG Binding Domain of MBD6 from <i>Arabidopsis thaliana</i>2022
- Author(s)
  Mahana Yutaka、Ohki Izuru、Walinda Erik、Morimoto Daichi、Sugase Kenji、Shirakawa Masahiro
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 4 Pages: 3212-3221
- DOI
  10.1021/acsomega.1c04917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00453, KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-22K06161, KAKENHI-PROJECT-20K15756
[Journal Article] Counter-flow phenomena studied by nuclear magnetic resonance (NMR) velocimetry and flow simulations2022
- Author(s)
  Kohn Benjamin、Walinda Erik、Sugase Kenji、Morimoto Daichi、Scheler Ulrich
- Journal Title
  
  Physics of Fluids
  
  Volume: 34 Issue: 7 Pages: 073608-073608
- DOI
  10.1063/5.0097543
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06161, KAKENHI-PROJECT-20K15756, KAKENHI-PROJECT-22K06168, KAKENHI-PROJECT-20K15757
[Journal Article] Rheo‐NMR Spectroscopy for Cryogenic‐Probe‐Equipped NMR Instruments to Monitor Protein Aggregation2022
- Author(s)
  Morimoto Daichi、Walinda Erik、Yamamoto Akihiko、Scheler Ulrich、Sugase Kenji
- Journal Title
  
  Current Protocols
  
  Volume: 2 Issue: 12
- DOI
  10.1002/cpz1.617
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06161, KAKENHI-PLANNED-22H05088, KAKENHI-PROJECT-21H02442, KAKENHI-PROJECT-20K15756, KAKENHI-PROJECT-22K06168, KAKENHI-PROJECT-20K15757
[Journal Article] Structural Dynamic Heterogeneity of Polyubiquitin Subunits Affects Phosphorylation Susceptibility2021
- Author(s)
  Morimoto Daichi、Walinda Erik、Takashima Shingo、Nishizawa Mayu、Iwai Kazuhiro、Shirakawa Masahiro、Sugase Kenji
- Journal Title
  
  Biochemistry
  
  Volume: 60 Issue: 8 Pages: 573-583
- DOI
  10.1021/acs.biochem.0c00619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15757, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19J13259, KAKENHI-PROJECT-18K19297, KAKENHI-PROJECT-18K14665
[Journal Article] Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB12021
- Author(s)
  Sorada Tomoki、Morimoto Daichi、Walinda Erik、Sugase Kenji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 562 Pages: 94-99
- DOI
  10.1016/j.bbrc.2021.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0075
[Journal Article] Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 β-Barrel2021
- Author(s)
  Iwakawa Naoto、Morimoto Daichi、Walinda Erik、Leeb Sarah、Shirakawa Masahiro、Danielsson Jens、Sugase Kenji
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 125 Issue: 10 Pages: 2521-2532
- DOI
  10.1021/acs.jpcb.0c11162
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-18KK0075, KAKENHI-PROJECT-18J22192, KAKENHI-PROJECT-18K19297, KAKENHI-PROJECT-18K14665
[Journal Article] Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures2021
- Author(s)
  Walinda Erik、Morimoto Daichi、Sorada Tomoki、Iwai Kazuhiro、Sugase Kenji
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 187 Pages: 105953-105953
- DOI
  10.1016/j.pep.2021.105953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0075, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-20K15756
[Journal Article] Multiple-State Monitoring of SOD1 Amyloid Formation at Single-Residue Resolution by Rheo-NMR Spectroscopy2021
- Author(s)
  Iwakawa Naoto、Morimoto Daichi、Walinda Erik、Shirakawa Masahiro、Sugase Kenji
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 28 Pages: 10604-10613
- DOI
  10.1021/jacs.1c02974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0075, KAKENHI-PROJECT-20H00453, KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-20K15756
[Journal Article] Effects of Weak Nonspecific Interactions with ATP on Proteins2021
- Author(s)
  Nishizawa Mayu、Walinda Erik、Morimoto Daichi、Kohn Benjamin、Scheler Ulrich、Shirakawa Masahiro、Sugase Kenji
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 31 Pages: 11982-11993
- DOI
  10.1021/jacs.0c13118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0075, KAKENHI-PROJECT-20H00453, KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-20K15756
[Journal Article] Rigorous analysis of the interaction between proteins and low water-solubility drugs by qNMR-aided NMR titration experiments2021
- Author(s)
  Hirakawa Takuya、Walinda Erik、Morimoto Daichi、Sugase Kenji
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 23 Issue: 38 Pages: 21484-21488
- DOI
  10.1039/d1cp03175a
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21391, KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-20K15756
[Journal Article] Backbone resonance assignments of the A2 domain of mouse von Willebrand factor2021
- Author(s)
  Morimoto Daichi、Osugi Masanori、Mahana Yutaka、Walinda Erik、Shirakawa Masahiro、Sugase Kenji
- Journal Title
  
