Okushin Kazuya 奥新和也

… Alternative Names

OKUSHIN KAZUYA 奥新和也

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Researcher Number	40753918
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2025: 東京大学, 医学部附属病院, 助教 2022 – 2023: 東京大学, 医学部附属病院, 助教 2020 – 2021: 東京大学, 医学部附属病院, 特任講師(病院) 2017 – 2019: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator BSEP / MRP2 / ノックアウトマウス / 非アルコール性脂肪肝炎 / 胆汁酸 / bile salt export pump / 胆汁酸代謝 / 非アルコール性脂肪性肝疾患 / MASH / MASLD … More / トランスポーター / 胆汁酸組成 / 非アルコール性脂肪性肝炎 / 網羅的遺伝子発現解析 / 腸内細菌叢 / Gut-Liver axis / 胆汁酸トランスポーター / 臨床 / 内科 / 発現制御 / LDLR / コレステロール代謝 / siRNA / 脂質代謝 Less

Investigation of the pathogenesis of MASLD and MASH with a focus on bile acid export transportersPrincipal Investigator
- Principal Investigator
  
  奥新和也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Elucidation of a novel mechanism of NASH focusing on bile acid transportersPrincipal Investigator
- Principal Investigator
  
  奥新和也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Investigation of a novel mechanism of NASH pathogenesis focused on bile acid transportersPrincipal Investigator
- Principal Investigator
  
  Okushin Kazuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Investigation of a novel mechanism of NASH pathogenesis focused on bile acid metabolism, and exploration of a new therapeutic strategyPrincipal Investigator
- Principal Investigator
  
  OKUSHIN KAZUYA
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2017

All Journal Article Presentation

[Journal Article] Differential peripheral memory T cell subsets sensitively indicate the severity of nonalcoholic fatty liver disease2024
- Author(s)
  Kado Akira、Tsutsumi Takeya、Yotsuyanagi Hiroshi、Ikeuchi Kazuhiko、Okushin Kazuya、Moriya Kyoji、Koike Kazuhiko、Fujishiro Mitsuhiro
- Journal Title
  
  Hepatology Research
  
  Volume: - Issue: 6 Pages: 525-539
- DOI
  10.1111/hepr.14009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004
[Journal Article] The impact of COVID-19 on the diagnosis and treatment of HCC: analysis of a nationwide registry for advanced liver diseases (REAL)2024
- Author(s)
  Okushin Kazuya、Tateishi Ryosuke、Hirakawa Shinya、Tachimori Hisateru、Uchino Koji、Nakagomi Ryo、Yamada Tomoharu、Nakatsuka Takuma、Minami Tatsuya、Sato Masaya、Fujishiro Mitsuhiro、Hasegawa Kiyoshi、Eguchi Yuichiro、Kanto Tatsuya、Yoshiji Hitoshi、Izumi Namiki、Kudo Masatoshi、Koike Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 2826-2826
- DOI
  10.1038/s41598-024-53199-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004, KAKENHI-PROJECT-23K06397
[Journal Article] Injection drug use and sexually transmitted infections among men who have sex with men: A retrospective cohort study at an HIV/AIDS referral hospital in Tokyo, 2013-20222023
- Author(s)
  Ikeuchi Kazuhiko、Saito Makoto、Adachi Eisuke、Koga Michiko、Okushin Kazuya、Tsutsumi Takeya、Yotsuyanagi Hiroshi
- Journal Title
  
  Epidemiology and Infection
  
  Volume: 151
- DOI
  10.1017/s0950268823001772
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004
[Journal Article] Treatment and outcome of hepatorenal syndrome in Japan: a retrospective cohort study using a national inpatient database2023
- Author(s)
  Okushin Kazuya、Yamana Hayato、Tateishi Ryosuke、Sato Masaya、Tsutsumi Takeya、Matsui Hiroki、Fushimi Kiyohide、Yasunaga Hideo、Koike Kazuhiko、Fujishiro Mitsuhiro
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 23 Issue: 1 Pages: 218-218
- DOI
  10.1186/s12876-023-02858-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004
[Journal Article] Ursodeoxycholic acid for coronavirus disease 2019 prevention2023
- Author(s)
  Okushin Kazuya、Kurano Makoto、Yatomi Yutaka、Moriya Kyoji、Fujishiro Mitsuhiro、Tsutsumi Takeya、UTH‐UDCA Study Group
- Journal Title
  
  Journal of Internal Medicine
  
  Volume: 295 Issue: 1 Pages: 106-109
- DOI
  10.1111/joim.13704
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004
[Journal Article] Noninvasive approach to indicate risk factors of nonalcoholic steatohepatitis overlapping autoimmune hepatitis based on peripheral lymphocyte pattern2023
- Author(s)
  Kado Akira、Tsutsumi Takeya、Yotsuyanagi Hiroshi、Ikeuchi Kazuhiko、Okushin Kazuya、Moriya Kyoji、Koike Kazuhiko、Fujishiro Mitsuhiro
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 58 Issue: 12 Pages: 1237-1251
- DOI
  10.1007/s00535-023-02038-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004
[Journal Article] Triglyceride level and soft drink consumption predict nonalcoholic fatty liver disease in nonobese male adolescents2023
- Author(s)
  Kado Akira、Inoue Yukiko、Moriya Kyoji、Tsutsumi Takeya、Ikeuchi Kazuhiko、Okushin Kazuya、Yotsuyanagi Hiroshi、Koike Kazuhiko、Fujishiro Mitsuhiro
- Journal Title
  
  Hepatology Research
  
  Volume: - Issue: 6 Pages: 497-510
- DOI
  10.1111/hepr.13889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17014, KAKENHI-PROJECT-22K08004
[Journal Article] Current status of primary liver cancer and decompensated cirrhosis in Japan: launch of a nationwide registry for advanced liver diseases (REAL)2022
- Author(s)
  Okushin Kazuya、Tateishi Ryosuke、Takahashi Arata、Uchino Koji、Nakagomi Ryo、Nakatsuka Takuma、Minami Tatsuya、Sato Masaya、Fujishiro Mitsuhiro、Hasegawa Kiyoshi、Eguchi Yuichiro、Kanto Tatsuya、Kubo Shoji、Yoshiji Hitoshi、Miyata Hiroaki、Izumi Namiki、Kudo Masatoshi、Koike Kazuhiko
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 57 Issue: 8 Pages: 587-597
- DOI
  10.1007/s00535-022-01893-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08004, KAKENHI-PROJECT-20K17014
[Journal Article] HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA.2022
- Author(s)
  Sekiba K, Otsuka M, Funato K, Miyakawa Y, Tanaka E, Seimiya T, Yamagami M, Tsutsumi T, Okushin K, Miyakawa K, Ryo A, Koike K.
- Journal Title
  
  J Hepatol.
  
  Volume: 76 Issue: 1 Pages: 53-62
- DOI
  10.1016/j.jhep.2021.08.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430, KAKENHI-PROJECT-20K17014
[Journal Article] Prevalence of HIV infection among non-elderly individuals with hepatitis C in Japan: a population-based cohort study using a health insurance claim data2022
- Author(s)
  Ikeuchi Kazuhiko、Okushin Kazuya、Saito Makoto、Adachi Eisuke、Tsutsumi Takeya、Takura Tomoyuki、Yotsuyanagi Hiroshi
- Journal Title
  
  BMC Infectious Diseases
  
  Volume: 22 Issue: 1 Pages: 167-167
- DOI
  10.1186/s12879-022-07152-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17014
[Journal Article] Fibrosis-4 index efficiently predicts chronic hepatitis and liver cirrhosis development based on a large-scale data of general population in Japan2022
- Author(s)
  Yamamichi Nobutake、Shimamoto Takeshi、Okushin Kazuya、Nishikawa Takako、Matsuzaki Hirotaka、Yakabi Seiichi、Takahashi Mami、Wada Ryoichi、Koike Kazuhiko、Fujishiro Mitsuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-24910-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004, KAKENHI-PROJECT-20K17014
[Journal Article] Gender-specific factors contributing to visceral obesity including the sleep-obesity relationship: a large-scale cross-sectional study from East Asia2022
- Author(s)
  Saito Katsuki、Shimamoto Takeshi、Takahashi Yu、Okushin Kazuya、Takahashi Mami、Masuda Yukari、Nishikawa Takako、Kakushima Naomi、Wada Ryoichi、Yamamichi Nobutake
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 20318-20318
- DOI
  10.1038/s41598-022-24863-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08004, KAKENHI-PROJECT-20K17014, KAKENHI-PROJECT-20K19203
[Journal Article] Change in hepatitis C virus positivity among needle-stick injury source patients: a 10-year experience in a Japanese tertiary hospital2021
- Author(s)
  Okushin Kazuya、Suzuki Rie、Tsutsumi Takeya、Okamoto Koh、Ikeuchi Kazuhiko、Kado Akira、Minatsuki Chihiro、Minami-Kobayashi Yuka、Satoh Nobuhiko、Ikeda Mahoko、Harada Sohei、Enooku Kenichiro、Fujinaga Hidetaka、Yotsuyanagi Hiroshi、Koike Kazuhiko、Moriya Kyoji
- Journal Title
  
  BMC Infectious Diseases
  
  Volume: 21 Issue: 1 Pages: 399-399
- DOI
  10.1186/s12879-021-06117-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17014
[Journal Article] Change in hepatitis C virus positivity among needle-stick injury source patients: A 10-year experience in a Japanese tertiary hospital.2021
- Author(s)
  Kazuya Okushin, Rie Suzuki, Takeya Tsutsumi, Koh Okamoto, Kazuhiko Ikeuchi, Akira Kado, Chihiro Minatsuki, Yuka Minami-Kobayashi, Nobuhiko Satoh, Mahoko Ikeda, Sohei Harada, Kenichiro Enooku, Hidetaka Fujinaga, Hiroshi Yotsuyanagi, Kazuhiko Koike, and Kyoji Moriya
- Journal Title
  
  BMC Infectious Diseases
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-20K17014
[Journal Article] Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients2020
- Author(s)
  Enooku K, Tsutsumi T, Kondo M, Fujiwara N, Sasako T, Shibahara J, Kado A, Okushin K, Fujinaga H, Nakagomi R, Minami T, Sato M, Uchino K, Nakagawa H, Kondo Y, Asaoka Y, Tateishi R, Ueki K, Ikeda H, Yoshida H, Moriya K, Yotsuyanagi H, Kadowaki T, Koike K
- Journal Title
  
  J Gastroenterol
  
  Volume: 55 Issue: 2 Pages: 227
- DOI
  10.1007/s00535-019-01633-2
- URL
  https://pure.teikyo.jp/en/publications/e52a22bc-2c45-40d7-8f11-787d7daeef17
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05789, KAKENHI-PROJECT-19H01052, KAKENHI-PROJECT-17K15929, KAKENHI-PROJECT-26000012
[Journal Article] Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet2020
- Author(s)
  Okushin Kazuya、Tsutsumi Takeya、Ikeuchi Kazuhiko、Kado Akira、Enooku Kenichiro、Fujinaga Hidetaka、Yamauchi Naoko、Ushiku Tetsuo、Moriya Kyoji、Yotsuyanagi Hiroshi、Koike Kazuhiko
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 8 Pages: e0234750-e0234750
- DOI
  10.1371/journal.pone.0234750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17014
[Journal Article] Noninvasive diagnostic criteria for nonalcoholic steatohepatitis based on gene expression levels in peripheral blood mononuclear cells.2019
- Author(s)
  Akira Kado,Takeya Tsutsumi,Kenichiro Enooku,Hidetaka Fujinaga,Kazuhiko Ikeuchi,Kazuya Okushin,Kyoji Moriya,Hiroshi Yotsuyanagi,Kazuhiko Koike
- Journal Title
  
