HOSSAIN MOHAMMAD ARIF ＨＯＳＳＡＩＮＡＲＩＦ

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HOSSAIN ARIF ホセインアリフ

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Researcher Number	40777893
Other IDs	https://orcid.org/0000-0002-6598-7403
Affiliation (Current)	2025: 一般財団法人脳神経疾患研究所, 先端医療研究センター, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2019: 一般財団法人脳神経疾患研究所, 先端医療研究センター, 研究員 2016: 一般財団法人脳神経疾患研究所, 先端医療研究センター, 研究員
Review Section/Research Field	Except Principal Investigator Pediatrics
Keywords	Except Principal Investigator iPS細胞 / lysosomal disease / MS/MS / iPS cells / ライソゾーム病 / NPC病 / プロテオミクス / iPS細胞作製 / ニーマンピック病 / ゴーシェ病 … More / TEM解析 / oxysterol / lysoGb3 / 蓄積脂質 / Niemann-Pick C病 / タンデムMS / オキシステロール、 / バイオマーカー / ファブリ病 / NPC / 電子顕微鏡 / Nestin / GM2-ganglioside / 細胞治療 / Miglustat / 神経細胞 / ポンぺ病 / Tay-Sacks病 / Pompe disease / Niemann-Pick disease / Fabry sisease / Tay-Sacks disease / MLD / Fabry 病 / Niemann-Pick病 / Tay-Sacks 病 / IPS 細胞 Less

Pathogenesis, Diagnosis and treatment of lysosomal diseases by Biomarker Analysis
- Principal Investigator
  
  Eto Yoshikatsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Pathogenetic Stidies and Novel Enzyme Treatment using Fabry, Pompe and Tay-Sacks iPS cells
- Principal Investigator
  
  Eto Yoshikatsu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Southen Tohoku Research Institute for Neuroscience

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Dysregulated DNA methylation of GLA gene was associated with dysfunction of autophagy.2019
- Author(s)
  Yanagisawa H, Hossain MA, Miyajima T, Nagao K, Miyashita T, Eto Y.
- Journal Title
  
  Molecular Genetics Metabolism
  
  Volume: S1096-7192(19) Pages: 30014-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10067
[Journal Article] Future clinical and biochemical predictions of Fabry disease in females by methylation studies of the GLA gene.2019
- Author(s)
  Hossain MA, Wu C, Yanagisawa H, Miyajima T, Akiyama K, Eto Y.
- Journal Title
  
  Mol. Genet. Metab. Rep.
  
  Volume: 2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10067
[Journal Article] Characteristics of PPT1 and TPP1 enzymes in neuronal ceroid lipofuscinosis (NCL) 1 and 2 by dried blood spots (DBS) and leukocytes and their application to newborn screening.2018
- Author(s)
  Itagaki R, Endo M, Yanagisawa H, Hossain MA, Akiyama K, Yaginuma K, Miyajima T, Wu C, Iwamoto T, Igarashi J, Kobayashi Y, Tohyama J, Iwama K, Matsumoto N, Shintaku H, Eto Y.
- Journal Title
  
  Mol Genet Metab.
  
  Volume: S1096-7192(18) Issue: 1 Pages: 30154-9
- DOI
  10.1016/j.ymgme.2018.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10067, KAKENHI-PROJECT-17H01539
[Journal Article] A Case of Adult-onset Pompe Disease with Cerebral Stroke and Left Ventricular Hypertrophy.2018
- Author(s)
  Hossain MA, Miyajima T, Akiyama K, Eto Y
- Journal Title
  
  J Stroke　Cerebrovasc
  
  Volume: Dis. 2018 Nov
- Data Source
  KAKENHI-PROJECT-17K10067
[Journal Article] Characteristics of PPT1 and TPP1 enzymes in neuronal ceroid lipofuscinosis (NCL) 1 and 2 by dried blood spots (DBS) and leukocytes and their application to newborn screening.2018
- Author(s)
  5.Itagaki R, Endo M, Yanagisawa H, Hossain MA, Akiyama K, Yaginuma K, Miyajima T, Wu C, Iwamoto T, Igarashi J, Kobayashi Y, Tohyama J, Iwama K, Matsumoto N, Shintaku H, Eto Y.
- Journal Title
  
  Mol Genet Metab.
  
