• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

OOKUBO Keishi  大久保 啓史

ORCIDConnect your ORCID iD *help
… Alternative Names

OKUBO Keishi  大久保 啓史

Less
Researcher Number 40772223
Affiliation (Current) 2025: 鹿児島大学, 医歯学域鹿児島大学病院, 助教
Affiliation (based on the past Project Information) *help 2019 – 2021: 鹿児島大学, 鹿児島大学病院, 医員
2016 – 2018: 鹿児島大学, 附属病院, 医員
2015: 鹿児島大学, 医学部・歯学部附属病院, 医員
Review Section/Research Field
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Digestive surgery / General surgery
Keywords
Except Principal Investigator
胃癌 / 免疫療法 / 免疫チェックポイント分子 / 免疫チェックポイント阻害剤 / T細胞性免疫応答 / Fibrinogen / 好中球リンパ球比 / 癌免疫機構 / リキッドバイオプシー / 免疫チェックポイント阻害薬 … More / 循環腫瘍細胞 / がん免疫療法 / Salvage chemotherapy / ニボルマブ / HHLA2 / PD-L1 / バイオマーカー / B7 ligand family / 免疫逃避機構 / infiltrating lymphocytes / CD3 / 免疫補助刺激分子 / 免疫応答 / 免疫回避機構 / 全身性炎症反応 Less
  • Research Projects

    (3 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (8 People)
  •  Development and clinical application of biomarkers for predicting response to immune therapy via targeting circulating tumor cells

    • Principal Investigator
      ARIGAMI TAKAAKI
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kagoshima University
  •  Functional analysis of immune checkpoint molecules and the new therapeutic development by targeting their regulation

    • Principal Investigator
      Arigami Takaaki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kagoshima University
  •  The Elucidation of an Immune Escape Mechanism and its control in Gastrointestinal Cancers

    • Principal Investigator
      Arigami Takaaki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Kagoshima University

All 2022 2021 2020 2018 2017 2016

All Journal Article Presentation Book

  • [Book] 臨床雑誌外科2022

    • Author(s)
      有上貴明, 松下大輔,大久保啓史,下之薗将貴,鶴田祐介,佐々木健,中条哲浩,大塚隆生
    • Total Pages
      5
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Journal Article] Changes in Chemotherapeutic Strategies and Their Prognostic Impact in Patients With Advanced Gastric Cancer2022

    • Author(s)
      Arigami T, Matsushita D, Okubo K, Tanaka T, Sasaki K, Tsuruda Y, Kita Y, Mori S, Kurahara H, Uenosono Y, Ohtsuka T
    • Journal Title

      In Vivo

      Volume: 36 Issue: 1 Pages: 409-415

    • DOI

      10.21873/invivo.12718

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09200, KAKENHI-PROJECT-21K08783
  • [Journal Article] Prognostic Significance of HER2 Expression for Gastric Cancer With Clinically Para-aortic Lymph Node Metastasis2021

    • Author(s)
      Arigami T, Matsushita D, Okubo K, Sasaki K, Tsuruda Y, Kita Y, Mori S, Yanagita S, Uenosono Y, Kurahara H, Ohtsuka T
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 6 Pages: 3099-3107

    • DOI

      10.21873/anticanres.15094

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09200, KAKENHI-PROJECT-21K08783
  • [Journal Article] Prognostic impact of surgery after chemotherapy for type 4 gastric cancer2021

    • Author(s)
      Arigami T, Matsushita D, Okubo K, Sasaki K, Noda M, Kita Y, Mori S, Kurahara H, Yanagita S, Uenosono Y, Ishigami S, Ohtsuka T
    • Journal Title

      Surgery Today

      Volume: 51 Issue: 11 Pages: 1851-1859

    • DOI

      10.1007/s00595-021-02320-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09200, KAKENHI-PROJECT-21K08783
  • [Journal Article] Indication and Prognostic Significance of Conversion Surgery in Patients with Liver Metastasis from Gastric Cancer.2020

    • Author(s)
      Arigami T, Matsushita D, Okubo K, Kawasaki Y, Iino S, Sasaki K, Noda M, Kita Y, Mori S, Kurahara H, Maemura K, Yanagita S, Uenosono Y, Ishigami S, Natsugoe S
    • Journal Title

      Oncology

      Volume: 1 Issue: 5 Pages: 1-7

    • DOI

      10.1159/000505555

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08687, KAKENHI-PROJECT-19K09200
  • [Journal Article] 術前補助化学療法を施行したstage III進行胃癌におけるリンパ節転移の臨床的意義2020

    • Author(s)
      有上貴明, 松下大輔, 大久保啓史, 田中貴子, 佐々木健, 野田昌宏, 喜多芳昭, 盛真一郎, 大塚隆生, 愛甲孝, 夏越祥次
    • Journal Title

      リンパ学

      Volume: 43 Pages: 69-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Journal Article] Response Rate and Prognostic Impact of Salvage Chemotherapy after Nivolumab in Patients with Advanced Gastric Cancer2020

    • Author(s)
      Arigami Takaaki、Matsushita Daisuke、Okubo Keishi、Yanagita Shigehiro、Ehi Katsuhiko、Sasaki Ken、Noda Masahiro、Kita Yoshiaki、Mori Shinichiro、Kurahara Hiroshi、Uenosono Yoshikazu、Ishigami Sumiya、Natsugoe Shoji
    • Journal Title

      Oncology

      Volume: 98 Issue: 9 Pages: 630-636

    • DOI

      10.1159/000507219

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Journal Article] Clinical Significance of Conversion Surgery for Gastric Cancer with Peritoneal Dissemination: A Retrospective Study2020

    • Author(s)
      Arigami Takaaki、Matsushita Daisuke、Okubo Keishi、Sasaki Ken、Noda Masahiro、Kita Yoshiaki、Mori Shinichiro、Kurahara Hiroshi、Yanagita Shigehiro、Uenosono Yoshikazu、Ishigami Sumiya、Ohtsuka Takao、Natsugoe Shoji
    • Journal Title

      Oncology

      Volume: 98 Issue: 11 Pages: 798-806

    • DOI

      10.1159/000509530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Journal Article] Recurrent gastric cancer sustaining a partial response after the nivolumab discontinuation because of immune-related adverse events: a case report2020

    • Author(s)
      Arigami Takaaki、Matsushita Daisuke、Okubo Keishi、Tanaka Takako、Sasaki Ken、Noda Masahiro、Kita Yoshiaki、Mori Shinichiro、Tsuruda Yusuke、Kurahara Hiroshi、Ohtsuka Takao
    • Journal Title

      Surgical Case Reports

      Volume: 6 Issue: 1 Pages: 271-271

    • DOI

      10.1186/s40792-020-01050-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Journal Article] Clinical application and outcomes of sentinel node navigation surgery in patients with early gastric cancer2017

    • Author(s)
      Arigami Takaaki、Uenosono Yoshikazu、Yanagita Shigehiro、Okubo Keishi、Kijima Takashi、Matsushita Daisuke、Amatatsu Masahiko、Hagihara Takahiko、Haraguchi Naoto、Mataki Yuko、Ehi Katsuhiko、Ishigami Sumiya、Natsugoe Shoji
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 43 Pages: 75607-75616

    • DOI

      10.18632/oncotarget.17584

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Journal Article] Clinical significance of circulating tumor cells in blood from patients with gastric cancer2017

    • Author(s)
      Arigami Takaaki、Uenosono Yoshikazu、Yanagita Shigehiro、Okubo Keishi、Kijima Takashi、Matsushita Daisuke、Amatatsu Masahiko、Kurahara Hiroshi、Maemura Kosei、Natsugoe Shoji
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 1 Issue: 1 Pages: 60-68

    • DOI

      10.1002/ags3.12005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Journal Article] 胃癌とリンパ節転移―リンパ行性微小転移の臨床的意義を中心に―2017

    • Author(s)
      有上貴明, 上之園芳一, 柳田茂寛, 松下大輔, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 下之薗将貴, 石神純也, 夏越祥次
    • Journal Title

      リンパ学

      Volume: 40 Pages: 113-116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Journal Article] A Novel Scoring System Based on Fibrinogen and the Neutrophil-Lymphocyte Ratio as a Predictor of Chemotherapy Response and Prognosis in Patients with Advanced Gastric Cancer2016

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Oncology

      Volume: 90 Issue: 4 Pages: 1977-84

    • DOI

      10.1159/000444494

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461955, KAKENHI-PROJECT-26462067, KAKENHI-PROJECT-15K10107, KAKENHI-PROJECT-16K10508
  • [Journal Article] Clinical Impact of Stomach-partitioning Gastrojejunostomy with Braun Enteroenterostomy for Patients with Gastric Outlet Obstruction Caused by Unresectable Gastric Cancer.2016

    • Author(s)
      Arigami T, Uenosono Y, Ishigami S, Yanagita S, Okubo K, Uchikado Y, Kita Y, Mori S, Kurahara H, Maemura K, Natsugoe S.
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 5431-5436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Journal Article] Clinical Significance of the Glasgow Prognostic Score in Patients with Gastrointestinal Stromal Tumors.2016

    • Author(s)
      Arigami T, Uenosono Y, Ishigami S, Yanagita S, Okubo K, Uchikado Y, Kita Y, Mori S, Kurahara H, Maemura K, Natsugoe S.
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 6687-6690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Journal Article] Sentinel node navigation surgery for gastroduodenal neuroendocrine tumors: Two case reports.2016

    • Author(s)
      Arigami T, Uenosono Y, Yanagita S, Okubo K, Kijima T, Matsushita D, Amatatsu M, Hagihara T, Haraguchi N, Mataki Y, Ehi K, Ishigami S, Natsugoe S.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95 Issue: 26 Pages: e4063-e4063

    • DOI

      10.1097/md.0000000000004063

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] 胃癌化学療法における栄養介入の適応とは?―治療効果とconversion surgeryの側面から―2022

    • Author(s)
      Takaaki Arigami, Daisuke Matsushita, Masataka Shimonosono, Yoshikazu Uenosono, Keishi Okubo, Shigehiro Yanagita, Ken Sasaki, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Takao Ohtsuka
    • Organizer
      第94回日本胃癌学会総会(ワークショップ)
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] The Current Status and Future Perspectives of Sentinel Node Navigation Surgery in Patients with Early Gastric Cancer2021

    • Author(s)
      Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Takako Tanaka, Ken Sasaki, Masahiro Noda, Yoshiaki Kita, Shinichiro Mori, Shigehiro Yanagita, Yoshikazu Uenosono, Takao Ohtsuka
    • Organizer
      第93回日本胃癌学会総会(ワークショップ)
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] 腹膜播種胃癌に対するConversion Surgeryの臨床的意義2021

    • Author(s)
      有上貴明, 松下大輔, 大久保啓史, 田中貴子, 佐々木健, 野田昌宏, 喜多芳昭, 盛真一郎, 大塚隆生
    • Organizer
      第17回日本消化管学会総会学術集会(ワークショップ)
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] 免疫チェックポイント分子B7-H3を用いた精度の高い胃癌腹膜播種診断法の開発2021

    • Author(s)
      有上貴明, 松下大輔, 大久保啓史, 佐々木健, 鶴田祐介, 下之薗将貴, 喜多芳昭, 盛真一郎, 大塚隆生
    • Organizer
      第45回日本リンパ学会総会(シンポジウム)
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] Prognostic Impact and Clinical Indications of Conversion Surgery after Trastuzumab-based Chemotherapy for HER2-positive Unresectable Gastric Cancer2021

    • Author(s)
      Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Masataka Shimonosono, Ken Sasaki, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Shigehiro Yanagita, Yoshikazu Uenosono, Takao Ohtsuka
    • Organizer
      第83回日本臨床外科学会総会 (ワークショップ)
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] Clinical significance of chemotherapy after nivolumab for advanced gastric cancer2020

    • Author(s)
      Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Yasuto Uchikado, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Masahiro Noda, Shoji Natsugoe
    • Organizer
      第92回日本胃癌学会総会
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] Clinical Significance of Surgery after Chemotherapy in Patients with Type 4 Gastric Cancer: A Retrospective Study2020

    • Author(s)
      Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Ken Sasaki, Masahiro Noda, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Shoji Natsugoe
    • Organizer
      第28回日本消化器関連学会週間 (JDDW)
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] 切除不能進行・再発胃癌に対するニボルマブ免疫療法を介した治療戦略2020

