Shibata Tomohiro 柴田智博

Researcher Number	40795986
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 横浜市立大学, 医学部, 助教 2023: 信州大学, 医学部, 特任講師 2020 – 2022: 信州大学, 医学部, 日本学術振興会特別研究員 2019: 九州大学, 薬学研究院, 特任助教 2017 – 2018: 九州大学, 薬学研究院, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 47040:Pharmacology-related / Medical pharmacy
Keywords	Principal Investigator 乳癌 / YB-1 / ER / TNBC / 内分泌治療薬 / エストロゲン受容体 / トリプルネガティブ乳癌 / 内分泌治療耐性 / 腫瘍血管成熟化 / ANP … More / 間質細胞 / ERα / がん間質細胞 / マクロファージ / 免疫細胞 / HER2 Less

Tumor vascular normalization by atrial natriuretic peptidesPrincipal Investigator
- Principal Investigator
  
  柴田智博
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Yokohama City University
Development of therapeutic drug against TNBC based on mechanism of ER inductionPrincipal Investigator
- Principal Investigator
  
  Shibata Tomohiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shinshu University
Development of the novel therapeutic strategy against TNBC based on mechanism of ER inductionPrincipal Investigator
- Principal Investigator
  
  Shibata Tomohiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shinshu University
Targeting YB-1 activation pathway overcomes progressive breast cancerPrincipal Investigator
- Principal Investigator
  
  Shibata Tomohiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shinshu University
  Kyushu University
Novel breast cancer therapeutic strategy by targeting Y-box binding protein 1 activation pathwaysPrincipal Investigator
- Principal Investigator
  
  Shibata Tomohiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Distinct RBC alloantibody responses in type 1 interferon-dependent and -independent lupus mouse models2024
- Author(s)
  Paul Kausik、Hernandez-Armengol Rosario、Lee June Young、Chang Che-Yu、Shibata Tomohiro、Yamashita Michifumi、Jefferies Caroline、Gibb David R.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1-10
- DOI
  10.3389/fimmu.2023.1304086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276
[Journal Article] Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ2024
- Author(s)
  Shibata Tomohiro、Bhat Shabir A.、Cao DuoYao、Saito Suguru、Bernstein Ellen A.、Nishi Erika、Medenilla Juliet D.、Wang Erica T.、Chan Jessica L.、Pisarska Margareta D.、Tourtellotte Warren G.、Giani Jorge F.、Bernstein Kenneth E.、Khan Zakir
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 1 Pages: 105486-105486
- DOI
  10.1016/j.jbc.2023.105486
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276
[Journal Article] Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis2023
- Author(s)
  Cao DuoYao、Saito Suguru、Xu LiMin、Fan Wei、Li Xiaomo、Ahmed Faizan、Jovanovic Predrag、Shibata Tomohiro、Che Mingtian、Bernstein Ellen A.、Gianni Jorge、Divakaruni Ajit S.、Okwan-Duodu Derick、Khan Zakir、Riera Celine E.、Chen Fanfan、Bernstein Kenneth E.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1-8
- DOI
  10.3389/fimmu.2023.1278383
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276
[Journal Article] Diverse biological functions of the renin‐angiotensin system2023
- Author(s)
  Rao Adithi、Bhat Shabir A.、Shibata Tomohiro、Giani Jorge F.、Rader Florian、Bernstein Kenneth E.、Khan Zakir
- Journal Title
  
  Medicinal Research Reviews
  
  Volume: 44 Issue: 2 Pages: 587-605
- DOI
  10.1002/med.21996
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276
[Journal Article] Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism2023
- Author(s)
  Cao DuoYao、Khan Zakir、Li Xiaomo、Saito Suguru、Bernstein Ellen A、Victor Aaron R、Ahmed Faizan、Hoshi Aoi O、Veiras Luciana C、Shibata Tomohiro、Che Mingtian、Cai Lei、Yamashita Michifumi、Temel Ryan E、Giani Jorge F、Luthringer Daniel J、Divakaruni Ajit S、Okwan-Duodu Derick、Bernstein Kenneth E
- Journal Title
  
  Cardiovascular Research
  
  Volume: 119 Issue: 9 Pages: 1825-1841
- DOI
  10.1093/cvr/cvad082
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276
[Journal Article] The non-cardiovascular actions of ACE2022
- Author(s)
  Cao DuoYao、Veiras Luciana、Ahmed Faizan、Shibata Tomohiro、Bernstein Ellen A.、Okwan-Duodu Derick、Giani Jorge F.、Khan Zakir、Bernstein Kenneth E.
- Journal Title
  
