Yamashita Kazuya 山下和哉

Researcher Number	40774518
Affiliation (based on the past Project Information) *help	2018 – 2020: 大阪大学, 医学系研究科, 招へい教員 2016 – 2017: 大阪大学, 医学部附属病院, 医員 2015: 大阪大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related Except Principal Investigator Neurology
Keywords	Principal Investigator NMO / インフラマソーム / 自然免疫 / NMOSD / ミトコンドリアDNA Except Principal Investigator 高次脳機能障害 / NMOSD / バイオマーカー / NMO / 多発性硬化症 / アストロサイト / 酢酸 / PET

Pathogenic role of mitochondrial DNA in neuromyelitis optica spectrum disorderPrincipal Investigator
- Principal Investigator
  
  Yamashita Kazuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Establishment of personalized medicine for NMO utilizing 11C-acetate PET
- Principal Investigator
  
  Nakatsuji Yuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Toyama
  Osaka University

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation2020
- Author(s)
  Mikito Shimizu, Tatsusada Okuno, Makoto Kinoshita, Hisae Sumi, Harutoshi Fujimura, Kazuya Yamashita, Tomoyuki Sugimoto, Shuhei Sakakibara, Kaori Sakakibara, Toru Koda, Satoru Tada, Teruyuki Ishikura, Hisashi Murata, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Yuji Nakatsuji, Atsushi Kumanogoh & Hideki Mochizuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 13274-13274
- DOI
  10.1038/s41598-020-70203-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-20K16577, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15451, KAKENHI-PROJECT-18K15452
[Journal Article] Beneficial effects of fingolimod in MS patients with high serum Sema4A levels2018
- Author(s)
  Koda Toru、Namba Akiko、Nakatsuji Yuji、Niino Masaaki、Miyazaki Yusei、Sugimoto Tomoyuki、Kinoshita Makoto、Takata Kazushiro、Yamashita Kazuya、Shimizu Mikito、Fukazawa Toshiyuki、Kumanogoh Atsushi、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: 1-10
- DOI
  10.1371/journal.pone.0193986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15452
[Journal Article] Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder2018
- Author(s)
  Yamashita Kazuya、Kinoshita Makoto、Miyamoto Katsuichi、Namba Akiko、Shimizu Mikito、Koda Toru、Sugimoto Tomoyuki、Mori Yuki、Yoshioka Yoshichika、Nakatsuji Yuji、Kumanogoh Atsushi、Kusunoki Susumu、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 15 Issue: 1 Pages: 125-125
- DOI
  10.1186/s12974-018-1162-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15451, KAKENHI-PROJECT-18K15452, KAKENHI-PROJECT-16H01849, KAKENHI-PROJECT-26282223
[Journal Article] Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner2017
- Author(s)
  Honorat Josephe A.、Nakatsuji Yuji、Shimizu Mikito、Kinoshita Makoto、Sumi-Akamaru Hisae、Sasaki Tsutomu、Takata Kazushiro、Koda Toru、Namba Akiko、Yamashita Kazuya、Sanda Eri、Sakaguchi Manabu、Kumanogoh Atsushi、Shirakura Takashi、Tamura Mizuho、Sakoda Saburo、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 11 Pages: e0187215-e0187215
- DOI
  10.1371/journal.pone.0187215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-16K15317
[Journal Article] 全身痙攣で発症し, 頭部MRIが診断に有用であったリウマチ性髄膜炎の1例2015
- Author(s)
  山下和哉, 寺崎泰和, 坂口学, 中辻裕司, 吉崎和幸, 望月秀樹
- Journal Title
  
  臨床神経
  
  Volume: 55 Pages: 926-931
- NAID
  130005116932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09339
[Journal Article] The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis2015
- Author(s)
  Okuno T, Nakatsuji Y, Kinoshita M, Takata K, Koda T, Yamashita K, Nanba A, Mochizuki H.
- Journal Title
  