  Journal of gastroenterology
  
  Volume: 54 Issue: 8 Pages: 730-741
- DOI
  10.1007/s00535-019-01565-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15929
[Presentation] FIB-4 indexは一般集団における将来的な慢性肝炎および肝硬変の発症を効率的に予測することが可能である2023
- Author(s)
  奥新和也, 山道信毅, 西川尚子, 池内和彦, 門輝, 堤武也, 小池和彦, 藤城光弘
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08004
[Presentation] Fibrosis-4 index efficiently predicts chronic hepatitis and liver cirrhosis development based on a large-scale data of general population in Japan2023
- Author(s)
  Okushin K, Yamamichi N, Nishikawa T, Ikeuchi K, Kado A, Tsutsumi T, Koike K, Fujishiro M
- Organizer
  The 3rd JSH International Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08004
[Presentation] 胆汁酸トランスポーターBSEPヘテロノックアウトマウスの腸内細菌叢は高脂肪食による肝脂肪化に抑制的作用を有する可能性がある2022
- Author(s)
  奥新和也, 堤武也, 池内和彦, 門輝, 藤永秀剛, 森屋恭爾, 四柳宏, 小池和彦, 藤城光弘
- Organizer
  第8回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-22K08004
[Presentation] 胆汁酸トランスポーターBSEPヘテロノックアウトマウスの腸内細菌叢は高脂肪食による肝脂肪化に抑制的作用を有する可能性がある2022
- Author(s)
  奥新和也, 堤武也, 池内和彦, 門輝, 藤永秀剛, 森屋恭爾, 四柳宏, 小池和彦, 藤城光弘
- Organizer
  第8回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-20K17014
[Presentation] Diagnostic approach of flow cytometry to identify nonalcoholic steatohepatitis with overlapping autoimmune hepatitis in differential patterns of peripheral lymphocytes2021
- Author(s)
  Kado A, Tsutsumi T, Ikeuchi K, Okushin K, Enooku K, Fujinaga H, Moriya K, Yotsuyanagi H, Koike K.
- Organizer
  American Association for the Study of Liver Diseases The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17014
[Presentation] 末梢血リンパ球比率を用いた自己免疫性肝炎合併を含む非アルコール性脂肪肝炎の診断アプローチ2021
- Author(s)
  門輝, 奥新和也, 榎奥健一郎, 藤永秀剛, 堤武也, 森屋恭爾, 四柳宏, 小池和彦
- Organizer
  第25回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-20K17014
[Presentation] CURRENT STATUS OF PRIMARY LIVER CANCER AND DECOMPENSATED CIRRHOSIS IN JAPAN: LAUNCH OF A NATIONWIDE REGISTRY2021
- Author(s)
  Kazuya Okushin, Ryosuke Tateishi, Arata Takahashi, Koji Uchino, Ryo Nakagomi, Kiyoshi Hasegawa, Yuichiro Eguchi, Tatsuya Kanto, Shoji Kubo, Hitoshi Yoshiji, Hiroaki Miyata, Namiki Izumi, Masatoshi Kudo, Kazuhiko Koike, et al.
- Organizer
  American Association for the Study of Liver Diseases The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17014
[Presentation] Current treatment selection for primary liver cancer in Japan -Real-world data from a nationwide registry based on multiple hospitalizations-2021
- Author(s)
  Kazuya Okushin, Ryosuke Tateishi, Arata Takahashi, Koji Uchino, Ryo Nakagomi, Kiyoshi Hasegawa, Yuichiro Eguchi, Tatsuya Kanto, Shoji Kubo, Hitoshi Yoshiji, Hiroaki Miyata, Namiki Izumi, Masatoshi Kudo, and Kazuhiko Koike
- Organizer
  JSH International Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17014
[Presentation] 胆汁酸トランスポーターBSEPのヘテロノックアウトは高脂肪食摂取マウスの肝脂肪化に対して抑制的作用を有する2020
- Author(s)
  奥新和也、堤武也、小池和彦
- Organizer
  第106回消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K15929
[Presentation] 胆汁酸トランスポーターBSEPのヘテロノックアウトは高脂肪食摂取マウスの肝脂肪化に対して抑制的作用を有する2020
- Author(s)
  奥新和也、堤武也、小池和彦
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K17014
[Presentation] disruption of the homeostasis in lipid metabolism by knock-down of bile salt export pump may be involved in NASH pathogenesis in mouse model2017
- Author(s)
  Kazuya Okushin, Takeya Tsutsumi, Kenichiro Enooku, Hidetaka Fujinaga, Akira Kado, Kyoji Moriya, Hiroshi Yotsuyanagi, and Kazuhiko Koike
- Organizer
  American Association for the Study of Liver Diseases (AASLD) 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15929

1. 大塚基之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okushin Kazuya 奥新 和也

OKUSHIN KAZUYA 奥新 和也

Research Projects

Research Products

Co-Researchers

Investigation of the pathogenesis of MASLD and MASH with a focus on bile acid export transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel mechanism of NASH focusing on bile acid transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of a novel mechanism of NASH pathogenesis focused on bile acid transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of a novel mechanism of NASH pathogenesis focused on bile acid metabolism, and exploration of a new therapeutic strategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Differential peripheral memory T cell subsets sensitively indicate the severity of nonalcoholic fatty liver disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of COVID-19 on the diagnosis and treatment of HCC: analysis of a nationwide registry for advanced liver diseases (REAL)2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Injection drug use and sexually transmitted infections among men who have sex with men: A retrospective cohort study at an HIV/AIDS referral hospital in Tokyo, 2013-20222023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment and outcome of hepatorenal syndrome in Japan: a retrospective cohort study using a national inpatient database2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ursodeoxycholic acid for coronavirus disease 2019 prevention2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noninvasive approach to indicate risk factors of nonalcoholic steatohepatitis overlapping autoimmune hepatitis based on peripheral lymphocyte pattern2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Triglyceride level and soft drink consumption predict nonalcoholic fatty liver disease in nonobese male adolescents2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current status of primary liver cancer and decompensated cirrhosis in Japan: launch of a nationwide registry for advanced liver diseases (REAL)2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevalence of HIV infection among non-elderly individuals with hepatitis C in Japan: a population-based cohort study using a health insurance claim data2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibrosis-4 index efficiently predicts chronic hepatitis and liver cirrhosis development based on a large-scale data of general population in Japan2022

Okushin Kazuya 奥新和也

OKUSHIN KAZUYA 奥新和也