OOKUBO Keishi 大久保啓史

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OKUBO Keishi 大久保啓史

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Researcher Number	40772223
Affiliation (Current)	2025: 鹿児島大学, 医歯学域鹿児島大学病院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2021: 鹿児島大学, 鹿児島大学病院, 医員 2016 – 2018: 鹿児島大学, 附属病院, 医員 2015: 鹿児島大学, 医学部・歯学部附属病院, 医員
Review Section/Research Field	Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / General surgery
Keywords	Except Principal Investigator 胃癌 / 免疫療法 / 免疫チェックポイント分子 / 免疫チェックポイント阻害剤 / T細胞性免疫応答 / Fibrinogen / 好中球リンパ球比 / 癌免疫機構 / リキッドバイオプシー / 免疫チェックポイント阻害薬 … More / 循環腫瘍細胞 / がん免疫療法 / Salvage chemotherapy / ニボルマブ / HHLA2 / PD-L1 / バイオマーカー / B7 ligand family / 免疫逃避機構 / infiltrating lymphocytes / CD3 / 免疫補助刺激分子 / 免疫応答 / 免疫回避機構 / 全身性炎症反応 Less

Development and clinical application of biomarkers for predicting response to immune therapy via targeting circulating tumor cells
- Principal Investigator
  
  ARIGAMI TAKAAKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kagoshima University
Functional analysis of immune checkpoint molecules and the new therapeutic development by targeting their regulation
- Principal Investigator
  
  Arigami Takaaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kagoshima University
The Elucidation of an Immune Escape Mechanism and its control in Gastrointestinal Cancers
- Principal Investigator
  
  Arigami Takaaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kagoshima University

All 2022 2021 2020 2018 2017 2016

All Journal Article Presentation Book

[Book] 臨床雑誌外科2022
- Author(s)
  有上貴明, 松下大輔，大久保啓史，下之薗将貴，鶴田祐介，佐々木健，中条哲浩，大塚隆生
- Total Pages
  5
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-19K09200
[Journal Article] Changes in Chemotherapeutic Strategies and Their Prognostic Impact in Patients With Advanced Gastric Cancer2022
- Author(s)
  Arigami T, Matsushita D, Okubo K, Tanaka T, Sasaki K, Tsuruda Y, Kita Y, Mori S, Kurahara H, Uenosono Y, Ohtsuka T
- Journal Title
  
  In Vivo
  
  Volume: 36 Issue: 1 Pages: 409-415
- DOI
  10.21873/invivo.12718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09200, KAKENHI-PROJECT-21K08783
[Journal Article] Prognostic Significance of HER2 Expression for Gastric Cancer With Clinically Para-aortic Lymph Node Metastasis2021
- Author(s)
  Arigami T, Matsushita D, Okubo K, Sasaki K, Tsuruda Y, Kita Y, Mori S, Yanagita S, Uenosono Y, Kurahara H, Ohtsuka T
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 6 Pages: 3099-3107
- DOI
  10.21873/anticanres.15094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09200, KAKENHI-PROJECT-21K08783
[Journal Article] Prognostic impact of surgery after chemotherapy for type 4 gastric cancer2021
- Author(s)
  Arigami T, Matsushita D, Okubo K, Sasaki K, Noda M, Kita Y, Mori S, Kurahara H, Yanagita S, Uenosono Y, Ishigami S, Ohtsuka T
- Journal Title
  
  Surgery Today
  
  Volume: 51 Issue: 11 Pages: 1851-1859
- DOI
  10.1007/s00595-021-02320-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09200, KAKENHI-PROJECT-21K08783
[Journal Article] Indication and Prognostic Significance of Conversion Surgery in Patients with Liver Metastasis from Gastric Cancer.2020
- Author(s)
  Arigami T, Matsushita D, Okubo K, Kawasaki Y, Iino S, Sasaki K, Noda M, Kita Y, Mori S, Kurahara H, Maemura K, Yanagita S, Uenosono Y, Ishigami S, Natsugoe S
- Journal Title
  
  Oncology
  
  Volume: 1 Issue: 5 Pages: 1-7
- DOI
  10.1159/000505555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08687, KAKENHI-PROJECT-19K09200
[Journal Article] 術前補助化学療法を施行したstage III進行胃癌におけるリンパ節転移の臨床的意義2020
- Author(s)
  有上貴明, 松下大輔, 大久保啓史, 田中貴子, 佐々木健, 野田昌宏, 喜多芳昭, 盛真一郎, 大塚隆生, 愛甲孝, 夏越祥次
- Journal Title
  