  Volume: 2018 May;124(1) Pages: 64-70
- Data Source
  KAKENHI-PROJECT-17K10067
[Journal Article] The severe clinical phenotype for a heterozygous Fabry female patient correlates to the methylation of non-mutated allele associated with chromosome 10q26 deletion syndrome.2017
- Author(s)
  Hossain MA, Yanagisawa H, Miyajima T, Wu C, Takamura A, Akiyama K, Itagaki R, Eto K, Iwamoto T, Yokoi T, Kurosawa K, Numabe H, Eto Y.
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 120 Issue: 3 Pages: 173-179
- DOI
  10.1016/j.ymgme.2017.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870831, KAKENHI-PROJECT-17K10067
[Journal Article] The severe clinical phenotype for a heterozygous Fabry female patient correlates to the methylation of non-mutated allele associated with chromosome 10q26 deletion syndrome.2017
- Author(s)
  Hossain MA, Yanagisawa H, Miyajima T, Wu C, Takamura A, Akiyama K, Itagaki R, Eto K, Iwamoto T, Yokoi T, Kurosawa K, Numabe H, Eto Y
- Journal Title
  
  Mol Genet Metab.
  
  Volume: 120(3) Pages: 173-179
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461536
[Journal Article] Early onset of Fazio-Londe syndrome: the first case report from the Arabian Peninsula.2017
- Author(s)
  Hossain MA, Obaid A, Rifai M, Alem H, Hazwani T, Al Shehri A, Alfadhel M, Eto Y, Eyaid W.
- Journal Title
  
  Hum Genome
  
  Volume: 4 Issue: 1 Pages: 17018-17018
- DOI
  10.1038/hgv.2017.18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10067
[Journal Article] Application of a diagnostic methodology by quantification of 26:0　lysophosphatidylcholine in dried blood spots for Japanese newborn screening of X-linked adrenoleukodystrophy.2017
- Author(s)
  Wu C, Iwamoto T, Igarashi J, Miyajima T, Hossain MA, Yanagisawa H, Akiyama K, Shintaku H, Eto Y.
- Journal Title
  
  Mol Genet Metab Rep.
  
  Volume: １１ Pages: 115-118
- DOI
  10.1016/j.ymgmr.2017.06.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10067
[Journal Article] Ten-year-long enzyme replacement therapy shows a poor effect in alleviating giant leg ulcers in a male with Fabry disease.2017
- Author(s)
  Okada J, Hossain MA, Wu C, Miyajima T, Yanagisawa H, Akiyama K, Eto Y.
- Journal Title
  
  Mol Genet Metab Rep.
  