  Biomolecular NMR Assignments
  
  Volume: 15 Issue: 2 Pages: 427-431
- DOI
  10.1007/s12104-021-10041-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0075, KAKENHI-PROJECT-20H00453, KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-20K15756
[Journal Article] Pinpoint analysis of a protein in slow exchange using F1F2-selective ZZ-exchange spectroscopy: assignment and kinetic analysis2020
- Author(s)
  Mayu Nishizawa、Erik Walinda、Daichi Morimoto、Kenji Sugase
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18503
[Journal Article] Chain-length dependent physical properties and degradation of ubiquitin chains2020
- Author(s)
  森本大智、白川昌宏
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 1 Pages: 7-13
- DOI
  10.14952/SEIKAGAKU.2020.920007
- ISSN
  0037-1017
- Year and Date
  2020-02-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K19297, KAKENHI-PROJECT-16K18503
[Journal Article] Quantitative monitoring of ubiquitination/deubiquitination reaction cycles by 18O-incorporation2020
- Author(s)
  Tanaka Yuka、Morimoto Daichi、Walinda Erik、Sugase Kenji、Shirakawa Masahiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 2 Pages: 418-424
- DOI
  10.1016/j.bbrc.2020.06.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15757, KAKENHI-PROJECT-18K19297, KAKENHI-PROJECT-18K14665
[Journal Article] Visualizing protein motion in Couette flow by all-atom molecular dynamics2020
- Author(s)
  Walinda Erik、Morimoto Daichi、Shirakawa Masahiro、Scheler Ulrich、Sugase Kenji
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1864 Issue: 2 Pages: 129383-129383
- DOI
  10.1016/j.bbagen.2019.06.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19297, KAKENHI-PROJECT-18KK0075, KAKENHI-PUBLICLY-18H04551, KAKENHI-WRAPUP-19H05452, KAKENHI-PROJECT-17K19196, KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-18K14665
[Journal Article] 高感度Rheo-NMRによるアミロイド線維化過程のその場観察2019
- Author(s)
  森本大智、菅瀬謙治
- Journal Title
  
  月刊「細胞」
  
  Volume: 685 Pages: 32-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0075
[Journal Article] 生体分子レオロジーNMRの開発と応用2019
- Author(s)
  森本大智、菅瀬謙治
- Journal Title
  
  日本核磁気共鳴学会機関誌
  
  Volume: 10 Pages: 64-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0075
[Journal Article] 生体分子レオロジーNMRの開発と応用2019
- Author(s)
  森本大智、菅瀬謙治
- Journal Title
  
  日本核磁気共鳴学会機関誌
  
  Volume: 10 Pages: 64-68
- Data Source
  KAKENHI-PROJECT-16K18503
[Journal Article] 高感度Rheo-NMRによるアミロイド線維化過程のその場観察2019
- Author(s)
  森本大智、菅瀬謙治
- Journal Title
  
