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Abe Taiki  阿部 太紀

Researcher Number 40810594
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6580-3734
Affiliation (Current) 2022: 東北大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help 2018 – 2021: 東北大学, 医学系研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 47060:Clinical pharmacy-related
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 52:General internal medicine and related fields
Keywords
Principal Investigator
RASopathies / RAS / Noonan症候群 / ユビキチン・プロテアソーム経路 / LZTR1 / RAS/MAPK / ポリユビキチン修飾 / 遺伝学 / 先天奇形症候群 / RAS/MAPKシグナル伝達経路 … More / MAPK / がん遺伝子産物 / 発がん抑制 / 発生異常 / がん原遺伝子 / プロテオスタシス / MAPKシグナル伝達経路 / ユビキチン修飾 / がん … More
Except Principal Investigator
がん原遺伝子 / シグナル伝達 / 先天異常 / 橈尺骨癒合 / 血小板減少症 / ゼブラフィッシュ / マウス / MECOM / 橈尺骨癒合症 / 骨髄不全 / リンパ管 / 変異 Less
  • Research Projects

    (5 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (11 People)
  •  Lymphatic abnormalities in RAS related disorders

    • Principal Investigator
      青木 洋子
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tohoku University
  •  New mechanisms and pathogenesis of Noonan syndrome adn related disorders

    • Principal Investigator
      青木 洋子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Tohoku University
  •  がん遺伝子産物RASに対する分解誘導戦略の構築Principal Investigator

    • Principal Investigator
      阿部 太紀
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Tohoku University
  •  無巨核球性血小板減少症を伴うあるいは伴わない橈尺骨癒合症の病態解析

    • Principal Investigator
      新堀 哲也
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Tohoku University
  •  Elucidation of pathogenesis of Noonan syndrome by novel causative gene LZTR1Principal Investigator

    • Principal Investigator
      Abe Taiki
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Tohoku University

All 2020 2019

All Journal Article Presentation

  • [Journal Article] Costello syndrome model mice with a Hras G12S mutation are susceptible to develop house dust mite-induced atopic dermatitis2020

    • Author(s)
      Katata Y, Inoue S-I, Asao A, Kobayashi S, Terui H, Inoue-Shibui A, Abe T, Niihori T, Aiba S, Ishii N, Kure S, Aoki Y
    • Journal Title

      Cell Death Dis.

      Volume: 11 Pages: 617-617

    • DOI

      10.1038/s41419-020-02845-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20H03637, KAKENHI-PROJECT-18K19504
  • [Journal Article] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019

    • Author(s)
      Abe Taiki、Umeki Ikumi、Kanno Shin-ichiro、Inoue Shin-ichi、Niihori Tetsuya、Aoki Yoko
    • Journal Title

      Cell Death & Differentiation

      Volume: 27 Pages: 1023-1035

    • DOI

      10.1038/s41418-019-0395-5

    • NAID

      130007898368

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223
  • [Journal Article] Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.2019

    • Author(s)
      Umeki Ikumi、Niihori Tetsuya、Abe Taiki、Kanno Shin-ichiro、Okamoto Nobuhiko、Mizuno Seiji、Kurosawa Kenji、Nagasaki Keisuke、Yoshida Makoto、Ohashi Hirofumi、Inoue Shin-ichi、Matsubara Yoichi、Fujiwara Ikuma、Kure Shigeo、Aoki Yoko
    • Journal Title

      Hum Genet.

      Volume: 138 Pages: 21-35

    • DOI

      10.1007/s00439-018-1951-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223, KAKENHI-PROJECT-15KK0293
  • [Journal Article] Germline-Activating RRAS2 Mutations Cause Noonan Syndrome2019

    • Author(s)
      Niihori Tetsuya、Nagai Koki、Fujita Atsushi、Ohashi Hirofumi、Okamoto Nobuhiko、Okada Satoshi、Harada Atsuko、Kihara Hirotaka、Arbogast Thomas、Funayama Ryo、Shirota Matsuyuki、Nakayama Keiko、Abe Taiki、Inoue Shin-ichi、Tsai I-Chun、Matsumoto Naomichi、Davis Erica E.、Katsanis Nicholas、Aoki Yoko
    • Journal Title

      The American Journal of Human Genetics

      Volume: 104 Pages: 1233-1240

    • DOI

      10.1016/j.ajhg.2019.04.014

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0228, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-17K10045, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223
  • [Presentation] 先天奇形症候群原因分子LZTR1による RASファミリー分解経路の解明2020

    • Author(s)
      阿部太紀, 梅木郁美、菅野新一郎, 井上晋一, 新堀哲也, 青木洋子
    • Organizer
      第47回日本毒性学会
    • Data Source
      KAKENHI-PROJECT-20H03398
  • [Presentation] がん原遺伝子産物RASの恒常性維持機構の解明2020

    • Author(s)
      阿部太紀, 梅木郁美、菅野新一郎, 井上晋一, 新堀哲也, 青木洋子
    • Organizer
      第93回日本生化学会
    • Data Source
      KAKENHI-PROJECT-20H03398
  • [Presentation] RRAS2 の活性化変異は ヌーナン症候群を引き起こす2020

    • Author(s)
      新堀哲也 , 永井康貴 , 藤田京志 , 大橋博文 , 岡本伸 彦 , 岡田賢 原田敦子 木原裕貴 , Thomas Arbogast, 舟山亮 , 城田松之 , 中山啓子 , 阿部太記 , 井上晋一 , I Chun Tsai, 松本直通 , Erica E. Davis, Nicholas Katsanis, 青木洋子
    • Organizer
      第 27 回遺伝子診療学会大会
    • Data Source
      KAKENHI-PROJECT-20H03637
  • [Presentation] Noonan症候群の原因遺伝子LZTR1―臨床的特徴と結合タンパクRAF1/PPP1CBの同定2019

    • Author(s)
      梅木郁美,新堀哲也,阿部太紀,長崎啓祐,井上晋一,藤原幾磨,呉繁夫,青木洋子
    • Organizer
      日本内分泌学会
    • Data Source
      KAKENHI-PROJECT-18K15657
  • [Presentation] Noonan症候群類縁疾患の網羅的解析とLZTR1の機能解明2019

    • Author(s)
      青木 洋子,梅木 郁美,阿部 太紀,岡本 伸彦,水野 誠司,黒澤 健司,長崎 啓祐,吉田 真,大橋 博文,井上 晋一,松原 洋一,藤原 幾磨,呉 繁夫,新堀 哲也
    • Organizer
      日本遺伝カウンセリング学会
    • Data Source
      KAKENHI-PROJECT-18K15657
  • [Presentation] Noonan症候群原因遺伝子産物LZTR1によるRAS分解促進機構の解明2019

    • Author(s)
      阿部 太紀、梅木 郁美、菅野 新一郎、井上 晋一、新堀 哲也、青木 洋子
    • Organizer
      第42回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18K15657
  • [Presentation] LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases2019

    • Author(s)
      Taiki Abe,Ikumi Umeki,Shin-ichiro Kanno,Shin-ichi Inoue,Tetsuya Niihori,Yoko Aoki
    • Organizer
      Tohoku University Thematic Forum for Creativity Cancer from Biology to Acceptance
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15657
  • 1.  青木 洋子 (80332500)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 8 results
  • 2.  新堀 哲也 (40436134)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 7 results
  • 3.  吉成 浩一 (60343399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  OKADA Satoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  石井 直人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  井上 晋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  松原 洋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  中山 啓子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  松本 直通
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  舟山 亮
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  城田 松之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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