Fujiwara Sachiko 藤原佐知子

Researcher Number	40771879
Affiliation (based on the past Project Information) *help	2021 – 2022: 生理学研究所, 生体機能調節研究領域, 特任助教 2017 – 2018: 大阪大学, 基礎工学研究科, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Cell biology / Basic Section 44010:Cell biology-related / Cell biology
Keywords	Principal Investigator 上皮細胞 / 細胞骨格 / 細胞-基質間接着 / 細胞収縮力 / 細胞－基質間接着 / 中間径フィラメント / 細胞間接着 / メカニカルストレス / Rho-GEF / 力覚応答 … More / 細胞集団運動 / アクチン細胞骨格 / 細胞運動 / 細胞接着 / タイトジャンクション / 蛋白質 / シグナル伝達 / メカノセンシング / Rhoファミリー活性化因子 Less

Roles of tight junctions in integrative control of cell mechanics in collective cell motilityPrincipal Investigator
- Principal Investigator
  
  Fujiwara Sachiko
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  National Institute for Physiological Sciences
Molecular mechanisms of cellular mechanosensing through Rho-GEF SoloPrincipal Investigator
- Principal Investigator
  
  Fujiwara Sachiko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
上皮細胞システムの力覚応答を司るＲｈｏシグナルと細胞骨格制御の統合的理解Principal Investigator
- Principal Investigator
  
  藤原佐知子
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Cell biology
- Research Institution
  Osaka University

All 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif2022
- Author(s)
  Sachiko Fujiwara, Thanh Phuong Nguyen, Kyoko Furuse, Yugo Fukazawa, Tetsuhisa Otani, Mikio Furuse
- Journal Title
  
  Ann N Y Acad Sci.
  
  Volume: 1516 Issue: 1 Pages: 85-94
- DOI
  10.1111/nyas.14881
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05286, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02523, KAKENHI-PROJECT-21K15095
[Journal Article] Keratin-binding ability of the N-terminal Solo domain of Solo is critical for its function in cellular mechanotransduction2019
- Author(s)
  Fujiwara, S., Matsui, T. S., Ohashi, K., Mizuno, K., and Deguchi, S.
- Journal Title
  
  Genes Cells
  
  Volume: 印刷中 Issue: 5 Pages: 390-402
- DOI
  10.1111/gtc.12682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19280, KAKENHI-PUBLICLY-17H05612, KAKENHI-PROJECT-16J04133, KAKENHI-PROJECT-16K07335, KAKENHI-PROJECT-16K12872, KAKENHI-PROJECT-17K15118, KAKENHI-PROJECT-18H03518
[Journal Article] Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells2018
- Author(s)
  Sachiko Fujiwara, Tsubasa S. Matsui, Kazumasa Ohashi, Shinji Deguchi, and Kensaku Mizuno
- Journal Title
  
  PLOS ONE
  
  Volume: 印刷中 Issue: 4 Pages: e0195124-e0195124
- DOI
  10.1371/journal.pone.0195124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15118, KAKENHI-PUBLICLY-16H00749, KAKENHI-PROJECT-16J04133, KAKENHI-PROJECT-18K19280, KAKENHI-PUBLICLY-17H05612, KAKENHI-PROJECT-16K07335, KAKENHI-PROJECT-16K12872, KAKENHI-PROJECT-18H03518
[Journal Article] Role of Intermediate Filaments in Cell Locomotion2017
- Author(s)
  Sachiko Fujiwara and Kensaku Mizuno
- Journal Title
  
  eLS. John Wiley & Sons, Ltd: Chichester.
  
  Volume: - Pages: 1-9
- DOI
  10.1002/9780470015902.a0026365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15118, KAKENHI-PUBLICLY-16H00749
[Journal Article] Roles of the cytoskeleton, cell adhesion, and Rho signaling in mechanosensing and mechanotransduction.2017
- Author(s)
  Ohashi, K., Fujiwara, S., and Mizuno, K.
- Journal Title
  
  J. Biochem.
  
  Volume: 161 Pages: 245-254
- DOI
  10.1093/jb/mvw082
- NAID
  40021162023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00749, KAKENHI-PROJECT-16J04133, KAKENHI-PROJECT-15K14469, KAKENHI-PROJECT-16K07335
[Journal Article] Roles of cytoskeletons and cell adhesions in mechano-sensing2016
- Author(s)
  藤原佐知子、大橋一正、水野健作
- Journal Title
  
  生化学
  
  Volume: 88 Issue: 4 Pages: 443-451
- DOI
  10.14952/SEIKAGAKU.2016.880443
- NAID
  40020948061
- ISSN
  0037-1017
- Year and Date
  2016-08-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 立体構造に基づく点変異導入を利用したタイトジャンクションタンパク質ZO-1の機能解析2022
- Author(s)
  藤原佐知子
- Organizer
  第95回　日本生化学会　大会
- Data Source
  KAKENHI-PROJECT-21K15095
[Presentation] タイトジャンクション形成はクローディンとZOタンパク質の結合に依存しない2022
- Author(s)
  藤原佐知子
- Organizer
  第12 回名古屋大学医学系研究科・生理学研究所合同シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15095
[Presentation] Physiological roles and molecular mechanisms of keratin intermediate filament-mediated cellular mechanotransduction.2021
- Author(s)
  藤原佐知子
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15095
[Presentation] 細胞収縮力の発生と上皮腺房形成における細胞内Rhoシグナルの制御機構と生理機能2018
- Author(s)
  藤原佐知子、松井翼、大橋一正、Thomas Magin、水野健作、出口真次
- Organizer
  日本機械学会第31回バイオエンジニアリング講演会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] RhoA-GEFのSoloは上皮細胞集団移動の速度を制御する2018
- Author(s)
  磯崎友亮、藤原佐知子、水野健作、大橋一正
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Hemidesmosomal cell-substrate adhesion and acinar morphogenesis of epithelial cells are organized by Rho-signaling through controlling mechanotransduction2018
- Author(s)
  Sachiko Fujiwara, Hiyori Abiko, Tsubasa S. Matsui, Kazumasa Ohashi, Kensaku Mizuno, Shinji Deguchi
- Organizer
  2018 World Congress of Biomechanics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] RhoA-GEFのSoloは上皮細胞集団移動の速度を制御する2018
- Author(s)
  磯崎友亮、藤原佐知子、水野健作、大橋一正
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] Hemidesmosomal cell-substrate adhesion and acinar morphogenesis of epithelial cells are organized by Rho-signaling through controlling mechanotransduction2018
- Author(s)
  Sachiko Fujiwara, Hiyori Abiko, Tsubasa S. Matsui, Kazumasa Ohashi, Kensaku Mizuno, Shinji Deguchi
- Organizer
  2018 World Congress of Biomechanics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Rho-signaling organizes hemidesmosomal cell-substrate adhesion and acinar morphogenesis of epithelial cells through controlling mechanotransduction2018
- Author(s)
  Sachiko Fujiwara, Tsubasa S. Matsui, Kazumasa Ohashi, Thomas M. Magin, Kensaku Mizuno, Shinji Deguchi
- Organizer
  DGZ 2018 (International Meeting of the German Society for Cell Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Physiological roles of Rho-GEF Solo in mechanotransduction and hemidesmosomal cell-substrate adhesion in epithelial cells2018
- Author(s)
  藤原佐知子、松井翼、大橋一正、Thomas Magin、水野健作、出口真次
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] Solo (ARHGEF40)はケラチン8/18ネットワークの再構築に関与し細胞集団移動の速度を制御する2018
- Author(s)
  磯崎友亮、酒井高輝、藤原佐知子、水野健作、大橋一正
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] Solo (ARHGEF40)はケラチン8/18ネットワークの再構築に関与し細胞集団移動の速度を制御する2018
- Author(s)
  磯崎友亮、酒井高輝、藤原佐知子、水野健作、大橋一正
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Rho-signaling plays crucial roles for cellular mechanotransduction and regulates actin and intermediate filament cytoskeletal reorganization2018
- Author(s)
  Sachiko Fujiwara, Hiyori Abiko, Tsubasa S. Matsui, Kazumasa Ohashi, Kensaku Mizuno, Shinji Deguchi
- Organizer
  2018 World Congress of Biomechanics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] Rho-signaling organizes hemidesmosomal cell-substrate adhesion and acinar morphogenesis of epithelial cells through controlling mechanotransduction2018
- Author(s)
  Sachiko Fujiwara, Tsubasa S. Matsui, Kazumasa Ohashi, Thomas M. Magin, Kensaku Mizuno, Shinji Deguchi
- Organizer
  DGZ 2018 (International Meeting of the German Society for Cell Biology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] Physiological roles of Rho-GEF Solo in mechanotransduction and hemidesmosomal cell-substrate adhesion in epithelial cells2018
- Author(s)
  藤原佐知子、松井翼、大橋一正、Thomas Magin、水野健作、出口真次
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 細胞収縮力の発生と上皮腺房形成における細胞内Rhoシグナルの制御機構と生理機能2018
- Author(s)
  藤原佐知子、松井翼、大橋一正、Thomas Magin、水野健作、出口真次
- Organizer
  日本機械学会第31回バイオエンジニアリング講演会
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Rho-signaling plays crucial roles for cellular mechanotransduction and regulates actin and intermediate filament cytoskeletal reorganization2018
- Author(s)
  Sachiko Fujiwara, Hiyori Abiko, Tsubasa S. Matsui, Kazumasa Ohashi, Kensaku Mizuno, Shinji Deguchi
- Organizer
  2018 World Congress of Biomechanics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Rho-GEF 'Solo' and keratin filaments play crucial roles in mechanical force-induced stress fiber formation.2017
- Author(s)
  Kensaku Mizuno, Sachiko Fujiwara, Kazumasa Ohashi
- Organizer
  The 5th International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
- Place of Presentation
  東京大学（東京都目黒区）
- Year and Date
  2017-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] SoloはミオシンIIを介して上皮管腔の形態を制御する2017
- Author(s)
  西村亮祐、加藤輝、藤原佐知子、大橋一正、水野健作
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] 力覚応答に関与するRhoGEF, Solo の上皮細胞の集団移動における機能解析2017
- Author(s)
  磯崎友亮、藤原佐知子、水野健作、大橋一正
- Organizer
  第83回日本生化学会東北支部回例会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] Rho-GEF Soloは細胞-基質間接着における力覚応答に関与し上皮腺房形成を制御する2017
- Author(s)
  藤原佐知子、松井翼、出口真次、水野健作
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] 上皮管腔組織の形態制御における上皮管腔組織の形態制御におけるRho-GEF, Soloの役割2017
- Author(s)
  西村亮祐、大橋一正、藤原佐知子、水野健作
- Organizer
  2017年生体運動合同研究班会議
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2017-01-06
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 上皮細胞の細胞-基質間接着と腺房形成におけるRho-GEF Soloの機能2017
- Author(s)
  藤原佐知子、勝野真美、大橋一正、水野健作
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Rho-GEF Soloは細胞-基質間接着における力覚応答に関与し上皮腺房形成を制御する2017
- Author(s)
  藤原佐知子、松井翼、出口真次、水野健作
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 上皮細胞の細胞-基質間接着と腺房形成におけるRho-GEF Soloの機能2017
- Author(s)
  藤原佐知子、勝野真美、大橋一正、水野健作
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-17K15118
[Presentation] メカノストレス応答に関与するRho-GEF, Soloの上皮管腔組織形成における役割2016
- Author(s)
  西村亮祐、大橋一正、藤原佐知子、水野健作
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 力覚応答に関与するRho-GEF, Soloの上皮細胞の管腔形成における機能解析2016
- Author(s)
  大橋一正、西村亮祐、藤原佐知子、水野健作
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 上皮細胞の力覚応答に対するRho-GEF Soloと中間径フィラメントの役割2016
- Author(s)
  藤原佐知子、大橋一正、水野健作
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター・東北大学（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 動物細胞の力覚応答における細胞骨格の役割2016
- Author(s)
  水野健作、藤原佐知子、大橋一正
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 上皮細胞の力覚応答と細胞骨格制御に対するRho-GEF Soloの機能2016
- Author(s)
  藤原佐知子、大橋一正、水野健作
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] 上皮管腔組織形成におけるSoloの機能解析2016
- Author(s)
  西村亮祐、大橋一正、藤原佐知子、水野健作
- Organizer
  第82回日本生化学会東北支部回例会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16J04133
[Presentation] Interplay between Rho-GEF Solo and keratin filaments is crucial for mechanotransduction in epithelial cells2016
- Author(s)
  Sachiko Fujiwara, Hiyori Abiko, Kazumasa Ohashi, Kensaku Mizuno
- Organizer
  2016 Annual meeting of the American Society for Cell Biology
- Place of Presentation
  Moscone Center (San Francisco, CA, USA)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J04133