  Clin Exp Neuroimm
  
  Volume: 6 Pages: 30-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] Pathogenic role of mitochondrial DNA through NLRP3 inflammasome in vitro and in vivo mouse model of neuromyelitis optica spectrum disorder2019
- Author(s)
  Kazuya Yamashita
- Organizer
  ECTRIMS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15451
[Presentation] Cerebrospinal fluid mitochondrial DNA elicits innate immune response in NMO spectrum disorder2018
- Author(s)
  山下和哉, 木下允, 宮本勝一, 南波明子, 清水幹人, 甲田亨, 杉本知之, 中辻裕司, 熊ノ郷淳, 楠進, 奥野龍禎, 望月秀樹
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15451
[Presentation] Cerebrospinal fluid mitochondrial DNA elicits innate immune response in NMOSD2018
- Author(s)
  Yamashita K, Kinoshita M, Miyamoto K, Namba A, Shimizu M, Koda T, Nakatsuji Y, Kumanogoh A, Kusunoki S, Mochizuki H, Okuno T
- Organizer
  ECTRIMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15451
[Presentation] NMOSDにおける髄液ミトコンドリアDNAの自然免疫活性化機序に関する研究2018
- Author(s)
  山下和哉、木下允、宮本勝一、南波明子、清水幹人、甲田亨、杉本知之、中辻裕司、熊ノ郷淳、楠進、望月秀樹、奥野龍禎
- Organizer
  第30回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15451
[Presentation] Amelioration of secondary progressive experimental Autoimmmune encephalomyelitis by restoring mitochondrial enegy production in a GOT2-dependent manner2017
- Author(s)
  Kinoshita M, Honorat A, Okuno T, Nakatsuji Y, Shimizu M, Namba A, Yamashita K, Shirakura T, Mochizuki H.
- Organizer
  7th Joint ECTRIMS-ACTRIMS Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] mTOR signaling plays a crucial role in IFN-β non-responsiveness in MS patients with high serum Sema4A levels2017
- Author(s)
  Namba A, Okuno T, Koda T, Yamashita M, Shimizu m, Kinoshita M, Kumanogho A, Miyazaki Y, Niino M, Miyamoto K, Nakatsuji Y, Mochizuki H
- Organizer
  7th Joint ECTRIMS-ACTRIMS Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] Sema4A as a biomarker for the selection of treatment of MS2016
- Author(s)
  uji Nakatsuji, Toru Koda, Tatsusada Okuno, Yusei Miyazaki, Masaaki Niino, Toshiyuki Fukazawa, Kazushiro Takata,　Akiko Namba, Kazuya Yamashita, Mikito Shimizu, Makoto Kinoshita, Saburo Sakoda, Atsushi Kumanogoh, Hideki Mochizuki
- Organizer
  Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  London, England
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症のフィンゴリモドによる治療効果とSema4A値の解析2016
- Author(s)
  甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深澤俊行、南波明子、山下和哉、熊ノ郷淳、佐古田三郎、望月秀樹
- Organizer
  日本神経学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症患者における血清Sema4A値高値群の臨床的特徴2016
- Author(s)
  南波明子，山下和哉，甲田亨，奥野龍禎，熊ノ郷淳，中辻裕司，望月秀樹
- Organizer
  日本神経学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] コハク酸はミトコンドリアストレスを介して多発性硬化症動物モデルを悪化させる2016
- Author(s)
  奥野龍禎，高田和城，山下和哉，甲田亨，望月秀樹，中辻裕司
- Organizer
  日本神経免疫学会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症治療選択バイオマーカーＳｅｍａ４Ａ～フィンゴリモドとの相関について2016
- Author(s)
  甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深沢俊行、南波明子，山下和哉、清水幹人、熊ノ郷淳、佐古田三郎、望月秀樹
- Organizer
  日本神経免疫学会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K09339

1. Nakatsuji Yuji (20332744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. 奥野龍禎 (00464248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. 甲田亨 (70626134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 南波明子 (80774504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 多田智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 清水幹人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Kazuya 山下 和哉

Research Projects

Research Products

Co-Researchers

Pathogenic role of mitochondrial DNA in neuromyelitis optica spectrum disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of personalized medicine for NMO utilizing 11C-acetate PET

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Beneficial effects of fingolimod in MS patients with high serum Sema4A levels2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 全身痙攣で発症し, 頭部MRIが診断に有用であったリウマチ性髄膜炎の1例2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis2015

Author(s)

Journal Title

Data Source

[Presentation] Pathogenic role of mitochondrial DNA through NLRP3 inflammasome in vitro and in vivo mouse model of neuromyelitis optica spectrum disorder2019

Author(s)

Organizer

Data Source

[Presentation] Cerebrospinal fluid mitochondrial DNA elicits innate immune response in NMO spectrum disorder2018

Author(s)

Organizer

Data Source

[Presentation] Cerebrospinal fluid mitochondrial DNA elicits innate immune response in NMOSD2018

Author(s)

Organizer

Data Source

[Presentation] NMOSDにおける髄液ミトコンドリアDNAの自然免疫 活性化機序に関する研究2018

Author(s)

Organizer

Data Source

[Presentation] Amelioration of secondary progressive experimental Autoimmmune encephalomyelitis by restoring mitochondrial enegy production in a GOT2-dependent manner2017

Author(s)

Organizer

Data Source

[Presentation] mTOR signaling plays a crucial role in IFN-β non-responsiveness in MS patients with high serum Sema4A levels2017

Author(s)

Organizer

Data Source

[Presentation] Sema4A as a biomarker for the selection of treatment of MS2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 多発性硬化症のフィンゴリモドによる治療効果とSema4A値の解析2016

Author(s)

Organizer

Place of Presentation

Year and Date

Yamashita Kazuya 山下和哉

[Presentation] NMOSDにおける髄液ミトコンドリアDNAの自然免疫活性化機序に関する研究2018