Watanabe Masaaki 渡辺正明

Researcher Number	40789848
Other IDs	https://orcid.org/0000-0001-9487-9420
Affiliation (Current)	2025: 北海道大学, 医学研究院, 特任講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 北海道大学, 医学研究院, 特任講師 2017: 北海道大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator 免疫寛容 / 細胞移植 / 膵島移植 / 幹細胞移植 / 細胞治療 / 移植・再生医療 / 肝細胞移植 Except Principal Investigator ヒト化マウス / 肝移植 / 冷阻血時間 … More / NLRP3 / インフラマソーム / 再発 / 生体ドナー / 脂肪肝 / 非アルコール性脂肪肝炎 / 免疫記憶 / 臓器移植 / TCF-1 / CD3抗体 / マウス心移植 / 免疫寛容 / 記憶T細胞 / 抗HLA抗体 / 慢性拒絶反応 / 原発性硬化性胆管炎 / 肝障害 / 胆汁うっ滞性疾患 / 抗ドナーHLA抗体 / ヒト皮膚移植 / 皮膚移植 / 原発性胆汁性胆管炎 Less

膵島移植、細胞移植における免疫寛容誘導を目的とした臨床応用可能な細胞治療法の開発Principal Investigator
- Principal Investigator
  
  渡辺正明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hokkaido University
The effect of inflammasome inhibitor during cold preservation on transplant tolerance induction
- Principal Investigator
  
  財津雅昭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hokkaido University
ヒト化マウスによる非アルコール性脂肪肝炎発症、肝移植後再発の免疫学的機序解明
- Principal Investigator
  
  後藤了一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hokkaido University
膵島移植における免疫寛容誘導を目的とした細胞治療法の開発Principal Investigator
- Principal Investigator
  
  渡辺正明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hokkaido University
The development of treatment and analysis for the mechanism on cholestatic liver disease by using humanized mouse model
- Principal Investigator
  
  Goto Ryoichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hokkaido University
Development of novel approach targeting on the specific molecule of memory lymphocytes
- Principal Investigator
  
  Ueki Shinya
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Hokkaido University
Development of a new strategy for long-term graft acceptance after pancreatic islet transplantationPrincipal Investigator
- Principal Investigator
  
  Watanabe Masaaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 膵島移植の進歩と現状2019
- Author(s)
  渡辺正明
- Total Pages
  35
- Publisher
  日本糖尿病協会
- Data Source
  KAKENHI-PROJECT-17K10501
[Journal Article] TCF1highPD-1+Ly108+CD8+ T Cells Are Associated with Graft Preservation in Sensitized Mice Treated with Non?Fc Receptor?Binding CD3 Antibodies2024
- Author(s)
  Ota Takuji、Goto Ryoichi、Harada Takuya、Forgioni Agustina、Kanazawa Ryo、Ganchiku Yoshikazu、Kawamura Norio、Watanabe Masaaki、Fukai Moto、Shimamura Tsuyoshi、Taketomi Akinobu
- Journal Title
  
  ImmunoHorizons
  
  Volume: 8 Issue: 4 Pages: 295-306
- DOI
  10.4049/immunohorizons.2300117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22646
[Journal Article] Long‐term risk of a fatty liver in liver donors2023
- Author(s)
  Goto Ryoichi、Kawamura Norio、Watanabe Masaaki、Ganchiku Yoshikazu、Nagatsu Akihisa、Okada Kazufumi、Ito Yoichi M.、Kamiyama Toshiya、Shimamura Tsuyoshi、Taketomi Akinobu
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 7 Issue: 4 Pages: 645-653
- DOI
  10.1002/ags3.12658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08687
[Journal Article] The impact of preformed donor‐specific antibodies in living donor liver transplantation according to graft volume2022
- Author(s)
  Goto Ryoichi、Ito Makoto、Kawamura Norio、Watanabe Masaaki、Ganchiku Yoshikazu、Kamiyama Toshiya、Shimamura Tsuyoshi、Taketomi Akinobu
- Journal Title
  
  Immunity, Inflammation and Disease
  
  Volume: 10 Issue: 3
- DOI
  10.1002/iid3.586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09064
[Journal Article] Novel immunological approach to asses donor reactivity of transplant recipients using a humanized mouse model2020
- Author(s)
  Fukasaku Yasutomo、Goto Ryoichi、Ganchiku Yoshikazu、Emoto Shin、Zaitsu Masaaki、Watanabe Masaaki、Kawamura Norio、Fukai Moto、Shimamura Tsuyoshi、Taketomi Akinobu
- Journal Title
  
  Human Immunology
  
  Volume: 81 Issue: 7 Pages: 342-353
- DOI
  10.1016/j.humimm.2020.04.007
- NAID
  120007099140
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09064, KAKENHI-PROJECT-20K08974, KAKENHI-PROJECT-18H02873, KAKENHI-PROJECT-20H03737
[Presentation] Immunomodulatory cell induction for tolerance state after pancreatic islet transplantation2023
- Author(s)
  Forgioni A, Watanabe M, Goto R, Harada T, Ota T, Taketomi A
- Organizer
  第123回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08635
[Presentation] Immunomodulatory Cell Inductionfor Tolerance after Pancreatic Islet Transplantation2023
- Author(s)
  Forgioni A, Watanabe M, Goto R, Harada T, Ota T, Taketomi A
- Organizer
  第50回膵・膵島移植学会
- Data Source
  KAKENHI-PROJECT-21K08635
[Presentation] Serostatus following live-attenuated vaccination for children after living donor liver transplantation2023
- Author(s)
  Masaaki Watanabe, Tsuyoshi Shimamura, Yasuyuki Koshizuka, Ryoichi Goto, Norio Kawamura, Yoshikazu Ganchiku, Takuji Ota, and Akinobu Taketomi
- Organizer
  American Transplant Congress,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08635
[Presentation] Liver transplantation for hepatocellular carcinoma: Japan criteria and current status2023
- Author(s)
  Masaaki Watanabe, Akinobu Taketomi, and Tsuyoshi Shimamura
- Organizer
  JDDW 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08635
[Presentation] Operational tolerance induced by a donor antigen specific immunomodulatory cell therapy in living donor liver transplantation2022
- Author(s)
  Masaaki Watanabe
- Organizer
  Asian Transplant Week 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08635
[Presentation] 当院におけるNASH肝硬変肝移植後NASH, NAFLD再発の検討2022
- Author(s)
  後藤了一,嶋村剛, 巖築慶一, 川村典生, 渡辺正明, 武冨紹信
- Organizer
  第108回日本消化器病学会定期学術集会
- Data Source
  KAKENHI-PROJECT-22K08687
[Presentation] アロ感作マウスを用いた異所性アロ心移植に対する抗CD3F(ab')2の効果の検討2022
- Author(s)
  太田拓児、後藤了一、原田拓弥、Agustina Forgioni、巖築慶一、川村典生、渡辺正明、深井原、嶋村剛、武冨紹信
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K22646
[Presentation] 臓器移植における免疫寛容2022
- Author(s)
  渡辺正明
- Organizer
  日本移植学会総会2022
- Invited
- Data Source
  KAKENHI-PROJECT-21K08635
[Presentation] 当院におけるNASHに対する肝移植後再発の検討2022
- Author(s)
  後藤了一,嶋村剛, 巖築慶一, 川村典生, 渡辺正明, 武冨紹信
- Organizer
  第40回日本肝移植学会
- Data Source
  KAKENHI-PROJECT-22K08687
[Presentation] 生体肝移植ドナー長期経過後脂肪肝発生リスク因子の検討2022
- Author(s)
  後藤了一, 太田拓児, 川村典生, 渡辺正明, 嶋村剛, 武冨紹信
- Organizer
  第58回日本移植学会
- Data Source
  KAKENHI-PROJECT-22K08687
[Presentation] The Efficacy of Delayed Fc-nonbinding Anti-CD3 Antibody Treatment in Sensitized Allogeneic Mouse Heart Transplantation2021
- Author(s)
  Ota T, Goto R, Kanazawa R, Shibuya K, Ganchiku Y, Kawamura N, Zaitsu M, Watanabe M, Fukai M, Shimamura T, Taketomi A
- Organizer
  American Transplant Congress
- Data Source
  KAKENHI-PROJECT-19K22646
[Presentation] Operational tolerance with a donor antigen specific immunomodulatory cell therapy in living donor liver transplantation2019
- Author(s)
  Masaaki Watanabe, Ryoichi Goto, Kenichiro Yamashita, Satoru Todo, Tsuyoshi Shimamura, and Akinobu Taketomi
- Organizer
  Asian-Pacific Hepato-Pancreato-Biliary Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10501
[Presentation] 当院における膵島移植の情報提供からみた臨床応用拡大への課題2019
- Author(s)
  渡辺正明　腰塚靖之　後藤了一　川村典生　財津雅昭　山本真由美　柏浦愛美　太田稔　嶋村剛　武冨紹信
- Organizer
  日本膵膵島移植研究会
- Data Source
  KAKENHI-PROJECT-17K10501
[Presentation] The efficacy of spheroidal hepatocytes for hepatocyte transplantation2019
- Author(s)
  K. Shibuya, M. Watanabe, Y. Ganchiku, R. Kanazawa, Y. Koshizuka, M. Zaitsu, R. Goto, A. Taketomi
- Organizer
  American Transplant Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10501
[Presentation] 生体肝移植におけるde novoドナー特異的HLA抗体高力価症例のグラフト線維化の危険因子2019
- Author(s)
  後藤了一、財津雅昭、川村典生、渡辺正明、神山俊哉、嶋村剛、武冨紹信
- Organizer
  第74回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-19K09064
[Presentation] The role of preformed donor-specific antibodies in living donor liver transplantation2019
- Author(s)
  後藤了一、伊藤誠、財津雅昭、川村典生、渡辺正明、神山俊哉、嶋村剛、武冨紹信.
- Organizer
  第31回日本肝胆膵外科学会
- Data Source
  KAKENHI-PROJECT-19K09064
[Presentation] 膵島移植の成績改善に向けて　我々のこれまでの取り組みとこれからの展開2019
- Author(s)
  渡辺正明腰塚靖之渋谷一陽蔵谷大輔小倉正臣吉田雅旭火華後藤了一財津雅昭川村典生嶋村剛山下健一郎藤堂省武冨紹信
- Organizer
  日本外科学会定期学術総会
- Data Source
  KAKENHI-PROJECT-17K10501
[Presentation] 当院における原発性胆汁性胆管炎に対する生体・脳死肝移植症例の特徴2019
- Author(s)
  後藤了一、巖築慶一、川村典生、渡辺正明、神山俊哉、嶋村剛、武冨紹信
- Organizer
  第55回日本移植学会
- Data Source
  KAKENHI-PROJECT-19K09064

1. Goto Ryoichi (10645287)

# of Collaborated Projects: 7 results

# of Collaborated Products: 19 results
2. 財津雅昭 (20768981)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. Ueki Shinya (30837258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山下健一郎 (00399940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 巖築慶一 (20895560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Watanabe Masaaki 渡辺 正明

Research Projects

Research Products

Co-Researchers

膵島移植、細胞移植における免疫寛容誘導を目的とした臨床応用可能な細胞治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of inflammasome inhibitor during cold preservation on transplant tolerance induction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト化マウスによる非アルコール性脂肪肝炎発症、肝移植後再発の免疫学的機序解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵島移植における免疫寛容誘導を目的とした細胞治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of treatment and analysis for the mechanism on cholestatic liver disease by using humanized mouse model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel approach targeting on the specific molecule of memory lymphocytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new strategy for long-term graft acceptance after pancreatic islet transplantationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 膵島移植の進歩と現状2019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] TCF1highPD-1+Ly108+CD8+ T Cells Are Associated with Graft Preservation in Sensitized Mice Treated with Non?Fc Receptor?Binding CD3 Antibodies2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long‐term risk of a fatty liver in liver donors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of preformed donor‐specific antibodies in living donor liver transplantation according to graft volume2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel immunological approach to asses donor reactivity of transplant recipients using a humanized mouse model2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Immunomodulatory cell induction for tolerance state after pancreatic islet transplantation2023

Author(s)

Organizer

Data Source

[Presentation] Immunomodulatory Cell Inductionfor Tolerance after Pancreatic Islet Transplantation2023

Author(s)

Organizer

Data Source

Watanabe Masaaki 渡辺正明

[Presentation] 膵島移植の成績改善に向けて　我々のこれまでの取り組みとこれからの展開2019