    • Author(s)
      Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Masahiro Noda, Takao Ohtsuka
    • Organizer
      第58回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] Stage IIIの切除可能進行胃癌に対する術前補助化学療法の臨床的意義:後方視的研究2020

    • Author(s)
      Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Ken Sasaki, Masahiro Noda, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Takao Ohtsuka
    • Organizer
      第82回日本臨床外科学会総会
    • Data Source
      KAKENHI-PROJECT-19K09200
  • [Presentation] Analysis of PD-L1 Expression and Neutrophil-Lymphocyte Ratio in Peripheral Blood of Gastric Cancer2018

    • Author(s)
      Takaaki Arigami, Masahiko Amatatsu, Shigehiro Yanagita, Daisuke Matsushita, Kosuke Kawagoe, Masataka Shimonosono, Keishi Okubo, Takashi Kijima, Yoshikazu Uenosono, Sumiya Ishigami, Shoji Natsugoe
    • Organizer
      第90回日本胃癌学会総会
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] 切除不能進行・再発胃癌における炎症と宿主免疫機能の関係:C-reactive proteinとNeutrophil-Lymphocyte Ratioの観点から2017

    • Author(s)
      有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 内門泰斗, 盛真一郎, 喜多芳昭, 柳田茂寛, 石神純也, 夏越祥次
    • Organizer
      第38回癌免疫外科研究会
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] 胃癌における免疫チェックポイント分子B7-H3およびB7-H4発現の臨床的意義と個別化治療への応用2017

    • Author(s)
      有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 柳田茂寛, 内門泰斗, 喜多芳昭, 尾本至, 佐々木健, 盛真一郎, 馬場研二, 石神純也, 夏越祥次
    • Organizer
      第50回制癌剤適応研究会
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] 胃癌における血小板数と血清Fibrinogenの臨床的意義:腫瘍進行度や予後の予測に有用な凝固系スコア―の検討2017

    • Author(s)
      有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 石神純也,柳田茂寛, 夏越祥次
    • Organizer
      第72回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] 胃癌に対する次世代の免疫療法ターゲットとしてのB7-H3およびB7-H4免疫チェックポイント分子―Liquid biopsyとしての血液検体を用いた個別化治療への応用―2017

    • Author(s)
      有上貴明, 上之園芳一, 柳田茂寛, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 松下大輔, 内門泰斗, 喜多芳昭, 尾本至, 佐々木健, 盛真一郎, 石神純也, 夏越祥次
    • Organizer
      第79回日本臨床外科学会総会
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] Gastrointestinal stromal tumor (GIST) に対する再発予測マーカーとしてのGlasgow Prognostic Scoreの臨床的意義―Fletcher分類との比較検討―2016

    • Author(s)
      有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 内門泰斗, 喜多芳昭, 盛真一郎, 柳田茂寛, 石神純也, 夏越祥次
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] 切除不能胃癌に対するNeutrophil-Lymphocyte RatioとPlatelet-Lymphocyte Ratioの意義2016

    • Author(s)
      有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 内門泰斗, 盛真一郎, 喜多芳昭,柳田茂寛, 石神純也, 夏越祥次
    • Organizer
      第54回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-16K10508
  • [Presentation] 胃癌に対するNeutrophil-Lymphocyte RatioとPlatelet-Lymphocyte Ratioの臨床的意義―炎症関連血液マーカーとしての有用性―2016

    • Author(s)
      有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 柳田茂寛, 内門泰斗, 喜多芳昭, 尾本至, 佐々木健, 盛真一郎, 馬場研二, 石神純也, 夏越祥次
    • Organizer
      第27回日本消化器癌発生学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島県鹿児島市)
    • Data Source
      KAKENHI-PROJECT-16K10508
  • 1.  NATSUGOE SHOJI (70237577)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 23 results
  • 2.  Arigami Takaaki (40527058)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 32 results
  • 3.  UENOSONO YOSHIKAZU (60398279)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 4.  石神 純也 (90325803)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  柳田 茂寛 (20444903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 6.  松下 大輔 (10724205)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 15 results
  • 7.  KITA Yoshiaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  盛 真一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi