Handa Tetsuya 半田哲也

Researcher Number	40772570
Other IDs	https://orcid.org/0000-0001-7707-0195
Affiliation (based on the past Project Information) *help	2017 – 2020: 東京工業大学, 科学技術創成研究院, 特任助教
Review Section/Research Field	Principal Investigator Molecular biology
Keywords	Principal Investigator CRISPR/Cas / エピゲノム操作 / RNA Polymerase 2 / エピゲノム編集 / CRISPR/Cas9 / 生細胞イメージング / クロマチン / ヒストン修飾 / 遺伝子発現制御 / エピジェネティクス

Kinetic analysis of gene expression regulation using visualization and epigenomic manipulation of specific genomic regionsPrincipal Investigator
- Principal Investigator
  
  Handa Tetsuya
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo Institute of Technology

All 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 実験医学別冊 - エピゲノムをもっと見るためのクロマチン解析実践プロトコール (分担執筆)2020
- Author(s)
  半田哲也
- Total Pages
  270
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17K17719
[Book] 遺伝子医学通巻31号 (復刊6号) 「ヒストン修飾解析の最前線」2020
- Author(s)
  半田哲也、木村宏
- Publisher
  (株)メディカルドゥ
- Data Source
  KAKENHI-PROJECT-17K17719
[Journal Article] Visualizing transcription sites in living cells using a genetically encoded probe specific for the elongating form of RNA polymerase II2021
- Author(s)
  Uchino Satoshi、Ito Yuma、Sato Yuko、Handa Tetsuya、Ohkawa Yasuyuki、Tokunaga Makio、Kimura Hitoshi
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 441582-441582
- DOI
  10.1101/2021.04.27.441582
- Open Access
- Data Source
  KAKENHI-PROJECT-20K06484, KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-17H01417, KAKENHI-PROJECT-19H03192, KAKENHI-PROJECT-17K17719, KAKENHI-PROJECT-17KK0143
[Journal Article] H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing2021
- Author(s)
  Tjalsma Sjoerd J D、Hori Mayako、Sato Yuko、Bousard Aurelie、Ohi Akito、Raposo Ana Claudia、Roensch Julia、Le Saux Agnes、Nogami Jumpei、Maehara Kazumitsu、Kujirai Tomoya、Handa Tetsuya、Bages‐Arnal Sandra、Ohkawa Yasuyuki、Kurumizaka Hitoshi、da Rocha Simao Teixeira、Zylicz Jan J、Kimura Hiroshi、Heard Edith
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 3
- DOI
  10.15252/embr.202051989
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06484, KAKENHI-PLANNED-18H05527, KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-19H04970, KAKENHI-PUBLICLY-20H05393, KAKENHI-PROJECT-17H01417, KAKENHI-PROJECT-19H03158, KAKENHI-PROJECT-17K17719, KAKENHI-PROJECT-17KK0143
[Journal Article] Euchromatin factors HULC and Set1C affect heterochromatin organization for mating-type switching in fission yeast Schizosaccharomyces pombe2021
- Author(s)
  Chavez Alfredo Esquivel、Maki Takahisa、Tsubouchi Hideo、Handa Testuya、Kimura Hiroshi、Haber James E.、Thon Genevieve、Iwasaki Hiroshi
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2021.03.23.436714
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17719
[Journal Article] Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input.2020
- Author(s)
  Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura.
- Journal Title
  
  Nat Protoc.
  
