Abe Taiki 阿部太紀

Researcher Number	40810594
Other IDs	https://orcid.org/0000-0001-6580-3734
Affiliation (Current)	2025: 静岡県立大学, 薬学部, 客員共同研究員
Affiliation (based on the past Project Information) *help	2024: 東北大学, 医学(系)研究科(研究院), 助教 2018 – 2024: 東北大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator RAS / RASopathies / MAPKシグナル伝達経路 / プロテオスタシス / MAPK / LZTR1 / Noonan症候群 / 難病 / がん / がん原遺伝子 … More / 発生異常 / がん遺伝子産物 / 発がん抑制 / AlphaFold2 / 上皮間葉転換(EMT) / COPII / SEC31A / KLHL12 / CUL3 / BTB-Kelchファミリー / プロテアソーム / ユビキチン修飾 / ヌーナン症候群 / がん遺伝子 / RAS/MAPKシグナル伝達経路 / 先天奇形症候群 / 遺伝学 / ポリユビキチン修飾 / RAS/MAPK / ユビキチン・プロテアソーム経路 … More Except Principal Investigator がん原遺伝子 / RASがん原遺伝子 / シグナル伝達 / 先天異常 / 低身長 / モデル生物 / ヌーナン症候群 / 先天性疾患 / 変異 / リンパ管 / リンパ管異形成 / がん遺伝子 / リンパ管内皮 / リンパ管発生 / 先天性心疾患 / マウス / ゼブラフィッシュ / 橈尺骨癒合 / 血小板減少症 / bone marrow failure / radioulnar synostosis / SMAD6 / 骨髄不全 / 橈尺骨癒合症 / MECOM / EVI1 Less

RASopathiesの病態解明を目的とした非古典型RASの包括的分子プロファイリングPrincipal Investigator
- Principal Investigator
  
  阿部太紀
- Project Period (FY)
  2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
Elucidation of novel mechanisms of RASopathies
- Principal Investigator
  
  青木洋子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Pathogenesis and development of gene therapy for rare genetic disorders focusing on proteostasis of the RAS-GTPasePrincipal Investigator
- Principal Investigator
  
  阿部太紀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
Lymphatic abnormalities in RAS related disorders
- Principal Investigator
  
  Aoki Yoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
Elucidation of molecular mechanisms of RAS degradation and understanding of LZTR1-related molecular networksPrincipal Investigator
- Principal Investigator
  
  Abe Taiki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
Pathophysiological analysis of radioulnar synostosis with or without amegakaryocytic thrombocytopenia
- Principal Investigator
  
  Niihori Tetsuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
New mechanisms and pathogenesis of Noonan syndrome adn related disorders
- Principal Investigator
  
  Aoki Yoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Elucidation of pathogenesis of Noonan syndrome by novel causative gene LZTR1Principal Investigator
- Principal Investigator
  
  Abe Taiki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] LZTR1 deficiency exerts high metastatic potential by enhancing sensitivity to EMT induction and controlling KLHL12-mediated collagen secretion2023
- Author(s)
  Abe Taiki、Kanno Shin-ichiro、Niihori Tetsuya、Terao Miho、Takada Shuji、Aoki Yoko
- Journal Title
  
  Cell Death and Disease
  
  Volume: 14 Issue: 8 Pages: 556-556
- DOI
  10.1038/s41419-023-06072-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06230
[Journal Article] Severe neuroglycopenicsymptoms due to nonketotic hypoglycemia in children withcardio-facio-cutaneous syndrome.2022
- Author(s)
  Shiohama, T., Fujii, K., Kosaki, R.,Watanabe, Y., Uchida, T., Hagiwara, S., Kinoshita, K., Sugita, K.,Aoki, Y., Shimojo, N.
- Journal Title
  
  American Journal of Medical Genetics
  
  Volume: 18A Issue: 12 Pages: 3505-3509
- DOI
  10.1002/ajmg.a.62926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21746, KAKENHI-PROJECT-20H03636
[Journal Article] Phenotypic heterogeneity in individuals with MECOM variants in 2 families.2022
- Author(s)
  Niihori T, Tanoshima R, Sasahara Y, Sato A, Irie M, Saito-Nanjo Y, Funayama R, Shirota M, Abe T, Okuyama Y, Ishii N, Nakayama K, Kure S, Imaizumi M, Aoki Y.
- Journal Title
  
  Blood Adv.
  
  Volume: - Issue: 18 Pages: 5257-5261
- DOI
  10.1182/bloodadvances.2020003812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03637, KAKENHI-PROJECT-21H02458, KAKENHI-PROJECT-19K08855, KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766
[Journal Article] Duplications in the G3 domain or switch II region in HRAS identified in patients with Costello syndrome2022
- Author(s)
  Nagai K, Niihori T, Okamoto N, Kondo A, Suga K, Ohhira T, Hayabuchi Y, Homma Y, Nakagawa R, Ifuku T, Abe T, Mizuguchi T, Matsumoto N, Aoki Y.
- Journal Title
  
  Hum Mutat
  
  Volume: 43 Issue: 1 Pages: 3-15
- DOI
  10.1002/humu.24287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08279, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-20H03636
[Journal Article] Costello syndrome model mice with a HRAS G12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.2020
- Author(s)
  Katata Y, Inoue S-I, Asao A, Kobayashi S, Terui H, Inoue-Shibui A, Abe T, Niihori T, Aiba S, Ishii N, Kure S, Aoki Y
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 8 Pages: 617-617
- DOI
  10.1038/s41419-020-02845-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20H03637, KAKENHI-PROJECT-18K19504
[Journal Article] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019
- Author(s)
  Abe Taiki、Umeki Ikumi、Kanno Shin-ichiro、Inoue Shin-ichi、Niihori Tetsuya、Aoki Yoko
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 27 Issue: 3 Pages: 1023-1035
- DOI
  10.1038/s41418-019-0395-5
- NAID
  130007898368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223
[Journal Article] Germline-Activating RRAS2 Mutations Cause Noonan Syndrome2019
- Author(s)
  Niihori Tetsuya、Nagai Koki、Fujita Atsushi、Ohashi Hirofumi、Okamoto Nobuhiko、Okada Satoshi、Harada Atsuko、Kihara Hirotaka、Arbogast Thomas、Funayama Ryo、Shirota Matsuyuki、Nakayama Keiko、Abe Taiki、Inoue Shin-ichi、Tsai I-Chun、Matsumoto Naomichi、Davis Erica E.、Katsanis Nicholas、Aoki Yoko
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 104 Issue: 6 Pages: 1233-1240
- DOI
  10.1016/j.ajhg.2019.04.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0228, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-17K10045, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223
[Journal Article] Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes2018
- Author(s)
  Umeki Ikumi、Niihori Tetsuya、Abe Taiki、Kanno Shin-ichiro、Okamoto Nobuhiko、Mizuno Seiji、Kurosawa Kenji、Nagasaki Keisuke、Yoshida Makoto、Ohashi Hirofumi、Inoue Shin-ichi、Matsubara Yoichi、Fujiwara Ikuma、Kure Shigeo、Aoki Yoko
- Journal Title
  
  Human Genetics
  
  Volume: 138 Issue: 1 Pages: 21-35
- DOI
  10.1007/s00439-018-1951-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223, KAKENHI-PROJECT-15KK0293
[Presentation] RASプロテオスタシス破綻に伴うが発がん促進機構の解明2024
- Author(s)
  阿部太紀、菅野新一郎、新堀哲也、寺尾美穂、高田修治、青木洋子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06230
[Presentation] LZTR1欠損はEMT誘導とKLHL12依存的なコラーゲン分泌を制御することで腫瘍増殖と腫瘍転移を促進する2023
- Author(s)
  阿部太紀、菅野新一郎、新堀哲也、寺尾美穂、高田修治、青木洋子
- Organizer
  第96回日本生化学会
- Data Source
  KAKENHI-PROJECT-23K06230
[Presentation] Somatic RASopathies: リンパ管腫症・Gorham病の原因検索2022
- Author(s)
  青木洋子、野澤明史、阿部太紀、新堀哲也、小関道夫
- Organizer
  第29回日本遺伝子診療学会大会
- Data Source
  KAKENHI-PROJECT-20H03636
[Presentation] Somatic RASopathies: リンパ管腫症・Gorham病の原因検索2022
- Author(s)
  青木洋子、野澤明史、阿部太紀、新堀哲也、小関道夫
- Organizer
  第29回日本遺伝子診療学会大会
- Data Source
  KAKENHI-PROJECT-21K19436
[Presentation] 幅広い臨床症状を呈したMECOM遺伝子変異を同定した2家系2022
- Author(s)
  新堀哲也、田野島玲大、笹原洋二、佐藤篤、入江正寛、南條由佳、舟山亮、城田松之、阿部太紀、奥山祐子、石井直人、中山啓子、呉繁夫、今泉益栄、青木洋子
- Organizer
  第125回小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03637
[Presentation] LZTR1, a substrate adaptor of ubiquitin E3 ligase, regulates RAS proteostasis and tumor growth2022
- Author(s)
  Taiki Abe, Kaho Morisaki, Tetsuya Niihori, Yoko Aoki
- Organizer
  日本人類遺伝学会
- Data Source
  KAKENHI-PROJECT-20H03398
[Presentation] LZTR1機能不全によるがん原遺伝子産物RASの異常蓄積と腫瘍増殖の亢進2022
- Author(s)
  阿部太紀、森崎佳歩、新堀哲也、青木洋子
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-20H03398
[Presentation] LZTR1機能不全によるがん原遺伝子産物RASの異常蓄積と腫瘍増殖の亢進2022
- Author(s)
  阿部太紀, 森崎佳歩, 新堀哲也, 青木洋子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03636
[Presentation] LZTR1, a substrate adaptor of ubiquitin E3 ligase, regulates RAS proteostasis and tumor growth2022
- Author(s)
  阿部太紀、森崎佳歩、新堀哲也、青木洋子
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-21K19436
[Presentation] 骨髄不全や四肢の先天異常を呈するMECOM異常症での表現型に関連しうるメカニズム2022
- Author(s)
  新堀哲也、永井康貴、阿部太紀、青木洋子
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-20H03637
[Presentation] HRAS遺伝子内重複患者の分子学的解析と臨床症状2021
- Author(s)
  永井康貴、新堀哲也、岡本伸彦、近藤朱音、須賀健一、大平智子、早渕康信、　本間友佳子、中川竜二、井福俊允、阿部太紀、水口剛、松本直通、青木洋子
- Organizer
  日本人類遺伝学会第66回大会　第28回日本遺伝子診療学会大会合同開催
- Data Source
  KAKENHI-PROJECT-20H03636
[Presentation] RRAS2の活性化変異はヌーナン症候群を引き起こす2020
- Author(s)
  新堀哲也、永井康貴、藤田京志、大橋博文、岡本伸彦、岡田賢、原田敦子、木原裕貴、Arbogast Thomas, 舟山亮、城田松之、中山啓子、阿部太紀、井上晋一、Tsai I-Chum、松本直通、Davis Erica, Katsanis Nicholas、青木洋子
- Organizer
  第27回遺伝子診療学会大会
- Data Source
  KAKENHI-PROJECT-20H03636
[Presentation] がん原遺伝子産物RASの恒常性維持機構の解明2020
- Author(s)
  阿部太紀, 梅木郁美、菅野新一郎, 井上晋一, 新堀哲也, 青木洋子
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PROJECT-20H03398
[Presentation] RRAS2 の活性化変異はヌーナン症候群を引き起こす2020
- Author(s)
  新堀哲也 , 永井康貴 , 藤田京志 , 大橋博文 , 岡本伸彦 , 岡田賢原田敦子木原裕貴 , Thomas Arbogast, 舟山亮 , 城田松之 , 中山啓子 , 阿部太記 , 井上晋一 , I Chun Tsai, 松本直通 , Erica E. Davis, Nicholas Katsanis, 青木洋子
- Organizer
  第 27 回遺伝子診療学会大会
- Data Source
  KAKENHI-PROJECT-20H03637
[Presentation] 先天奇形症候群原因分子LZTR1による RASファミリー分解経路の解明2020
- Author(s)
  阿部太紀, 梅木郁美、菅野新一郎, 井上晋一, 新堀哲也, 青木洋子
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-20H03398
[Presentation] Noonan症候群類縁疾患の網羅的解析とLZTR1の機能解明2019
- Author(s)
  青木洋子,梅木郁美,阿部太紀,岡本伸彦,水野誠司,黒澤健司,長崎啓祐,吉田真,大橋博文,井上晋一,松原洋一,藤原幾磨,呉繁夫,新堀哲也
- Organizer
  日本遺伝カウンセリング学会
- Data Source
  KAKENHI-PROJECT-18K15657
[Presentation] Noonan症候群原因遺伝子産物LZTR1によるRAS分解促進機構の解明2019
- Author(s)
  阿部太紀、梅木郁美、菅野新一郎、井上晋一、新堀哲也、青木洋子
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K15657
[Presentation] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019
- Author(s)
  Taiki Abe,Ikumi Umeki,Shin-ichiro Kanno,Shin-ichi Inoue,Tetsuya Niihori,Yoko Aoki
- Organizer
  Tohoku University Thematic Forum for Creativity Cancer from Biology to Acceptance
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15657
[Presentation] Noonan症候群の原因遺伝子LZTR1―臨床的特徴と結合タンパクRAF1/PPP1CBの同定2019
- Author(s)
  梅木郁美,新堀哲也,阿部太紀,長崎啓祐,井上晋一,藤原幾磨,呉繁夫,青木洋子
- Organizer
  日本内分泌学会
- Data Source
  KAKENHI-PROJECT-18K15657

1. Niihori Tetsuya (40436134)

# of Collaborated Projects: 6 results

# of Collaborated Products: 17 results
2. Aoki Yoko (80332500)

# of Collaborated Projects: 6 results

# of Collaborated Products: 17 results
3. 吉成浩一 (60343399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HAYABUCHI Yasunobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. OKADA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 杉田克生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 石井直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Abe Taiki 阿部 太紀

Research Projects

Research Products

Co-Researchers

RASopathiesの病態解明を目的とした非古典型RASの包括的分子プロファイリングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel mechanisms of RASopathies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogenesis and development of gene therapy for rare genetic disorders focusing on proteostasis of the RAS-GTPasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lymphatic abnormalities in RAS related disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms of RAS degradation and understanding of LZTR1-related molecular networksPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological analysis of radioulnar synostosis with or without amegakaryocytic thrombocytopenia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New mechanisms and pathogenesis of Noonan syndrome adn related disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis of Noonan syndrome by novel causative gene LZTR1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] LZTR1 deficiency exerts high metastatic potential by enhancing sensitivity to EMT induction and controlling KLHL12-mediated collagen secretion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severe neuroglycopenicsymptoms due to nonketotic hypoglycemia in children withcardio-facio-cutaneous syndrome.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenotypic heterogeneity in individuals with MECOM variants in 2 families.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Duplications in the G3 domain or switch II region in HRAS identified in patients with Costello syndrome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Costello syndrome model mice with a HRAS G12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019

Author(s)

Journal Title

Abe Taiki 阿部太紀

[Presentation] RRAS2 の活性化変異はヌーナン症候群を引き起こす2020