Akama Yuichi 赤間悠一

Researcher Number	40763313
Other IDs	https://orcid.org/0000-0002-7040-1307
Affiliation (Current)	2025: 三重大学, 医学系研究科, リサーチアソシエイト
Affiliation (based on the past Project Information) *help	2022 – 2023: 三重大学, 医学系研究科, リサーチアソシエイト 2019 – 2023: 三重大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 55040:Respiratory surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator IL-13 / PD-1 / 自然リンパ球 / 敗血症 / ミオパチー / PD-L1 / エキソソーム / ミトコンドリア / 骨格筋 / ICU-AW … More / ILC2 / ILC / ST2 / KLRG1 / IL-33KOマウス / 肺傷害 / ２型自然リンパ球 (ILC2) / 免疫抑制 / ショック / 炎症 / 感染症 / 免疫 … More Except Principal Investigator 敗血症 / 細胞外小胞 / エクソソーム / エキソソーム / インテグリン / サイトカイン / 腸管上皮 / 遺伝子発現制御 / バイオマーカー / マイクロRNA / 腸管上皮細胞 / 術後急性増悪 / 2型自然リンパ球 / インターロイキン33 / エクソソーム表面タンパク / 急性増悪 / 間質性肺炎 / 制御性T細胞（Treg） / エフェクターT細胞の疲弊化 / エキソソームPDL1 / 腎機能障害 / 免疫麻痺 / ショック / β1、β2、β3インテグリン / Tリンパ球 / SIRS / PD-L1 / 敗血症関連脳症 / miRNA / fMRI / ICU-AW / マイオソーム / マイオカイン / 骨格筋エキソソーム / インテグリンα5β1 / インテグリンα4β1 / インテグリンα4β7 / 細胞接着 / インテグリンαLβ2 / 細胞接着アッセイ / PICS / イリシン / ミオカイン Less

間質性肺炎急性増悪の新規メカニズム：エクソソーム型サイトカインによる線維化作用
- Principal Investigator
  
  伊藤温志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Mie University
Study of the roles played by exosomal microRNAs of intestinal epithelial cells in downregulating septic inflammations
- Principal Investigator
  
  朴恩正
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Mie University
Elucidation of the mechanism by which exosomal PD-L1 induces septic immune paralysis
- Principal Investigator
  
  川本英嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Mie University
ILC2 exhaustion and metabolic dysregulation in septic myopathy: implications of PD-L1 exosomesPrincipal Investigator
- Principal Investigator
  
  赤間悠一
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Mie University
The trafficking and effector function of the group 2 innate lymphoid cells in sepsis-induced lung injuryPrincipal Investigator
- Principal Investigator
  
  Akama Yuichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Mie University
Aberrant skeletal muscle-brain communication in sepsis-associated encephalopathy: Elucidating the pathogenic roles of skeletal muscle-derived exosomes
- Principal Investigator
  
  川本英嗣
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Mie University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] 敗血症モデルマウスの腸管上皮細胞のマイクロRNAプロファイル2023
- Author(s)
  朴恩正, Siqingaowa　Caidengbate , 赤間悠一, Anik Banerjee, Khwanchanok Mokmued, 川本英嗣, 阿栄高娃, Juneyoung Lee, Louise D. McCullough, 島岡要
- Journal Title
  
  Shock: 日本Shock学会雑誌
  
  Volume: 37 Pages: 83-83
- Data Source
  KAKENHI-PROJECT-22K09160
[Journal Article] MicroRNA Profiles in Intestinal Epithelial Cells in a Mouse Model of Sepsis2023
- Author(s)
  Caidengbate Siqingaowa、Akama Yuichi、Banerjee Anik、Mokmued Khwanchanok、Kawamoto Eiji、Gaowa Arong、McCullough Louise D.、Shimaoka Motomu、Lee Juneyoung、Park Eun Jeong
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 5 Pages: 726-726
- DOI
  10.3390/cells12050726
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06910, KAKENHI-PROJECT-22K07001, KAKENHI-PROJECT-22K09160, KAKENHI-PROJECT-20K17858, KAKENHI-PROJECT-19KK0196, KAKENHI-PROJECT-19KK0224, KAKENHI-PROJECT-21K09015, KAKENHI-PROJECT-21K09070, KAKENHI-PROJECT-22K09117
[Journal Article] 敗血症マウスモデルでのICU関連筋力低下に対するProgrammed cell Death protein-1(PD-1)阻害の効果2022
- Author(s)
  赤間悠一, 朴恩正, 佐藤尚子, 川本英嗣, 高娃阿栄, 伊藤温志, 江角亮, 池尻薫, 今井寛, 島岡要
- Journal Title
  