  月刊「細胞」
  
  Volume: 51 Pages: 32-36
- Data Source
  KAKENHI-PROJECT-16K18503
[Journal Article] NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin2018
- Author(s)
  Ishii Naoki、Walinda Erik、Iwakawa Naoto、Morimoto Daichi、Iwai Kazuhiro、Sugase Kenji、Shirakawa Masahiro
- Journal Title
  
  Biomolecular NMR Assignments
  
  Volume: 13 Issue: 1 Pages: 149-153
- DOI
  10.1007/s12104-018-09868-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-18K14665
[Journal Article] Backbone and side-chain resonance assignments of the methyl-CpG-binding domain of MBD6 from Arabidopsis thaliana2018
- Author(s)
  Iwakawa Naoto、Mahana Yutaka、Ono Arina、Ohki Izuru、Walinda Erik、Morimoto Daichi、Sugase Kenji、Shirakawa Masahiro
- Journal Title
  
  Biomolecular NMR Assignments
  
  Volume: 13 Issue: 1 Pages: 59-62
- DOI
  10.1007/s12104-018-9851-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06083, KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-18K14665, KAKENHI-PLANNED-26119004
[Journal Article] Hydrogen-Deuterium Exchange Profiles of Polyubiquitin Fibrils2018
- Author(s)
  Morimoto Daichi、Nishizawa Ryo、Walinda Erik、Takashima Shingo、Sugase Kenji、Shirakawa Masahiro
- Journal Title
  
  Polymers
  
  Volume: 10 Issue: 3 Pages: 240-240
- DOI
  10.3390/polym10030240
- NAID
  120006501309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18503
[Journal Article] Isolation and characterization of a minimal building block of polyubiquitin fibrils2018
- Author(s)
  Morimoto Daichi、Walinda Erik、Shinke Mayo、Sugase Kenji、Shirakawa Masahiro
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2711-2711
- DOI
  10.1038/s41598-018-21144-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18503, KAKENHI-PLANNED-26119004
[Journal Article] Overview of Relaxation Dispersion NMR Spectroscopy to Study Protein Dynamics and Protein-Ligand Interactions2018
- Author(s)
  Walinda Erik、Morimoto Daichi、Sugase Kenji
- Journal Title
  
  Current Protocols in Protein Science
  
  Volume: 92 Issue: 1
- DOI
  10.1002/cpps.57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-15H04342, KAKENHI-PUBLICLY-18H04551
[Journal Article] Resolving biomolecular motion and interactions by R2 and R1ρ relaxation dispersion NMR2018
- Author(s)
  Walinda Erik、Morimoto Daichi、Sugase Kenji
- Journal Title
  
  Methods
  
  Volume: 148 Pages: 28-38
- DOI
  10.1016/j.ymeth.2018.04.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-18K14665, KAKENHI-PUBLICLY-18H04551, KAKENHI-PROJECT-15H04342
[Journal Article] Practical considerations for investigation of protein conformational dynamics by 15N R 1ρ relaxation dispersion.2017
- Author(s)
  Walinda E, Morimoto D, Shirakawa M, Sugase K.
- Journal Title
  
  Biomol NMR.
  
  Volume: 印刷中 Issue: 3 Pages: 201-209
- DOI
  10.1007/s10858-017-0097-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-15H04342, KAKENHI-PROJECT-16K18503
[Journal Article] High-sensitivity Rheo-NMR spectroscopy for protein studies.2017
- Author(s)
  Morimoto D., Walinda E., Iwakawa N., Nishizawa M., Kawata Y., Yamamoto A., Shirakawa M., Scheler U., Sugase K.
- Journal Title
  
  Anal. Chem.
  
