Kishimoto Shinji 岸本真治

Researcher Number	40814330
Other IDs
Affiliation (Current)	2023: 静岡県立大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2019 – 2022: 静岡県立大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related Except Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields
Keywords	Principal Investigator 酵素反応 / 糸状菌二次代謝 / ヘム / 新規化合物 / 基質選択性 / シクロペナーゼ / 反応機構 / ベンゾフラン / フミマイシン / 構造多様化 … More Except Principal Investigator … More 天然物 / 生合成 / Diels-Alder / 反応メカニズム / Diels-Alderase / 生合成酵素 / Diels-Alder反応 / 天然物生合成 / 酵素反応機構 / [4+2]環化反応 / spiro-carbon / monooxygenase / FAD / epoxidation / 天然物化学 / 酸化反応 / 計算化学 / コリバクチン / 大腸がん / がん化学予防法 Less

Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymes
- Principal Investigator
  
  渡辺賢二
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka
複数の遺伝子領域が関与する糸状菌二次代謝物の構造多様化機構の解明Principal Investigator
- Principal Investigator
  
  岸本真治
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  University of Shizuoka
Mechanism of quinolone formation by hemocyanin-like enzyme cyclopenasePrincipal Investigator
- Principal Investigator
  
  Kishimoto Shinji
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  University of Shizuoka
Integrating Computational and Experimental Approaches for New Paradigms in Molecule Synthesis
- Principal Investigator
  
  Watanabe Kenji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  University of Shizuoka

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Alkaloid Biosynthetic Enzyme Generates Diastereomeric Pair via Two Distinct Mechanisms2022
- Author(s)
  Kishimoto Shinji、Matsubara Yuya、Watanabe Kenji
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Pages: 5485-5493
- DOI
  10.1021/jacs.1c13621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14795
[Journal Article] Isolation of Natural Prodrug-Like Metabolite by Simulating Human Prodrug Activation in Filamentous Fungus2022
- Author(s)
  Okamoto Takumi、Kishimoto Shinji、Watanabe Kenji
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 70 Issue: 4 Pages: 304-308
- DOI
  10.1248/cpb.c21-01099
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14795
[Journal Article] Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels-Alderase2021
- Author(s)
  Sato Michio、Kishimoto Shinji、Yokoyama Mamoru、Jamieson Cooper S.、Narita Kazuto、Maeda Naoya、Hara Kodai、Hashimoto Hiroshi、Tsunematsu Yuta、Houk Kendall N.、Tang Yi、Watanabe Kenji
- Journal Title
  
  Nature Catalysis
  
  Volume: 4 Pages: 223-232
- DOI
  10.1038/s41929-021-00577-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05866, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19KK0150
[Journal Article] Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis2020
- Author(s)
  Matsushita Takuma、Kishimoto Shinji、Hara Kodai、Hashimoto Hiroshi、Watanabe Kenji
- Journal Title
  
  Biochemistry
  
  Volume: 59 Pages: 4787-4792
- DOI
  10.1021/acs.biochem.0c00896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K15757
[Journal Article] Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis2019
- Author(s)
  Kishimoto Shinji、Tsunematsu Yuta、Matsushita Takuma、Hara Kodai、Hashimoto Hiroshi、Tang Yi、Watanabe Kenji
- Journal Title
  