  Shock: 日本Shock学会雑誌
  
  Volume: 36 Pages: 37-37
- Data Source
  KAKENHI-PROJECT-22K09160
[Journal Article] Possible Metastatic Stage-Dependent ILC2 Activation Induces Differential Functions of MDSCs through IL-13/IL-13Rα1 Signaling during the Progression of Breast Cancer Lung Metastasis2022
- Author(s)
  Ito Atsushi、Akama Yuichi、Satoh-Takayama Naoko、Saito Kanako、Kato Takuma、Kawamoto Eiji、Gaowa Arong、Park Eun Jeong、Takao Motoshi、Shimaoka Motomu
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 13 Pages: 3267-3267
- DOI
  10.3390/cancers14133267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09015, KAKENHI-PROJECT-21K09070, KAKENHI-PROJECT-22K06910, KAKENHI-PROJECT-22K07001, KAKENHI-PROJECT-22K09117, KAKENHI-PROJECT-22K09160, KAKENHI-PROJECT-20K17858, KAKENHI-PROJECT-19KK0196, KAKENHI-PROJECT-19KK0224, KAKENHI-PROJECT-19K18210
[Journal Article] Elevated Plasma Soluble PD-L1 Levels in Out-of-Hospital Cardiac Arrest Patients2021
- Author(s)
  Sumiyoshi Miho、Kawamoto Eiji、Nakamori Yuki、Esumi Ryo、Ikejiri Kaoru、Shinkai Toru、Akama Yuichi、Ito-Masui Asami、Imai Hiroshi、Gaowa Arong、Park Eun Jeong、Shimaoka Motomu
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Issue: 18 Pages: 4188-4188
- DOI
  10.3390/jcm10184188
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08916, KAKENHI-PROJECT-19K07479, KAKENHI-PROJECT-19K18318, KAKENHI-PROJECT-21K09015, KAKENHI-PROJECT-21K09070, KAKENHI-PROJECT-19K18242, KAKENHI-PROJECT-20K17835, KAKENHI-PROJECT-20K17858, KAKENHI-PROJECT-20K17859, KAKENHI-PROJECT-19KK0224
[Journal Article] Cellular and exosomal regulations of sepsis-induced metabolic alterations2021
- Author(s)
  Appiah G. Michael, Park Eun Jeong, Akama Y, Nakamori Y, Kawamoto E, Gaowa A, Shimaoka M
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 15 Pages: 8295-8295
- DOI
  10.3390/ijms22158295
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09392, KAKENHI-PROJECT-19K18318, KAKENHI-PROJECT-21K09015, KAKENHI-PROJECT-21K09070, KAKENHI-PROJECT-20K17858, KAKENHI-PROJECT-19KK0224
[Journal Article] 免疫チェックポイントと2型自然リンパ球2021
- Author(s)
  伊藤温志、赤間悠一、島岡要
- Journal Title
  
  Medical Science Digest
  
  Volume: 47 Pages: 97-100
- Data Source
  KAKENHI-PROJECT-19K18317
[Journal Article] Veno-arterial extracorporeal membrane oxygenation and targeted temperature management in tricyclic antidepressant-induced cardiac arrest2021
- Author(s)
  Ikejiri Kaoru、Akama Yuichi、Ieki Yohei、Kawamoto Eiji、Suzuki Kei、Yokoyama Kazuto、Ishikura Ken、Imai Hiroshi
- Journal Title
  
  Medicine
  
  Volume: 100 Issue: 9 Pages: e24980-e24980
- DOI
  10.1097/md.0000000000024980
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18349, KAKENHI-PROJECT-19K18317, KAKENHI-PROJECT-19K18318, KAKENHI-PROJECT-21K09015, KAKENHI-PROJECT-21K09070, KAKENHI-PROJECT-20K17858, KAKENHI-PROJECT-19KK0224
[Journal Article] The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin.2021
- Author(s)
  Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui-Ito A, Akama Y, Darkwah S, Appiah MG, Myint PK, Obeng G, Ito A, Caidengbate S, Esumi R, Yamaguchi T, Park EJ, Imai H, Shimaoka M.
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 2 Pages: 162-162
- DOI
  10.3390/biomedicines9020162
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07479, KAKENHI-PROJECT-19K08583, KAKENHI-PROJECT-19K09392, KAKENHI-PROJECT-20K09287, KAKENHI-PROJECT-18K08917, KAKENHI-PROJECT-19K18317, KAKENHI-PROJECT-19K20164, KAKENHI-PROJECT-18K08916, KAKENHI-PROJECT-19K18318, KAKENHI-PROJECT-21K09015, KAKENHI-PROJECT-21K09070, KAKENHI-PROJECT-20K17858, KAKENHI-PROJECT-21K17650, KAKENHI-PROJECT-19KK0224
[Journal Article] Sepsis Induces Deregulation of IL-13 Production and PD-1 Expression in Lung Group 2 Innate Lymphoid Cells.2021
- Author(s)
  Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto E, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M.
- Journal Title
  
