mochizuki makiko 望月牧子

… Alternative Names

Mochizuki Makiko 望月牧子

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Researcher Number	40751300
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京女子医科大学, 医学部, 助教 2017: 千葉大学, 大学院医学研究院, 特任研究員 2016: 千葉大学, 大学院医学研究院, 特別研究員(RPD)
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 造血幹細胞 / ファンコニ貧血 / 骨髄不全症 / FA / HSC / マイトファジー / 鎌状赤血球症 / ミトコンドリア代謝 / Fancd2 / BMF … More / RS / 骨髄不全症候群 / TPOシグナル / エネルギー代謝 / DNAダメージ修復 / 分化 / ヒストン修飾 / MMSET / Nsd2 / H3K36me2/3 / Nsd1 / Whsc1 / Mmset … More Except Principal Investigator とトンボポエチン / ライソソーム / 血小板分化 / ミトコンドリア / オルガネラ / 血小板 / 巨核球 / 造血幹細胞 Less

ファンコニ貧血における胎児造血幹細胞増殖不全の外的環境要因の特定Principal Investigator
- Principal Investigator
  
  望月牧子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University
BMF造血幹細胞における細胞小器官における変化の意義の解明Principal Investigator
- Principal Investigator
  
  望月牧子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University
Analysis of organelle functions for the homeostasis of hematopoietic stem cells and platelet production
- Principal Investigator
  
  石津綾子
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University
造血幹細胞におけるRSと細胞内小器官との関連検討によるBMF発症メカニズムの解明Principal Investigator
- Principal Investigator
  
  望月牧子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University
Role of H3K36 methyltransferase Mmset in Hematopoietic stem cellsPrincipal Investigator
- Principal Investigator
  
  Mochizuki Makiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University

All 2024 2023 2022 2021 2017 2016

All Journal Article Presentation

[Journal Article] Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model2024
- Author(s)
  orrell C, Peters AM, Zhang Q, Balaji N, Baradar K, Mochizuki-Kashio M, Major A, Finegold M, Liu C, Lu K, Grompe M
- Journal Title
  
  Pediatric Blood & Cancer
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08425
[Journal Article] Abcb10 regulates murine hematopoietic stem cell potential and erythroid differentiation2024
- Author(s)
  Yahagi Ayano、Mochizuki-Kashio Makiko、Sorimachi Yuriko、Takubo Keiyo、Nakamura-Ishizu Ayako
- Journal Title
  
  Experimental Hematology
  
  Volume: - Pages: 104191-104191
- DOI
  10.1016/j.exphem.2024.104191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0266, KAKENHI-PROJECT-21K08425, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957
[Journal Article] Deregulated protein homeostasis constrains fetal hematopoietic stem cell pool expansion in Fanconi anemia2024
- Author(s)
  Kovuru Narasaiah、Mochizuki-Kashio Makiko、Menna Theresa、Jeffrey Greer、Hong Yuning、me Yoon Young、Zhang Zhe、Kurre Peter
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1
- DOI
  10.1038/s41467-024-46159-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0266, KAKENHI-PROJECT-21K08425
[Journal Article] Editorial: Advances in predisposition to bone marrow failure and hematopoietic neoplasms2024
- Author(s)
  Sahoo Sushree S.、Abdelhamed Sherif、Mochizuki-Kashio Makiko、Wahlster Lara
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 14
- DOI
  10.3389/fonc.2024.1377974
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0266, KAKENHI-PROJECT-21K08425
[Journal Article] Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model.2024
- Author(s)
  Dorrell C, Peters AM, Zhang Q, Balaji N, Baradar K, Mochizuki-Kashio M, Major A, Finegold M, Liu C, Lu K, Grompe M
- Journal Title
  