  Volume: 89 Issue: 14 Pages: 7286-7290
- DOI
  10.1021/acs.analchem.7b01816
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19196, KAKENHI-PROJECT-16K18503
[Journal Article] Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches2017
- Author(s)
  Morimoto Daichi、Walinda Erik、Sugase Kenji、Shirakawa Masahiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 6 Pages: 1145-1145
- DOI
  10.3390/ijms18061145
- NAID
  120006318888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18503, KAKENHI-PLANNED-26119004
[Journal Article] Real-time observation of the interaction between thioflavin T and an amyloid protein by using high-sensitivity Rheo-NMR.2017
- Author(s)
  Iwakawa N., Morimoto D., Walinda E., Kawata Y., Shirakawa M., Sugase K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 18 Issue: 11 Pages: 2271-2271
- DOI
  10.3390/ijms18112271
- NAID
  120006501319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19196, KAKENHI-PROJECT-16K18503, KAKENHI-PLANNED-26119004
[Journal Article] F1F2-selective NMR spectroscopy2017
- Author(s)
  Walinda Erik、Morimoto Daichi、Shirakawa Masahiro、Sugase Kenji
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 68 Issue: 1 Pages: 41-52
- DOI
  10.1007/s10858-017-0113-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18503, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-15H04342
[Journal Article] Structure of the Dnmt1 reader module complexed with a unique two-mono-ubiquitin mark on histone H3 reveals the basis for DNA methylation maintenance.2017
- Author(s)
  Ishiyama S, Nishiyama A, Saeki Y, Moritsugu K Morimoto D, Yamaguchi L, Arai N, Matsumura R, Kawakami T, Mishima Y, Hojo H, Shimamura S, Ishikawa F, Tajima S, Tanaka K, Ariyoshi M, Shirakawa M, Ikeguchi M, Kidera A, Suetake I, Arita K, Nakanishi M
- Journal Title
  
  Mol Cell
  
  Volume: 68 Issue: 2 Pages: 350-360
- DOI
  10.1016/j.molcel.2017.09.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14418, KAKENHI-PROJECT-16K14714, KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-16H04780, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-15K05565, KAKENHI-PROJECT-15K18520, KAKENHI-PROJECT-26000014
[Journal Article] Efficient identification and analysis of chemical exchange in biomolecules by R1rho relaxation dispersion with Amaterasu2016
- Author(s)
  Walinda, E. Morimoto, D. Nishizawa, M. Shirakawa, M. Sugase, K.
- Journal Title
  
  Bioinformatics
  
  Volume: 32 Issue: 16 Pages: 2539-2541
- DOI
  10.1093/bioinformatics/btw188
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04342, KAKENHI-PROJECT-16K18503
[Journal Article] Ubiquitylation Directly Induces Fold Destabilization of Proteins.2016
- Author(s)
  Morimoto D , Walinda E, Fukada H, Sugase K, Shirakawa M
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 39453-39453
- DOI
  10.1038/srep39453
- NAID
  120005947214
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-16K18503
[Journal Article] Dual Function of Phosphoubiquitin in E3 Activation of Parkin2016
- Author(s)
  Walinda, E. Morimoto, D. Sugase, K. Shirakawa, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 32 Pages: 16879-16891
- DOI
  10.1074/jbc.m116.728600
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04342, KAKENHI-PROJECT-16K18503
[Journal Article] The evolving world of ubiquitin: transformed polyubiquitin chains.2016
- Author(s)
  Morimoto, D. and Shirakawa, M.
- Journal Title
  