1. 水野健作

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 大谷哲久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujiwara Sachiko 藤原 佐知子

Research Projects

Research Products

Co-Researchers

Roles of tight junctions in integrative control of cell mechanics in collective cell motilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of cellular mechanosensing through Rho-GEF SoloPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

上皮細胞システムの力覚応答を司るＲｈｏシグナルと細胞骨格制御の統合的理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Keratin-binding ability of the N-terminal Solo domain of Solo is critical for its function in cellular mechanotransduction2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Intermediate Filaments in Cell Locomotion2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of the cytoskeleton, cell adhesion, and Rho signaling in mechanosensing and mechanotransduction.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Roles of cytoskeletons and cell adhesions in mechano-sensing2016

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Presentation] 立体構造に基づく点変異導入を利用したタイトジャンクションタンパク質ZO-1の機能解析2022

Author(s)

Organizer

Data Source

[Presentation] タイトジャンクション形成はクローディンとZOタンパク質の結合に依存しない2022

Author(s)

Organizer

Data Source

[Presentation] Physiological roles and molecular mechanisms of keratin intermediate filament-mediated cellular mechanotransduction.2021

Author(s)

Organizer

Data Source

[Presentation] 細胞収縮力の発生と上皮腺房形成における細胞内Rhoシグナルの制御機構と生理機能2018

Author(s)

Organizer

Data Source

[Presentation] RhoA-GEFのSoloは上皮細胞集団移動の速度を制御する2018

Author(s)

Organizer

Data Source

[Presentation] Hemidesmosomal cell-substrate adhesion and acinar morphogenesis of epithelial cells are organized by Rho-signaling through controlling mechanotransduction2018

Author(s)

Organizer

Fujiwara Sachiko 藤原佐知子

[Presentation] 上皮管腔組織の形態制御における上皮管腔組織の形態制御におけるRho-GEF, Soloの役割2017