  Pediatric Blood & Cancer
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0266
[Journal Article] Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells.2023
- Author(s)
  Makiko Mochizuki-Kashio, Noriko Otsuki, Kota Fujiki, Sherif Abdelhamd, Peter Kurre, Markus Grompe, Atsushi Iwama, Kayoko Saito, Ayako Nakamura-Ishizu
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 13 Pages: 1108430-1108430
- DOI
  10.3389/fonc.2023.1108430
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07052, KAKENHI-PROJECT-21K08425, KAKENHI-PROJECT-22K06586, KAKENHI-PROJECT-23K24366
[Journal Article] Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism2021
- Author(s)
  Mochizuki-Kashio Makiko、Shiozaki Hiroko、Suda Toshio、Nakamura-Ishizu Ayako
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 9 Pages: 4627-4627
- DOI
  10.3390/ijms22094627
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08425
[Journal Article] Ezh2 regulates the Lin28/let-7 pathway to re- strict activation of fetal gene signature in adult hematopoietic stem cells.2016
- Author(s)
  Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt GR, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A.
- Journal Title
  
  Exp Hematol.
  
  Volume: 44(4) Pages: 282-296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19566
[Journal Article] The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.2016
- Author(s)
  Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, and Iwama A.
- Journal Title
  
  J Exp Med
  
  Volume: 25;213(8) Pages: 1459-1477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19566
[Presentation] TPO agonist rescued developmental hematopoietic stem cell in hereditary bone marrow failure syndrome2024
- Author(s)
  Makiko Mochizuki-Kashio, Ayano Yahagi, Tomomasa Yokomizo, Ayako Nakamura-Ishizu
- Organizer
  3rd Regional Symposium on Myelodysplastic Syndromes (MDSR 2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] TPO agonist rescued developmental hematopoietic stem cell in hereditary bone marrow failure syndrome2024
- Author(s)
  Makiko Mochizuki-Kashio, Ayano Yahagi, Tomomasa Yokomizo, Ayako Nakamura-Ishizu
- Organizer
  3rd Regional Symposium on Myelodysplastic Syndromes (MDSR 2024)(国際学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0266
[Presentation] Life stage-dependent regulation of distinct hematopoietic stem and progenitor populations via Thrombopoietin signaling2024
- Author(s)
  Makiko Mochizuki-Kashio, Ayano Yahagi, Tomomasa Yokomizo, Ayako Nakamura-Ishizu
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] Life stage-dependent regulation of distinct hematopoietic stem and progenitor populations via Thrombopoietin signaling2023
- Author(s)
  Makiko Mochizuki-Kashio, Ayano Yahagi, Tomomasa Yokomizo, Ayako Nakamura-Ishizu
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-22KK0266
[Presentation] Ptprd regulates hematopoietic stem cells through their microelement domains2022
- Author(s)
  望月牧子
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-23K24366
[Presentation] Fanconi anemia-related replication stress activates metabolism in fetal liver hematopoietic stem cells2022
- Author(s)
  望月牧子
- Organizer
  19th Stem Cell Research Symposium
- Data Source
  KAKENHI-PROJECT-23K24366
[Presentation] Ptprd regulates hematopoietic stem cells through their miniexon domains2022
- Author(s)
  Makiko Mochizuki-Kashio, Kohtaro Takizawa, Fumio Nakamura, Ayako Nakamura-Ishizu
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] Fanconi Anemia-related replication stress increases metabolic activity in fetal liver hematopoietic stem cells2022
- Author(s)
  Makiko Mochizuki-Kashio, Ayako Nakamura-Ishizu
- Organizer
  9thSCRS
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] Fanconi Anemia-related replication stress increases cytosolic activity2022
- Author(s)
  Makiko Mochizuki-Kashio
- Organizer
  64th ASH
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] Fanconi Anemia protein FANCD2 confers with Replication Stress through the Hematopoietic Stem Cell expansion in Fetal Liver2021
- Author(s)
  Makiko Mochizuki-Kashio, Young me Yoon, Theresa Menna, Ayako Nakamura-Ishizu, Markus Grompe and Peter Kurre
- Organizer
  第18回　幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] Replication stress accelerates myeloid-bias through the activation of mitochondrial OXPHOS in hematopoietic stem cells2021
- Author(s)
  Makiko Mochizuki-Kashio, Ayako Nakamura-Ishizu
- Organizer
  50th ISEH
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] Replication stress accelerates myeloid-bias through the activation of mitochondrial OXPHOS in hematopoietic stem cells2021
- Author(s)
  Makiko Mochizuki-Kashio, Ayako Nakamura-Ishizu
- Organizer
  第83回　日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08425
[Presentation] メチル化転移酵素Nsd2の機能の解明2017
- Author(s)
  望月（樫尾）牧子、横田貴文、藤木亮次、杉尾ジュリー、鈴木慈、前田亮、岩間厚志、浦聖恵
- Organizer
  染色体ワークショップ
- Place of Presentation
  かずさアカデミアホール202B会議場（千葉県・木更津市）
- Year and Date
  2017-01-11
- Data Source
  KAKENHI-PROJECT-16K19566
[Presentation] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Eh1-dependent manner2016
- Author(s)
  Makiko Mochizuki-Kashio, Kazumasa Aoyama, Goro Sashida, Motohiko Oshima, Changshan Wang, Atushi Iwama
- Organizer
  幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県・淡路市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16K19566
[Presentation] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Eh1-dependent manner2016
- Author(s)
  Makiko Mochizuki-Kashio, Kazumasa Aoyama, Goro Sashida, Motohiko Oshima, Changshan Wang, Atushi Iwama
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club Resort（千葉県・浦安市）
- Year and Date
  2016-07-13
- Data Source
  KAKENHI-PROJECT-16K19566
[Presentation] Ezh2の機能欠損による造血器腫瘍の形成には造血幹・前駆細胞におけるEzh1の発現が必須である2016
- Author(s)
  樫尾（望月）　牧子、青山　和正、指田　吾郎、大島　基彦、王　長山、岩間　厚志
- Organizer
  麒麟塾
- Place of Presentation
  コクヨホール（東京都・品川区）
- Data Source
  KAKENHI-PROJECT-16K19566
[Presentation] ヒストンH3K36転移酵素Whsc1の造血幹細胞における機能の解明2016
- Author(s)
  望月（樫尾）牧子、岩間厚志、浦聖恵
- Organizer
  転写サイクル班会議2016
- Place of Presentation
  松島一の坊（宮城県・松島町）
- Year and Date
  2016-09-05
- Data Source
  KAKENHI-PROJECT-16K19566

