LOO TZE MUN 羅智文

Researcher Number	40816998
Affiliation (Current)	2025: 公益財団法人がん研究会, がん研究所細胞老化研究部, 特任研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人がん研究会, がん研究所細胞老化研究部, 特任研究員 2023: 東京大学, 大学院薬学系研究科(薬学部), 特任研究員 2018 – 2022: 公益財団法人がん研究会, がん研究所細胞老化プロジェクト, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator 細胞老化 / Ferroptosis / 代謝 / 脂肪肝 / 膵がん / がん関連繊維芽細胞 / 肥満 / エクソソーム / 肥満誘導性肝癌

Mechanism of resistance to ferroptosis by metabolic abnormalities in senescent cellsPrincipal Investigator
- Principal Investigator
  
  羅智文
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Development of Novel Therapies Targeting Senescent Stromal CellsPrincipal Investigator
- Principal Investigator
  
  羅智文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
  Japanese Foundation for Cancer Research
Elucidation of the mechanism of tumorigenesis by the interaction between hepatic stellate cells and hepatocytes in the cancer microenvironment.Principal Investigator
- Principal Investigator
  
  LOO Tze mun
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Japanese Foundation for Cancer Research
The role of senescent cell-derived exosomes in obesity-induced liver cancerPrincipal Investigator
- Principal Investigator
  
  LOO TZE MUN
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Japanese Foundation for Cancer Research

All 2024 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer2021
- Author(s)
  Kenichi Miyata, Yoshinori Imai, Satoshi Hori, Mika Nishio, Tze Mun Loo, Ryo Okada, Liying Yang, Tomoyoshi Nakadai, et. al.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 118 Issue: 35
- DOI
  10.1073/pnas.2025647118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07651, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-20K16163, KAKENHI-PUBLICLY-20H04789, KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-18H04034, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-19H03507
[Journal Article] A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.2020
- Author(s)
  Wakita M, Takahashi A, Sano O, Loo TM, Imai Y, Narukawa M, Iwata H, Matsudaira T, Kawamoto S, Ohtani N, Yoshimori T, Hara E.
- Journal Title
  
  Nat Commun
  
  Volume: 1935 Issue: 1 Pages: 1935-1935
- DOI
  10.1038/s41467-020-15719-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15188, KAKENHI-PROJECT-20K07446, KAKENHI-PROJECT-20K16163, KAKENHI-PROJECT-19K16612, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-18K15065, KAKENHI-PROJECT-19K22571, KAKENHI-PROJECT-20K16156
[Journal Article] SASP因子の機能解析2020
- Author(s)
  羅　智文、菅原　祥、高橋暁子
- Journal Title
  
  老年内科
  
  Volume: ２ Pages: 610-618
- Data Source
  KAKENHI-PROJECT-20K16163
[Journal Article] DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses2020
- Author(s)
  Hitomi Kazuhiro、Okada Ryo、Loo Tze Mun、Miyata Kenichi、Nakamura Asako J.、Takahashi Akiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3720-3720
- DOI
  10.3390/ijms21103720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15073, KAKENHI-PROJECT-20K16163, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-19K22571, KAKENHI-PROJECT-18J10977
[Journal Article] Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer2019
- Author(s)
  Loo Tze Mun、Miyata Kenichi、Tanaka Yoko、Takahashi Akiko
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 304-311
- DOI
  10.1111/cas.14266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-19J00796, KAKENHI-PROJECT-18K15073, KAKENHI-PROJECT-18K15254, KAKENHI-PROJECT-19K22571
[Patent] フェロプトーシス誘導促進剤2024
- Inventor(s)
  高橋　暁子、羅　智文、周　翔宇
- Industrial Property Rights Holder
  公益財団法人がん研究会
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-22K07198
[Presentation] The Analysis of Epigenetic alteration in cellular senescence and cancer : 細胞老化とがんにおけるエピゲノム異常の解析2020
- Author(s)
  高橋　暁子、宮田　憲一、羅　智文、菅原　祥
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16163

1. IMAI Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 河本新平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 中太智義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

LOO TZE MUN 羅 智文

Research Projects

Research Products

Co-Researchers

Mechanism of resistance to ferroptosis by metabolic abnormalities in senescent cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Novel Therapies Targeting Senescent Stromal CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of tumorigenesis by the interaction between hepatic stellate cells and hepatocytes in the cancer microenvironment.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of senescent cell-derived exosomes in obesity-induced liver cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SASP因子の機能解析2020

Author(s)

Journal Title

Data Source

[Journal Article] DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer2019

Author(s)

Journal Title

DOI

Data Source

[Patent] フェロプトーシス誘導促進剤2024

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] The Analysis of Epigenetic alteration in cellular senescence and cancer : 細胞老化とがんにおけるエピゲノム異常の解析2020

Author(s)

Organizer

Data Source

LOO TZE MUN 羅智文