Higuchi Yumiko 樋口由美子

Researcher Number	40757241
Other IDs
Affiliation (Current)	2025: 信州大学, 医学部, 講師(特定雇用)
Affiliation (based on the past Project Information) *help	2021 – 2023: 信州大学, 医学部, 講師(特定雇用) 2020 – 2022: 信州大学, 学術研究院保健学系, 講師(特定雇用)
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 炎症 / シトルリン化フィブリノゲン / 好中球 / PAD4 / がん / 感染症 / PAD / NETs / 好中球細胞外トラップ Except Principal Investigator NETs … More / 形質転換能 / 遊走能 / 皮膚線維芽細胞 / 血管内皮細胞 / フィブリン / THP-1 / M1-マクロファージ / NETｓ形成能 / 好中球 / NETs形成能 / 内皮間葉転換能 / 細胞遊走能 / アミロイドβ1-42 / M1-Mφ分化 / 管状構造形成能 / 異常フィブリノゲン / フィブリノゲン Less

シトルリン化フィブリノゲンの好中球エフェクター機能に及ぼす影響Principal Investigator
- Principal Investigator
  
  樋口由美子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Evaluation for extra-cellular function of dysfunctional fibrinogen and identification of its important residues
- Principal Investigator
  
  Okumura Nobuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Detection of neutrophil extracellular traps by measuring citrullinated fibrinogen in serumPrincipal Investigator
- Principal Investigator
  
  Higuchi Yumiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients.2021
- Author(s)
  Fujimura S, Higuchi Y, Usami Y, Yamaura M, Higuchi T, Terasawa F, Okumura N.
- Journal Title
  
  Clin Chim Acta .
  
  Volume: 512 Pages: 127-134
- DOI
  10.1016/j.cca.2020.10.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07822, KAKENHI-PROJECT-20K07799
[Journal Article] Novel variant fibrinogen γ p.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment2021
- Author(s)
  Yoda M, Kaido T, Kamijo T, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Int J Hematology
  
  Volume: 114 Issue: 3 Pages: 325-333
- DOI
  10.1007/s12185-021-03174-y
- NAID
  120007180888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K15945
[Journal Article] 28年間で解析した長野県内のフィブリノゲン異常症18家系28例2021
- Author(s)
  上條途夢，海藤貴大, 依田将宏, 平千明,　樋口由美子，新井慎平,　竹澤由夏，奥村伸生．
- Journal Title
  