1. 石津綾子 (10548548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 菊田幸子 (10367089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 矢作綾野 (10584873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IWAMA Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. URA Kiyoe

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. FUJIKI Kota

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 須田年生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

mochizuki makiko 望月 牧子

Mochizuki Makiko 望月 牧子

Research Projects

Research Products

Co-Researchers

ファンコニ貧血における胎児造血幹細胞増殖不全の外的環境要因の特定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

BMF造血幹細胞における細胞小器官における変化の意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of organelle functions for the homeostasis of hematopoietic stem cells and platelet production

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

造血幹細胞におけるRSと細胞内小器官との関連検討によるBMF発症メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of H3K36 methyltransferase Mmset in Hematopoietic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model2024

Author(s)

Journal Title

Data Source

[Journal Article] Abcb10 regulates murine hematopoietic stem cell potential and erythroid differentiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deregulated protein homeostasis constrains fetal hematopoietic stem cell pool expansion in Fanconi anemia2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Editorial: Advances in predisposition to bone marrow failure and hematopoietic neoplasms2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model.2024

Author(s)

Journal Title

Data Source

[Journal Article] Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ezh2 regulates the Lin28/let-7 pathway to re- strict activation of fetal gene signature in adult hematopoietic stem cells.2016

Author(s)

Journal Title

Data Source

[Journal Article] The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.2016

Author(s)

Journal Title

Data Source

[Presentation] TPO agonist rescued developmental hematopoietic stem cell in hereditary bone marrow failure syndrome2024

Author(s)

Organizer

Data Source

mochizuki makiko 望月牧子

Mochizuki Makiko 望月牧子