Osonoi Sho 遅野井祥

Researcher Number	40816261
Other IDs	https://orcid.org/0000-0003-3018-5862
Affiliation (Current)	2025: 弘前大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2020: 弘前大学, 医学研究科, 客員研究員 2019 – 2020: 弘前大学, 医学研究科, 助手 2018: 弘前大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator AGEs（終末糖化産物） / AGR-RAGEシグナル / インスリンシグナル / 逆行性軸索輸送 / 軸索輸送 / RAGE / 終末糖化産物 / マクロファージ / 糖尿病性神経障害

Development of novel treatment approach for diabetic polyneuropathy targeting RAGE signaling and macrophage polarizationPrincipal Investigator
- Principal Investigator
  
  Osonoi Sho
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hirosaki University

All 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production2020
- Author(s)
  Takahashi Masaya、Miyatsuka Takeshi、Suzuki Luka、Osonoi Sho、Himuro Miwa、Miura Masaki、Katahira Takehiro、Wakabayashi Yuka、Fukunaka Ayako、Nishida Yuya、Fujitani Yoshio、Takeda Satoru、Mizukami Hiroki、Itakura Atsuo、Watada Hirotaka
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 4962-4962
- DOI
  10.1038/s41598-020-61850-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08971, KAKENHI-PROJECT-18K16220, KAKENHI-PROJECT-16K09765
[Journal Article] Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.2020
- Author(s)
  Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 1156-1156
- DOI
  10.1038/s41598-020-57883-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587, KAKENHI-PROJECT-18K16220, KAKENHI-PROJECT-19K09036
[Journal Article] Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation2019
- Author(s)
  Moon Joon Ho、Kim Yeong Gi、Kim Kyuho、Osonoi Sho、Wang Shuang、Saunders Diane C.、Wang Juehu、Yang Katherine、Kim Hyeongseok、Lee Junguee、Jeong Ji-Seon、Banerjee Ronadip R.、Kim Seung K.、Wu Yingjie、Mizukami Hiroki、Powers Alvin C.、German Michael S.、Kim Hail
- Journal Title
  
  Diabetes
  
  Volume: 69 Issue: 2 Pages: 205-214
- DOI
  10.2337/db19-0546
- NAID
  40022434505
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16220
[Journal Article] Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population2019
- Author(s)
  Itabashi Chieko、Mizukami Hiroki、Osonoi Sho、Takahashi Kazuhisa、Kudo Kazuhiro、Wada Kanichiro、Inaba Wataru、Danyang Guo、Uchida Chiaki、Umetsu Satoko、Igawa Akiko、Ogasawara Saori、Ryuzaki Masaki、Komeda Kouji、Ishibashi Yasuyuki、Yagihashi Soroku、Nakaji Shigeyuki
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 10
- DOI
  10.3389/fendo.2019.00651
- Data Source
  KAKENHI-PROJECT-18K16220
[Presentation] 糖尿病性神経障害においてRAGEシグナルはマクロファージを活性化し末梢神経のインスリン抵抗性と逆行性軸索輸送障害を惹起する2021
- Author(s)
  遅野井　祥
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K16220
[Presentation] RAGE-Dependent Macrophage Activation Aggravates Retrograde Axonal Transport via Attenuated Insulin Signaling of Peripheral Nerves in Experimental Diabetic Polyneuropathy2021
- Author(s)
  Sho Osonoi
- Organizer
  American Diabetes Association 81th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16220
[Presentation] マクロファージのRAGEシグナルは糖尿病性神経障害の発症、進展に関与している2020
- Author(s)
  遅野井　祥
- Organizer
  第35回日本糖尿病合併症学会総会
- Data Source
  KAKENHI-PROJECT-18K16220
[Presentation] 糖尿病性神経障害の病期と病態2019
- Author(s)
  遅野井祥，水上浩哉
- Organizer
  第34回日本糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K16220
[Presentation] Deficit of Retrograde Axonal Transportation Was Mediated via Activation of Macrophage RAGE Signaling in Experimental Diabetic Polyneuropathy2019
- Author(s)
  Sho Osonoi, Hiroki Mizukami, Saori Ogasawara, Kazunori Sango, Kazuhisa Takahashi, Yasuhiko Yamamoto, Hiroshi Yamamoto, Soroku Yagihashi
- Organizer
  American Diabetes Association 79th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16220
[Presentation] Suppression of Neuropathy Development in Diabetic Rage-Deficient Mice Is Associated with Absence of M1/M2 Macrophage Skewing in the Sciatic Nerve2018
- Author(s)
  Sho Osonoi, Hiroki Mizukami, Saori Ogasawara, Kazunori Sango, Kazuhisa Takahashi, Yasuhiko Yamamoto, Hiroshi Yamamoto, Soroku Yagihashi
- Organizer
  American Diabetes Association 78th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16220

1. FUKUNAKA Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KUDO Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 袴田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Osonoi Sho 遅野井 祥

Research Projects

Research Products

Co-Researchers

Development of novel treatment approach for diabetic polyneuropathy targeting RAGE signaling and macrophage polarizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 糖尿病性神経障害においてRAGEシグナルはマクロファージを活性化し末梢神経のインスリン抵抗性と逆行性軸索輸送障害 を惹起する2021

Author(s)

Organizer

Data Source

[Presentation] RAGE-Dependent Macrophage Activation Aggravates Retrograde Axonal Transport via Attenuated Insulin Signaling of Peripheral Nerves in Experimental Diabetic Polyneuropathy2021

Author(s)

Organizer

Data Source

[Presentation] マクロファージのRAGEシグナルは糖尿病性神経障害の発症、進展に関与している2020

Author(s)

Organizer

Data Source

[Presentation] 糖尿病性神経障害の病期と病態2019

Author(s)

Organizer

Data Source

[Presentation] Deficit of Retrograde Axonal Transportation Was Mediated via Activation of Macrophage RAGE Signaling in Experimental Diabetic Polyneuropathy2019

Author(s)

Organizer

Data Source

[Presentation] Suppression of Neuropathy Development in Diabetic Rage-Deficient Mice Is Associated with Absence of M1/M2 Macrophage Skewing in the Sciatic Nerve2018

Author(s)

Organizer

Data Source

Osonoi Sho 遅野井祥

[Presentation] 糖尿病性神経障害においてRAGEシグナルはマクロファージを活性化し末梢神経のインスリン抵抗性と逆行性軸索輸送障害を惹起する2021