Mizoguchi Emiko 溝口恵美子

Researcher Number	40782157
Other IDs
Affiliation (Current)	2025: 久留米大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 久留米大学, 医学部, 教授 2018 – 2020: 久留米大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 59040:Nutrition science and health science-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 核内移行 / CHI3L1 / 炎症性腸疾患 / p53 / 上皮異形成 / Chitinase 3-like 1 / 大腸上皮 / 異形成 / アミノ酸核局在配列 / 癌抑制蛋白 … More / 大腸癌 / 上皮細胞 / ｐ53 / 大腸炎関連癌 / キチナーゼ3様タンパク / 慢性炎症関連性大腸炎 / サイクリン結合部位 / 核局在配列 / ペントキシフィリン / カフェイン / キサンチン誘導体 … More Except Principal Investigator CAC / 癌化 / 潰瘍性大腸炎 / 食と栄養 / 栄養 / 腸管炎症 / 疫学 / 動脈硬化 / CEACAM family / マイクロアレイ解析 / 慢性炎症 / 大腸炎関連がん / 異所性発現 / AICDA / inflammation / colonic epithelial cells / ectopic expression / AID / 接着性侵襲性大腸菌 / CHI3L1 / claudin-2 / CLDN2 / CH3L1 / CEACAM6 Less

Mechanism and role of nuclear translocation of CHI3L1 in the process of colonic epithelial cell transformation from colonic inflammation to cancerPrincipal Investigator
- Principal Investigator
  
  溝口恵美子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kurume University
慢性炎症環境に大腸陰窩が適応するためのAIDによる変異獲得メカニズムの解明
- Principal Investigator
  
  岡田季之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kurume University
潰瘍性大腸炎における炎症誘導大腸癌発症に関連する特異的因子の機能解析と臨床応用
- Principal Investigator
  
  衣笠哲史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kurume University
Epidemiological study of the relationship between atherosclerosis and intestinal inflammation and food
- Principal Investigator
  
  深水亜子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kurume University
Mechanisms of CHI3L1-mediated p53 suppression in the early stage of colon cancerPrincipal Investigator
- Principal Investigator
  
  溝口恵美子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kurume University
Analysis of inflammation-induced colon cancer development mechanism by adhesive invasive Escherichia coli (AIEC) related molecule
- Principal Investigator
  
  KINUGASA TETSUSHI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  International University of Health and Welfare
Ptotective effect of xanthine derivatives on colitis-associated dysplasiaPrincipal Investigator
- Principal Investigator
  
  Mizoguchi Emiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kurume University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Recently updated role of Chitinase ３-like １ on various cell types as a major influencer of chronic inflammation.2024
- Author(s)
  Mizoguchi E, Sadanaga T, Nanni L, Wang S, Mizoguci A
- Journal Title
  
  Cells
  
  Volume: 13 Issue: 8 Pages: 678-678
- DOI
  10.3390/cells13080678
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07996
[Journal Article] Landscape of inflammatory bowel disease in Singapore2022
- Author(s)
  Low Daren、Swarup Nidhi、Okada Toshiyuki、Mizoguchi Emiko
- Journal Title
  
  Intestinal Research
  
  Volume: 2021.00089. Issue: 3 Pages: 00089-00089
- DOI
  10.5217/ir.2021.00089
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08318, KAKENHI-PROJECT-21K07996
[Journal Article] Chitinase 3-like 1, Carcinoembryonic Antigen-related Cell Adhesion Molecule 6, and Ectopic Claudin-2 in the Carcinogenic Processes of Ulcerative Colitis2022
- Author(s)
  KINUGASA TETSUSHI、TSUNODA TOSHIYUKI、MIZOGUCHI EMIKO、OKADA TOSHIYUKI、SUDO TOMOYA、KAWAHARA AKIHIKO、AKIBA JUN、AKAGI YOSHITO
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 8 Pages: 4119-4127
- DOI
  10.21873/anticanres.15910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08318, KAKENHI-PROJECT-20K09114
[Journal Article] Chitinase 3-like 1, Carcinoembryonic antigen-related cell adhesion molecule 6, and ectopic Claudin-2 in the carcinogenic processes of ulcerative colitis.2022
- Author(s)
  MKinugasa T, Tsunoda T, Mizoguchi E, Okada T, Sudo T, Kawahara A, Akiba J, Akagi Y.
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Pages: 4119-4127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07996
[Journal Article] Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-192021
- Author(s)
  Kamie S, Ma B, He CH, Akosman B, Zhou Y, Lee CM, El-Deiry WS, Huntington K, Liang O, Machan JT, Kang MJ, Shin HJ, Mizoguchi E, Lee CG, Elias JA
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 21
- DOI
  10.1172/jci.insight.148749
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07996
[Journal Article] A Review of Selected IBD Biomarkers: From Animal Models to Bedside2021
- Author(s)
  Emiko Mizoguchi, Renuka Subramaniam, Toshiyuki Okada, and Atsushi Mizoguchi
- Journal Title
  
  Diagnostics
  
  Volume: 11 Issue: 2 Pages: 207-207
- DOI
  10.3390/diagnostics11020207
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08318, KAKENHI-PROJECT-21K07996, KAKENHI-PROJECT-18K07987
[Journal Article] Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis2021
- Author(s)
  Mizoguchi Emiko、Sadanaga Takayuki、Okada Toshiyuki
- Journal Title
  
  International Journal of Translational Medicine
  
  Volume: 1 Issue: 3 Pages: 187-204
- DOI
  10.3390/ijtm1030014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08318, KAKENHI-PROJECT-21K07996
[Journal Article] Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in CPVID-19.2021
- Author(s)
  Kamle S, Ma B, He CH, Akosman B, Zhou Y, Lee CM, El-Deiry WS, Huntington K, Liang O, Machan JT, Kang MJ,Shin HJ, Mizoguchi E, Lee CG, Elias JA.
- Journal Title
  
  bioRxiv Preprint
  
  Volume: -
- DOI
  10.1101/2021.01.05.425478
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07987
[Journal Article] キサンチン誘導体の慢性炎症関連性大腸癌発症抑制における役割について2020
- Author(s)
  溝口恵美子、一万田莉麻、衣笠哲矢、岡田季之、溝口充志
- Journal Title
  
  女性健康科学研究会誌
  
  Volume: 9 Pages: 30-34
- Data Source
  KAKENHI-PROJECT-18K07987
[Journal Article] Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models2020
- Author(s)
  Emiko Mizoguchi, Daren Low, Yui Ezaki, Toshiyuki Okada
- Journal Title
  
  Intestinal Research
  
  Volume: 18 Pages: 151-167
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07987
[Journal Article] Clinical importance of IL-22 cascade in IBD.2018
- Author(s)
  Mizoguchi A, Yano A, Himuro H, Ezaki Y, Sadanaga T, Mizoguchi E.
- Journal Title
  
  J Gastroenterol
  
  Volume: 53(4) Issue: 4 Pages: 465-474
- DOI
  10.1007/s00535-017-1401-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19867, KAKENHI-PROJECT-18K07987
[Patent] 口腔白斑症の癌化を予測する方法及び航空扁平上皮癌の浸潤の有無を判定する方法2021
- Inventor(s)
  溝口恵美子、寺谷由唯
- Industrial Property Rights Holder
  溝口恵美子、寺谷由唯
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-21K07996
[Presentation] Loss of AID expression under inflammatory condition alters the Nid1 and Fbln2 induction and exacerbates intestinal injury2023
- Author(s)
  Toshiyuki Okada, Yusuke Toyoda, Takayuki Sadanaga, Tomoi Noda, Risako Onitsuka, Atsushi Mizoguchi, Emiko Mizoguchi, Shigeaki Saitoh
- Organizer
  Japanese society for Immunology 2023
- Data Source
  KAKENHI-PROJECT-23K07384
[Presentation] 炎症により大腸上皮細胞に異所性発現するAIDは、DNAの脱メチル化を引き起こすことで標的遺伝子の発現に影響を与える2023
- Author(s)
  岡田季之、豊田雄介、溝口充志、齋藤成昭
- Organizer
  分子生物学会2023
- Data Source
  KAKENHI-PROJECT-23K07384
[Presentation] 四半世紀の在米経験を通じたIBD基礎研究と国際医学交流2023
- Author(s)
  溝口恵美子
- Organizer
  広島大学再生・免疫・感染・アレルギーグループWeb会議
- Invited
- Data Source
  KAKENHI-PROJECT-21K07996
[Presentation] Role of putative cyclin-binding　domain　in　nuclear　localization　sequence　of　Chitinase　3-like　1　in　colonic　epithelial　cells2021
- Author(s)
  Mizoguchi E, Okada T, Lee CG, Elias JA, Mizoguchi A
- Organizer
  日本免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07996
[Presentation] 口腔扁平上皮癌におけるChitinase3-like 1の関与2020
- Author(s)
  寺谷由唯、楠川仁悟、岡田季之、溝口充志、溝口恵美子
- Organizer
  日本消化器免疫学会（JSMI）
- Data Source
  KAKENHI-PROJECT-18K07987
[Presentation] 大腸炎によって異所性発現するAIDの役割2020
- Author(s)
  岡田孝之、溝口充志、溝口恵美子、齋藤成昭
- Organizer
  第57回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07987
[Presentation] プロポリスの炎症性腸疾患における粘膜保護および抗炎症性作用2020
- Author(s)
  溝口恵美子
- Organizer
  第11回みつばち研究助成基金成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07987
[Presentation] 腸炎における制御性形質芽細胞Preg2020
- Author(s)
  矢野有紗、西田淳史、小松誠和、溝口恵美子、安藤朗、溝口充志
- Organizer
  第57回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07987
[Presentation] 口腔扁平上皮癌におけるChitinase 3-like 1の関与2020
- Author(s)
  寺谷由唯、楠川仁悟、岡田孝之、溝口充志、溝口恵美子
- Organizer
  第57回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07987
[Presentation] Role of chitosome (CHI3L1/IL13Ra2/TMEM219) complex in oral squamous cell carcinoma and precancerous stage2019
- Author(s)
  Yui Ezaki, Atsushi Mizoguchi, Emiko Mizoguchi
- Organizer
  Japanese Society for Immunology (JSI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07987
[Presentation] Animal models for IBD study2019
- Author(s)
  Emiko Mizoguchi
- Organizer
  Asian Organization of Crohn's and Colitis (AOCC)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07987

1. KINUGASA TETSUSHI (90279266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 角田俊之 (70444817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岡田季之 (10607328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 主藤朝也 (50309803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 深水亜子 (90449926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 氷室秀知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizoguchi Emiko 溝口 恵美子

Research Projects

Research Products

Co-Researchers

Mechanism and role of nuclear translocation of CHI3L1 in the process of colonic epithelial cell transformation from colonic inflammation to cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

慢性炎症環境に大腸陰窩が適応するためのAIDによる変異獲得メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

潰瘍性大腸炎における炎症誘導大腸癌発症に関連する特異的因子の機能解析と臨床応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epidemiological study of the relationship between atherosclerosis and intestinal inflammation and food

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of CHI3L1-mediated p53 suppression in the early stage of colon cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of inflammation-induced colon cancer development mechanism by adhesive invasive Escherichia coli (AIEC) related molecule

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ptotective effect of xanthine derivatives on colitis-associated dysplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Recently updated role of Chitinase ３-like １ on various cell types as a major influencer of chronic inflammation.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Landscape of inflammatory bowel disease in Singapore2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chitinase 3-like 1, Carcinoembryonic Antigen-related Cell Adhesion Molecule 6, and Ectopic Claudin-2 in the Carcinogenic Processes of Ulcerative Colitis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chitinase 3-like 1, Carcinoembryonic antigen-related cell adhesion molecule 6, and ectopic Claudin-2 in the carcinogenic processes of ulcerative colitis.2022

Author(s)

Journal Title

Data Source

[Journal Article] Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-192021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Review of Selected IBD Biomarkers: From Animal Models to Bedside2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis2021

Author(s)

Journal Title

DOI

Data Source

Mizoguchi Emiko 溝口恵美子

[Presentation] Role of putative cyclin-binding　domain　in　nuclear　localization　sequence　of　Chitinase　3-like　1　in　colonic　epithelial　cells2021