Abe Taiki 阿部太紀

Researcher Number	40810594
Other IDs	https://orcid.org/0000-0001-6580-3734
Affiliation (Current)	2022: 東北大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2021: 東北大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator RASopathies / RAS / Noonan症候群 / ユビキチン・プロテアソーム経路 / LZTR1 / RAS/MAPK / ポリユビキチン修飾 / 遺伝学 / 先天奇形症候群 / RAS/MAPKシグナル伝達経路 … More Except Principal Investigator がん原遺伝子 / シグナル伝達 / 先天異常 / 橈尺骨癒合 / 血小板減少症 / ゼブラフィッシュ / マウス / MECOM / 橈尺骨癒合症 / 骨髄不全 / リンパ管 / 変異 Less

Lymphatic abnormalities in RAS related disorders
- Principal Investigator
  
  青木洋子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
New mechanisms and pathogenesis of Noonan syndrome adn related disorders
- Principal Investigator
  
  青木洋子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
がん遺伝子産物RASに対する分解誘導戦略の構築Principal Investigator
- Principal Investigator
  
  阿部太紀
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
無巨核球性血小板減少症を伴うあるいは伴わない橈尺骨癒合症の病態解析
- Principal Investigator
  
  新堀哲也
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Elucidation of pathogenesis of Noonan syndrome by novel causative gene LZTR1Principal Investigator
- Principal Investigator
  
  Abe Taiki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University

All 2020 2019

All Journal Article Presentation

[Journal Article] Costello syndrome model mice with a Hras G12S mutation are susceptible to develop house dust mite-induced atopic dermatitis2020
- Author(s)
  Katata Y, Inoue S-I, Asao A, Kobayashi S, Terui H, Inoue-Shibui A, Abe T, Niihori T, Aiba S, Ishii N, Kure S, Aoki Y
- Journal Title
  
  Cell Death Dis.
  
  Volume: 11 Pages: 617-617
- DOI
  10.1038/s41419-020-02845-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20H03637, KAKENHI-PROJECT-18K19504
[Journal Article] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019
- Author(s)
  Abe Taiki、Umeki Ikumi、Kanno Shin-ichiro、Inoue Shin-ichi、Niihori Tetsuya、Aoki Yoko
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 27 Pages: 1023-1035
- DOI
  10.1038/s41418-019-0395-5
- NAID
  130007898368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223
[Journal Article] Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.2019
- Author(s)
  Umeki Ikumi、Niihori Tetsuya、Abe Taiki、Kanno Shin-ichiro、Okamoto Nobuhiko、Mizuno Seiji、Kurosawa Kenji、Nagasaki Keisuke、Yoshida Makoto、Ohashi Hirofumi、Inoue Shin-ichi、Matsubara Yoichi、Fujiwara Ikuma、Kure Shigeo、Aoki Yoko
- Journal Title
  
  Hum Genet.
  
  Volume: 138 Pages: 21-35
- DOI
  10.1007/s00439-018-1951-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223, KAKENHI-PROJECT-15KK0293
[Journal Article] Germline-Activating RRAS2 Mutations Cause Noonan Syndrome2019
- Author(s)
  Niihori Tetsuya、Nagai Koki、Fujita Atsushi、Ohashi Hirofumi、Okamoto Nobuhiko、Okada Satoshi、Harada Atsuko、Kihara Hirotaka、Arbogast Thomas、Funayama Ryo、Shirota Matsuyuki、Nakayama Keiko、Abe Taiki、Inoue Shin-ichi、Tsai I-Chun、Matsumoto Naomichi、Davis Erica E.、Katsanis Nicholas、Aoki Yoko
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 104 Pages: 1233-1240
- DOI
  10.1016/j.ajhg.2019.04.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0228, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-17K10045, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223
[Presentation] 先天奇形症候群原因分子LZTR1による RASファミリー分解経路の解明2020
- Author(s)
  阿部太紀, 梅木郁美、菅野新一郎, 井上晋一, 新堀哲也, 青木洋子
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-20H03398
[Presentation] がん原遺伝子産物RASの恒常性維持機構の解明2020
- Author(s)
  阿部太紀, 梅木郁美、菅野新一郎, 井上晋一, 新堀哲也, 青木洋子
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PROJECT-20H03398
[Presentation] RRAS2 の活性化変異はヌーナン症候群を引き起こす2020
- Author(s)
  新堀哲也 , 永井康貴 , 藤田京志 , 大橋博文 , 岡本伸彦 , 岡田賢原田敦子木原裕貴 , Thomas Arbogast, 舟山亮 , 城田松之 , 中山啓子 , 阿部太記 , 井上晋一 , I Chun Tsai, 松本直通 , Erica E. Davis, Nicholas Katsanis, 青木洋子
- Organizer
  第 27 回遺伝子診療学会大会
- Data Source
  KAKENHI-PROJECT-20H03637
[Presentation] Noonan症候群の原因遺伝子LZTR1―臨床的特徴と結合タンパクRAF1/PPP1CBの同定2019
- Author(s)
  梅木郁美,新堀哲也,阿部太紀,長崎啓祐,井上晋一,藤原幾磨,呉繁夫,青木洋子
- Organizer
  日本内分泌学会
- Data Source
  KAKENHI-PROJECT-18K15657
[Presentation] Noonan症候群類縁疾患の網羅的解析とLZTR1の機能解明2019
- Author(s)
  青木洋子,梅木郁美,阿部太紀,岡本伸彦,水野誠司,黒澤健司,長崎啓祐,吉田真,大橋博文,井上晋一,松原洋一,藤原幾磨,呉繁夫,新堀哲也
- Organizer
  日本遺伝カウンセリング学会
- Data Source
  KAKENHI-PROJECT-18K15657
[Presentation] Noonan症候群原因遺伝子産物LZTR1によるRAS分解促進機構の解明2019
- Author(s)
  阿部太紀、梅木郁美、菅野新一郎、井上晋一、新堀哲也、青木洋子
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K15657
[Presentation] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019
- Author(s)
  Taiki Abe,Ikumi Umeki,Shin-ichiro Kanno,Shin-ichi Inoue,Tetsuya Niihori,Yoko Aoki
- Organizer
  Tohoku University Thematic Forum for Creativity Cancer from Biology to Acceptance
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15657

1. 青木洋子 (80332500)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. 新堀哲也 (40436134)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. 吉成浩一 (60343399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OKADA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 石井直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 井上晋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 松原洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中山啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 松本直通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 舟山亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 城田松之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Abe Taiki 阿部 太紀

Research Projects

Research Products

Co-Researchers

Lymphatic abnormalities in RAS related disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New mechanisms and pathogenesis of Noonan syndrome adn related disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん遺伝子産物RASに対する分解誘導戦略の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

無巨核球性血小板減少症を伴うあるいは伴わない橈尺骨癒合症の病態解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis of Noonan syndrome by novel causative gene LZTR1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Costello syndrome model mice with a Hras G12S mutation are susceptible to develop house dust mite-induced atopic dermatitis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Germline-Activating RRAS2 Mutations Cause Noonan Syndrome2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 先天奇形症候群原因分子LZTR1による RASファミリー分解経路の解明2020

Author(s)

Organizer

Data Source

[Presentation] がん原遺伝子産物RASの恒常性維持機構の解明2020

Author(s)

Organizer

Data Source

[Presentation] RRAS2 の活性化変異は ヌーナン症候群を引き起こす2020

Author(s)

Organizer

Data Source

[Presentation] Noonan症候群の原因遺伝子LZTR1―臨床的特徴と結合タンパクRAF1/PPP1CBの同定2019

Author(s)

Organizer

Data Source

[Presentation] Noonan症候群類縁疾患の網羅的解析とLZTR1の機能解明2019

Author(s)

Organizer

Data Source

[Presentation] Noonan症候群原因遺伝子産物LZTR1によるRAS分解促進機構の解明2019

Author(s)

Organizer

Data Source

[Presentation] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019

Abe Taiki 阿部太紀

[Presentation] RRAS2 の活性化変異はヌーナン症候群を引き起こす2020