Negishi Naoko 根岸尚子

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NEGISHI Naoko 根岸尚子

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Researcher Number	40784294
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 助手
Affiliation (based on the past Project Information) *help	2024: 順天堂大学, 大学院医学研究科, 助手 2021 – 2022: 順天堂大学, 大学院医学研究科, 特任助教 2019 – 2020: 順天堂大学, 医学(系)研究科(研究院), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator T細胞 / 免疫寛容 / TIGIT / 移植 / 免疫チェックポイント分子 / IL-2 / 制御性T細胞 / Treg / STAT5 / IL-2/IL-2R … More / 免疫チェックポイント / Treg細胞 / CD155 / IL-2/IL-2レセプター / 抗原特異的免疫寛容 / トレランスの伝承 Less

The molecular mechanism of TIGIT-CD155 signaling in transmitting immunological tolerance to naive T cellsPrincipal Investigator
- Principal Investigator
  
  根岸尚子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Juntendo University
Investigation of molecular mechanism for serial transmission of tolerant status of T cells -Role of CD155 transducing signaling mediated by TIGIT-Principal Investigator
- Principal Investigator
  
  NEGISHI Naoko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Juntendo University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Anti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model2022
- Author(s)
  Zhu J, Inomata T, Nakamura M, Fujimoto K, Akasaki Y, Fujio K, Yanagawa A, Uchida K, Sung J, Negishi N, Nagino K, Okumura Y, Miura M, Shokirova H, Kuwahara M, Hirosawa K, Midorikawa-Inomata A, Eguchi A, Huang T, Yagita H, Habu S, Okumura K, Murakami A.
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 4853-4853
- DOI
  10.1038/s41598-022-08949-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09810, KAKENHI-PROJECT-19K18041
[Journal Article] Ex Vivo?Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice2021
- Author(s)
  Zhu Jun、Inomata Takenori、Fujimoto Keiichi、Uchida Koichiro、Fujio Kenta、Nagino Ken、Miura Maria、Negishi Naoko、Okumura Yuichi、Akasaki Yasutsugu、Hirosawa Kunihiko、Kuwahara Mizu、Eguchi Atsuko、Shokirova Hurramhon、Yanagawa Ai、Midorikawa-Inomata Akie、Murakami Akira
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 62 Issue: 7 Pages: 3-3
- DOI
  10.1167/iovs.62.7.3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18041, KAKENHI-PROJECT-21K16884, KAKENHI-PROJECT-20K22985, KAKENHI-PROJECT-20K09810
[Journal Article] Novel immunotherapeutic effects of topically administered ripasudil (K-115) on corneal allograft survival2020
- Author(s)
  Inomata Takenori、Fujimoto Keiichi、Okumura Yuichi、Zhu Jun、Fujio Kenta、Shokirova Hurramhon、Miura Maria、Okano Mikiko、Funaki Toshinari、Sung Jaemyoung、Negishi Naoko、Murakami Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19817-19817
- DOI
  10.1038/s41598-020-76882-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09810, KAKENHI-PROJECT-19K18041
[Journal Article] CD300f is a potential therapeutic target for the treatment of food allergy2019
- Author(s)
  Uchida Shino、Izawa Kumi、Ando Tomoaki、Yamada Hiromichi、Uchida Koichiro、Negishi Naoko、Kaitani Ayako、Maehara Akie、Nagamine Masakazu、Kamei Anna、Takamori Ayako、Maeda Keiko、Nakano Nobuhiro、Shimizu Toshiaki、Ogawa Hideoki、Okumura Ko、Nagahara Akihito、Watanabe Sumio、Kitaura Jiro
- Journal Title
  
  Allergy
  
  Volume: 75 Issue: 2 Pages: 471-474
- DOI
  10.1111/all.14034
- NAID
  40022209298
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10253, KAKENHI-PROJECT-18K08416, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-19K17895, KAKENHI-PROJECT-17H04217, KAKENHI-PROJECT-19K18041
[Presentation] Suppressive function in TIGIT+ iTreg cells is serially transmitted into newstimulated T cells via CD 155 signaling with recall of TIGIT expression.2022
- Author(s)
  根岸尚子, 内田浩一郎, 渋谷和子, 北浦次郎, 奥村康、垣生園子
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18041
[Presentation] TIGIT plays a critical role as a ligand for inducing CD155 mediated suppressor potential to be tolerance2021
- Author(s)
  根岸尚子、佐藤健人、渋谷和子、内田浩一郎、亀谷美恵、北浦次郎、奥村康、垣生園子
- Organizer
  第 50 回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18041
[Presentation] 免疫寛容を伝達する分子機構ー CD4+ T 細胞の抑制機能の伝承はTIGIT→CD155経路を介するー2019
- Author(s)
  根岸尚子, 垣生園子
- Organizer
  第29回 Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-19K18041
[Presentation] “Infectious suppression”の機序ーTIGIT->CD155シグナルを介して伝承されるT細胞の抑制機能は生体内でも誘導されるー2019
- Author(s)
  根岸尚子
- Organizer
  第34回自己免疫研究会
- Data Source
  KAKENHI-PROJECT-19K18041
[Presentation] Tolerant status of T cells via TIGIT-CD155 axis is transferable in vivo2019
- Author(s)
  根岸尚子、佐藤健人、金丸由美、渋谷和子、内田浩一郎、亀谷美恵、奥村康、垣生園子
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18041

1. 安藤智暁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 猪俣武範

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 中村正裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Negishi Naoko 根岸 尚子

NEGISHI Naoko 根岸 尚子

Research Projects

Research Products

Co-Researchers

The molecular mechanism of TIGIT-CD155 signaling in transmitting immunological tolerance to naive T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of molecular mechanism for serial transmission of tolerant status of T cells -Role of CD155 transducing signaling mediated by TIGIT-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Anti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ex Vivo?Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel immunotherapeutic effects of topically administered ripasudil (K-115) on corneal allograft survival2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD300f is a potential therapeutic target for the treatment of food allergy2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Suppressive function in TIGIT+ iTreg cells is serially transmitted into newstimulated T cells via CD 155 signaling with recall of TIGIT expression.2022

Author(s)

Organizer

Data Source

[Presentation] TIGIT plays a critical role as a ligand for inducing CD155 mediated suppressor potential to be tolerance2021

Author(s)

Organizer

Data Source

[Presentation] 免疫寛容を伝達する分子機構 ー CD4+ T 細胞の抑制機能の伝承はTIGIT→CD155経路を介するー2019

Author(s)

Organizer

Data Source

[Presentation] “Infectious suppression”の機序ーTIGIT->CD155シグナルを介して伝承されるT細胞の抑制機能は生体内でも誘導されるー2019

Author(s)

Organizer

Data Source

[Presentation] Tolerant status of T cells via TIGIT-CD155 axis is transferable in vivo2019

Author(s)

Organizer

Data Source

Negishi Naoko 根岸尚子

NEGISHI Naoko 根岸尚子

[Presentation] 免疫寛容を伝達する分子機構ー CD4+ T 細胞の抑制機能の伝承はTIGIT→CD155経路を介するー2019