Suzuki Koya 鈴木浩也

Researcher Number	40788551
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 非常勤助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 博士研究員 2021: 順天堂大学, 大学院医学研究科, 非常勤助教 2019 – 2020: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 低分子化合物 / NMD / テロメア転写酵素 / ナンセンス依存mRNA分解機構 / Hippo経路 / TERT / SMG6 / LATS2 / 合成致死 / 悪性中皮腫 … More Except Principal Investigator … More 高齢者 / 白血病幹細胞 / バイオマーカー / Single-Cell ATAC-Seq / DNAメチル基転移酵素 / 難治性白血病 / RNA-seq / single cell ATAC-seq / single cell RNA-seq / DNAメチル化 / BCL-2 / RNA-seq解析 / メチル化アレイ解析 / BCL-2阻害剤 / 骨髄微小環境 / シングルセル解析 / インターフェロン誘導遺伝子 / DNAメチル化阻害剤 / BCL-2 阻害剤 / 急性骨髄性白血病 Less

SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesotheliomaPrincipal Investigator
- Principal Investigator
  
  Suzuki Koya
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
Leukemic stem cell signatures to identify therapeutic targets of elderly acute myeloid leukemia
- Principal Investigator
  
  田部陽子
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Juntendo University

All 2022 2021 2020 2019 Other

All Journal Article Presentation Patent Other

[Journal Article] Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML2022
- Author(s)
  Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, Ikeo K, Ruvolo V, Zhang W, Mak PY, Kaczkowski B, Harada H, Katayama K, Sugimoto Y, Myslinski J, Hato T, Miida T, Konopleva M, Hayashizaki Y, Carter BZ, Tabe Y, Andreeff M
- Journal Title
  
  Translational Oncology
  
  Volume: 18 Pages: 101354-101354
- DOI
  10.1016/j.tranon.2022.101354
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-21K06585, KAKENHI-PROJECT-21K07226, KAKENHI-PROJECT-21K20913, KAKENHI-PROJECT-19KK0221, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-23K24235
[Journal Article] Damage and Cell Survival in Hippo Pathway Kinase LATS2-Inactivated Malignant Mesothelioma2022
- Author(s)
  Suzuki K,Tange M,Yamagishi R, Hanada H, Mukai S, Sato T, Tanaka T, Akashi T, Kadomatsu K, Maeda T, Miida T, Takeuchi T, Murakami H, Sekido Y, Murakami-Tonami Y
- Journal Title
  
  Cell Death Discovery
  
  Volume: 8 Issue: 1 Pages: 446-446
- DOI
  10.1038/s41420-022-01232-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06863, KAKENHI-PROJECT-21K18251, KAKENHI-PROJECT-19K16809, KAKENHI-PROJECT-21K20854
[Journal Article] Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.2021
- Author(s)
  Saito K, Zhang Q, Yang H, Yamatani K, Ai T, Ruvolo V, Baran N, Cai T, Ma H, Jacamo R, Kuruvilla V, Imoto J, Kinjo S, Ikeo K, Moriya K, Suzuki K, Miida T, Kim YM, Vellano CP, Andreeff M, Marszalek JR, Tabe Y, Konopleva M.
- Journal Title
  
  Blood Adv
  
  Volume: 5 Issue: 20 Pages: 4233-4255
- DOI
  10.1182/bloodadvances.2020003661
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07424, KAKENHI-PROJECT-19K16809, KAKENHI-PROJECT-19KK0221
[Journal Article] Synthesis and Biological Evaluation of NMDI-14 Derivatives as anti-Mesothelioma Agents2020
- Author(s)
  Hong Nhung Nguyen, Koya Suzuki, Yasuaki Kimura, Takatsugu Hirokawa, Yuko Murakami-Tonami, and Hiroshi Abe
- Journal Title
  
  Heterocycles
  
  Volume: 100 Issue: 2 Pages: 253-266
- DOI
  10.3987/com-19-14191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06979, KAKENHI-PROJECT-19K16809, KAKENHI-PUBLICLY-18H04398
[Journal Article] Preβ1-HDL metabolism is delayed in patients with chronic kidney disease not on hemodialysis.2020
- Author(s)
  Kotoko Yamatani, Satoshi Hirayama, Utako Seino, Akiko Hirayama, Atsushi Hori, Koya Suzuki, Mayumi Idei, Masaki Kitahara, Takashi Miida
- Journal Title
  
  J Clin Lipidol
  
  Volume: 14 Issue: 5 Pages: 730-739
- DOI
  10.1016/j.jacl.2020.07.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07477, KAKENHI-PROJECT-19K07874, KAKENHI-PROJECT-19K16809
[Patent] LATS2変異疾患のための分子標的及びその利用2019
- Inventor(s)
  村上優子、鈴木浩也、三井田孝、関戸好孝、向井里美、山岸良多
- Industrial Property Rights Holder
  村上優子、鈴木浩也、三井田孝、関戸好孝、向井里美、山岸良多
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] 悪性中皮腫原因遺伝子の変異細胞特異的に細胞増殖を抑制する化合物候補の探索2022
- Author(s)
  丹下将希,鈴木浩也,竹内稔紘,西谷優佑,三井田孝,村上浩士,関戸好孝,早川一郎,佐藤綾人,村上(渡並)優子.
- Organizer
  第95回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] LATS2変異悪性中皮腫においてSMG6はDNA損傷及び細胞増殖を制御する.2022
- Author(s)
  鈴木浩也,山岸良多,向井智美,紅朋浩,竹内一郎,門松健治,前田徹,村上浩士,三井田孝,関戸好孝,村上(渡並)優子.
- Organizer
  第95回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] LATS2 変異悪性中皮腫に対する新規合成致死遺伝子を標的とした抗腫瘍活性の包括的評価2021
- Author(s)
  鈴木浩也、向井智美、三井田孝、関戸好孝、村上 (渡並)優子
- Organizer
  第25回がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] 悪性中皮腫において BAP1 変異と合成致死表現型を示す遺伝子の機能解析2021
- Author(s)
  小林輝星、鈴木浩也、三井田孝、関戸好孝、村上（渡並）優子
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] 肺がん細胞株 A549 における FGF13 の発現とシスプラチン耐性の関係2021
- Author(s)
  大石紫緒里、松本展希、鈴木浩也、岡田知子、今村亨、村上（渡並）優子
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] BAP1 変異悪性中皮腫細胞株における CHK2 の役割2021
- Author(s)
  丹下将希、鈴木浩也、三井田孝、関戸好孝、村上（渡並）優子
- Organizer
  第25回がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] LATS2変異を有した悪性中皮腫に対する合成致死誘導機構の検討2020
- Author(s)
  鈴木浩也、山岸良多、向井智美、田部陽子、三井田孝、村上浩士、関戸好孝、村上(渡並) 優子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] 低分子化合物ライブラリーを用いた悪性中皮腫の新規合成致死標的の探索2020
- Author(s)
  村上（渡並）優子、鈴木浩也、三井田孝、阿部洋、関戸好孝
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] The direct interactions with bone marrow microenvronment confer resistance to the inhibition of Oxidative Phosphorylation in AML2020
- Author(s)
  Yoko Tabe, Kaori Saitoh, Kotoko Yamatani, Haeun Yang, Rodrigo Jacamo, Helen Ma, Vivian Ruvolo3, Qi Zhang, Vinitha Kuruvilla, Natalia Baran, Junichi Imoto, Kazuho Ikeo5, Kaori Moriya, Yuko Murakami-Tonami, Koya Suzuki, Takashi Miida, Michael Andreeff, Christopher P. Vellano, Joseph R. Marszalek, Marina Konopleva
- Organizer
  American Society of Hematology Annual Meeting
- Data Source
  KAKENHI-PROJECT-19KK0221
[Presentation] タイトジャンクションの変化はマウス胃腫瘍形成へのシグナルカスケードを活性化する2020
- Author(s)
  田村淳、鈴木浩也、田中啓雄、矢野智樹、仙谷和弘、大島正伸、安井弥、月田早智子
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] LATS2変異を有した悪性中皮腫におけるSMG6発現抑制による合成致死誘導機構の検討2020
- Author(s)
  鈴木浩也、山岸良多、向井智美、田部陽子、三井田孝、関戸好孝、村上(渡並) 優子
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] 悪性中皮腫原因遺伝子変異に対する新規合成致死標的の探索2020
- Author(s)
  村上（渡並）優子、佐藤綾人、鈴木浩也、三井田孝、村上浩士、関戸好孝
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] LATS2変異を有した悪性腫瘍における合成致死を基盤とした細胞死誘導機構の検討2019
- Author(s)
  2)鈴木浩也、山岸良多、向井智美、田部陽子、三井田孝、村上浩士、関戸好孝、村上(渡並)優子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H.pylori Infection2019
- Author(s)
  Koya Suzuki
- Organizer
  nternational Conference on Clinical andPharmaceutical Microbiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16809
[Presentation] LATS2変異を有した悪性腫瘍における合成致死を基盤とした細胞死誘導機構の検討2019
- Author(s)
  鈴木浩也、向井智美、田部陽子、三井田孝、関戸好孝、村上(渡並)優子
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16809
[]
[]

1. 田部陽子 (70306968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 藍智彦 (00570128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 早津徳人 (80543058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岡崎康司 (80280733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. アブドラハサーウネ (20964802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. HIRAYAMA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 三井田孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 村上優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Suzuki Koya 鈴木 浩也

Research Projects

Research Products

Co-Researchers

SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesotheliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Leukemic stem cell signatures to identify therapeutic targets of elderly acute myeloid leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Damage and Cell Survival in Hippo Pathway Kinase LATS2-Inactivated Malignant Mesothelioma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Biological Evaluation of NMDI-14 Derivatives as anti-Mesothelioma Agents2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preβ1-HDL metabolism is delayed in patients with chronic kidney disease not on hemodialysis.2020

Author(s)

Journal Title

DOI

Data Source

[Patent] LATS2変異疾患のための分子標的及びその利用2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 悪性中皮腫原因遺伝子の変異細胞特異的に細胞増殖を抑制する化合物候補の探索2022

Author(s)

Organizer

Data Source

[Presentation] LATS2変異悪性中皮腫においてSMG6はDNA損傷及び細胞増殖を制御する.2022

Author(s)

Organizer

Data Source

[Presentation] LATS2 変異悪性中皮腫に対する新規合成致死遺伝子を標的とした抗腫瘍活性の包括的評価2021

Author(s)

Organizer

Data Source

[Presentation] 悪性中皮腫において BAP1 変異と合成致死表現型を示す遺伝子の機能解析2021

Author(s)

Organizer

Data Source

[Presentation] 肺がん細胞株 A549 における FGF13 の発現とシスプラチン耐性の関係2021

Author(s)

Organizer

Data Source

[Presentation] BAP1 変異悪性中皮腫細胞株における CHK2 の役割2021

Author(s)

Organizer

Data Source

[Presentation] LATS2変異を有した悪性中皮腫に対する合成致死誘導機構の検討2020

Author(s)

Organizer

Data Source

[Presentation] 低分子化合物ライブラリーを用いた悪性中皮腫の新規合成致死標的の探索2020

Author(s)

Organizer

Data Source

[Presentation] The direct interactions with bone marrow microenvronment confer resistance to the inhibition of Oxidative Phosphorylation in AML2020

Suzuki Koya 鈴木浩也