  Biomolecular Concepts
  
  Volume: 7 Issue: 3 Pages: 157-67
- DOI
  10.1515/bmc-2016-0009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18503
[Patent] 剪断流を発生させる器具2023
- Inventor(s)
  菅瀬謙治、森本大智、山本昭彦、保科好秀
- Industrial Property Rights Holder
  国立大学法人京都大学、エアープロ株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-170462
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-18KK0075
[Presentation] 電場中におけるタンパク質の動的構造解析基盤の構築と凝集化機構解明への応用2024
- Author(s)
  首藤佑輔、Walinda Erik、森本大智、菅瀬謙治
- Organizer
  凝集系の理論化学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0098
[Presentation] 生体内の流れによるタンパク質の構造破壊2023
- Author(s)
  森本大智
- Organizer
  第1回CCC講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06168
[Presentation] NMR緩和実験と粗視化MD計算の統合的アプローチによる環状マルチドメインタンパク質の構造ダイナミクスの理解2023
- Author(s)
  森本大智、空田知樹、Erik Walinda、白川昌宏、菅瀬謙治
- Organizer
  第62回NMR討論会
- Data Source
  KAKENHI-PROJECT-22K06168
[Presentation] 生体内環境がタンパク質凝集に与える影響2023
- Author(s)
  森本大智
- Organizer
  第8回生体分子凝縮体勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06168
[Presentation] Atomic-level elucidation of amyloid formation mechanism by NMR spectroscopy2022
- Author(s)
  森本大智
- Organizer
  第61回NMR討論会
- Invited
- Data Source
  KAKENHI-PROJECT-20K15757
[Presentation] Multiple-state monitoring of amyloid formation at atomic resolution by Rheology NMR spectroscopy2022
- Author(s)
  森本大智
- Organizer
  第22回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K15757
[Presentation] 溶液NMR法を用いたタンパク質のその場観察2022
- Author(s)
  森本大智
- Organizer
  第22回若手NMR研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06168
[Presentation] Atomic-level elucidation of amyloid formation mechanism by NMR spectroscopy2022
- Author(s)
  森本大智
- Organizer
  第61回NMR討論会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06168
[Presentation] レオロジーNMR法によるSOD1アミロイド形成の多状態その場観察2022
- Author(s)
  森本大智
- Organizer
  第60回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06168
[Presentation] 溶液NMR法を用いたタンパク質のその場観察2022
- Author(s)
  森本大智
- Organizer
  第22回若手NMR研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K15757
[Presentation] レオロジーNMR法によるSOD1アミロイド形成の多状態その場観察2022
- Author(s)
  森本大智
- Organizer
  第60回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K15757
[Presentation] Multiple-state monitoring of amyloid formation at atomic resolution by Rheology NMR spectroscopy2022
- Author(s)
  森本大智
- Organizer
  第22回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06168
[Presentation] バイオレオロジーNMR法の開発と応用2019
- Author(s)
  Morimoto Daichi
- Organizer
  The 20th Young NMR Scientist Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Amyloid formation of poly-ubiquitin chains investigated by biological rheo-NMR spectroscopy2019
- Author(s)
  Morimoto Daichi、Walinda Erik、Iwakawa Naoto、Yamamoto Akihiko、Shirakawa Masahiro、Scheler Ulrich、Sugase Kenji
- Organizer
  EUROISMAR 2019
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Fibrillar protein aggregate formation of poly-ubiquitin revealed by physical property analysis2019
- Author(s)
  Morimoto Daichi、Walinda Erik、Sugase Kenji、Shirakawa Masahiro
- Organizer
  The 92nd annual meeting of the japanese biochemical society
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Amyloid formation of poly-ubiquitin chains investigated by biological rheo-NMR spectroscopy2019
- Author(s)
  Daichi Morimoto
- Organizer
  EUROMAR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0075
[Presentation] Amyloid fibril formation of poly-ubiquitin revealed by physical property analysis2019
- Author(s)
  Morimoto Daichi、Walinda Erik、Sugase Kenji、Shirakawa Masahiro
- Organizer
  Joint Annual Meeting of 71st JSCB and 19th PSSJ
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Elucidation of amyloid fibril formation mechanism by using novel Rheo-NMR spectroscopy2018
- Author(s)
  Morimoto Daichi、Walinda Erik、Iwakawa Naoto、Scheler Ulrich、Yamamoto, Akihiko、Sugase Kenji、Shirakawa Masahiro
- Organizer
  EUROMAR 2018
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Atomic-level structural characterization of amyloid formation by using Rheo-NMR spectroscopy2018
- Author(s)
  Morimoto Daichi、Walinda Erik、Iwakawa Naoto、Sugase Kenji、Shirakawa Masahiro
- Organizer
  The 18th Annual Meeting of the Protein Science Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Development of high-sensitivity Rheo-NMR spectroscopy2018
- Author(s)
  Morimoto Daichi、Walinda Erik、Scheler Ulrich、Yamamoto, Akihiko、Sugase Kenji、Shirakawa Masahiro
- Organizer
  The 19th Young NMR Scientist Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Elucidation of amyloid fibril formation mechanism by using Rheo-NMR spectroscopy2017
- Author(s)
  Daichi Morimoto, Erik Walinda, Naoto Iwakawa, Ulrich Scheler, Akihiko Yamamoto, Masahiro Shirakawa, and Kenji Sugase
- Organizer
  The 56th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan.
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Detection of Metastable States of Polyubiquitin Fibrils.2016
- Author(s)
  Morimoto, D., Walinda, E., Shinke, M., Sugase, K., and Shirakawa, M.
- Organizer
  The XXVIIth International Conference on Magnetic Resonance in Biological Systems.
- Place of Presentation
  Kyoto
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Functional regulation of protein by SUMOylation and ubiquitylation.2016
- Author(s)
  Morimoto, D.
- Organizer
  The 371st CBI meeting.
- Place of Presentation
  Osaka
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Highly Sensitive Rheo-NMR Spectroscopy For Proteins.2016
- Author(s)
  Morimoto, D., Walinda, E., Nishizawa, M., Scheler, U., Yamamoto, A., Shirakawa, M., and Sugase, K.
- Organizer
  The 55th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan.
- Place of Presentation
  Hiroshima
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Ubiquitylation-induced protein aggregation.2016
- Author(s)
  Morimoto, D., Walinda, E., Fukada, H, Sugase, K., Hoshino, M., Fujii, T., Namba, K., Komatsu, M., Tanaka, K., and Shirakawa, M.
- Organizer
  The 54th Annual Meeting of the Biophysical Society of Japan.
- Place of Presentation
  Tsukuba
- Year and Date
  2016-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503
[Presentation] Elucidation of formation mechanism of ubiquitin-positive aggregates in cells.2016
- Author(s)
  Morimoto, D., Walinda, E., Fukada, H, Sugase, K., Kageyama, S., Hoshino, M., H., Namba, K., Komatsu, M., Tanaka, K., and Shirakawa, M.
- Organizer
  The 89th Annual Meeting of the Japanese Biochemical Society.
- Place of Presentation
  Sendai
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K18503

