MAKINO Kosyo 牧野宏章

… Alternative Names

Makino Kosho 牧野宏章

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Researcher Number	40784369
Other IDs
Affiliation (Current)	2025: 武蔵野大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 武蔵野大学, 薬学部, 助教 2019 – 2021: 東京理科大学, 薬学部薬学科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator 天然物合成 / 自発的カルシウム振動 / 神経 / alanense / 生理活性物質 / 不斉誘起反応 / 動的速度論的光学分割法 / スルホキシド / 光ラセミ化 / 安定性 … More / 医薬品 / アルケン / 光 / 光増感剤 / キラルスルホキシド / ラセミ化 / 光化学 … More Except Principal Investigator 炎症シグナリング / 生体内分子置換反応 / ドラッグデザイン / がん / タンパク質の立体構造 / 脂質ナノ粒子 / 癌微小環境 / 血中滞留性素子 / ＭＲＩ / ＮＭＲ / システイン Less

NMR・MRIを用いた新規作用機序の抗炎症化合物の開発
- Principal Investigator
  
  吉永壮佐
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kumamoto University
神経細胞の自発的カルシウム振動に着目した神経疾患治療に対する天然物化合物の活用Principal Investigator
- Principal Investigator
  
  牧野宏章
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Musashino University
機能性システインの化学修飾に基づく新規作用機序の炎症制御化合物の開発
- Principal Investigator
  
  寺沢宏明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kumamoto University
Control of tumor microenvironment by lipid nanoparticles modified with novel blood-circulating molecules
- Principal Investigator
  
  濱進
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Musashino University
Control of sulfoxide stereochemistry using visible lights and application to the medicinal drugs.Principal Investigator
- Principal Investigator
  
  Makino Kosho
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Musashino University
  Tokyo University of Science

All 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B2 Catalyst Under Visible Light Irradiation2022
- Author(s)
 Suga Mayuko、Makino Kosho、Tabata Hidetsugu、Oshitari Tetsuta、Natsugari Hideaki、Takahashi Hideyo
- Journal Title
 
 Pharmaceutical Research
 
 Volume: 39 Issue: 3 Pages: 577
- DOI
 10.1007/s11095-022-03203-3
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K16454, KAKENHI-PROJECT-22K06537
[Journal Article] Rapid Photoracemization of Chiral Alkyl Aryl Sulfoxides2021
- Author(s)
  Makino Kosho、Tozawa Kumi、Tanaka Yuki、Inagaki Akiko、Tabata Hidetsugu、Oshitari Tetsuta、Natsugari Hideaki、Takahashi Hideyo
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 86 Issue: 23 Pages: 17249
- DOI
  10.1021/acs.joc.1c02320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16454
[Journal Article] Atropisomeric Properties of N-Acyl/ N-Sulfonyl 5 H-Dibenzo[ b, d]azepin-7(6 H)-ones2021
- Author(s)
  Namba Takuya、Hotta Mayuno、Tabata Hidetsugu、Makino Kosho、Oshitari Tetsuta、Natsugari Hideaki、Takahashi Hideyo
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 86 Issue: 11 Pages: 7563
- DOI
  10.1021/acs.joc.1c00594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06980, KAKENHI-PROJECT-19K16454
[Journal Article] Conformational Preference of 2′-Fluoro-Substituted Acetophenone Derivatives Revealed by Through-Space 1H-19F and 13C-19F Spin-Spin Couplings2021
- Author(s)
 Otake Chinatsu、Namba Takuya、Tabata Hidetsugu、Makino Kosho、Hirano Kiriko、Oshitari Tetsuta、Natsugari Hideaki、Kusumi Takenori、Takahashi Hideyo
- Journal Title
 
 The Journal of Organic Chemistry
 
 Volume: 86 Issue: 6 Pages: 4638
- DOI
 10.1021/acs.joc.1c00051
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K16454
[Journal Article] Transcriptional induction of cystathionine γ-lyase, a reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured vascular endothelial cells2020
- Author(s)
  Tomoya Fujie, Akane Takahashi, Musubu Takahashi, Takato Hara, Asuka Soyama, Kosho Makino, Hideyo Takahashi, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka and Toshiyuki Kaji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6053-6053
- DOI
  10.3390/ijms21176053
- NAID
  120007163377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K16454, KAKENHI-PROJECT-18H05293
[Journal Article] Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors2020
- Author(s)
  Tanuma Sei-ichi、Katsuragi Kiyotaka、Oyama Takahiro、Yoshimori Atsushi、Shibasaki Yuri、Asawa Yasunobu、Yamazaki Hiroaki、Makino Kosho、Okazawa Miwa、Ogino Yoko、Sakamoto Yoshimi、Nomura Miyuki、Sato Akira、Abe Hideaki、Nakamura Hiroyuki、Takahashi Hideyo、Tanuma Nobuhiro、Uchiumi Fumiaki
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 16 Pages: 3633-3633
- DOI
  10.3390/molecules25163633
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16454, KAKENHI-PROJECT-18H02685
[Journal Article] Conformational properties and M1 antimuscarinic activity of 4-substituted pirenzepine/telenzepine analogues2020
- Author(s)
 Takahashi Hideyo、Kanase Yuki、Makino Kosho、Yoshinaga Takashi、Tabata Hidetsugu、Oshitari Tetsuta、Natsugari Hideaki
- Journal Title
 
 HETEROCYCLES
 
 Volume: 101 Issue: 1 Pages: 273
- DOI
 10.3987/com-19-s(f)23
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K16454
[Journal Article] Elucidation of the conformational properties of 3-pyridinoyl indoles as intermediates of cannabimimetics2019
- Author(s)
  Takahashi Hideyo、Araki Koji、Tabata Hidetsugu、Makino Kosho、Ujiie Ryohei、Sezaki Kohei、Nakayama Hiroshi、Oshitari Tetsuta、Natsugari Hideaki
- Journal Title
  
  HETEROCYCLES
  
  Volume: 98 Issue: 10 Pages: 1423
- DOI
  10.3987/com-19-14161
- NAID
  40022091342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06980, KAKENHI-PROJECT-19K16454
[Journal Article] Chemoselective Demethylation of Methoxypyridine2019
- Author(s)
  Kosho, Makino; Yumi, Hasegawa; Takahide, Inoue; Koji, Araki; Hidetsugu, Tabata; Tetsuta, Oshitari; Kiyomi, Ito; Hideaki, Natsugari; Hideyo, Takahashi;
- Journal Title
  
  SYNLETT
  
  Volume: 30 Issue: 8 Pages: 951
- DOI
  10.1055/s-0037-1612427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16454
[Patent] エナンチオマー調製システム及びエナンチオマー調製システム用光照射装置2021
- Inventor(s)
  高橋秀依、牧野宏章、金丸国夫
- Industrial Property Rights Holder
  高橋秀依、牧野宏章、金丸国夫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-032905
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K16454
[Patent] スルホキシド化合物のエナンチオマー調製方法及び調製システム2020
- Inventor(s)
  高橋秀依, 牧野宏章, 顧嘉悦, 田中優希
- Industrial Property Rights Holder
  高橋秀依, 牧野宏章, 顧嘉悦, 田中優希
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K16454
[Presentation] 光ラセミ化を利用したキラルスルホキシドの収束的供給法の確立2021
- Author(s)
  田中優希、牧野宏章、田畑英嗣、忍足鉄太、夏苅英昭、高橋秀依
- Organizer
  第１４１年会日本薬学年会
- Data Source
  KAKENHI-PROJECT-19K16454
[Presentation] スルホキシドの高速光ラセミ化反応を利用したキラルなスルホキシドの供給法の開発2021
- Author(s)
  牧野宏章、斗沢紅美、田中優希、稲垣昭子、田畑英嗣、忍足鉄太、夏苅英昭、高橋秀依
- Organizer
  第47回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16454
[Presentation] S-オキシド誘導体の光によるラセミ化現象とその応用2019
- Author(s)
  牧野宏章1、顧嘉悦1、木村翼2、田畑英嗣2、忍足鉄太2、夏苅英昭3、高橋秀依1
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16454

1. 吉永壮佐 (00448515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 寺島裕也 (90538729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 寺沢宏明 (10300956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松島綱治 (50222427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 澤智裕 (30284756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 高橋秀依 (10266348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 濱進 (60438041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鍛冶利幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MAKINO Kosyo 牧野 宏章

Makino Kosho 牧野 宏章

Research Projects

Research Products

Co-Researchers

NMR・MRIを用いた新規作用機序の抗炎症化合物の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経細胞の自発的カルシウム振動に着目した神経疾患治療に対する天然物化合物の活用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

機能性システインの化学修飾に基づく新規作用機序の炎症制御化合物の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of tumor microenvironment by lipid nanoparticles modified with novel blood-circulating molecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of sulfoxide stereochemistry using visible lights and application to the medicinal drugs.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B<sub>2</sub> Catalyst Under Visible Light Irradiation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid Photoracemization of Chiral Alkyl Aryl Sulfoxides2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Atropisomeric Properties of N-Acyl/ N-Sulfonyl 5 H-Dibenzo[ b, d]azepin-7(6 H)-ones2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conformational Preference of 2′-Fluoro-Substituted Acetophenone Derivatives Revealed by Through-Space <sup>1</sup>H-<sup>19</sup>F and <sup>13</sup>C-<sup>19</sup>F Spin-Spin Couplings2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional induction of cystathionine γ-lyase, a reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured vascular endothelial cells2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conformational properties and M<sub>1</sub> antimuscarinic activity of 4-substituted pirenzepine/telenzepine analogues2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elucidation of the conformational properties of 3-pyridinoyl indoles as intermediates of cannabimimetics2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Chemoselective Demethylation of Methoxypyridine2019

Author(s)

Journal Title

MAKINO Kosyo 牧野宏章

Makino Kosho 牧野宏章