• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Yamashita Kazuya  山下 和哉

ORCIDConnect your ORCID iD *help
Researcher Number 40774518
Affiliation (based on the past Project Information) *help 2018 – 2020: 大阪大学, 医学系研究科, 招へい教員
2016 – 2017: 大阪大学, 医学部附属病院, 医員
2015: 大阪大学, 医学部附属病院, その他
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related
Except Principal Investigator
Neurology
Keywords
Principal Investigator
NMO / インフラマソーム / 自然免疫 / NMOSD / ミトコンドリアDNA
Except Principal Investigator
高次脳機能障害 / NMOSD / バイオマーカー / NMO / 多発性硬化症 / アストロサイト / 酢酸 / PET
  • Research Projects

    (2 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (6 People)
  •  Pathogenic role of mitochondrial DNA in neuromyelitis optica spectrum disorderPrincipal Investigator

    • Principal Investigator
      Yamashita Kazuya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Osaka University
  •  Establishment of personalized medicine for NMO utilizing 11C-acetate PET

    • Principal Investigator
      Nakatsuji Yuji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      University of Toyama
      Osaka University

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation2020

    • Author(s)
      Mikito Shimizu, Tatsusada Okuno, Makoto Kinoshita, Hisae Sumi, Harutoshi Fujimura, Kazuya Yamashita, Tomoyuki Sugimoto, Shuhei Sakakibara, Kaori Sakakibara, Toru Koda, Satoru Tada, Teruyuki Ishikura, Hisashi Murata, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Yuji Nakatsuji, Atsushi Kumanogoh & Hideki Mochizuki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 13274-13274

    • DOI

      10.1038/s41598-020-70203-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-20K16577, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15451, KAKENHI-PROJECT-18K15452
  • [Journal Article] Beneficial effects of fingolimod in MS patients with high serum Sema4A levels2018

    • Author(s)
      Koda Toru、Namba Akiko、Nakatsuji Yuji、Niino Masaaki、Miyazaki Yusei、Sugimoto Tomoyuki、Kinoshita Makoto、Takata Kazushiro、Yamashita Kazuya、Shimizu Mikito、Fukazawa Toshiyuki、Kumanogoh Atsushi、Mochizuki Hideki、Okuno Tatsusada
    • Journal Title

      PLoS One

      Volume: 13 Issue: 3 Pages: 1-10

    • DOI

      10.1371/journal.pone.0193986

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15452
  • [Journal Article] Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder2018

    • Author(s)
      Yamashita Kazuya、Kinoshita Makoto、Miyamoto Katsuichi、Namba Akiko、Shimizu Mikito、Koda Toru、Sugimoto Tomoyuki、Mori Yuki、Yoshioka Yoshichika、Nakatsuji Yuji、Kumanogoh Atsushi、Kusunoki Susumu、Mochizuki Hideki、Okuno Tatsusada
    • Journal Title

      Journal of Neuroinflammation

      Volume: 15 Issue: 1 Pages: 125-125

    • DOI

      10.1186/s12974-018-1162-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15451, KAKENHI-PROJECT-18K15452, KAKENHI-PROJECT-16H01849, KAKENHI-PROJECT-26282223
  • [Journal Article] Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner2017

    • Author(s)
      Honorat Josephe A.、Nakatsuji Yuji、Shimizu Mikito、Kinoshita Makoto、Sumi-Akamaru Hisae、Sasaki Tsutomu、Takata Kazushiro、Koda Toru、Namba Akiko、Yamashita Kazuya、Sanda Eri、Sakaguchi Manabu、Kumanogoh Atsushi、Shirakura Takashi、Tamura Mizuho、Sakoda Saburo、Mochizuki Hideki、Okuno Tatsusada
    • Journal Title

      PLoS One

      Volume: 12 Issue: 11 Pages: e0187215-e0187215

    • DOI

      10.1371/journal.pone.0187215

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-16K15317
  • [Journal Article] 全身痙攣で発症し, 頭部MRIが診断に有用であったリウマチ性髄膜炎の1例2015

    • Author(s)
      山下和哉, 寺崎泰和, 坂口学, 中辻裕司, 吉崎和幸, 望月秀樹
    • Journal Title

      臨床神経

      Volume: 55 Pages: 926-931

    • NAID

      130005116932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Journal Article] The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis2015

    • Author(s)
      Okuno T, Nakatsuji Y, Kinoshita M, Takata K, Koda T, Yamashita K, Nanba A, Mochizuki H.
    • Journal Title