  Biochemistry,
  
  Volume: 58 Pages: 3933-3937
- DOI
  10.1021/acs.biochem.9b00702
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K15757, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840
[Presentation] 糸状菌Aspergillus lentulus由来新規化合物lentopeptin A, Bの生合成機構2022
- Author(s)
  松原有也、岸本真治、渡辺賢二
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] ベンゾフラン骨格を有する糸状菌由来天然物fumimycinおよびlentofuranineの生合成研究2022
- Author(s)
  南歩実、渡邉正悟、岸本真治、渡辺賢二
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] ベンゾフラン骨格を有する糸状菌由来天然物fumimycinおよびlentofuranineの生合成研究2022
- Author(s)
  南歩実、渡邉正悟、岸本真治、渡辺賢二
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] 糸状菌Aspergillus lentulus由来新規化合物lentopeptin A, Bの生合成機構2022
- Author(s)
  松原有也、岸本真治、渡辺賢二
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] 特異なベンゾフラン骨格を有する糸状菌由来天然物の生合成研究2021
- Author(s)
  南歩実、岸本真治、渡辺賢二
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2021
- Author(s)
  佐藤道大、岸本真治、Cooper S. Jamiesonc、原幸大、橋本博、恒松雄太、Houk N. Kendall、Yi Tang、渡辺賢二
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] 糸状菌Aspergillus lentulus由来新規化合物lentopeptin類の単離・構造決定および生合成2021
- Author(s)
  松原有也、岸本真治、渡辺賢二
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K15757
[Presentation] ベンゾフラン骨格を有する糸状菌由来天然物fumimycinおよびlentofuranineの生合成研究2021
- Author(s)
  南歩実、岸本真治、渡辺賢二
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] 糸状菌Aspergillus lentulus由来新規化合物lentopeptin類の単離・構造決定および生合成2021
- Author(s)
  松原有也、岸本真治、渡辺賢二
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K15757
[Presentation] Aspergillus属糸状菌が産生する免疫抑制化合物sphingofungin類の生合成機構の解明2021
- Author(s)
  永井拓実、岸本真治、渡辺賢二
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] 病原性アスペルギルス属真菌が産生する免疫抑制化合物sphingofungin類の生合成機構の解明2021
- Author(s)
  永井拓実、岸本真治、渡辺賢二
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] 二次代謝における酵素反応と非酵素反応2021
- Author(s)
  岸本真治
- Organizer
  日本生薬学会第67回年会　若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] Aspergillus lentulusの生産する新規天然物lentopeptin A,Bの構造決定と生合成解析2021
- Author(s)
  松原有也、岸本真治、渡辺賢二
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] 糸状菌Aspergillus lentulusの生産する新規天然物lentopeptin類の単離、構造決定および生合成2021
- Author(s)
  松原有也、岸本真治、渡辺賢二
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14795
[Presentation] 特異な骨格を有する糸状菌由来天然物fumimycinの生合成研究2021
- Author(s)
  南歩実、岸本真治、渡辺賢二
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K15757
[Presentation] 特異な骨格を有する糸状菌由来天然物fumimycinの生合成研究2021
- Author(s)
  南歩実、岸本真治、渡辺賢二
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K15757
[Presentation] 酵素的Diels-Alder反応におけるジアステレオ選択性の制御機構2020
- Author(s)
  佐藤道大, 岸本真治, Jamieson Cooper, 成田一仁, 前田直哉, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
- Organizer
  日本薬学会第140年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] Diels-Alderase のジアステレオ選択性および生成物阻害回避メカニズムの解明2020
- Author(s)
  佐藤道大, 岸本真治, Cooper S. Jamieson, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
- Organizer
  第62回天然有機化合物討論会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0150
[Presentation] Fumagillin生合成酵素Fma-P450の触媒する多段階酸化反応2020
- Author(s)
  蜂矢志保美、岸本真治、渡辺賢二
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K15757
[Presentation] Diels-Alderase CghA の全容解明2020
- Author(s)
  岸本真治, 佐藤道大, Jamieson Cooper, 横山葵, 成田一仁, 前田直哉, 恒松雄太, 原幸大, 橋本博, Houk Kendall N., 渡辺賢二
- Organizer
  日本農芸化学会2020年度大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0150

1. Watanabe Kenji (50360938)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 佐藤道大 (10629695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 恒松雄太 (30629697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 橋本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 原幸大

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kishimoto Shinji 岸本 真治

Research Projects

Research Products

Co-Researchers

Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

複数の遺伝子領域が関与する糸状菌二次代謝物の構造多様化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of quinolone formation by hemocyanin-like enzyme cyclopenasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrating Computational and Experimental Approaches for New Paradigms in Molecule Synthesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Alkaloid Biosynthetic Enzyme Generates Diastereomeric Pair via Two Distinct Mechanisms2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of Natural Prodrug-Like Metabolite by Simulating Human Prodrug Activation in Filamentous Fungus2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels-Alderase2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 糸状菌Aspergillus lentulus由来新規化合物lentopeptin A, Bの生合成機構2022

Author(s)

Organizer

Data Source

[Presentation] ベンゾフラン骨格を有する糸状菌由来天然物fumimycinおよびlentofuranineの生合成研究2022

Author(s)

Organizer

Data Source

[Presentation] ベンゾフラン骨格を有する糸状菌由来天然物fumimycinおよびlentofuranineの生合成研究2022

Author(s)

Organizer

Data Source

[Presentation] 糸状菌Aspergillus lentulus由来新規化合物lentopeptin A, Bの生合成機構2022

Author(s)

Organizer

Data Source

[Presentation] 特異なベンゾフラン骨格を有する糸状菌由来天然物の生合成研究2021

Author(s)

Organizer

Data Source

[Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2021

Author(s)

Organizer

Data Source

[Presentation] 糸状菌Aspergillus lentulus由来新規化合物lentopeptin類の単離・構造決定および生合成2021

Kishimoto Shinji 岸本真治