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bizen norihisa  備前 典久

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Bizen Norihisa  備前 典久

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Researcher Number 40751053
Other IDs
Affiliation (Current) 2025: 新潟大学, 医歯学系, 助教
Affiliation (based on the past Project Information) *help 2023: 新潟大学, 医歯学系, 医学部准教授
2015 – 2022: 新潟大学, 医歯学系, 助教
Review Section/Research Field
Principal Investigator
Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / Neurochemistry/Neuropharmacology
Except Principal Investigator
General anatomy (including histology/embryology)
Keywords
Principal Investigator
オリゴデンドロサイト / ミエリン / p53 / グリア-ニューロン相互作用 / RNA / 脱髄疾患 / ノックアウトマウス / Olig2 / 恒常性 / 相互作用 … More / ニューロン / Ddx20 / グリア・ニューロン相互作用 / グリア-ニューロン間相互作用 / 神経変性 / グリア / 分化 / 軸索変性 / 脱髄 / スプライシング / RNA代謝 / 転写 / 分化促進 / 細胞死 / 細胞増殖 / DNA損傷 / 神経幹細胞 / 転写因子 … More
Except Principal Investigator
dystonin (Dst) / 神経科学 / dystonin / モデルマウス / ジストニア / 増殖 / オリゴデンドロサイト前駆細胞 / 運動ニューロン / マクロファージ / 咬筋 / 運動神経 / 三叉神経運動核 / ジストニン Less
  • Research Projects

    (5 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (15 People)
  •  オリゴデンドロサイトRNA代謝調節因子による神経細胞恒常性維持機構の解明Principal Investigator

    • Principal Investigator
      備前 典久
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48010:Anatomy-related
    • Research Institution
      Niigata University
  •  Elucidation of the molecular basis underlying p53-mediated neurodegeneration induced by oligodendrocyte dysfunctionPrincipal Investigator

    • Principal Investigator
      Bizen Norihisa
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48010:Anatomy-related
    • Research Institution
      Niigata University
  •  Elucidation of the molecular mechanisms underlying the coupling between transcription and RNA metabolism during myelinationPrincipal Investigator

    • Principal Investigator
      Bizen Norihisa
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Niigata University
  •  Elucidation of molecular mechanisms underlying a novel Olig2 binding factor-mediated oligodendrocyte differentiationPrincipal Investigator

    • Principal Investigator
      Bizen Norihisa
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Niigata University
  •  Analysis on neuronal circuits responsible for involuntary movements

    • Principal Investigator
      Takebayashi Hirohide
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Niigata University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Brain‐specific glycosylation of protein tyrosine phosphatase receptor type Z ( <scp>PTPRZ</scp> ) marks a demyelination‐associated astrocyte subtype2023

    • Author(s)
      Takahashi Kazuto、Kanekiyo Kenji、Sakuda Kanoko、Muto Yui、Iguchi Masahiro、Matsuda Nozomu、Hashimoto Yuko、Kanai Kazuaki、Ogawa Haruko、Hirase Hajime、Kakita Akiyoshi、Bizen Norihisa、Takebayashi Hirohide、Kawaguchi Yasushi、Uzuki Miwa、Kitazume Shinobu
    • Journal Title

      Journal of Neurochemistry

      Volume: - Issue: 3 Pages: 547-559

    • DOI

      10.1111/jnc.15820

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07241, KAKENHI-PROJECT-22K16448, KAKENHI-PROJECT-23K06300
  • [Journal Article] Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.2023

    • Author(s)
      Tran DM, Yoshioka N, Bizen N, Mori-Ochiai Y, Yano M, Yanai S, Hasegawa J, Miyashita S, Hoshino M, Sasaki J, Sasaki T, Takebayashi H
    • Journal Title

      Dis Model Mech

      Volume: 16 Issue: 7 Pages: 192-206

    • DOI

      10.1242/dmm.050169

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15912, KAKENHI-PROJECT-23K14295, KAKENHI-PROJECT-23K06300, KAKENHI-PROJECT-23K06317, KAKENHI-PROJECT-22K19287, KAKENHI-PROJECT-19H03543, KAKENHI-PROJECT-21H02652, KAKENHI-PUBLICLY-22H05589, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-23K23993, KAKENHI-PROJECT-23K27319
  • [Journal Article] Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression2022