  Peptides
  
  Volume: 152 Pages: 170769-170769
- DOI
  10.1016/j.peptides.2022.170769
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276, KAKENHI-PROJECT-20J00393
[Journal Article] miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC2022
- Author(s)
  Shibata Tomohiro、Cao Duo-Yao、Dar Tahir B.、Ahmed Faizan、Bhat Shabir A.、Veiras Luciana C.、Bernstein Ellen A.、Khan Abdul Arif、Chaum Manita、Shiao Stephen L.、Tourtellotte Warren G.、Giani Jorge F.、Bernstein Kenneth E.、Cui Xiaojiang、Vail Eric、Khan Zakir
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 21 Pages: 5273-5273
- DOI
  10.3390/cancers14215273
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276, KAKENHI-PROJECT-20J00393
[Journal Article] Epidermal growth factor receptor activation confers resistance to lenvatinib in thyroid cancer cells2022
- Author(s)
  Ohno Koichi、Shibata Tomohiro、Ito Ken‐ichi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 9 Pages: 3193-3210
- DOI
  10.1111/cas.15465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276, KAKENHI-PROJECT-20J00393, KAKENHI-PROJECT-20K08953
[Journal Article] Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-192022
- Author(s)
  Bhat Shabir A.、Shibata Tomohiro、Leong Matthew、Plummer Jasmine、Vail Eric、Khan Zakir
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 10 Pages: 2182-2182
- DOI
  10.3390/v14102182
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276, KAKENHI-PROJECT-20J00393
[Journal Article] The mechanisms involved in the resistance of estrogen receptor-positive breast cancer cells to palbociclib are multiple and change over time2021
- Author(s)
  Ono Mayu、Oba Takaaki、Shibata Tomohiro、Ito Ken-ichi
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 147 Issue: 11 Pages: 3211-3224
- DOI
  10.1007/s00432-021-03722-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20J00393, KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21KK0276
[Journal Article] Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer2021
- Author(s)
  Watanabe Takayuki、Oba Takaaki、Tanimoto Keiji、Shibata Tomohiro、Kamijo Shinobu、Ito Ken-ichi
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 6 Pages: e0252822-e0252822
- DOI
  10.1371/journal.pone.0252822
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J00393, KAKENHI-PROJECT-21K06641, KAKENHI-PROJECT-21K10073, KAKENHI-PROJECT-21KK0276
[Journal Article] NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells2020
- Author(s)
  Watari Kosuke、Shibata Tomohiro、Fujita Hideaki、Shinoda Ai、Murakami Yuichi、Abe Hideyuki、Kawahara Akihiko、Ito Hiroshi、Akiba Jun、Yoshida Shigeo、Kuwano Michihiko、Ono Mayumi
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 107-107
- DOI
  10.1038/s42003-020-0829-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07169, KAKENHI-PROJECT-18K09450, KAKENHI-PROJECT-19K16449
[Journal Article] Selective Covalent Targeting of Mutated EGFR(T790M) with Chloroacetamide-Pyrimidines2020
- Author(s)
  Mami Sato, Hirkazu Fuchida, Naoya Shindo, Keiko Kuwata, Keisuke Tokunaga, Guo Xiao-Lin, Ryo Inamori, Keitaro Horokawa, Kosuke Watari, Tomohiro Shibata, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Mayumi Ono, Akio Ojida
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 11 Issue: 6 Pages: 1137-1144
- DOI
  10.1021/acsmedchemlett.9b00574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02854, KAKENHI-PROJECT-20J00393, KAKENHI-PROJECT-19K16449, KAKENHI-PLANNED-17H06349
[Journal Article] Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma2020
- Author(s)
  Ito Hiroshi、Watari Kosuke、Shibata Tomohiro、Miyamoto Tomofumi、Murakami Yuichi、Nakahara Yukiko、Izumi Hiroto、Wakimoto Hiroaki、Kuwano Michihiko、Abe Tatsuya、Ono Mayumi
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 2 Pages: 234-248
- DOI
  10.1158/0008-5472.can-19-0438
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16449, KAKENHI-PROJECT-19K16804, KAKENHI-PROJECT-17K07169, KAKENHI-PROJECT-18K08998
[Journal Article] Targeting Phosphorylation of Y-Box Binding Protein YBX1 by TAS0612 and Everolimus in Overcoming Antiestrogen Resistance2020
- Author(s)
  Shibata Tomohiro、Watari Kosuke、Kawahara Akihiko、Sudo Tomoya、Hattori Satoshi、Murakami Yuichi、Izumi Hiroto、Itou Junji、Toi Masakazu、Akiba Jun、Akagi Yoshito、Tanaka Maki、Kuwano Michihiko、Ono Mayumi
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 19 Issue: 3 Pages: 882-894