1. Sugase Kenji (00300822)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. Walinda Erik (80782391)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. 白川昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 大木出

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 末武勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 川上徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morimoto Daichi 森本 大智

Research Projects

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Co-Researchers

流れストレスセンサータンパク質の開発Principal Investigator

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Development of analytical platform for proteins in electric field and its application

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Elucidation of chain shape-dependent physical properties of polyubiquitin related with stress granule formationPrincipal Investigator

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Elucidation of the mechanism of amyloid fibrillation of alpha-synuclein starting from liquid-liquid phase separation

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Elucidation of physical properties and intracellular functions of unanchored atypical ubiquitin chainsPrincipal Investigator

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Velocity imaging of turbulence flow using Rheo-NMR

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Analysis of structure and formation mechanism of polyubiquitin fibrilsPrincipal Investigator

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[Book] ＮＭＲによる有機材料分析と その試料前処理、データ解釈2021

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[Journal Article] An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi‐domain protein2023

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[Journal Article] タンパク質を多角的に捉えるNMR測定法2023

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[Journal Article] Conformational Fluctuations and Induced Orientation of a Protein, Its Solvation Shell, and Bulk Water in Weak Non-Unfolding External Electric Fields2023

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[Journal Article] NMRによるアミロイド形成の原子レベル機構解明2023

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[Journal Article] Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity2023

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[Journal Article] Structural Insights into Methylated DNA Recognition by the Methyl-CpG Binding Domain of MBD6 from <i>Arabidopsis thaliana</i>2022

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Morimoto Daichi 森本大智

[Book] ＮＭＲによる有機材料分析とその試料前処理、データ解釈2021