  Volume: 14 Pages: 68-72
- DOI
  10.1016/j.ymgmr.2017.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] Development of neuropathological model using Niemann-Pick type C patient-derived iPSCs2020
- Author(s)
  Saito R., Miyajima T., Wu Chen, M. Arif Hossain, Itagaki R., Akiyama K., Iwamoto T., Eto Y
- Organizer
  The 140th Annual Meeting of the Pharmaceutical Society of Japan
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] Development of neuropathological model using Niemann-Pick type C patients derived iPSCs2020
- Author(s)
  Saito R., Miyajima T., Wu Chen, M. Arif Hossain, Itagaki R., Akiyama K., Iwamoto T., Eto Y.,
- Organizer
  World symposium, 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] DNA methylation study of GLA gene and its association with autophagy and clinical severity of heterozygous Fabry disease females.2020
- Author(s)
  M. Arif Hossain, Wu Chen, Yanagisawa H., Miyajima T., Saito R., Akiyama K., Eto Y.
- Organizer
  World sy,mposiu, 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] An update on biomarkers of 7-ketocholesterol, lyso-sphingomyelin, bile acid and glucosyl-sphingosine for Niemann-Pick disease type C2020
- Author(s)
  Wu Chen, Iwamoto T. M. Arif Hossain, Akiyama K. Igarashi J., Miyajima T., Saito R., Eto Y.,
- Organizer
  World symposium, 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] Future clinical and biochemical predictions of Fabry disease in females by methylation studies of the GLA gene.; M. Arif Hossain2019
- Author(s)
  M. Arif Hossain, Wu Chen, Yanagisawa H., Miyajima T., Akiyama K., Saito R., Eto Y
- Organizer
  The 61st Annual Meeting of the Japanese Society for Inherited Metabolic Diseases
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] 重度ヘテロ結合Fabry女性の予測診断に向けたメチル化に関する研究2017
- Author(s)
  Mohammad Arif Hossain, Chen Wu, 宮島任司, 柳澤比呂子, 秋山けい子, 岩本武夫, 衞藤義勝.
- Organizer
  日本人類遺伝学会　第62回大会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] ファブリー病患者の年齢、性別、及び酵素補充療法に起因する抗体価と血漿中LysoGb3の相関関係2017
- Author(s)
  Chen Wu, 岩本武夫, Mohammad Arif Hossain, 宮島任司, 秋山けい子, 柳澤比呂子, 五十嵐純子, 衞藤義勝
- Organizer
  日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] 乾燥濾紙血（DBS）を用いたムコ多糖症Ⅶ型（MPS Ⅶ）のハイリスクスクリーニングの検討2017
- Author(s)
  宮島任司, 五十嵐純子, Chen Wu, 柳澤比呂子, Mohammad Arif Hossain,　秋山けい子, 濱﨑考史, 岩本武夫, 衞藤義勝
- Organizer
  日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] Application of Lysosphingomyelin Measuremane for Diagonosis of Japanese patients with Niemann Pick Type C by MS/MS.2017
- Author(s)
  Chen Wu, 岩本武夫, 柳澤比呂子, 秋山けい子, 宮島任司, 五十嵐純子, Mohammad Arif Hossain, 衞藤義勝。
- Organizer
  第22回日本ライソゾーム病研究会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] ニーマンピックC型の診断バイオマーカー：血清Lysosphongomyelin 測定の有用性に関する研究2017
- Author(s)
  衞藤義勝,　Chen Wu, 岩本武夫, 柳澤比呂子, 秋山けい子, 宮島任司, 五十嵐純子, Mohammad Arif Hossain
- Organizer
  第31回日本小児脂質研究会学術集会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] 乾燥濾紙血（DBS）を用いたムコ多糖症Ⅶ型（MPS Ⅶ）のハイリスクスクリーニングの検討2017
- Author(s)
  宮島任司, 五十嵐純子, Chen Wu, 柳澤比呂子, Mohammad Arif Hossain,秋山けい子, 濱﨑考史, 岩本武夫, 衞藤義勝
- Organizer
  日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] An adult onset Pompe Disease with cerebral stroke and left ventricular hypertrophy.2017
- Author(s)
  Mohammad Arif Hossain, Takashi Miyajima, Keiko Akiyama, Hiroko Yanagisawa, Chen Wu, Takeo Iwamoto, Yoshikatsu Eto.
- Organizer
  第22回日本ライソゾーム病研究会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] 多変量解析で得た新規診断マーカー候補によるニーマンピック病C型の診断2017
- Author(s)
  Chen Wu, 岩本武夫, 柳澤比呂子, 秋山けい子, 宮島任司, 五十嵐純子, Mohammad Arif Hossain, 衞藤義勝
- Organizer
  日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] 女性ヘテロ結合ファブリー病患者におけるオートファジーとメチル化との関連2017
- Author(s)
  柳澤比呂子, ホセイン・モハンマド・アリフ, 宮島任司, 秋山けい子, 衞藤義勝
- Organizer
  日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-17K10067
[Presentation] CpG アイランドのメチル化によるFabry ヘテロ接合女性患者の臨床表現型予測について2017
- Author(s)
  Mohammad Arif Hossain, Chen Wu, 宮島任司, 柳澤比呂子, 秋山けい子, 岩本武夫, 衞藤義勝
- Organizer
  日本先天代謝異常学会　10月　川越
- Data Source
  KAKENHI-PROJECT-17K10067