- DOI
  10.1158/1535-7163.mct-19-0690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16449
[Journal Article] Oncogenic Y‐box binding protein‐1 as an effective therapeutic target in drug‐resistant cancer2019
- Author(s)
  Kuwano Michihiko、Shibata Tomohiro、Watari Kosuke、Ono Mayumi
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 5 Pages: 1536-1543
- DOI
  10.1111/cas.14006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15508
[Journal Article] Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer2018
- Author(s)
  Shibata Tomohiro、Tokunaga Eriko、Hattori Satoshi、Watari Kosuke、Murakami Yuichi、Yamashita Nami、Oki Eiji、Itou Junji、Toi Masakazu、Maehara Yoshihiko、Kuwano Michihiko、Ono Mayumi
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 98 Pages: 37216-37228
- DOI
  10.18632/oncotarget.26469
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15508, KAKENHI-PROJECT-15H05792
[Presentation] The activated YB-1 as an effective therapeutic target in human progressive cancers2019
- Author(s)
  Tomohiro Shibata, Kosuke Watari, Michihiko Kuwano, Mayumi Ono
- Organizer
  COLD SHOCK PROTEIN SYMPOSIUM 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16449
[Presentation] Overcoming endocrine therapy resistance by drugs targeting YBX1 activation pathway in breast cancer2019
- Author(s)
  Tomohiro Shibata, Kosuke Watari, Akihiko Kawahara, Tomoya Sudo, Yuichi Murakami, Eriko Tokunaga, Nami Yamashita, Eiji Oki, Yoshihiko Maehara, Jun Akiba, Yoshito Akagi, Maki Tanaka, Michihiko Kuwano, Mayumi Ono.
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15508
[Presentation] Y-box binding protein YB-1活性化シグナルを標的とした乳癌の内分泌治療耐性の新規克服治療2019
- Author(s)
  柴田智博、渡公佑、河原明彦、和泉弘人、村上雄一、桑野信彦、小野眞弓
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16449
[Presentation] Y-box binding protein YB-1リン酸化シグナル阻害薬による乳癌の内分泌治療耐性克服2019
- Author(s)
  柴田智博、渡公佑、河原明彦、主藤朝也、村上雄一、和泉弘人、秋葉純、桑野信彦、小野眞弓
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16449
[Presentation] Y-box binding protein YB-1活性化を標的とした乳癌の内分泌治療耐性の克服治療2018
- Author(s)
  柴田智博, 渡公佑, 河原明彦, 和泉弘人, 村上雄一, 桑野信彦, 小野眞弓
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15508
[Presentation] Y-box binding protein YB-1活性化抑制による乳癌の内分泌治療耐性克服2018
- Author(s)
  柴田智博、渡公佑、河原明彦、主藤朝也、村上雄一、和泉弘人、秋葉純、桑野信彦、小野眞弓
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15508
[Presentation] Y-box binding protein YB-1は乳癌のERαとHER2発現を制御して内分泌治療耐性2017
- Author(s)
  柴田智博、渡公佑、河原明彦、主藤朝也、村上雄一、和泉弘人、伊藤研一、秋葉純、桑野信彦、小野眞弓
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15508
[Presentation] ERαとHER2発現のY-box binding protein-1 (YB-1)による制御と乳癌内分泌治療耐性2017
- Author(s)
  柴田智博、渡公佑、河原明彦、和泉弘人、村上雄一、桑野信彦、小野眞弓
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15508

1. 徳留健 (00443474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 渡公佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 進藤直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shibata Tomohiro 柴田 智博

Research Projects

Research Products

Co-Researchers

Tumor vascular normalization by atrial natriuretic peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic drug against TNBC based on mechanism of ER inductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the novel therapeutic strategy against TNBC based on mechanism of ER inductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting YB-1 activation pathway overcomes progressive breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel breast cancer therapeutic strategy by targeting Y-box binding protein 1 activation pathwaysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Distinct RBC alloantibody responses in type 1 interferon-dependent and -independent lupus mouse models2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diverse biological functions of the renin‐angiotensin system2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The non-cardiovascular actions of ACE2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epidermal growth factor receptor activation confers resistance to lenvatinib in thyroid cancer cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-192022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The mechanisms involved in the resistance of estrogen receptor-positive breast cancer cells to palbociclib are multiple and change over time2021

Shibata Tomohiro 柴田智博