  Volume: 15 Issue: 10 Pages: 3334-3360
- DOI
  10.1038/s41596-020-0375-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21398, KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-19H04970, KAKENHI-PUBLICLY-19H05244, KAKENHI-PUBLICLY-19H05425, KAKENHI-PUBLICLY-20H04846, KAKENHI-PUBLICLY-20H05368, KAKENHI-PUBLICLY-20H05393, KAKENHI-PROJECT-17H01417, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03158, KAKENHI-PROJECT-19H03211, KAKENHI-PROJECT-17K17719, KAKENHI-PROJECT-19H03424
[Journal Article] Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene2020
- Author(s)
  Forero-Quintero Linda S.、Raymond William、Handa Tetsuya、Saxton Matthew、Morisaki Tatsuya、Kimura Hiroshi、Bertrand Edouard、Munsky Brian、Stasevich Timothy J.
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 024414-024414
- DOI
  10.1101/2020.04.03.024414
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-17K17719
[Journal Article] Modeling population size independent tissue epigenomes by ChIL-seq with single-thin sections2020
- Author(s)
  Maehara Kazumitsu、Tomimatsu Kosuke、Harada Akihito、Tanaka Kaori、Sato Shoko、Okada Seiji、Handa Tetsuya、Kurumizaka Hitoshi、Kimura Hiroshi、Ohkawa Yasuyuki
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 423434-423434
- DOI
  10.1101/2020.12.18.423434
- Open Access
- Data Source
  KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-17K17719
[Journal Article] Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging2019
- Author(s)
  Kazuo Yamagata, Kouhei Nagai, Hiroshi Miyamoto, ...., Tetsuya Handa (17番目), Hiroshi Kimura, Yoshihiko Hosoi, Tasuku Mitani, Kazuya Matsumoto, Akira Iritani
- Journal Title
  
  Scientific Reports
  
  Volume: 9 巻 Issue: 1 Pages: 4050-4050
- DOI
  10.1038/s41598-019-40546-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17719, KAKENHI-PLANNED-18H05527, KAKENHI-PROJECT-18H02357, KAKENHI-PROJECT-18K05693, KAKENHI-PROJECT-18K06021, KAKENHI-PLANNED-18H05528, KAKENHI-PROJECT-17H05045
[Journal Article] Detailed protocol ─ Chromatin Integration labeling2019
- Author(s)
  Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Yasuyuki Ohkawa, Hiroshi Kimura
- Journal Title
  
  Protocol Exchange
  
  Volume: 122 Pages: 122-122
- DOI
  10.1038/protex.2018.122
- Data Source
  KAKENHI-PROJECT-17K17719
[Journal Article] A chromatin integration labelling method enables epigenomic profiling with lower input2018
- Author(s)
  Harada Akihito、Maehara Kazumitsu、Handa Tetsuya、Arimura Yasuhiro、Nogami Jumpei、Hayashi-Takanaka Yoko、Shirahige Katsuhiko、Kurumizaka Hitoshi、Kimura Hiroshi、Ohkawa Yasuyuki
- Journal Title
  
  Nature Cell Biology
  
  Volume: 21 Issue: 2 Pages: 287-296
- DOI
  10.1038/s41556-018-0248-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19432, KAKENHI-PROJECT-17K17719, KAKENHI-INTERNATIONAL-15K21761, KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05976, KAKENHI-PUBLICLY-18H04802, KAKENHI-PUBLICLY-18H04904, KAKENHI-PLANNED-18H05527, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-17H01417, KAKENHI-PROJECT-17H03608, KAKENHI-PROJECT-17K19356
[Journal Article] Shelterin promotes tethering of late replication origins to telomeres for replication‐timing control2018
- Author(s)
  Ogawa Shiho、Kido Sayuri、Handa Tetsuya、Ogawa Hidesato、Asakawa Haruhiko、Takahashi Tatsuro S、Nakagawa Takuro、Hiraoka Yasushi、Masukata Hisao
- Journal Title
  
  The EMBO Journal
  
  Volume: 37 Issue: 15 Pages: 15-15
- DOI
  10.15252/embj.201898997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07285, KAKENHI-PROJECT-17K17719, KAKENHI-PUBLICLY-18H04716, KAKENHI-PLANNED-18H05533, KAKENHI-PROJECT-17H01444, KAKENHI-PROJECT-17H01876, KAKENHI-PROJECT-15K14450, KAKENHI-PROJECT-18K06060
[Journal Article] Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase2017
- Author(s)
  Yamazaki Taiga、Hatano Yu、Handa Tetsuya、Kato Sakiko、Hoida Kensuke、Yamamura Rui、Fukuyama Takashi、Uematsu Takayuki、Kobayashi Noritada、Kimura Hiroshi、Yamagata Kazuo
- Journal Title
  
  PLoS ONE
  
  Volume: 12 Issue: 5 Pages: 1-18
- DOI
  10.1371/journal.pone.0177764
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09585, KAKENHI-PROJECT-17K16578, KAKENHI-PROJECT-17K17719, KAKENHI-PLANNED-25116005, KAKENHI-PROJECT-15K14924
[Presentation] 特定ゲノム領域の生細胞イメージングとエピゲノム操作による遺伝子発現制御2019
- Author(s)
  半田哲也、木村宏
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K17719
[Presentation] Multi-ChIL法による少数細胞の複数エピゲノムの同時解析2019
- Author(s)
  半田哲也、原田哲仁、前原一満、大川恭行、木村宏
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K17719
[Presentation] A chromatin integration labeling method enables epigenomic profiling with lower input2018
- Author(s)
  Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Yasuhiro Arimura, Jumpei Nogami, Yoko Hayashi-Takanaka, Katsuhiko Shirahige, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura
- Organizer
  3R&3C Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17719
[Presentation] Chromatin integration labeling technology enables low-input epigenomic profiling2018
- Author(s)
  Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Yasuhiro Arimura, Jumpei Nogami, Yoko Hayashi-Takanaka, Katsuhiko Shirahige, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura
- Organizer
  2018 Cold Spring Harbor meeting: Nuclear Organization & Function
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17719
[Presentation] 特定ゲノム領域の生細胞イメージングとエピゲノム操作による遺伝子発現制御2018
- Author(s)
  半田　哲也
- Organizer
  日本ゲノム編集学会第3回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K17719
[Presentation] Dynamics of Histone Modifications and RNA Polymerase II in Heat Shock Response2017
- Author(s)
  Tetsuya Handa, Hiroshi Kimura
- Organizer
  EMBO Conference: Chromatin and Epigenetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17719
[Presentation] 熱ショック応答におけるヒストン修飾とRNA Polymerase 2 の動態解析2017
- Author(s)
  半田哲也、木村宏
- Organizer
  第２回クロマチン動構造ワークショップ
- Data Source
  KAKENHI-PROJECT-17K17719
[Presentation] 熱ショック応答におけるヒストン修飾とRNA Polymerase 2 の動態解析2017
- Author(s)
  半田哲也、木村宏
- Organizer
  第11回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K17719

1. OHKAWA Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. OGAWA Hidesato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. ITO YUMA

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 佐藤優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 植松崇之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 原田哲仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 木村宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Handa Tetsuya 半田 哲也

Research Projects

Research Products

Co-Researchers

Kinetic analysis of gene expression regulation using visualization and epigenomic manipulation of specific genomic regionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学別冊 - エピゲノムをもっと見るための クロマチン解析実践プロトコール (分担執筆)2020

Author(s)

Total Pages

Publisher

Data Source

[Book] 遺伝子医学 通巻31号 (復刊6号) 「ヒストン修飾解析の最前線」2020

Author(s)

Publisher

Data Source

[Journal Article] Visualizing transcription sites in living cells using a genetically encoded probe specific for the elongating form of RNA polymerase II2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Euchromatin factors HULC and Set1C affect heterochromatin organization for mating-type switching in fission yeast Schizosaccharomyces pombe2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modeling population size independent tissue epigenomes by ChIL-seq with single-thin sections2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detailed protocol ─ Chromatin Integration labeling2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A chromatin integration labelling method enables epigenomic profiling with lower input2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Shelterin promotes tethering of late replication origins to telomeres for replication‐timing control2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 特定ゲノム領域の生細胞イメージングとエピゲノム操作による遺伝子発現制御2019

Author(s)

Organizer

Data Source

[Presentation] Multi-ChIL法による少数細胞の複数エピゲノムの同時解析2019

Author(s)

Handa Tetsuya 半田哲也

[Book] 実験医学別冊 - エピゲノムをもっと見るためのクロマチン解析実践プロトコール (分担執筆)2020

[Book] 遺伝子医学通巻31号 (復刊6号) 「ヒストン修飾解析の最前線」2020