  リンパ学
  
  Volume: 43 Pages: 69-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09200
[Journal Article] Response Rate and Prognostic Impact of Salvage Chemotherapy after Nivolumab in Patients with Advanced Gastric Cancer2020
- Author(s)
  Arigami Takaaki、Matsushita Daisuke、Okubo Keishi、Yanagita Shigehiro、Ehi Katsuhiko、Sasaki Ken、Noda Masahiro、Kita Yoshiaki、Mori Shinichiro、Kurahara Hiroshi、Uenosono Yoshikazu、Ishigami Sumiya、Natsugoe Shoji
- Journal Title
  
  Oncology
  
  Volume: 98 Issue: 9 Pages: 630-636
- DOI
  10.1159/000507219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09200
[Journal Article] Clinical Significance of Conversion Surgery for Gastric Cancer with Peritoneal Dissemination: A Retrospective Study2020
- Author(s)
  Arigami Takaaki、Matsushita Daisuke、Okubo Keishi、Sasaki Ken、Noda Masahiro、Kita Yoshiaki、Mori Shinichiro、Kurahara Hiroshi、Yanagita Shigehiro、Uenosono Yoshikazu、Ishigami Sumiya、Ohtsuka Takao、Natsugoe Shoji
- Journal Title
  
  Oncology
  
  Volume: 98 Issue: 11 Pages: 798-806
- DOI
  10.1159/000509530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09200
[Journal Article] Recurrent gastric cancer sustaining a partial response after the nivolumab discontinuation because of immune-related adverse events: a case report2020
- Author(s)
  Arigami Takaaki、Matsushita Daisuke、Okubo Keishi、Tanaka Takako、Sasaki Ken、Noda Masahiro、Kita Yoshiaki、Mori Shinichiro、Tsuruda Yusuke、Kurahara Hiroshi、Ohtsuka Takao
- Journal Title
  
  Surgical Case Reports
  
  Volume: 6 Issue: 1 Pages: 271-271
- DOI
  10.1186/s40792-020-01050-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09200
[Journal Article] Clinical application and outcomes of sentinel node navigation surgery in patients with early gastric cancer2017
- Author(s)
  Arigami Takaaki、Uenosono Yoshikazu、Yanagita Shigehiro、Okubo Keishi、Kijima Takashi、Matsushita Daisuke、Amatatsu Masahiko、Hagihara Takahiko、Haraguchi Naoto、Mataki Yuko、Ehi Katsuhiko、Ishigami Sumiya、Natsugoe Shoji
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 43 Pages: 75607-75616
- DOI
  10.18632/oncotarget.17584
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10508
[Journal Article] Clinical significance of circulating tumor cells in blood from patients with gastric cancer2017
- Author(s)
  Arigami Takaaki、Uenosono Yoshikazu、Yanagita Shigehiro、Okubo Keishi、Kijima Takashi、Matsushita Daisuke、Amatatsu Masahiko、Kurahara Hiroshi、Maemura Kosei、Natsugoe Shoji
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 1 Issue: 1 Pages: 60-68
- DOI
  10.1002/ags3.12005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10508
[Journal Article] 胃癌とリンパ節転移―リンパ行性微小転移の臨床的意義を中心に―2017
- Author(s)
  有上貴明, 上之園芳一, 柳田茂寛, 松下大輔, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 下之薗将貴, 石神純也, 夏越祥次
- Journal Title
  
  リンパ学
  
  Volume: 40 Pages: 113-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10508
[Journal Article] A Novel Scoring System Based on Fibrinogen and the Neutrophil-Lymphocyte Ratio as a Predictor of Chemotherapy Response and Prognosis in Patients with Advanced Gastric Cancer2016
- Author(s)
  Takaaki Arigami
- Journal Title
  
  Oncology
  
  Volume: 90 Issue: 4 Pages: 1977-84
- DOI
  10.1159/000444494
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461955, KAKENHI-PROJECT-26462067, KAKENHI-PROJECT-15K10107, KAKENHI-PROJECT-16K10508
[Journal Article] Clinical Impact of Stomach-partitioning Gastrojejunostomy with Braun Enteroenterostomy for Patients with Gastric Outlet Obstruction Caused by Unresectable Gastric Cancer.2016
- Author(s)
  Arigami T, Uenosono Y, Ishigami S, Yanagita S, Okubo K, Uchikado Y, Kita Y, Mori S, Kurahara H, Maemura K, Natsugoe S.
- Journal Title
  
  Anticancer Research
  
  Volume: 36 Pages: 5431-5436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10508
[Journal Article] Clinical Significance of the Glasgow Prognostic Score in Patients with Gastrointestinal Stromal Tumors.2016
- Author(s)
  Arigami T, Uenosono Y, Ishigami S, Yanagita S, Okubo K, Uchikado Y, Kita Y, Mori S, Kurahara H, Maemura K, Natsugoe S.
- Journal Title
  
  Anticancer Research
  
  Volume: 36 Pages: 6687-6690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10508
[Journal Article] Sentinel node navigation surgery for gastroduodenal neuroendocrine tumors: Two case reports.2016
- Author(s)
  Arigami T, Uenosono Y, Yanagita S, Okubo K, Kijima T, Matsushita D, Amatatsu M, Hagihara T, Haraguchi N, Mataki Y, Ehi K, Ishigami S, Natsugoe S.
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 95 Issue: 26 Pages: e4063-e4063
- DOI
  10.1097/md.0000000000004063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] 胃癌化学療法における栄養介入の適応とは？―治療効果とconversion surgeryの側面から―2022
- Author(s)
  Takaaki Arigami, Daisuke Matsushita, Masataka Shimonosono, Yoshikazu Uenosono, Keishi Okubo, Shigehiro Yanagita, Ken Sasaki, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Takao Ohtsuka
- Organizer
  第94回日本胃癌学会総会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] The Current Status and Future Perspectives of Sentinel Node Navigation Surgery in Patients with Early Gastric Cancer2021
- Author(s)
  Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Takako Tanaka, Ken Sasaki, Masahiro Noda, Yoshiaki Kita, Shinichiro Mori, Shigehiro Yanagita, Yoshikazu Uenosono, Takao Ohtsuka
- Organizer
  第93回日本胃癌学会総会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] 腹膜播種胃癌に対するConversion Surgeryの臨床的意義2021
- Author(s)
  有上貴明, 松下大輔, 大久保啓史, 田中貴子, 佐々木健, 野田昌宏, 喜多芳昭, 盛真一郎, 大塚隆生
- Organizer
  第17回日本消化管学会総会学術集会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] 免疫チェックポイント分子B7-H3を用いた精度の高い胃癌腹膜播種診断法の開発2021
- Author(s)
  有上貴明, 松下大輔, 大久保啓史, 佐々木健, 鶴田祐介, 下之薗将貴, 喜多芳昭, 盛真一郎, 大塚隆生
- Organizer
  第45回日本リンパ学会総会（シンポジウム）
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] Prognostic Impact and Clinical Indications of Conversion Surgery after Trastuzumab-based Chemotherapy for HER2-positive Unresectable Gastric Cancer2021
- Author(s)
  Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Masataka Shimonosono, Ken Sasaki, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Shigehiro Yanagita, Yoshikazu Uenosono, Takao Ohtsuka
- Organizer
  第83回日本臨床外科学会総会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] Clinical significance of chemotherapy after nivolumab for advanced gastric cancer2020
- Author(s)
  Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Yasuto Uchikado, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Masahiro Noda, Shoji Natsugoe
- Organizer
  第92回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] Clinical Significance of Surgery after Chemotherapy in Patients with Type 4 Gastric Cancer: A Retrospective Study2020
- Author(s)
  Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Ken Sasaki, Masahiro Noda, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Shoji Natsugoe
- Organizer
  第28回日本消化器関連学会週間 (JDDW)
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] 切除不能進行・再発胃癌に対するニボルマブ免疫療法を介した治療戦略2020
- Author(s)
  Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Masahiro Noda, Takao Ohtsuka
- Organizer
  第58回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] Stage IIIの切除可能進行胃癌に対する術前補助化学療法の臨床的意義：後方視的研究2020
- Author(s)
  Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Ken Sasaki, Masahiro Noda, Yusuke Tsuruda, Yoshiaki Kita, Shinichiro Mori, Takao Ohtsuka
- Organizer
  第82回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-19K09200
[Presentation] Analysis of PD-L1 Expression and Neutrophil-Lymphocyte Ratio in Peripheral Blood of Gastric Cancer2018
- Author(s)
  Takaaki Arigami, Masahiko Amatatsu, Shigehiro Yanagita, Daisuke Matsushita, Kosuke Kawagoe, Masataka Shimonosono, Keishi Okubo, Takashi Kijima, Yoshikazu Uenosono, Sumiya Ishigami, Shoji Natsugoe
- Organizer
  第90回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] 切除不能進行・再発胃癌における炎症と宿主免疫機能の関係：C-reactive proteinとNeutrophil-Lymphocyte Ratioの観点から2017
- Author(s)
  有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 内門泰斗, 盛真一郎, 喜多芳昭, 柳田茂寛, 石神純也, 夏越祥次
- Organizer
  第38回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] 胃癌における免疫チェックポイント分子B7-H3およびB7-H4発現の臨床的意義と個別化治療への応用2017
- Author(s)
  有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 柳田茂寛, 内門泰斗, 喜多芳昭, 尾本至, 佐々木健, 盛真一郎, 馬場研二, 石神純也, 夏越祥次
- Organizer
  第50回制癌剤適応研究会
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] 胃癌における血小板数と血清Fibrinogenの臨床的意義：腫瘍進行度や予後の予測に有用な凝固系スコア―の検討2017
- Author(s)
  有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 石神純也,柳田茂寛, 夏越祥次
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] 胃癌に対する次世代の免疫療法ターゲットとしてのB7-H3およびB7-H4免疫チェックポイント分子―Liquid biopsyとしての血液検体を用いた個別化治療への応用―2017
- Author(s)
  有上貴明, 上之園芳一, 柳田茂寛, 大久保啓史, 貴島孝, 天辰仁彦, 川越浩輔, 松下大輔, 内門泰斗, 喜多芳昭, 尾本至, 佐々木健, 盛真一郎, 石神純也, 夏越祥次
- Organizer
  第79回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] Gastrointestinal stromal tumor (GIST) に対する再発予測マーカーとしてのGlasgow Prognostic Scoreの臨床的意義―Fletcher分類との比較検討―2016
- Author(s)
  有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 内門泰斗, 喜多芳昭, 盛真一郎, 柳田茂寛, 石神純也, 夏越祥次
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] 切除不能胃癌に対するNeutrophil-Lymphocyte RatioとPlatelet-Lymphocyte Ratioの意義2016
- Author(s)
  有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 内門泰斗, 盛真一郎, 喜多芳昭,柳田茂寛, 石神純也, 夏越祥次
- Organizer
  第54回日本癌治療学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-16K10508
[Presentation] 胃癌に対するNeutrophil-Lymphocyte RatioとPlatelet-Lymphocyte Ratioの臨床的意義―炎症関連血液マーカーとしての有用性―2016
- Author(s)
  有上貴明, 上之園芳一, 大久保啓史, 貴島孝, 天辰仁彦, 柳田茂寛, 内門泰斗, 喜多芳昭, 尾本至, 佐々木健, 盛真一郎, 馬場研二, 石神純也, 夏越祥次
- Organizer
  第27回日本消化器癌発生学会総会
- Place of Presentation
  城山観光ホテル（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-16K10508

1. NATSUGOE SHOJI (70237577)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. Arigami Takaaki (40527058)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
3. UENOSONO YOSHIKAZU (60398279)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
4. 石神純也 (90325803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 柳田茂寛 (20444903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 松下大輔 (10724205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
7. KITA Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 盛真一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OOKUBO Keishi 大久保 啓史

OKUBO Keishi 大久保 啓史

Research Projects

Research Products

Co-Researchers

Development and clinical application of biomarkers for predicting response to immune therapy via targeting circulating tumor cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of immune checkpoint molecules and the new therapeutic development by targeting their regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Elucidation of an Immune Escape Mechanism and its control in Gastrointestinal Cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 臨床雑誌外科2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Changes in Chemotherapeutic Strategies and Their Prognostic Impact in Patients With Advanced Gastric Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic Significance of HER2 Expression for Gastric Cancer With Clinically Para-aortic Lymph Node Metastasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic impact of surgery after chemotherapy for type 4 gastric cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Indication and Prognostic Significance of Conversion Surgery in Patients with Liver Metastasis from Gastric Cancer.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 術前補助化学療法を施行したstage III進行胃癌におけるリンパ節転移の臨床的意義2020

Author(s)

Journal Title

Data Source

[Journal Article] Response Rate and Prognostic Impact of Salvage Chemotherapy after Nivolumab in Patients with Advanced Gastric Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Significance of Conversion Surgery for Gastric Cancer with Peritoneal Dissemination: A Retrospective Study2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recurrent gastric cancer sustaining a partial response after the nivolumab discontinuation because of immune-related adverse events: a case report2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical application and outcomes of sentinel node navigation surgery in patients with early gastric cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of circulating tumor cells in blood from patients with gastric cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 胃癌とリンパ節転移―リンパ行性微小転移の臨床的意義を中心に―2017

Author(s)

Journal Title

OOKUBO Keishi 大久保啓史

OKUBO Keishi 大久保啓史