  Shock
  
  Volume: 55 Issue: 3 Pages: 357-370
- DOI
  10.1097/shk.0000000000001647
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07479, KAKENHI-PROJECT-19K09392, KAKENHI-PROJECT-18K07189, KAKENHI-PROJECT-18K08917, KAKENHI-PROJECT-19K18317, KAKENHI-PROJECT-19K18318, KAKENHI-PROJECT-21K09015, KAKENHI-PROJECT-21K09070, KAKENHI-PROJECT-20K17858, KAKENHI-PROJECT-19KK0224
[Journal Article] Pyogenic spondylodiscitis of the lumbar spine related to anastomotic fistula after surgery for esophageal cancer: a case report2020
- Author(s)
  Akama Yuichi、Matsutani Takeshi、Hagiwara Nobutoshi、Umezawa Hiroki、Nomura Tsutomu、Hanawa Hidetsugu、Mishima Keisuke、Taniai Nobuhiko、Yoshida Hiroshi
- Journal Title
  
  Surgical Case Reports
  
  Volume: 6 Issue: 1 Pages: 155-155
- DOI
  10.1186/s40792-020-00922-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18317
[Journal Article] The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation.2020
- Author(s)
  Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto E, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M.
- Journal Title
  
  Diagnostics (Basel)
  
  Volume: 10 Issue: 10 Pages: 808-808
- DOI
  10.3390/diagnostics10100808
- NAID
  120006941006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07479, KAKENHI-PROJECT-19K09392, KAKENHI-PROJECT-18K07189, KAKENHI-PROJECT-18K08917, KAKENHI-PROJECT-19K18317
[Journal Article] Intestinal Epithelium-Derived Luminally Released Extracellular Vesicles in Sepsis Exhibit the Ability to Suppress TNF-a and IL-17A Expression in Mucosal Inflammation.2020
- Author(s)
  Appiah MG, Park EJ, Darkwah S, Kawamoto E, Akama Y, Gaowa A, Kalsan M, Ahmad S, Shimaoka M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 22 Pages: 8445-8445
- DOI
  10.3390/ijms21228445
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07479, KAKENHI-PROJECT-19K09392, KAKENHI-PROJECT-18K08917, KAKENHI-PROJECT-19K18317, KAKENHI-PROJECT-21K09070
[Journal Article] Anti-adhesive effects of human soluble thrombomodulin and its domains2019
- Author(s)
  Kawamoto Eiji、Nago Nodoka、Okamoto Takayuki、Gaowa Arong、Masui-Ito Asami、Sakakura Yosuke、Akama Yuichi、Soe Zay Yar、Prajuabjinda Onmanee、Darkwah Samuel、Appiah Michael G.、Myint Phyoe Kyawe、Obeng Gideon、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 511 Issue: 2 Pages: 312-317
- DOI
  10.1016/j.bbrc.2019.02.041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20387, KAKENHI-PROJECT-16K08581, KAKENHI-PROJECT-16K09513, KAKENHI-PROJECT-16K15759, KAKENHI-PROJECT-18K08916, KAKENHI-PROJECT-18K08917, KAKENHI-PROJECT-19K08583, KAKENHI-PROJECT-19K09392, KAKENHI-PROJECT-19K20164, KAKENHI-PROJECT-19KK0224
[Presentation] 敗血症モデルマウスの腸管上皮細胞のマイクロRNAプロファイル2023
- Author(s)
  朴恩正, Siqingaowa Caidengbate, 赤間悠一, Anik Banerjee, Khwanchanok Mokmued, 川本英嗣, 阿栄高娃, Juneyoung Lee, Louise D. McCullough, 島岡要
- Organizer
  第37回日本Shock学会総会
- Data Source
  KAKENHI-PROJECT-22K09160
[Presentation] 敗血症マウスモデルでのICU関連筋力低下に対するProgrammed cell Death protein-1 (PD-1) 阻害の効果2022
- Author(s)
  赤間悠一, 朴恩正, 佐藤尚子, 川本英嗣, 阿栄高娃, 伊藤温志, 江角亮, 池尻薫, 今井寛, 島岡要
- Organizer
  第36回日本ショック学会総会
- Data Source
  KAKENHI-PROJECT-22K09160
[Presentation] 敗血症マウスモデルでのICU関連筋力低下に対するProgrammed cell Death protein-1(PD-1)阻害の効果2022
- Author(s)
  赤間悠一, 朴恩正, 佐藤尚子, 川本英嗣, 阿栄高娃, 伊藤温志, 江角亮, 池尻薫, 今井寛, 島岡要
- Organizer
  第36回日本Shock学会総会
- Data Source
  KAKENHI-PROJECT-21K09069
[Presentation] PD-1が敗血症性肺傷害における２型自然リンパ球の疲弊を起こす2021
- Author(s)
  赤間悠一、朴恩正、佐藤尚子、川本英嗣、阿栄高娃、伊藤温志、江角亮、池尻薫、今井寛、島岡要
- Organizer
  第35回日本Shock学会総会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 救急外来におけるCT室への搬送距離延長がICU入室患者にもたす影響2020
- Author(s)
  赤間悠一, 金子唯, 鈴木圭, 武田多一, 石倉健, 横山和人, 川本英嗣, 家城洋平, 佐々木賢, 今井寛
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 病院前12誘導心電図伝送による緊急カテーテルチームのワークライフバランス改善の可能性について　三重ACSレジストリより2020
- Author(s)
  石倉健, 奥野郁斗, 池尻薫, 江角亮, 赤間悠一, 伊藤亜紗実, 新貝達, 鈴木圭, 金子唯, 今井寛
- Organizer
  第48回日本救急医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 院外心停止へのECPR対応へむけた病院前因子の検討2020
- Author(s)
  金子唯, 山口貴則, 赤間悠一, 伊藤亜紗実, 宮村岳, 家城洋平, 鈴木圭, 石倉健, 武田多一, 今井寛
- Organizer
  第23回日本臨床救急医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 敗血症性肺傷害における2型自然リンパ球の機能解析2020
- Author(s)
  赤間悠一、朴恩正、佐藤尚子、川本英嗣、伊藤亜紗実、伊藤温志、江角亮、池尻薫、今井寛、島岡要
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 敗血症性肺傷害における2型自然リンパ球の機能解析2020
- Author(s)
  赤間悠一, 朴恩正, 佐藤尚子, 川本英嗣, 伊藤亜紗実, 伊藤温志, 江角亮, 池尻薫, 今井寛, 島岡要
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 院外心停止に対するECPRの予後良好に関わる因子の検討2020
- Author(s)
  金子唯, 山口貴則, 赤間悠一, 新貝達, 伊藤亜紗実, 家城洋平, 川本英嗣, 横山和人, 石倉健, 今井寛
- Organizer
  第48回日本救急医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 急性肺血栓塞栓症による心肺停止に対して、肺循環維持をした人工心肺補助装置管理で救命できた一例2020
- Author(s)
  石倉健, 奥野郁斗, 池尻薫, 江角亮, 赤間悠一, 川本英嗣, 鈴木圭, 横山和人, 金子唯, 今井寛
- Organizer
  第47回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18317
[Presentation] 地方大学病院での外傷カンファレンスを通じた診療体制づくりの試み2020
- Author(s)
  江角亮, 家城洋平, 赤間悠一, 新貝達, 金子唯, 今井寛, 石倉健
- Organizer
  第34回日本外傷学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K18317

1. 島岡要 (40281133)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. 川本英嗣 (20577415)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. 朴恩正 (20644587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
4. 高娃阿栄 (50643805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. 佐藤尚子 (90732446)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 亀井政孝 (60443503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中森裕毅 (80815994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 池尻薫 (90813014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤温志 (80783133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IMAI HIROSHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鈴木圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊藤亜紗実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akama Yuichi 赤間 悠一

Research Projects

Research Products

Co-Researchers

間質性肺炎急性増悪の新規メカニズム：エクソソーム型サイトカインによる線維化作用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the roles played by exosomal microRNAs of intestinal epithelial cells in downregulating septic inflammations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism by which exosomal PD-L1 induces septic immune paralysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ILC2 exhaustion and metabolic dysregulation in septic myopathy: implications of PD-L1 exosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The trafficking and effector function of the group 2 innate lymphoid cells in sepsis-induced lung injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Aberrant skeletal muscle-brain communication in sepsis-associated encephalopathy: Elucidating the pathogenic roles of skeletal muscle-derived exosomes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] 敗血症モデルマウスの腸管上皮細胞のマイクロRNAプロファイル2023

Author(s)

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Akama Yuichi 赤間悠一

[Presentation] 病院前12誘導心電図伝送による緊急カテーテルチームのワークライフバランス改善の可能性について　三重ACSレジストリより2020