  長臨技会誌
  
  Volume: 10 Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] Congenital fibrinogen disorder with a compound heterozygote possessing two novel FGB mutations, one qualitative and the other quantitative2020
- Author(s)
  Yoda M, Kaido T, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 196 Pages: 152-158
- DOI
  10.1016/j.thromres.2020.08.031
- NAID
  120007180892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] A novel amino acid substitution, fibrinogen Bβp.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion2020
- Author(s)
  Kaido T, Yoda M, Kamijo T, Arai S, Taira C, Higuchi Y, Okumura N.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 9422-9422
- DOI
  10.3390/ijms21249422
- NAID
  120007180887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] Validation of a sandwich enzyme-linked immunosorbent assay to determine serum citrullinated fibrinogen concentration2022
- Author(s)
  Tomoki Ichikawa, Tsubasa Sue, Satoshi Fujimura, Yoko Usami, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine (ASCPaLM)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] 好中球細胞外トラップ検出のためのMyeloperoxidase-DNA複合体測定法の基礎的検討2022
- Author(s)
  市川　友喜、須江　翼、藤村　哲士、宇佐美　陽子、樋口　由美子
- Organizer
  第40回日本臨床化学甲信越支部総会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] Citrullinated fibrinogen for detection of neutrophil extracellular traps2022
- Author(s)
  Tsubasa Sue, Tomoki Ichikawa, Satoshi Fujimura, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] がん細胞株におけるフィブリノゲンのシトルリン化とPAD発現2022
- Author(s)
  服部周生, 須江翼, 市川友喜, 大谷ひかる, 藤村哲士, 樋口由美子
- Organizer
  第 46 回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] 新型コロナウイルス感染症における血中シトルリン化フィブリノゲン濃度の検討2022
- Author(s)
  大谷ひかる、市川友喜、藤村哲士、須江翼、服部周生、樋口由美子
- Organizer
  第 46 回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] 好中球細胞外トラップ検出のためのMyeloperoxidase-DNA複合体測定法の基礎的検討2022
- Author(s)
  市川　友喜、須江　翼、藤村　哲士、宇佐美　陽子、樋口　由美子
- Organizer
  第40回日本臨床化学甲信越支部総会
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] Validation of a sandwich enzyme-linked immunosorbent assay to determine serum citrullinated fibrinogen concentration2022
- Author(s)
  omoki Ichikawa, Tsubasa Sue, Satoshi Fujimura, Yoko Usami, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] Citrullinated fibrinogen for detection of neutrophil extracellular traps2022
- Author(s)
  Tsubasa Sue, Tomoki Ichikawa, Satoshi Fujimura, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine (ASCPaLM)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] 新型コロナウイルス感染症における血中シトルリン化フィブリノゲン濃度の検討2022
- Author(s)
  大谷ひかる、市川友喜、藤村哲士、須江翼、服部周生、樋口由美子
- Organizer
  第 46 回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] がん細胞株におけるフィブリノゲンのシトルリン化とPAD発現2022
- Author(s)
  服部周生, 須江翼, 市川友喜, 大谷ひかる, 藤村哲士, 樋口由美子
- Organizer
  第 46 回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] 急性大動脈解離におけるシトルリン化フィブリノゲンの動態2021
- Author(s)
  藤村哲士、樋口由美子、伊澤淳、宇佐美陽子、山浦洵、奥村伸生
- Organizer
  第67回　日本臨床検査医学会　学術集会
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] 菌血症患者における血清中シトルリン化フィブリノゲンと炎症マーカーの関連2021
- Author(s)
  藤村哲士，樋口由美子，宇佐美陽子，山浦　洵，樋口　司，寺澤文子，奥村伸生
- Organizer
  第68回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07799

1. Okumura Nobuo (60252110)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. 平千明 (40779310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 新井慎平 (70866053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Higuchi Yumiko 樋口 由美子

Research Projects

Research Products

Co-Researchers

シトルリン化フィブリノゲンの好中球エフェクター機能に及ぼす影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation for extra-cellular function of dysfunctional fibrinogen and identification of its important residues

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Detection of neutrophil extracellular traps by measuring citrullinated fibrinogen in serumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel variant fibrinogen γ p.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 28年間で解析した長野県内のフィブリノゲン異常症18家系28例2021

Author(s)

Journal Title

Data Source

[Journal Article] Congenital fibrinogen disorder with a compound heterozygote possessing two novel FGB mutations, one qualitative and the other quantitative2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A novel amino acid substitution, fibrinogen Bβp.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Validation of a sandwich enzyme-linked immunosorbent assay to determine serum citrullinated fibrinogen concentration2022

Author(s)

Organizer

Data Source

[Presentation] 好中球細胞外トラップ検出のためのMyeloperoxidase-DNA複合体測定法の基礎的検討2022

Author(s)

Organizer

Data Source

[Presentation] Citrullinated fibrinogen for detection of neutrophil extracellular traps2022

Author(s)

Organizer

Data Source

[Presentation] がん細胞株におけるフィブリノゲンのシトルリン化とPAD発現2022

Author(s)

Organizer

Data Source

[Presentation] 新型コロナウイルス感染症における血中シトルリン化フィブリノゲン濃度の検討2022

Author(s)

Organizer

Data Source

[Presentation] 好中球細胞外トラップ検出のためのMyeloperoxidase-DNA複合体測定法の基礎的検討2022

Author(s)

Organizer

Data Source

[Presentation] Validation of a sandwich enzyme-linked immunosorbent assay to determine serum citrullinated fibrinogen concentration2022

Author(s)

Organizer

Data Source

[Presentation] Citrullinated fibrinogen for detection of neutrophil extracellular traps2022

Author(s)

Organizer

Higuchi Yumiko 樋口由美子