      Clin Exp Neuroimm

      Volume: 6 Pages: 30-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Presentation] Pathogenic role of mitochondrial DNA through NLRP3 inflammasome in vitro and in vivo mouse model of neuromyelitis optica spectrum disorder2019

    • Author(s)
      Kazuya Yamashita
    • Organizer
      ECTRIMS 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15451
  • [Presentation] Cerebrospinal fluid mitochondrial DNA elicits innate immune response in NMO spectrum disorder2018

    • Author(s)
      山下和哉, 木下允, 宮本勝一, 南波明子, 清水幹人, 甲田亨, 杉本知之, 中辻裕司, 熊ノ郷淳, 楠進, 奥野龍禎, 望月秀樹
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K15451
  • [Presentation] Cerebrospinal fluid mitochondrial DNA elicits innate immune response in NMOSD2018

    • Author(s)
      Yamashita K, Kinoshita M, Miyamoto K, Namba A, Shimizu M, Koda T, Nakatsuji Y, Kumanogoh A, Kusunoki S, Mochizuki H, Okuno T
    • Organizer
      ECTRIMS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15451
  • [Presentation] NMOSDにおける髄液ミトコンドリアDNAの自然免疫 活性化機序に関する研究2018

    • Author(s)
      山下和哉、木下 允、宮本 勝一、南波 明子、清水 幹人、甲田 亨、杉本 知之、中辻 裕司、熊ノ郷 淳、楠 進、望月 秀樹、奥野 龍禎
    • Organizer
      第30回日本神経免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15451
  • [Presentation] Amelioration of secondary progressive experimental Autoimmmune encephalomyelitis by restoring mitochondrial enegy production in a GOT2-dependent manner2017

    • Author(s)
      Kinoshita M, Honorat A, Okuno T, Nakatsuji Y, Shimizu M, Namba A, Yamashita K, Shirakura T, Mochizuki H.
    • Organizer
      7th Joint ECTRIMS-ACTRIMS Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Presentation] mTOR signaling plays a crucial role in IFN-β non-responsiveness in MS patients with high serum Sema4A levels2017

    • Author(s)
      Namba A, Okuno T, Koda T, Yamashita M, Shimizu m, Kinoshita M, Kumanogho A, Miyazaki Y, Niino M, Miyamoto K, Nakatsuji Y, Mochizuki H
    • Organizer
      7th Joint ECTRIMS-ACTRIMS Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Presentation] Sema4A as a biomarker for the selection of treatment of MS2016

    • Author(s)
      uji Nakatsuji, Toru Koda, Tatsusada Okuno, Yusei Miyazaki, Masaaki Niino, Toshiyuki Fukazawa, Kazushiro Takata, Akiko Namba, Kazuya Yamashita, Mikito Shimizu, Makoto Kinoshita, Saburo Sakoda, Atsushi Kumanogoh, Hideki Mochizuki
    • Organizer
      Congress of the European Committee for Treatment and Research in Multiple Sclerosis
    • Place of Presentation
      London, England
    • Year and Date
      2016-09-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Presentation] 多発性硬化症のフィンゴリモドによる治療効果とSema4A値の解析2016

    • Author(s)
      甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深澤俊行、南波明子、山下和哉、熊ノ郷淳、佐古田三郎、望月秀樹
    • Organizer
      日本神経学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Presentation] 多発性硬化症患者における血清Sema4A値高値群の臨床的特徴2016

    • Author(s)
      南波 明子,山下 和哉,甲田 亨,奥野 龍禎,熊ノ郷 淳,中辻 裕司,望月 秀樹
    • Organizer
      日本神経学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Presentation] コハク酸はミトコンドリアストレスを介して多発性硬化症動物モデルを悪化させる2016

    • Author(s)
      奥野 龍禎,高田和城,山下 和哉,甲田 亨,望月 秀樹,中辻 裕司
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      長崎
    • Year and Date
      2016-09-29
    • Data Source
      KAKENHI-PROJECT-15K09339
  • [Presentation] 多発性硬化症治療選択バイオマーカーSema4A~フィンゴリモドとの相関について2016

    • Author(s)
      甲田 亨、奥野 龍禎、中辻 裕司、宮崎雄生、新野正明、深沢俊行、南波明子,山下 和哉、清水幹人、熊ノ郷淳、佐古田三郎、望月 秀樹
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      長崎
    • Year and Date
      2016-09-29
    • Data Source
      KAKENHI-PROJECT-15K09339
  • 1.  Nakatsuji Yuji (20332744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 2.  奥野 龍禎 (00464248)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 3.  甲田 亨 (70626134)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 4.  南波 明子 (80774504)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 5.  多田 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  清水 幹人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi