Chen I-shan 陳以珊

… Alternative Names

Chen I-Shan 陳以珊

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Researcher Number	40757770
Other IDs
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 和歌山県立医科大学, 医学部, 講師 2016 – 2020: 生理学研究所, 分子細胞生理研究領域, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related / Basic Section 48020:Physiology-related / General physiology Except Principal Investigator Basic Section 48020:Physiology-related
Keywords	Principal Investigator イオンチャネル / イオンチャネル病 / イオン選択性 / 生理学 / GPCR / Orphan GPCR / 新規受容体 / Receptor / Ligand Except Principal Investigator カップリング / 非典型的膜電位依存性ゲーティング / イオン透過 / イオンチャネル

チャネルにおけるイオン透過と非典型的膜電位依存性ゲーティングのカップリングの検証
- Principal Investigator
  
  久保義弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Institute for Physiological Sciences
GIRKチャネルの病因性変異による異常イオン透過機構の解明と異常透過抑制薬の探索Principal Investigator
- Principal Investigator
  
  陳以珊
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Wakayama Medical University
Identification of novel drug on the regulation of abnormal ion selectivity of channels: toward the therapy for channelopathyPrincipal Investigator
- Principal Investigator
  
  Chen I-Shan
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Wakayama Medical University
  National Institute for Physiological Sciences
Behavioral analyses and ligand screening toward the identification of the physiological roles of an orphan metabotropic receptor Prrt3Principal Investigator
- Principal Investigator
  
  Chen I-Shan
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Institute for Physiological Sciences
The physiological ligand and activation mechanisms of an orphan metabotropic receptor Prrt3Principal Investigator
- Principal Investigator
  
  Chen I-Shan
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Licorice metabolite 18β‐glycyrrhetinic acid activates G protein‐gated inwardly rectifying K<sup>+</sup> channels2023
- Author(s)
  Chen I‐Shan、Yasuda Jumpei、Notomi Takuya、Nakamura Tomoe Y.
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 181 Issue: 3 Pages: 447-463
- DOI
  10.1111/bph.16228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06834, KAKENHI-PROJECT-23K06366
[Journal Article] A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K + channel2022
- Author(s)
  Chen IS, Eldstrom J, Fedida D, Kubo Y.
- Journal Title
  
  Journal of Physiology
  
  Volume: 600 Issue: 3 Pages: 603-622
- DOI
  10.1113/jp282430
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-20K07304
[Journal Article] Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.2019
- Author(s)
  Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y
- Journal Title
  
  Br J Pharmacol
  
  Volume: 176 Issue: 17 Pages: 3161-3179
- DOI
  10.1111/bph.14717
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-18K15020
[Journal Article] Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.2018
- Author(s)
  Chen IS, Kubo Y.
- Journal Title
  
  J Physiol
  
  Volume: 印刷中 Issue: 10 Pages: 1833-1845
- DOI
  10.1113/jp275236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-16K18999
[Journal Article] Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation.2017
- Author(s)
  Chen, I.S., Tateyama, M., Fukata, Y., Uesugi, M., & Kubo, Y.
- Journal Title
  
  Journal of Physiology
  
  Volume: 595 Issue: 17 Pages: 5895-5912
- DOI
  10.1113/jp274871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-16K18999
[Presentation] Subunit-specific inhibition of GIRK channel activity by a steroid alkaloid conessine and its region of action2024
- Author(s)
  Misaki Yoshimasu, Ayaki Tsuda, I-Shan Chen, Tomoe Y. Nakamura-Nishitani
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K06366
[Presentation] Structual determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist2024
- Author(s)
  Chang Liu, I-Shan Chen, Yoshihiro Kubo
- Organizer
  The 101th Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-23K27358
[Presentation] Identification of novel drugs targeting GIRK channel and the modulatory mechanism of drug action2024
- Author(s)
  I-Shan Chen, Jumpei Yasuda, Yoshihiro Kubo, Tomoe Y. Nakamura-Nishitani
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K06366
[Presentation] Effects and underlying mechanisms of bioactive components of licorice on GIRK channel activity2023
- Author(s)
  陳以珊、西谷(中村)友重
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] Identification of novel mechanisms underlying the ion selectivity of pathological GIRK mutants2023
- Author(s)
  陳以珊
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K06366
[Presentation] Effects of licorice ingredients on GIRK channel activity and atrial function2023
- Author(s)
  I-Shan Chen, Jumpei Yasuda, Tomoe Y. Nakamura-Nishitani
- Organizer
  The 10th Federation of the Asian and Ocecanian Physiological Societies Congress (FAOPS2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06366
[Presentation] 新規GIRKチャネル作用薬の発見と作用機序の解明2022
- Author(s)
  陳以珊、西谷(中村)友重
- Organizer
  第114回近畿生理学談話会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] GIRKチャネルとその疾患関連変異体への新規作用薬の同定2022
- Author(s)
  陳以珊、西谷友重
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] GIRK2チャネル遺伝子変異による異常なイオン選択性のメカニズムの解明2022
- Author(s)
  陳以珊、久保義弘
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] Effects of glycyrrhizic acid and its metabolite on the GIRK channel activity2022
- Author(s)
  陳以珊、西谷(中村)友重
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] GIRKチャネル遺伝子変異による異常なイオン選択性の新規制御機構2021
- Author(s)
  陳以珊、久保義弘
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] 遺伝性疾患に関連する変異GIRKチャネルのイオン選択性の新規制御機構の解明2021
- Author(s)
  陳以珊、久保義弘
- Organizer
  第113回近畿生理学談話会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] Inhibitory mechanisms of G-protein-gated inwardly rectifying K+ channel by antihistamines2020
- Author(s)
  I-Shan Chen, Chang Liu, Michihiro Tateyama, Izhar Barbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo
- Organizer
  The 64th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15020
[Presentation] GIRKチャネルの変異による異常なイオン選択性の発生の新規機構の解明2020
- Author(s)
  陳以珊,久保義弘
- Organizer
  第67回中部日本生理学会
- Data Source
  KAKENHI-PROJECT-20K07304
[Presentation] Physiological roles of Prrt3, an orphan metabotropic receptor: Comprehensive behavioral test battery analysis using homozygous full gene knock-out mice derived from flox mice2020
- Author(s)
  Tomomi Yamamoto, Satoko Hattori, Li Zhou, Rie Natsume, Kohtarou Konno, I-Shan Chen, Masahiko Watanabe, Kenji Sakimura, Tsuyoshi Miyakawa, Yoshihiro Kubo
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18K15020
[Presentation] Regulation mechanisms of G-protein-gated inwardly rectifying K+ channel by small molecules2019
- Author(s)
  I-Shan Chen, Chang Liu and Yoshihiro Kubo
- Organizer
  The 9th Federation of Asian and Oceanian Physiological Societies Congress: FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15020
[Presentation] Effects and activation mechanisms of ivermectin on G-protein-gated inwardly rectifying potassium channels2018
- Author(s)
  I-Shan Chen, Michihiro Tateyama, Yuko Fukata, Motonari Uesugi, Yoshihiro Kubo
- Organizer
  The 62nd Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18999
[Presentation] Novel regulation mechanisms of the GIRK channel activity by small molecules2018
- Author(s)
  I-Shan Chen, Yoshihiro Kubo
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K18999
[Presentation] Behavioral analyses of forebrain specific knock-out mice of an orphan metabotropic receptor Prrt3 and screening of small molecule library toward identification of its ligand2017
- Author(s)
  I-Shan Chen, Tomomi Yamamoto, Li Zhou, Rie Natsume, Kohtaro Konno, Motonari Uesugi, Masahiko Watanabe, Keizo Takao, Tsuyoshi Miyakawa, Kenji Sakimura, Yoshihiro Kubo
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K18999
[Presentation] Effects and activation mechanisms of antiparasitic agents on GIRK channels2017
- Author(s)
  I-Shan Chen, Yoshihiro Kubo
- Organizer
  第94回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K18999
[Presentation] Behavioral analyses of forebrain specific knock-out mice of an orphan metabotropic receptor Prrt3 and screening of small molecule library toward identification of its ligand2017
- Author(s)
  I-Shan Chen
- Organizer
  The 40th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Makuhari Messe, chiba, chiba
- Year and Date
  2017-07-20
- Data Source
  KAKENHI-PROJECT-16K18999
[Presentation] Activation mechanisms of G-protein-gated inwardly rectifying K+ channel by ivermectin2017
- Author(s)
  I-Shan Chen, Michihiro Tateyama, Yuko Fukata, Motonari Uesugi, Yoshihiro Kubo
- Organizer
  第64回中部日本生理学会
- Data Source
  KAKENHI-PROJECT-16K18999

1. 久保義弘 (80211887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. TATEYAMA Michihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. YAMAMOTO Tomomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. FUKATA Yuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. UESUGI Motonari

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 西谷友重

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chen I-shan 陳 以珊

Chen I-Shan 陳 以珊

Research Projects

Research Products

Co-Researchers

チャネルにおけるイオン透過と非典型的膜電位依存性ゲーティングのカップリングの検証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GIRKチャネルの病因性変異による異常イオン透過機構の解明と異常透過抑制薬の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel drug on the regulation of abnormal ion selectivity of channels: toward the therapy for channelopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Behavioral analyses and ligand screening toward the identification of the physiological roles of an orphan metabotropic receptor Prrt3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The physiological ligand and activation mechanisms of an orphan metabotropic receptor Prrt3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Licorice metabolite 18β‐glycyrrhetinic acid activates G protein‐gated inwardly rectifying K<sup>+</sup> channels2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K + channel2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Subunit-specific inhibition of GIRK channel activity by a steroid alkaloid conessine and its region of action2024

Author(s)

Organizer

Data Source

[Presentation] Structual determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist2024

Author(s)

Organizer

Data Source

[Presentation] Identification of novel drugs targeting GIRK channel and the modulatory mechanism of drug action2024

Author(s)

Organizer

Data Source

[Presentation] Effects and underlying mechanisms of bioactive components of licorice on GIRK channel activity2023

Author(s)

Organizer

Data Source

[Presentation] Identification of novel mechanisms underlying the ion selectivity of pathological GIRK mutants2023

Author(s)

Organizer

Data Source

Chen I-shan 陳以珊

Chen I-Shan 陳以珊