1. Eto Yoshikatsu (50056909)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 柳澤比呂子 (60416659)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
3. 藤崎美和 (50642641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 辻嘉代子 (60584232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. WU CHEN (90790840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
6. 衛藤義勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 24 results
7. 高村歩美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOSSAIN MOHAMMAD ARIF ＨＯＳＳＡＩＮ ＡＲＩＦ

HOSSAIN ARIF ホセイン アリフ

Research Projects

Research Products

Co-Researchers

Pathogenesis, Diagnosis and treatment of lysosomal diseases by Biomarker Analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenetic Stidies and Novel Enzyme Treatment using Fabry, Pompe and Tay-Sacks iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dysregulated DNA methylation of GLA gene was associated with dysfunction of autophagy.2019

Author(s)

Journal Title

Data Source

[Journal Article] Future clinical and biochemical predictions of Fabry disease in females by methylation studies of the GLA gene.2019

Author(s)

Journal Title

Data Source

[Journal Article] Characteristics of PPT1 and TPP1 enzymes in neuronal ceroid lipofuscinosis (NCL) 1 and 2 by dried blood spots (DBS) and leukocytes and their application to newborn screening.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Case of Adult-onset Pompe Disease with Cerebral Stroke and Left Ventricular Hypertrophy.2018

Author(s)

Journal Title

Data Source

[Journal Article] Characteristics of PPT1 and TPP1 enzymes in neuronal ceroid lipofuscinosis (NCL) 1 and 2 by dried blood spots (DBS) and leukocytes and their application to newborn screening.2018

Author(s)

Journal Title

Data Source

[Journal Article] The severe clinical phenotype for a heterozygous Fabry female patient correlates to the methylation of non-mutated allele associated with chromosome 10q26 deletion syndrome.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The severe clinical phenotype for a heterozygous Fabry female patient correlates to the methylation of non-mutated allele associated with chromosome 10q26 deletion syndrome.2017

Author(s)

Journal Title

Data Source

[Journal Article] Early onset of Fazio-Londe syndrome: the first case report from the Arabian Peninsula.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of a diagnostic methodology by quantification of 26:0 lysophosphatidylcholine in dried blood spots for Japanese newborn screening of X-linked adrenoleukodystrophy.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ten-year-long enzyme replacement therapy shows a poor effect in alleviating giant leg ulcers in a male with Fabry disease.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Development of neuropathological model using Niemann-Pick type C patient-derived iPSCs2020

Author(s)

Organizer

Data Source

[Presentation] Development of neuropathological model using Niemann-Pick type C patients derived iPSCs2020

Author(s)

Organizer

Data Source

[Presentation] DNA methylation study of GLA gene and its association with autophagy and clinical severity of heterozygous Fabry disease females.2020

Author(s)

Organizer

Data Source

[Presentation] An update on biomarkers of 7-ketocholesterol, lyso-sphingomyelin, bile acid and glucosyl-sphingosine for Niemann-Pick disease type C2020

Author(s)

Organizer

Data Source

[Presentation] Future clinical and biochemical predictions of Fabry disease in females by methylation studies of the GLA gene.; M. Arif Hossain2019

Author(s)

HOSSAIN MOHAMMAD ARIF ＨＯＳＳＡＩＮＡＲＩＦ

HOSSAIN ARIF ホセインアリフ

[Journal Article] Application of a diagnostic methodology by quantification of 26:0　lysophosphatidylcholine in dried blood spots for Japanese newborn screening of X-linked adrenoleukodystrophy.2017