    • Author(s)
      Norihisa Bizen, Asim K Bepari, Li Zhou, Manabu Abe, Kenji Sakimura, Katsuhiko Ono, Hirohide Takebayashi
    • Journal Title

      Cell Death Differentiation

      Volume: Jan 1 Issue: 5 Pages: 1-14

    • DOI

      10.1038/s41418-021-00915-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07242, KAKENHI-PROJECT-20K07241, KAKENHI-PROJECT-21H02652
  • [Journal Article] RNA代謝調節因子Ddx20による神経前駆細胞およびオリゴデンドロサイト前駆細胞維持機構2022

    • Author(s)
      備前典久、竹林浩秀
    • Journal Title

      神経化学トピックス

      Volume: -

    • DOI

      10.11481/topics163

    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Journal Article] Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression2021

    • Author(s)
      Simankova Anna、Bizen Norihisa、Saitoh Sei、Shibata Shinsuke、Ohno Nobuhiko、Abe Manabu、Sakimura Kenji、Takebayashi Hirohide
    • Journal Title

      Glia

      Volume: 69 Issue: 11 Pages: 2559-2574

    • DOI

      10.1002/glia.24058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02592, KAKENHI-PROJECT-20K07241, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-21H02652
  • [Journal Article] Diverse mutations in dystonin gene cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in dystonia musculorum mice.2020

    • Author(s)
      Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran MD, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, Takebayashi H
    • Journal Title

      Disease Models and Mechanisms

      Volume: 13 Issue: 5 Pages: 041608-041608

    • DOI

      10.1242/dmm.041608

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04939, KAKENHI-PROJECT-17K15542, KAKENHI-PROJECT-20K07241, KAKENHI-PROJECT-18H02592
  • [Journal Article] Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons2019

    • Author(s)
      Wang YZ, Fan H, Ji Y, Reynolds K, Gu R, Gan Q, Yamagami T, Zhao T, Hamad S, Bizen N, Takebayashi H, Chen Y, Wu S, Pleasure D, Lam K, Zhou CJ
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: - Issue: 18 Pages: 3597-3609

    • DOI

      10.1007/s00018-019-03385-x

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04939, KAKENHI-PROJECT-17K15542, KAKENHI-PROJECT-18H02592
  • [Journal Article] Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.2019

    • Author(s)
      Terumitsu-Tsujita M, Kitaura H, Miura I, Kiyama Y, Goto F, Muraki Y, Ominato S, Hara N, Simankova A, Bizen N, Kashiwagi K, Ito T, Toyoshima Y, Kakita A, Manabe T, Wakana S, Takebayashi H, Igarashi H
    • Journal Title

      Journal of Neurochemistry

      Volume: jnc.14887 Issue: 1 Pages: 1-16

    • DOI

      10.1111/jnc.14887

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07799, KAKENHI-PUBLICLY-18H04939, KAKENHI-PUBLICLY-19H04876, KAKENHI-PROJECT-19H03321, KAKENHI-PROJECT-17K15542, KAKENHI-PROJECT-18H02592
  • [Journal Article] A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche.2016

    • Author(s)
      Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, Taga T.
    • Journal Title

      Stem Cells

      Volume: 34 Issue: 5 Pages: 1151-1162

    • DOI

      10.1002/stem.2299

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14346, KAKENHI-PROJECT-15K18373, KAKENHI-PROJECT-15K20970, KAKENHI-PROJECT-15H04292, KAKENHI-PROJECT-25460471, KAKENHI-PROJECT-26440118
  • [Journal Article] Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.2016

    • Author(s)
      Muona M, Ishimura R, Laari A,...... , Komatsu M.
    • Journal Title

      Am J Hum Genet.

      Volume: 99 Issue: 3 Pages: 683-94

    • DOI

      10.1016/j.ajhg.2016.06.020

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-16J07037, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-15K18373, KAKENHI-PROJECT-26000014
  • [Journal Article] Endoplasmic reticulum-localized transmembrane protein Dpy19L1 is required for neurite outgrowth.2016

    • Author(s)
      Watanabe K, Bizen N, Sato N, Takebayashi H
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 12 Pages: e0167985-e0167985

    • DOI

      10.1371/journal.pone.0167985

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06736, KAKENHI-PROJECT-15K18373
  • [Presentation] RNA代謝調節因子Ddx20によるオリゴデンドロサイト最終分化および恒常性維持機構の解明2024

    • Author(s)
      備前典久, Anna Simankova, 竹林浩秀
    • Organizer
      第129回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-23K06300
  • [Presentation] Elucidation of the mechanisms underlying Ddx20-mediated regulation of oligodendrocyte development and homeostasis2023

    • Author(s)
      Norihisa Bizen
    • Organizer
      第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K06300
  • [Presentation] Development of synthetic polymer scaffolds mimicking a niche that maintains neural stem cells in a growth factor- and serum-free system2023

    • Author(s)
      Norihisa Bizen, Kouichi Tabu, Mei Wu, Christian Mangani, Rong Zhang, Mark Bradley, Tetsuya Taga
    • Organizer
      第21回幹細胞シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K06300
  • [Presentation] オリゴデンドロサイト異常によるp53誘導性神経変性機構の解明2023

    • Author(s)
      備前典久, Anna Simankova, 竹林浩秀
    • Organizer
      第128回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] 5-methylcytosine hydroxylase Tet3 endows embryonic neural stem/precursor cells with astrogliogenic competence2022

    • Author(s)
      Norihisa Bizen, Toshinobu Nakamura, Toru Nakano, Tetsuya Taga
    • Organizer
      The 19th Stem Cell Research Symposium
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] RNA helicase Ddx20 in oligodendrocytes contributes to neuronal survival in the central nervous system2022

    • Author(s)
      Norihisa Bizen, Anna Simankova, Hirohide Takebayashi
    • Organizer
      Neuro2022
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] 発達期の中枢神経系におけるオリゴデンドロサイト-ニューロン間相互作用の解析2022

    • Author(s)
      備前典久, Anna Simankova, 竹林浩秀
    • Organizer
      第127回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] RNAヘリカーゼDdx20によるオリゴデンドロサイトの発生・分化制御およびオリゴデンドロサイト-ニューロン間相互作用機構の解明2022

    • Author(s)
      備前典久, Anna Simankova, 竹林浩秀
    • Organizer
      第45回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] RNAヘリカーゼDdx20によるオリゴデンドロサイトの発生および分化・成熟機構の解明2022

    • Author(s)
      備前典久, Anna Simankova, 竹林浩秀
    • Organizer
      第6回日本ミエリン研究会発表会
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] 中枢神経系における新規Olig2結合因子による神経前駆細胞およびオリゴデンドロサイト前駆細胞維持機構の解明2021

    • Author(s)
      備前典久, Asim K Bepari, 矢野真人, 周麗, 阿部学, 崎村建司, 小野勝彦, 竹林浩秀
    • Organizer
      第126回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] 神経前駆細胞およびオリゴデンドロサイト前駆細胞の維持に関わる分子機構の解明2021

    • Author(s)
      備前典久, Anna Simankova, Asim K Bepari, 周麗, 阿部学, 崎村建司, 小野勝彦,竹林浩秀
    • Organizer
      日本解剖学会第109回関東支部学術集会
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] 新規Olig2結合因子による神経前駆細胞およびオリゴデンドロサイト維持機構の解明2021

    • Author(s)
      備前典久, 竹林浩秀
    • Organizer
      第14回神経発生討論会
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] A novel Olig2-binding factor is indispensable for survival of neural and oligodendrocyte progenitor cells in the central nervous system2021

    • Author(s)
      Norihisa Bizen, Asim K. Bepari, Masato Yano, Li Zhou, Manabu Abe, Kenji Sakimura, Katsuhiko Ono, Hirohide Takebayashi
    • Organizer
      第44回日本神経科学大会/第1回CJK国際会議
    • Data Source
      KAKENHI-PROJECT-20K07241
  • [Presentation] 新規Olig2結合因子による神経前駆細胞およびオリゴデンドロサイト前駆細胞維持機構の解明2020

