Ihara Fumie 伊原史英

Researcher Number	40779906
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2019: 千葉大学, 大学院医学研究院, 特任助教 2018: 千葉大学, 大学院医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator 腫瘍浸潤細胞 / MDSC / Treg / 免疫学 / NKT細胞 / effector Treg / 骨髄性抑制細胞 / 頭頸部扁平上皮癌 / 制御性T細胞 Except Principal Investigator 移植・再生医療 … More / 癌 / 免疫学 / トランスレーショナルリサーチ / 唾液腺がん / がん免疫 / トランスレーショナル・リサーチ / 唾液腺癌 / 免疫療法 / mesothelin / キメラ抗原受容体 Less

活性型制御性T細胞を標的とした頭頸部癌患者を対象とする新規治療法の開発Principal Investigator
- Principal Investigator
  
  伊原史英
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chiba University
唾液腺がんに対するCAR T細胞とNKT細胞の併用療法に関する橋渡し研究
- Principal Investigator
  
  國井直樹
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of novel treatment to target immune suppressive cells in tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Ihara Fumie
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University

All 2019 2018 2017

All Journal Article Presentation

[Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019
- Author(s)
  Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H., Motohashi, S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 3 Pages: 888-902
- DOI
  10.1111/cas.13933
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-17H01592, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-18K16274, KAKENHI-PROJECT-16H02778, KAKENHI-PROJECT-18H02892
[Journal Article] Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer2018
- Author(s)
  Makita Yuji、Kunii Naoki、Sakurai Daiju、Ihara Fumie、Motohashi Shinichiro、Suzuki Akane、Nakayama Toshinori、Okamoto Yoshitaka
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1 Pages: 1254-1254
- DOI
  10.1186/s12885-018-5179-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
[Journal Article] Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells2018
- Author(s)
  Sakurai D, Uchida R, Ihara F, Kunii N, Nakagawa T, Chazono H, Hanazawa T, Motohashi S, Okamoto Y
- Journal Title
  
  BMC Research Notes
  
  Volume: 11 Issue: 1 Pages: 479-479
- DOI
  10.1186/s13104-018-3587-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
[Journal Article] Invariant natural killer T infiltration in neuroblastoma with favorable outcome.2018
- Author(s)
  Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
- Journal Title
  
  Pediatr. Surg. Int.
  
  Volume: 34 Issue: 2 Pages: 195-201
- DOI
  10.1007/s00383-017-4189-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26462705, KAKENHI-PROJECT-16K19974, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-17H01592
[Journal Article] Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors.2018
- Author(s)
  Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
- Journal Title
  
  Pediatr. Surg. Int.
  
  Volume: 34 Issue: 2 Pages: 169-176
- DOI
  10.1007/s00383-017-4185-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26462705, KAKENHI-PROJECT-16K19974, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-17H01592
[Journal Article] CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma2017
- Author(s)
  Ihara Fumie、Sakurai Daiju、Horinaka Atsushi、Makita Yuji、Fujikawa Akira、Sakurai Toshioki、Yamasaki Kazuki、Kunii Naoki、Motohashi Shinichiro、Nakayama Toshinori、Okamoto Yoshitaka
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 66 Issue: 10 Pages: 1275-1285
- DOI
  10.1007/s00262-017-2021-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26221305
[Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の有効性に関する前臨床研究2019
- Author(s)
  國井直樹、伊原史英、松島可奈、飯沼智久、米倉修二、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] 頭頸部癌患者の免疫抑制と免疫細胞療法による治療戦略2019
- Author(s)
  伊原史英、櫻井大樹、飯沼智久、國井直樹、米倉修二、岡本美孝
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の有効性に関する前臨床研究2019
- Author(s)
  國井直樹、伊原史英、松島可奈、飯沼智久、米倉修二、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] 制御性T細胞が頭頸部癌患者に及ぼす免疫抑制作用からの克服を目指した治療法の検討2018
- Author(s)
  伊原史英、櫻井大樹、米倉修二、飯沼智久、岡本美孝
- Organizer
  第36回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] 頭頸部扁平上皮癌患者における制御性T細胞の臨床的意義2018
- Author(s)
  伊原史英、高見真理子、國井直樹、櫻井大樹、岡本美孝、本橋新一郎
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] A Phase II study of α-Galactosylceramide-pulsed antigen presenting cells for advanced or recurrent non-small cell lung cancer2018
- Author(s)
  Motohashi S, Kamata T, Toyoda, T, Tanaka T, Ihara F, Takami M, Yosino I, Nakayama,T
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] A role for immune checkpoint inhibitors in iNKT cell-based immunotherapy.2018
- Author(s)
  Negawa M, Ihara F, Kamata T, Takami M, Motohashi S.
- Organizer
  The 2nd Chiba University - UC San Diego Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] 頭頸部扁平上皮癌患者における末梢血制御性T細胞の臨床的意義2017
- Author(s)
  伊原史英、櫻井大樹、堀中敦史、國井直樹、本橋新一郎、岡本美孝
- Organizer
  第21回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] A role of AhR signaling in NKT cell immunotherapy.2017
- Author(s)
  Takami, M., Ihara, F., Kamata, T., Motohashi, S.
- Organizer
  CD1-MR1 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] 唾液腺がんに対するメソテリン特異的キメラ抗原受容体導入T細胞と活性化NKT細胞を併用したがん免疫療法2017
- Author(s)
  國井直樹、蒔田勇治、伊原史英、中川拓也、山﨑一樹、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
- Organizer
  第118回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] Regulatory T cells increased in advanced head and neck cancer patients suppress NKT cell function and correlate with disease progression.2017
- Author(s)
  Ihara, F., Sakura, D., Takami, M., Okamoto, Y., Motohashi, S.
- Organizer
  CD1-MR1 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16892
[Presentation] NKT細胞免疫系を利用した頭頸部扁平上皮癌患者に対する免疫細胞療法2017
- Author(s)
  國井直樹、櫻井大樹、伊原史英、岡本美孝
- Organizer
  第41回日本頭頸部癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11376

1. 國井直樹 (00456047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 本橋新一郎 (60345022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 高見真理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 岡本美孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 岡本好海

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ihara Fumie 伊原 史英

Research Projects

Research Products

Co-Researchers

活性型制御性T細胞を標的とした頭頸部癌患者を対象とする新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

唾液腺がんに対するCAR T細胞とNKT細胞の併用療法に関する橋渡し研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel treatment to target immune suppressive cells in tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Invariant natural killer T infiltration in neuroblastoma with favorable outcome.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の 有効性に関する前臨床研究2019

Author(s)

Organizer

Data Source

[Presentation] 頭頸部癌患者の免疫抑制と免疫細胞療法による治療戦略2019

Author(s)

Organizer

Data Source

[Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の有効性に関する前臨床研究2019

Author(s)

Organizer

Data Source

[Presentation] 制御性T細胞が頭頸部癌患者に及ぼす免疫抑制作用からの克服を目指した治療法の検討2018

Author(s)

Organizer

Data Source

[Presentation] 頭頸部扁平上皮癌患者における制御性T細胞の臨床的意義2018

Author(s)

Organizer

Data Source

[Presentation] A Phase II study of α-Galactosylceramide-pulsed antigen presenting cells for advanced or recurrent non-small cell lung cancer2018

Author(s)

Organizer

Data Source

[Presentation] A role for immune checkpoint inhibitors in iNKT cell-based immunotherapy.2018

Author(s)

Organizer

Data Source

Ihara Fumie 伊原史英

[Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の有効性に関する前臨床研究2019