Ayano Masahiro 綾野雅宏

… Alternative Names

綾野雅宏アヤノマサヒロ

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Researcher Number	40773677
Other IDs
Affiliation (Current)	2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2023: 九州大学, 大学病院, 助教 2016 – 2021: 九州大学, 医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology
Keywords	Principal Investigator 全身性エリテマトーデス / 倦怠感 / 膠原病 / バイオマーカー / B細胞 / ループス腎炎 / CD226 / 免疫学 / 膠原病学 / エフェクター細胞 … More / T細胞 / CD8 / 強皮症 / CD8陽性T細胞 / 全身性強皮症 / ホスファチジルセリン / アポトーシス / CD300a Less

寛解期膠原病患者に残存する倦怠感の要因解明と治療戦略の確立Principal Investigator
- Principal Investigator
  
  綾野雅宏
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kyushu University
Roles of CD226 in the pathogenesis of systemic lupus erythematosusPrincipal Investigator
- Principal Investigator
  
  Masahiro Ayano
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyushu University
Roles of CD300a in the pathogenesis of systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  Ayano Masahiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells2022
- Author(s)
  Kawano Shotaro、Mitoma Hiroki、Inokuchi Shoichiro、Yamauchi Yusuke、Yokoyama Kana、Nogami Jumpei、Semba Yuichiro、Ayano Masahiro、Kimoto Yasutaka、Akahoshi Mitsuteru、Ono Nobuyuki、Arinobu Yojiro、Akashi Koichi、Horiuchi Takahiko、Niiro Hiroaki
- Journal Title
  
  The Journal of Immunology
  
  Volume: 208 Issue: 5 Pages: 1057-1065
- DOI
  10.4049/jimmunol.2100323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-21K08460
[Journal Article] Increased proportion of CD226+ B Cells is associated with the disease activitiy and prognosis of systemic lupus erythematosus.2021
- Author(s)
  61.Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, Mitoma H, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Front Immunol
  
  Volume: 12 Pages: 713225-713225
- DOI
  10.3389/fimmu.2021.713225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-21K08460
[Journal Article] Hydroxychloroquine versus tacrolimus for the treatment of persistently active systemic lupus erythematosus2021
- Author(s)
  Ayano Masahiro、Kimoto Yasutaka、Mitoma Hiroki、Akahoshi Mitsuteru、Ono Nobuyuki、Arinobu Yojiro、Akashi Koichi、Horiuchi Takahiko、Niiro Hiroaki
- Journal Title
  
  Modern Rheumatology
  
  Volume: 32 Issue: 2 Pages: 345-350
- DOI
  10.1093/mr/roab010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17887
[Journal Article] HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: retrospective study.2021
- Author(s)
  64.Kushimoto K, Ayano M, Nishimura K, Nakano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 23 Issue: 1 Pages: 238-238
- DOI
  10.1186/s13075-021-02618-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-21K08460
[Journal Article] Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus2021
- Author(s)
  Nakano Miki、Ayano Masahiro、Kushimoto Kazuo、Kawano Shotaro、Higashioka Kazuhiko、Inokuchi Shoichiro、Mitoma Hiroki、Kimoto Yasutaka、Akahoshi Mitsuteru、Ono Nobuyuki、Arinobu Yojiro、Akashi Koichi、Horiuchi Takahiko、Niiro Hiroaki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-95711-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17887
[Journal Article] Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus2021
- Author(s)
  Inokuchi S, Mitoma H, Kawano S, Ayano M, Kimoto Y, Akahoshi M, Arinobu Y, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Clin Exp Rheumatol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17887
[Journal Article] Predictive factors of fetal and maternal pregnancy outcomes in Japanese patients with systemic lupus erythematosus.2021
- Author(s)
  Irino K, Arinobu Y, Ayano M, Kawano S, Kimoto Y, Mitoma H, Akahoshi M, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Lupus
  
  Volume: 30 Issue: 10 Pages: 1637-1643
- DOI
  10.1177/09612033211031989
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887
[Journal Article] Human PD-1 hi CD8 + T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis2021
- Author(s)
  Higashioka K, Yoshimura M, Sakuragi T, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Horiuchi T, Akashi K, Niiro H.
- Journal Title
  
  Front Immunol.
  
  Volume: 12 Pages: 654623-654623
- DOI
  10.3389/fimmu.2021.654623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-21K08460
[Journal Article] Type 1 helper T cells generate CXCL9/10-producing T-bet + effector B cells potentially involved in the pathogenesis of rheumatoid arthritis2021
- Author(s)
  Nakayama T, Yoshimura M, Higashioka K, Miyawaki K, Ota Y, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Cell Immunol.
  
  Volume: 360 Pages: 104263-104263
- DOI
  10.1016/j.cellimm.2020.104263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-18K08410
[Journal Article] Generation of a novel CD30 + B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis2020
- Author(s)
  Higashioka K, Kikushige Y, Ayano M, Kimoto Y, Mitoma H, Kikukawa M, Akahoshi M, Arinobu Y, Horiuchi T, Akashi K, Niiro H.
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: 201 Issue: 3 Pages: 233-243
- DOI
  10.1111/cei.13477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-19H03564
[Journal Article] Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells.2020
- Author(s)
  Inokuchi S, Mitoma H, Kawano S, et. al.
- Journal Title
  
  J Immunol.
  
  Volume: 204 Issue: 8 Pages: 2088-2097
- DOI
  10.4049/jimmunol.1901304
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-19H03564
[Journal Article] Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents2020
- Author(s)
  Wang Q, Oryoji D, Mitoma H, Kimoto Y, Koyanagi M, Yokoyama K, Ayano M, Akahoshi M, Arinobu Y, Niiro H, Akashi K, Horiuchi T.
- Journal Title
  
  Front Immunol.
  
  Volume: 14 Pages: 2042-2042
- DOI
  10.3389/fimmu.2020.02042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-19H03564
[Journal Article] Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease.2020
- Author(s)
  Higashioka K, Ota Y, Maehara T, et. al.
- Journal Title
  
  BMC Immunol.
  
  Volume: 21 Issue: 1 Pages: 31-31
- DOI
  10.1186/s12865-020-00361-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-18K08410
[Journal Article] Shoulder ultrasound and serum lactate dehydrogenase predict inadequate response to glucocorticoid treatment in patients with polymyalgia rheumatica.2020
- Author(s)
  Ayano M, Arinobu Y, Tsukamoto H, Ota SI, Misaki K, Nishimura K, Kimoto Y, Mitoma H, Akahoshi M, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Rheumatology International
  
  Volume: - Issue: 7 Pages: 1101-1109
- DOI
  10.1007/s00296-020-04512-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19599, KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-19H03564
[Journal Article] CD34-selected versus unmanipulated autologous hematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: a post hoc analysis of a phase I/II clinical trial conducted in Japan.2019
- Author(s)
  Ayano M, Tsukamoto H, Mitoma H, Kimoto Y, Akahoshi M, Arinobu Y, Miyamoto T, Horiuchi T, Niiro H, Nagafuji K, Harada M, Akashi K
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 21 Issue: 1 Pages: 30-30
- DOI
  10.1186/s13075-019-1823-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09897, KAKENHI-PROJECT-16K09898, KAKENHI-PROJECT-16K19603, KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-19H03564
[Journal Article] CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines2019
- Author(s)
  Takaki-Kuwahara Ayako、Arinobu Yojiro、Miyawaki Kohta、Yamada Hisakata、Tsuzuki Hirofumi、Irino Kensuke、Ayano Masahiro、Kimoto Yasutaka、Mitoma Hiroki、Akahoshi Mitsuteru、Tsukamoto Hiroshi、Horiuchi Takahiko、Niiro Hiroaki、Akashi Koichi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 21 Issue: 1 Pages: 198-198
- DOI
  10.1186/s13075-019-1984-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-19H03564
[Journal Article] Long-term efficacy of infliximab treatment and the predictors of treatment outcomes in patients with refractory uveitis associated with Behcet’s disease.2018
- Author(s)
  (1)Ueda S, Akahoshi M, Takeda A, Inoue Y, Omoto A, Ayano M, Kimoto Y, Mitoma H, Arinobu Y, Niiro H, Tsukamoto H, Horiuchi T, Hikita SI, Fukuhara T, Ishibashi T, Sonoda KH, Akashi K
- Journal Title
  
  Eur J Rheumatol
  
  Volume: 5 Issue: 1 Pages: 9-15
- DOI
  10.5152/eurjrheum.2017.17068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-16K19603, KAKENHI-PROJECT-15K10896, KAKENHI-PROJECT-18K09471
[Journal Article] Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study2018
- Author(s)
  (2)Otsuka Y, Kiyohara C, Kashiwado Y, Sawabe T, Nagano S, Kimoto Y, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Niiro H, Akashi K, Horiuchi T
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 4 Pages: e0196368-e0196368
- DOI
  10.1371/journal.pone.0196368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-16K09897, KAKENHI-PROJECT-16K19603
[Presentation] 全身性エリテマトーデスに対するアニフロルマブの有用性：バイオナイーブ症例とスイッチ症例の比較検討2023
- Author(s)
  綾野雅宏, 上田尚靖, 三嶋耕司, 大田俊一郎, 久志本和郎, 田中淳, 都留智巳, 洲崎みどり, 前川真貴子, 木本泰孝, 小野伸之, 有信洋二郎, 新納宏昭
- Organizer
  第67回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K06868
[Presentation] 全身性エリテマトーデス診療における患者全般評価の臨床的意義：多施設データを用いた検討2023
- Author(s)
  綾野雅宏, 三嶋耕司, 上田尚靖, 田中淳, 大田俊一郎, 久志本和郎, 都留智巳, 洲崎みどり, 西村直矢, 河野正太郎, 中山剛志, 大本史, 前川真貴子, 柏戸佑介, 赤星光輝, 新納宏昭
- Organizer
  第66回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-23K06868
[Presentation] 膠原病に伴う間質性肺疾患に対するニンテダニブの有用性の検討：開始量による比較2023
- Author(s)
  綾野雅宏, 福元遼, 三苫弘喜, 木本泰孝, 小野伸之, 有信洋二郎, 堀内孝彦, 新納宏昭
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K06868
[Presentation] 全身性エリテマトーデスにおける血清補体蛋白の経時的変化2023
- Author(s)
  綾野雅宏, 木本泰孝, 三苫弘喜, 小野伸之, 有信洋二郎, 堀内孝彦, 新納宏昭
- Organizer
  第59回日本補体学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06868
[Presentation] 全身性エリテマトーデス患者における血清可溶型CD226濃度の臨床的意義2019
- Author(s)
  中野未来、綾野雅宏、久志本和郎、河野正太郎、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17887
[Presentation] 全身性強皮症に対する自家造血幹細胞移植の長期成績2019
- Author(s)
  綾野雅宏、三苫弘喜、塚本浩、柏戸佑介、木本泰孝、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17887
[Presentation] 全身性エリテマトーデスに対するヒドロキシクロロキンのステロイド減量効果：タクロリムスとの比較検討2019
- Author(s)
  綾野雅宏、赤星光輝、木本泰孝、三苫弘喜、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17887
[Presentation] ループス腎炎に対するタクロリムスの長期使用成績：10年間の検討2018
- Author(s)
  綾野雅宏、中野未来、河野正太郎、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K19603
[Presentation] 全身性エリテマトーデス患者の長期予後に関する検討2018
- Author(s)
  綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第56回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-16K19603
[Presentation] 全身性強皮症に対する自家造血幹細胞移植の長期成績2018
- Author(s)
  綾野雅宏、三苫弘喜、塚本浩、柏戸佑介、木本泰孝、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第56回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-16K19603

1. ARINOBU Yojiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. NIIRO Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 西村啓佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ayano Masahiro 綾野 雅宏

綾野 雅宏 アヤノ マサヒロ

Research Projects

Research Products

Co-Researchers

寛解期膠原病患者に残存する倦怠感の要因解明と治療戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of CD226 in the pathogenesis of systemic lupus erythematosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of CD300a in the pathogenesis of systemic sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased proportion of CD226+ B Cells is associated with the disease activitiy and prognosis of systemic lupus erythematosus.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydroxychloroquine versus tacrolimus for the treatment of persistently active systemic lupus erythematosus2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: retrospective study.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus2021

Author(s)

Journal Title

Data Source

[Journal Article] Predictive factors of fetal and maternal pregnancy outcomes in Japanese patients with systemic lupus erythematosus.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human PD-1 hi CD8 + T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Type 1 helper T cells generate CXCL9/10-producing T-bet + effector B cells potentially involved in the pathogenesis of rheumatoid arthritis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of a novel CD30 + B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents2020

Author(s)

Journal Title

Ayano Masahiro 綾野雅宏

綾野雅宏アヤノマサヒロ