    • Author(s)
      備前典久, 矢野真人, 周麗, 阿部学, 崎村建司, 竹林浩秀
    • Organizer
      第125回日本解剖学会総会全国学術集会
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] Mice lacking a novel Olig2-binding factor displays the attenuation of oligodendrocyte differentiation and myelination in the central nervous system2020

    • Author(s)
      Norihisa Bizen, Anna Simankova, Nobuhiko Ohno, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
    • Organizer
      ABiS international symposium
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] Identification of a novel Olig2-binding factor indispensable for the maintenance of oligodendrocyte precursor cells in the central nervous system2019

    • Author(s)
      Norihisa Bizen, Masato Yano, Anna Simankova, Li Zhou, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
    • Organizer
      Neuro 2019
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] Analysis of the Effect of a Novel Olig2-Binding Factor on the Oligodendrocyte Differentiation and Myelination in Central Nervous System2019

    • Author(s)
      Norihisa Bizen, Anna Simankova, Nobuhiko Ohno, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
    • Organizer
      The 66th NIBB Conference -ABiS International Symposium-
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] 新規Olig2結合因子によるオリゴデンドロサイト前駆細胞維持機構の解明2019

    • Author(s)
      備前典久、矢野真人、周麗、阿部学、崎村建司、竹林浩秀
    • Organizer
      第124回日本解剖学会総会全国学術集会
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] Elucidation of the mechanisms underlying a novel Olig2 binding factor-mediated maintenance of oligodendrocyte precursor cells2019

    • Author(s)
      Norihisa Bizen, Masato Yano, Zhou Li, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
    • Organizer
      IBRO 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] 新規Olig2結合因子によるオリゴデンドロサイト発生機構の解析2018

    • Author(s)
      備前典久、矢野真人、周麗、崎村建司、竹林浩秀
    • Organizer
      第23回グリアクラブ
    • Data Source
      KAKENHI-PROJECT-15K18373
  • [Presentation] 新規Olig2結合因子によるオリゴデンドロサイト発生機構の解明2018

    • Author(s)
      備前典久、矢野真人、周麗、崎村建司、竹林浩秀
    • Organizer
      第123回日本解剖学会総会全国学術集会
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] 新規Olig2結合因子によるオリゴデンドロサイト発生機構の解明2018

    • Author(s)
      備前典久、矢野真人、周麗、崎村建司、竹林浩秀
    • Organizer
      第123回日本解剖学会総会全国学術集会
    • Data Source
      KAKENHI-PROJECT-15K18373
  • [Presentation] 新規Olig2結合因子によるオリゴデンドロサイト発生機構の解析2018

    • Author(s)
      備前典久、矢野真人、周麗、崎村建司、竹林浩秀
    • Organizer
      第23回グリアクラブ
    • Data Source
      KAKENHI-PROJECT-17K15542
  • [Presentation] Identification of a novel Olig2-binding factor indispensable for oligodendrogenesis in central nervous system2017

    • Author(s)
      Norihisa Bizen, Masato Yano, Li Zhou, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
    • Organizer
      2017年度次世代脳プロジェクト 冬のシンポジウム
    • Data Source
      KAKENHI-PROJECT-15K18373
  • [Presentation] 新規Olig2結合因子によるオリゴデンドロサイト分化機構の解析2017

    • Author(s)
      備前 典久、松岡 崇史、Hossain MD Ibrahim、周 麗、崎村 建司、竹林 浩秀
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学 医学部 (長崎県長崎市)
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15K18373
  • [Presentation] Identification of a novel Olig2-binding factor indispensable for oligodendrogenesis in central nervous system2017

    • Author(s)
      Norihisa Bizen, Masato Yano, Zhou Li, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K15542
  • 1.  Takebayashi Hirohide (60353439)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 2.  NAMBU ATSUSHI (80180553)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  CHIKEN SATOMI (30396262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SANO HIROMI (00363755)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  HORIE MASAO (70322716)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  HOSSAIN MD IBRAHIM
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MORI YUKIKO
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  BRADLEY Mark
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  WATANABE Keisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  KIYAMA Yuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  吉岡 望
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  田賀 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  小松 雅明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  周 麗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  崎村 建司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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